Article
Immunology
Johnna R. Swartz, Angelica F. Carranza, Annchen R. Knodt, Michael R. Irwin, Camelia E. Hostinar
Summary: This study examined the association between peripheral inflammation and amygdala activity and connectivity in adolescents. The results showed that peripheral inflammation was associated with increased amygdala activity to emotional face stimuli and reduced connectivity with occipital and parietal regions. These findings enhance our understanding of the relationship between peripheral inflammation and neural response to emotional faces in adolescents.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Article
Neurosciences
Yimeng Zeng, Fuxiang Tao, Zaixu Cui, Liyun Wu, Jiahua Xu, Wenshan Dong, Chao Liu, Zhi Yang, Shaozheng Qin
Summary: The study identified two distinct dynamic states of intrinsic connectivity patterns based on BLA and CMA using fMRI and K-means clustering in two groups of young healthy individuals. Higher skin conductance level was found in the integration state compared to the segregation state in another dataset. Additionally, machine learning analysis revealed that the time-varying BLA and CMA intrinsic connectivity patterns had higher predictive values for fluctuations in skin conductance level in the integration state.
Article
Neurosciences
Mareike Bayer, Oksana Berhe, Isabel Dziobek, Tom Johnstone
Summary: Recent research suggests that personal relevance of faces can be decoded within 100 ms, with representations starting prior to structural encoding in the visual cortex and involving prefrontal and midline regions. The study highlights the importance of updating models of face perception to include rapid detection of personal relevance in cortical circuitry.
Article
Neurosciences
Kun Il Kim, Wi Hoon Jung, Choong-Wan Woo, Hackjin Kim
Summary: This study investigates the individual variability in context-dependent facial expression estimation and its neural circuitry, providing novel insights into the predictive accounts of affective states.
Article
Clinical Neurology
Yuanshu Chen, Congcong Liu, Fei Xin, Haochen Zou, Yulan Huang, Jinyu Wang, Jing Dai, Zhili Zou, Stefania Ferraro, Keith M. Kendrick, Bo Zhou, Xiaolei Xu, Benjamin Becker
Summary: Major depression (MDD) and generalized anxiety disorder (GAD) are leading causes of disability globally, with marked interpersonal and social impairments. This study used fMRI to investigate whether MDD and GAD share a neural basis during interpersonal processing. Results suggest that the dlPFC is involved in emotion-specific alteration during interpersonal processing, with depression symptom load positively associated with dlPFC reactivity to sad facial expressions. Dysregulated communication between the amygdala and salience network may be specific to depression.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2023)
Article
Clinical Neurology
Laurie Compere, Greg J. Siegle, Emily Riley, Sair Lazzaro, Marlene Strege, Elizabeth Pacoe, Gia Canovali, Scott Barb, Theodore Huppert, Kymberly Young
Summary: By using real-time fMRI neurofeedback training to increase amygdala reactivity during positive memory recall, combined with cognitive behavioral therapy (CBT), depressive symptoms can be decreased and clinical improvement can be sustained in patients with major depressive disorder (MDD). This approach enhances the efficacy of CBT by increasing focus on positive memories and thoughts.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Psychology, Multidisciplinary
Katja Koelkebeck, Jochen Bauer, Thomas Suslow, Patricia Ohrmann
Summary: This case report describes a male patient with right amygdala damage and an ASD. He displayed a non-response of the amygdala to fearful faces and tended to misinterpret fearful expressions. Moreover, a non-reactivity of both amygdalae to emotional facial expressions at an implicit processing level was revealed.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Clinical Neurology
Maria Athanassiou, Alexandre Dumais, Veronica Iammatteo, Luigi De Benedictis, Jean-Luc Dubreucq, Stephane Potvin
Summary: This study revealed the differences in brain activation and connectivity between suicidal schizophrenia patients and non-suicidal patients when processing angry faces. The results suggest that suicidal schizophrenia patients exhibit abnormal brain activation and connectivity when facing anger, highlighting the neglected role of anger in investigating the neural alterations underlying suicidal behaviors in schizophrenia.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Review
Neurosciences
Florence Steiner, Natalia Fernandez, Joris Dietziker, Philipp Stampfli, Erich Seifritz, Anton Rey, Sascha Fruhholz
Summary: Affective speech communication involves decoding of affect information in the cortico-limbic brain systems. Previous research neglected the social nature of affective communication and underestimated its real-time adaptive dynamics. Using real-time neuroimaging, we found that live adaptive affective speech is acoustically distinct, adaptive, and individualized, and makes more efficient use of neural affect decoding mechanisms.
PROGRESS IN NEUROBIOLOGY
(2022)
Article
Psychology, Multidisciplinary
Daniela Ballotta, Riccardo Maramotti, Eleonora Borelli, Fausta Lui, Giuseppe Pagnoni
Summary: This study aimed to identify the neural circuits involved in processing positive and negative valence of facial expressions and words. Using fMRI, the researchers found that early visual cortices were the only areas showing differential response to negative and positive valence, with faces eliciting stronger activations. The effect was mediated by the amygdala for positive faces and the fusiform face area for negative faces, while for words, it was mainly imputable to the primary visual cortex.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Neurosciences
Lea Marie Reisch, Martin Wegrzyn, Malena Mielke, Alexandra Mehlmann, Friedrich G. Woermann, Johanna Kissler, Christian G. Bien
Summary: The study suggests that negative stimuli can lead to increased activation in the visual cortex, possibly due to modulating feedback from the amygdala. There are differential effects of left and right amygdala lesions on the visual cortex, with the right amygdala influencing visual processing more broadly and the left amygdala specifically contributing to emotion processing.
HUMAN BRAIN MAPPING
(2022)
Article
Psychology, Biological
Nicola Sambuco
Summary: Recent findings questioned the replicability of fMRI in affective processing studies, suggesting that poor replicability may be due to a lack of emotional engagement. The current study tested the replicability of emotional enhancement using a large sample size, showing that replicability increased with increasing sample size. Importantly, even with relatively small samples, fMRI replicability during emotional compared to neutral scene viewing was good to excellent, indicating the importance of successful emotional engagement in task-related brain regions.
Article
Behavioral Sciences
Naomi B. Fine, Naama Schwartz, Talma Hendler, Tal Gonen, Gal Sheppes
Summary: This study aimed to investigate the association between emotion regulation ability and preference. By conducting neuroimaging tasks and behavioral selection tasks, the researchers found that a decrease in amygdala activity during implementation was associated with a higher preference for using the distraction strategy.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2022)
Article
Behavioral Sciences
Preston P. Thakral, Ryan Bottary, Elizabeth A. Kensinger
Summary: This study aimed to examine the processing and encoding of multisensory emotional experiences in memory. The results showed that negative emotions were more closely associated with activity in visual and auditory processing regions, and the amplification of negative emotion signals was related to the activity in the hippocampus and amygdala. However, for neutral stimuli, stronger representations in visuo-auditory regions were related to subsequent memory, while they were related to subsequent forgetting of positive and negative stimuli.
Article
Psychology, Developmental
Arianna M. Gard, Andrea M. Maxwell, Daniel S. Shaw, Colter Mitchell, Jeanne Brooks-Gunn, Sara S. McLanahan, Erika E. Forbes, Christopher S. Monk, Luke W. Hyde
Summary: Studies suggest that early childhood neighborhood socioeconomic disadvantage has specific and independent effects on amygdala reactivity. These effects remain even when accounting for family-level adversities, highlighting the importance of neighborhood economic resources in brain development.
DEVELOPMENTAL SCIENCE
(2021)
Article
Psychology, Clinical
Unyoung Chavez-Baldini, Dorien H. Nieman, Amos Keestra, Anja Lok, Roel J. T. Mocking, Pelle de Koning, Valeria V. Krzhizhanovskaya, Claudi L. H. Bockting, Geeske van Rooijen, Dirk J. A. Smit, Arjen L. Sutterland, Karin J. H. Verweij, Guido van Wingen, Johanna T. W. Wigman, Nienke C. Vulink, Damiaan Denys
Summary: Cognitive deficits and psychopathology have independent but related dimensions, and interact in a transdiagnostic manner. Depressive and anxiety symptoms, verbal memory, and visual attention are especially relevant in this network. Future research should take a transdiagnostic approach, focusing on symptom-specific interactions with cognitive domains.
PSYCHOLOGICAL MEDICINE
(2023)
Review
Psychology, Developmental
David Coghill, Tobias Banaschewski, Samuele Cortese, Philip Asherson, Daniel Brandeis, Jan Buitelaar, David Daley, Marina Danckaerts, Ralf W. Dittmann, Manfred Doepfner, Maite Ferrin, Chris Hollis, Martin Holtmann, Santosh Paramala, Edmund Sonuga-Barke, Cesar Soutullo, Hans-Christoph Steinhausen, Saskia van der Oord, Ian C. K. Wong, Alessandro Zuddas, Emily Simonoff
Summary: ADHD is a common neurodevelopmental disorder in children and adolescents, and timely interventions are a priority. However, current research reports and reviews on interventions for ADHD often lack consistency and are difficult to interpret. Clinicians need to consider methodological issues and gaps in the evidence when evaluating treatments for ADHD.
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
(2023)
Article
Psychology, Developmental
Karen Fischer, Jacintha M. Tieskens, Michiel A. J. Luijten, Josjan Zijlmans, Hedy A. van Oers, Rowdy de Groot, Daniel van der Doelen, Hanneke van Ewijk, Helen Klip, Rikkert M. van der Lans, Ronald De Meyer, Malindi van der Mheen, Maud M. van Muilekom, I. Hyun Ruisch, Lorynn Teela, Germie van den Berg, Hilgo Bruining, Rachel van der Rijken, Jan Buitelaar, Pieter J. Hoekstra, Ramon Lindauer, Kim J. Oostrom, Wouter Staal, Robert Vermeiren, Ronald Cornet, Lotte Haverman, Meike Bartels, Tinca J. C. Polderman, Arne Popma
Summary: The study aimed to assess internalizing problems before and during the COVID-19 pandemic. The results showed that internalizing problems were higher during the first peak of the pandemic in the general population, but similar or lower levels were observed over the course of the pandemic. Children in the clinical population reported more internalizing symptoms during the pandemic, while parents did not report differences. These findings indicate negative effects of the pandemic on children and adolescents' internalizing problems in both general and clinical populations.
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
(2023)
Article
Psychology, Clinical
Melissa G. Guineau, N. Ikani, M. Rinck, R. M. Collard, P. van Eijndhoven, I Tendolkar, A. H. Schene, E. S. Becker, J. N. Vrijsen
Summary: This study found that anhedonia severity and depression symptom severity play a central role in the network. The results suggest that anhedonia severity may predict the severity of symptom clusters in MDD, AS, ADHD, and ASD. Additionally, the severity of MDD symptoms may predict the severity of AS and ADHD symptoms. These findings indicate that anhedonia may serve as a common underlying psychopathology feature, predictive of symptom severity in depression, AS, ADHD, and ASD. Therefore, clinicians should be vigilant in screening for anhedonia and depression severity in individuals with anxiety disorders, ADHD, and/or ASD.
PSYCHOLOGICAL MEDICINE
(2023)
Review
Clinical Neurology
S. E. Cohen, J. B. Zantvoord, B. N. Wezenberg, J. G. Daams, C. L. H. Bockting, D. Denys, G. A. van Wingen
Summary: This study assessed the accuracy of electroencephalography (EEG) in predicting treatment response in major depressive disorder. The results showed that EEG can accurately predict the response to antidepressant treatment, but further validation studies are needed to develop a clinical tool for guiding interventions in MDD.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Chemistry, Multidisciplinary
Shu Liu, Abdel Abdellaoui, Karin J. H. Verweij, Guido A. van Wingen
Summary: This study investigates the impact of gene expression on brain structural and functional abnormalities in MDD. By comparing gray matter volume and resting-state functional measures in a Chinese sample, the study finds that whole gene expression is positively associated with structural abnormalities while negatively associated with functional abnormalities. Furthermore, the study identifies individual genes with opposite relationships between expression levels and brain abnormalities in MDD patients. The MDD-related genes are enriched in brain tissue, cortical cells, and biological pathways.
Article
Psychiatry
J. J. E. Rovers, P. Vissers, D. Loef, J. A. van Waarde, J. P. A. J. Verdijk, B. F. P. Broekman, A. C. M. Vergouwen, M. L. Oudega, E. van Exel, R. Coenen, D. S. Everaerd, I. Tendolkar, A. Dols, P. F. P. van Eijndhoven
Summary: This study investigates the association between treatment resistance and the outcome and course of electroconvulsive therapy (ECT) in major depressive disorder (MDD). The results showed that higher levels of treatment resistance were associated with smaller reductions in depression symptoms and lower chances of response. Furthermore, patients with lower treatment resistance required fewer ECT sessions and had fewer switches to bilaterally electrode placement, potentially reducing the risk of cognitive side effects.
ACTA PSYCHIATRICA SCANDINAVICA
(2023)
Article
Clinical Neurology
W. van Leeuwen, A. van der Straten, S. A. Bogemann, D. Denys, H. van Marle, G. van Wingen
Summary: This study examined the effect of psychological distress on neural reactivity in the salience network during a symptom provocation task in patients with OCD. The results showed that psychological distress decreased dACC reactivity to emotionally salient pictures in OCD patients, while it increased dACC reactivity in healthy controls.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Engineering, Biomedical
Egill A. Fridgeirsson, Melisse N. Bais, Nadine Eijsker, Rajat M. Thomas, Dirk J. A. Smit, Isidoor O. Bergfeld, P. Richard Schuurman, Pepijn van den Munckhof, Pelle de Koning, Nienke Vulink, Martijn Figee, Ali Mazaheri, Guido A. van Wingen, Damiaan Denys
Summary: We identified a suitable biomarker in the ventral striatum for obsessive-compulsive disorder through a symptom provocation task with 11 patients undergoing deep brain stimulation treatment. Machine learning models trained on intracranial signals from deep brain stimulation electrodes successfully predicted symptoms, with different performances for different patients.
JOURNAL OF NEURAL ENGINEERING
(2023)
Article
Psychiatry
M. van Verseveld, R. J. T. Mocking, D. Scheepens, F. ten Doesschate, M. Westra, R. A. Schoevers, A. H. Schene, G. A. van Wingen, J. A. van Waarde, H. G. Ruhe
Summary: This study provides the first indication that polyunsaturated fatty acids (PUFAs) are associated with the efficacy of electroconvulsive therapy (ECT). The results suggest that PUFAs may affect ECT outcomes by influencing neuronal electrochemical properties and neurogenesis. PUFAs could potentially serve as a modifiable factor predicting ECT outcomes and further investigation is warranted in other ECT cohorts.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Article
Psychiatry
J. D. Kist, J. N. Vrijsen, P. C. R. Mulders, P. F. P. van Eijndhoven, I. Tendolkar, R. M. Collard
Summary: This study aimed to investigate the impact of different transdiagnostic symptom profiles of psychiatric disorders on well-being and the mediating role of functional limitations. Eight transdiagnostic symptom profiles were identified, and mood and self-image showed the strongest association with well-being. Functional limitations were significantly associated with well-being and fully mediated the relationship between cognitive focus and well-being.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Selene Gallo, Ahmed El-Gazzar, Paul Zhutovsky, Rajat M. Thomas, Nooshin Javaheripour, Meng Li, Lucie Bartova, Deepti Bathula, Udo Dannlowski, Christopher Davey, Thomas Frodl, Ian Gotlib, Simone Grimm, Dominik Grotegerd, Tim Hahn, Paul J. Hamilton, Ben J. Harrison, Andreas Jansen, Tilo Kircher, Bernhard Meyer, Igor Nenadic, Sebastian Olbrich, Elisabeth Paul, Lukas Pezawas, Matthew D. Sacchet, Philipp Saemann, Gerd Wagner, Henrik Walter, Martin Walter, Guido van Wingen
Summary: The promise of machine learning in psychiatric diagnostic tools has been hindered by the absence of large datasets. This study used machine learning and deep learning algorithms to differentiate patients with major depressive disorder (MDD) and identify neurophysiological signatures of depression. The results showed that whole brain resting-state connectivity is a reliable but poor biomarker for MDD.
MOLECULAR PSYCHIATRY
(2023)
Article
Psychiatry
Rianne van Hal, Dirk Geurts, Philip van Eijndhoven, Joosje Kist, Rose M. Collard, Indira Tendolkar, Janna N. Vrijsen
Summary: This study aimed to differentiate participants diagnosed with MDD, ADHD, comorbid MDD + ADHD, and healthy controls using common symptom measures and cognitive dysfunction. The findings showed that all patient groups exhibited clinically relevant levels of ADHD symptomatology, executive dysfunction, and diminished cognitive performances in the domain of attention. Discriminant function analysis based on self-reported symptoms of MDD, ADHD, and executive dysfunction correctly classified all healthy controls and patients diagnosed with ADHD or MDD to a relatively good extent.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Article
Psychology, Biological
Shu Liu, Abdel Abdellaoui, Karin J. H. Verweij, Guido A. van Wingen
Summary: Using the UK Biobank neuroimaging dataset, researchers found that large-scale neuroimaging data are important for replicable brain-phenotype associations, which can be mitigated by preselection of individuals, and small-scale studies may have reported false positive findings.
NATURE HUMAN BEHAVIOUR
(2023)
Article
Behavioral Sciences
Gijsbert Schuur, Joey P. A. J. Verdijk, Freek ten Doesschate, Guido A. van Wingen, Jeroen A. van Waarde
Summary: In this retrospective study, the prevalence of severe postictal confusion (sPIC) in 295 electroconvulsive therapy (ECT) patients was found to be 25.1%. Male sex, history of cerebrovascular incident, higher-dose succinylcholine use, and flumazenil pretreatment were associated with sPIC. However, no significant predictive model for sPIC was identified in the independent data set.
Article
Psychiatry
Yafit Levin, Rahel Bachem, Dorit Brafman, Menachem Ben-Ezra
Summary: Negative symptoms of schizophrenia have been overlooked, and this study found an association between negative symptoms and the risk of dissociative disorder, independently of depression and anxiety symptoms. It is important to consider both negative symptoms and dissociative symptoms in clinical practice to better understand their interaction.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Review
Psychiatry
Roland Mergl, Sarah M. Quaatz, Vanessa Lemke, Antje-Kathrin Allgaier
Summary: Women who have had miscarriages or stillbirths have an increased risk for depressive symptoms and disorders, with a wide range of prevalence rates. However, depressive symptoms tend to diminish over time.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Hai-Yang Wang, Lin Zhang, Bei-Yan Guan, Shi-Yao Wang, Cui-Hong Zhang, Ming-Fei Ni, Yan-Wei Miao, Bing-Wei Zhang
Summary: This study investigates the association between cognitive reappraisal and panic disorder (PD), and finds that PD patients have weakened functional connectivity between the prefrontal cortex (PFC) and the amygdala, which is associated with the severity of PD symptoms. Additionally, cognitive reappraisal is negatively correlated with PD severity, and the PFC-amygdala functional connectivity plays a mediating role in this association.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Yanqiang Tao, Xinyuan Zou, Qihui Tang, Wenxin Hou, Shujian Wang, Zijuan Ma, Gang Liu, Xiangping Liu
Summary: Depression and anxiety are prevalent mental disorders among adolescents. The study utilized network analysis to examine the symptom dimension of depression and anxiety in different age groups of adolescents. The results indicated that different age groups have different key symptoms and bridging symptoms, highlighting the importance of targeting specific symptoms at different stages of adolescence in treatment to alleviate the comorbidity of anxiety and depression.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Philip J. Batterham, Aliza Werner-Seidler, Bridianne O'Dea, Alison L. Calear, Kate Maston, Andrew Mackinnon, Helen Christensen
Summary: Screening for psychological distress in adolescents is important, and the Distress Questionnaire-5 (DQ5) is a reliable measure for this purpose. The study found that DQ5 had good fit to a unidimensional construct, strong criterion and predictive validity, and sensitivity to change. The brevity and ease of interpretation of DQ5 make it suitable for screening in schools.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Xiaoli Liu, Qianqian Chen, Fang Cheng, Wenhao Zhuang, Wenwu Zhang, Yiping Tang, Dongsheng Zhou
Summary: This study found working memory defects in adolescents with major depressive disorder compared to healthy controls based on mean oxy-hemoglobin changes, which can be useful for distinguishing adolescents with MDD from healthy controls.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Anders Nordahl-Hansen, Hugo Cogo-Moreira, Sareh Panjeh, Daniel S. Quintana
Summary: This article aims to determine empirically-derived effect size thresholds associated with psychotherapy for depressive disorders by calculating the effect size distribution. The findings indicate that the observed effect size thresholds are larger than the suggested guidelines, which has implications for interpreting study effects and planning future research.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Guangli Zhao, Liyong Yu, Peixin Chen, Keli Zhu, Lu Yang, Wenting Lin, Yucai Luo, Zeyang Dou, Hao Xu, Pan Zhang, Tianmin Zhu, Siyi Yu
Summary: This study investigated the neural mechanisms underlying emotional attention bias in patients with CID using ERP and rs-FC approaches. The results revealed abnormalities in attention processing and connectivity in the emotion-cognition networks of CID patients. This study provides a neural basis for understanding attention bias in CID.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Seungyeon Lee, Sora Mun, Jiyeong Lee, Hee-Gyoo Kang
Summary: Major depressive disorder is a prevalent condition worldwide, but the proportion of patients receiving treatment has not increased. Biomarkers related to drug-treatment responses can be used to monitor the effectiveness of medication. Serum protein levels were compared among patients with depression who received medication, those who did not, and a control group. Eight biomarkers were identified, which can be used to monitor the effectiveness of drug treatment.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Alfredo L. Sklar, Fang -Cheng Yeh, Mark Curtis, Dylan Seebold, Brian A. Coffman, Dean F. Salisbury
Summary: This study investigated semantic verbal fluency (SVF) impairments in first-episode psychosis patients within the schizophrenia spectrum. The findings revealed disruptions in both functional and structural connectivity in these patients, as well as an association between enhanced connectivity in the right hemisphere and worse SVF performance and longer disease duration.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Maksymilian Rejek, Blazej Misiak
Summary: This study investigates the association of the exposome score (ES) with psychosis risk in a non-clinical population. The results show that the ES is associated with the extended psychosis phenotype, suggesting its potential to identify individuals who may benefit from further psychosis risk assessment.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)