期刊
JOURNAL OF PSYCHIATRIC RESEARCH
卷 43, 期 4, 页码 353-359出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jpsychires.2008.04.004
关键词
GABA; CSF; Impulsivity; Aggression; Suicidality; Personality
类别
资金
- National Institute of Mental Health [RO-1 MH46848, KO-2 MH00095]
- Department of Veterans Affairs Medical Research Service
- NATIONAL INSTITUTE OF MENTAL HEALTH [K02MH000095] Funding Source: NIH RePORTER
The objective of this study was to assess the relationship between cerebrospinal fluid concentrations of the neurotransmitter gamma-aminobutyric acid (GABA) and measures of impulsivity and related behaviors (aggression and suicidality) in healthy volunteer and personality disordered subjects. CSF GABA levels, and measures of impulsivity, aggression, and history of suicidal behavior were obtained by morning lumbar puncture in 57 healthy volunteer subjects and in Subjects with personality disorder. CSF GABA levels were not found to correlate with measures of aggression but were found to correlate directly with measures of impulsivity; e.g., a composite measure of impulsivity in all subjects (r = 0.35, df = 46, P = 0.015) and in personality disordered subjects examined separately (r = 0.39, df = 30, P = 0.029). In the personality disorder group, CSF GABA levels were higher among subjects with a history of suicidal behavior compared with those without this history. These data suggest that central GABAergic function correlates directly with impulsiveness and history of suicidal behavior, but not aggressiveness, in personality disordered subjects. This may be consistent with observations that high doses of benzodiazepines can lead to behavioral disinhibition in human subjects. Further work assessing this and other aspects of the central GABA system in personality disordered subjects arc warranted. (C) 2008 Elsevier Ltd. All rights reserved.
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