Article
Psychiatry
Jane E. Persons, Paul Lodder, William H. Coryell, John Nurnberger, Jess G. Fiedorowicz
Summary: This study found that manic and anxiety symptoms did not significantly contribute to suicidal ideation and behavior in individuals with bipolar disorder during a depressive state, with the main risk factor being severe depressive symptoms. The limitations of small sample size and measurement tools may have influenced these findings, suggesting future studies would benefit from larger samples and more rigorous assessments.
PSYCHIATRY RESEARCH
(2022)
Review
Clinical Neurology
Guido Cereda, Paolo Enrico, Valentina Ciappolino, Giuseppe Delvecchio, Paolo Brambilla
Summary: Most studies found no significant differences in vitamin D levels between bipolar disorder patients and other psychiatric disorders, with the average values in the bipolar population being sub-threshold for deficiency. Although an association between vitamin D levels and clinical symptoms was observed, it is not a specific marker for bipolar disorder but a common characteristic shared with other psychiatric disorders. Additionally, vitamin D supplementation was linked to a reduction in depressive and manic symptoms.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Psychology, Clinical
Ole Kohler-Forsberg, Louisa G. Sylvia, Vicki Fung, Lindsay Overhage, Michael Thase, Joseph R. Calabrese, Thilo Deckersbach, Mauricio Tohen, Charles L. Bowden, Melvin McInnis, James H. Kocsis, Edward S. Friedman, Terence A. Ketter, Susan L. McElroy, Richard C. Shelton, Michael J. Ostacher, Dan V. Iosifescu, Andrew A. Nierenberg
Summary: In this study, adjunctive antidepressant treatment was not associated with lower depressive symptoms or higher mania symptoms in outpatients with bipolar disorder. There were no differences in treatment effects on mania scales, and potential biases due to nonrandomized design complicated causal interpretations, with no evidence suggesting better treatment effects of adjunctive antidepressants.
DEPRESSION AND ANXIETY
(2021)
Article
Psychiatry
Catarina Rodrigues Cordeiro, Beatriz Romao Corte-Real, Rodrigo Saraiva, Benicio N. Frey, Flavio Kapczinski, Taiane de Azevedo Cardoso
Summary: This systematic review aimed to identify triggers of acute mood episodes in bipolar disorder (BD). The review found that pharmacotherapy, particularly the use of antidepressants, was the trigger with the strongest evidence for manic/hypomanic relapse. Other identified triggers for mania included brain stimulation, energy drinks, acetyl-lcarnitine, St. John's wort, seasonal changes, hormonal changes, and viral infections. However, there is a lack of evidence regarding triggers for depressive relapses in BD, highlighting the need for further research in this area.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Article
Psychiatry
Rebecca E. Easter, Kelly A. Ryan, Ryne Estabrook, David F. Marshall, Melvin G. McInnis, Scott A. Langenecker
Summary: This study found that cognitive performance is largely unrelated to depressive and manic symptoms in patients with bipolar disorder. The results suggest that cognitive dysfunction is stable in BD and is not dependent on mood state. Future research could investigate how treatment affects the relationship between cognition and mood.
ACTA PSYCHIATRICA SCANDINAVICA
(2022)
Article
Psychiatry
Marta Migo, Kendra Simpson, Amy Peters, Kristen K. Ellard, Tina Chou, Andrew A. Nierenberg, Darin D. Dougherty, Thilo Deckersbach
Summary: By dimensionally analyzing symptom severity in patients with bipolar disorder, more accurate differences in neural responses to emotional stimuli can be captured. There is a correlation between symptom severity and brain activation, with depression severity associated with increased activation in various brain regions and mania severity associated with both increased and decreased activation.
PSYCHIATRY RESEARCH
(2022)
Article
Psychiatry
Norio Sugawara, Naoto Adachi, Yukihisa Kubota, Yoichiro Watanabe, Kazuhira Miki, Takaharu Azekawa, Koji Edagawa, Eiichi Katsumoto, Seiji Hongo, Eiichiro Goto, Hitoshi Ueda, Masaki Kato, Reiji Yoshimura, Atsuo Nakagawa, Toshiaki Kikuchi, Takashi Tsuboi, Koichiro Watanabe, Kazutaka Shimoda, Norio Yasui-Furukori
Summary: This study investigated the long-term clinical outcomes of patients with bipolar disorder (BD) and identified several predictors of these outcomes. The findings can assist clinicians in predicting the course of the illness based on demographic and clinical characteristics.
JOURNAL OF PSYCHIATRIC RESEARCH
(2022)
Article
Clinical Neurology
James A. Karantonis, Susan L. Rossell, Michael Berk, Tamsyn E. Van Rheenen
Summary: The study found a significant increase in subjective cognitive dysfunction in patients with bipolar disorder during the COVID-19 pandemic, but no substantial differences were observed in mood symptoms, fear of COVID-19, lifestyle factors, and social rhythms between patients and healthy controls, indicating a degree of resilience in bipolar disorder patients.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Review
Biochemistry & Molecular Biology
Lorenza Lucidi, Mauro Pettorruso, Federica Vellante, Francesco Di Carlo, Franca Ceci, Maria Chiara Santovito, Ilenia Di Muzio, Michele Fornaro, Antonio Ventriglio, Carmine Tomasetti, Alessandro Valchera, Alessandro Gentile, Yong-Ku Kim, Giovanni Martinotti, Silvia Fraticelli, Massimo Di Giannantonio, Domenico De Berardis
Summary: The gut microbiota plays a crucial role in maintaining homeostasis, growth, and digestive processes. It also influences the intercommunication system between the gut and the brain, potentially impacting the pathogenesis and clinical management of Bipolar Disorder. Current literature suggests a relationship between compositional alterations in the gut microbiota and BD, with potential benefits in treating BD symptoms through modifications in the microbiota composition. Further research is needed to explore the potential of correcting gut microbiota alterations as a novel strategy in BD management.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Geriatrics & Gerontology
Lisa T. Eyler, Farren B. S. Briggs, Annemiek Dols, Soham Rej, Osvaldo P. Almeida, Alexandra J. M. Beunders, Hilary P. Blumberg, Brent P. Forester, Regan E. Patrick, Orestes Forlenza, Ariel Gildengers, Esther Jimenez, Eduard Vieta, Benoit H. Mulsant, Sigfried Schouws, Nadine P. G. Paans, Sergio Strejilevich, Ashley Sutherland, Shangying Tsai, Martha Sajatovic
Summary: This study analyzed the symptom mixity in older-age bipolar disorder (OABD) and its association with everyday function. The results showed that mixed features are predominant in OABD and are associated with worse everyday function. Among those with mixed symptoms, the severity of depression is the main driver of poorer functioning.
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
(2022)
Review
Psychiatry
Anna Grunze, Sergey Mosolov, Heinz Grunze, Christoph Born
Summary: This narrative review examines the epidemiology, consequences, and treatment options of tobacco use disorder (TUD) and nicotine dependence (ND) in individuals with bipolar disorder (BD). The study found that smoking rates are 2-3 times higher in individuals with BD compared to community samples. Smoking has a detrimental impact on both mental and physical health as well as mortality in individuals with BD. Treatment options include pharmacological interventions and psychosocial interventions.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Psychiatry
Xiuhua Song, Yufang Feng, Lei Yi, Baoliang Zhong, Yi Li
Summary: The objective of this case-control study is to determine whether the blood thyroid hormone levels in bipolar disorder patients are associated with different types of first onset. The study found that thyroid dysfunction may be involved in the disease progression of bipolar disorder and correlated with the clinical symptoms in patients with depression or mania as the first episode.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Medicine, General & Internal
Ioanna Mylona, Georgios D. Floros
Summary: Recent clinical studies suggest that blocking shorter-wavelength blue light may benefit the treatment of bipolar disorder. This critical review aims to evaluate the quality of evidence supporting these claims and explore the underlying neurobiology, while introducing a common set of research criteria for the field.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Clinical Neurology
Madison K. Titone, Namni Goel, Tommy H. Ng, Laura E. MacMullen, Lauren B. Alloy
Summary: This study examined the relationships between impulsivity, sleep and circadian rhythm disturbance, and symptoms in individuals at high-risk for or with recent-onset bipolar spectrum disorders. The findings revealed that less total sleep time predicted increased next-day mood symptoms, and the relationship between impulsivity and mood symptoms was moderated by sleep time and circadian rhythm alterations.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Clinical Neurology
Madison K. Titone, Namni Goel, Tommy H. Ng, Laura E. MacMullen, Lauren B. Alloy
Summary: Impulsivity, sleep disturbance, and circadian rhythm alterations are closely associated with bipolar spectrum disorders. Less total sleep time predicts increased mood symptoms, and individuals with less sleep and later circadian rhythms are more likely to exhibit a positive relationship between impulsivity and mood symptoms.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Review
Psychiatry
Sonya Grewal, Stuart McKinlay, Flavio Kapczinski, Bianca Pfaffenseller, Bianca Wollenhaupt-Aguiar
Summary: This systematic review examines the biological markers associated with illness progression in bipolar disorder. It finds that increased ventricular size and reduction of grey matter volume are common brain changes associated with the progression of the disorder. In addition, peripheral inflammatory markers also play a role in this process.
AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY
(2023)
Article
Public, Environmental & Occupational Health
Mario Simjanoski, Taiane de Azevedo Cardoso, Bianca Wollenhaupt-Aguiar, Bianca Pfaffenseller, Vicent Balanza-Martinez, Luciano Minuzzi, Flavio Kapczinski
Summary: This study investigated the association between lifestyle behaviors and symptoms of depression and anxiety during the COVID-19 pandemic in Canada. The results showed that unhealthy lifestyle behaviors were associated with depression and anxiety symptoms, emphasizing the importance of lifestyle medicine education and targeted interventions.
AMERICAN JOURNAL OF LIFESTYLE MEDICINE
(2023)
Article
Psychiatry
Leticia Sanguinetti Czepielewski, Marcia Kaurer-Sant Anna, Flavio Kapczinski, Joana Bucker
EUROPEAN JOURNAL OF PSYCHIATRY
(2023)
Article
Clinical Neurology
Lauro Estivalete Marchionatti, Paula Blaya-Rocha, Pedro V. S. Magalhaes
Summary: This article discusses the definition and meaning of the term mood stabilizer, proposes a theoretical model for a mood stabilizer, and validates this model through clinical evidence. The prophylactic effects are considered the core aspect of a mood stabilizer.
Article
Clinical Neurology
Karen Jansen, Mateus Grellert, Adile Nexha, Jean Pierre Oses, Ricardo Azevedo da Silva, Luciano Dias de Mattos Souza, Flavio Kapczinski, Benicio N. Frey, Taiane de Azevedo Cardoso
Summary: This study examines whether the link between mothers diagnosed with bipolar disorder and emotional and behavioral problems in their offspring is mediated by disruptions in the offspring's biological rhythms. The findings show that offspring of mothers with bipolar disorder have more difficulty in maintaining biological rhythms and a higher prevalence of emotional and behavioral problems compared to offspring of mothers without bipolar disorder. Therefore, disruptions in the biological rhythms of the offspring fully mediate the impact of the mother's bipolar disorder on their emotional and behavioral problems.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Letter
Pharmacology & Pharmacy
Ingrid Maria de Souza Melo, Pedro Vieira da Silva Magalhaes
JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY
(2023)
Article
Psychiatry
Sandra L. Grimm, Emily F. Mendez, Laura Stertz, Thomas D. Meyer, Gabriel R. Fries, Tanmay Gandhi, Rupa Kanchi, Sudhakar Selvaraj, Antonio L. Teixeira, Thomas R. Kosten, Preethi Gunaratne, Cristian Coarfa, Consuelo Walss-Bass
Summary: To understand the mechanisms and potential targets for intervention in opioid use disorder, researchers examined postmortem brains and blood samples to explore the role of microRNAs (miRNA) in gene regulation. They found that miRNAs identified in the brains and blood had distinct profiles but targeted the same genes and pathways related to tissue development, morphogenesis, and MAPK signaling pathways. Additionally, the study identified cell-type specific miRNA targets associated with opioid use disorder and revealed correlations with various biological processes and pathways. These findings shed new light on the impact of opioid drugs and provide potential leads for intervention.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Psychiatry
Catarina Rodrigues Cordeiro, Beatriz Romao Corte-Real, Rodrigo Saraiva, Benicio N. Frey, Flavio Kapczinski, Taiane de Azevedo Cardoso
Summary: This systematic review aimed to identify triggers of acute mood episodes in bipolar disorder (BD). The review found that pharmacotherapy, particularly the use of antidepressants, was the trigger with the strongest evidence for manic/hypomanic relapse. Other identified triggers for mania included brain stimulation, energy drinks, acetyl-lcarnitine, St. John's wort, seasonal changes, hormonal changes, and viral infections. However, there is a lack of evidence regarding triggers for depressive relapses in BD, highlighting the need for further research in this area.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Article
Psychiatry
Jennifer E. Siegel-Ramsay, Bryan Wu, Flavio Kapczinski, Teresa Lanza di Scalea, Spelber David, Benicio N. Frey, Stephen M. Strakowski, Jorge R. C. Almeida
Summary: The Functional Assessment Short Test (FAST) is a validated clinician-administered assessment scale for measuring psychosocial dysfunction in individuals with bipolar disorder. This study found significant positive correlations between self-report and clinician-administered FAST scores, supporting the use of FAST as a self-report scale. The self-report application of FAST will increase its utility in busy clinical workflows and contribute to comprehensive clinical assessments and interventions.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Article
Neurosciences
Camila N. C. Lima, Emese H. C. Kovacs, Salahudeen Mirza, Alexandra Del Favero-Campbell, Alexandre Paim Diaz, Joao Quevedo, Benney M. R. Argue, Jenny Gringer Richards, Aislinn Williams, John A. Wemmie, Vincent A. Magnotta, Jess G. Fiedorowicz, Jair C. Soares, Marie E. Gaine, Gabriel R. Fries
Summary: Bipolar disorder (BD) is associated with premature mortality and aging, including accelerated epigenetic aging. Suicide attempts (SA) are significantly higher in BD and are linked to decreased lifespan, biological aging, and poorer clinical outcomes. This study investigated the relationship between GrimAge, an epigenetic clock, and SA in BD individuals.
NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Angelita Maria Ferreira Machado Rios, Kleber Cardoso Crespo, Murilo Martini, Lisieux Elaine De Borba Telles, Pedro V. S. Magalhaes
Summary: Female homicide is a global issue, with higher prevalence in Asian, African, and American countries. In Brazil, female homicides compromise life expectancy and have become a growing social problem. This study aimed to analyze the characteristics of female homicides in Porto Alegre, showing a significant increase in standardized rates, particularly due to non-gender-related factors such as urban violence and involvement in crimes like drug trafficking and robbery resulting in death. Young, non-White women were the most affected. Obtaining specific data on victims and violence is crucial for addressing the issue and directing public policies.
Article
Geriatrics & Gerontology
Steven Paul Woods, Antonio L. Teixeira, Lais B. Martins, Gabriel R. Fries, Gabriela D. Colpo, Natalia P. Rocha
Summary: The number of older persons with HIV (PWH) disease has significantly increased in the past 20 years, but our understanding of the biological factors and clinical correlates in this population remains limited. A study was conducted involving 149 individuals aged 50 and older, including 107 PWH and 42 seronegatives. Results showed that PWH had higher levels of epigenetic aging acceleration compared to seronegatives on four indicators. Furthermore, higher levels of epigenetic aging acceleration were associated with lower CD4 count, AIDS diagnoses, higher scores on the Veterans Aging Cohort Study Index, lower telomere values, and lower health literacy among PWH. It was concluded that PWH experience accelerated aging, which may be linked to immune compromise and all-cause mortality risk. Improving health literacy could help mitigate the risk of accelerated aging among older PWH.
Review
Clinical Neurology
Beatriz Corte-Real, Rodrigo Saraiva, Catarina Rodrigues Cordeiro, Benicio N. Frey, Flavio Kapczinski, Taiane de Azevedo Cardoso
Summary: The study aimed to investigate whether atypical antipsychotics (AA) can induce mania in mood disorders. A systematic review and meta-analysis showed that AA-induced mania is rare and the use of AA is more effective in preventing the development of mania compared to placebo.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Biochemistry & Molecular Biology
Rafaela C. Cordeiro, Camila N. C. Lima, Gabriel R. Fries, Giovana Zunta-Soares, Jair C. Soares, Joao Quevedo, Giselli Scaini
Summary: This study investigates the impact of mitochondrial dysfunction on bipolar disorder (BD). The study finds that BD patients have a lower mitochondrial health index (MHI) compared to non-psychiatry controls, with a negative correlation between MHI and cell-free mtDNA levels. The study further reveals that MHI is related to the expression of mitochondria quality control (MQC) proteins, and a longer illness duration, worse functional status, and higher depressive symptoms are associated with lower MHI and higher cell-free mtDNA levels.
MOLECULAR PSYCHIATRY
(2023)
Article
Cell Biology
Carine Moigneu, Soumia Abdellaoui, Mariana Ramos-Brossier, Bianca Pfaffenseller, Bianca Wollenhaupt-Aguiar, Taiane de Azevedo Cardoso, Aurelie Chiche, Nicolas Kuperwasser, Ricardo Azevedo da Silva, Fernanda Pedrotti Moreira, Han Li, Franck Oury, Flavio Kapczinski, Pierre-Marie Lledo, Lida Katsimpardi
Summary: Moigneu, Abdellaoui and colleagues discovered that GDF11 can alleviate depression symptoms and improve memory in aged mice by promoting neuronal autophagy and inhibiting mTOR activity. Low levels of GDF11 are associated with depression in human patients. This study provides insights into the mechanisms of GDF11 in the brain and suggests its potential as an antidepressant candidate and biomarker.
Article
Psychiatry
Yafit Levin, Rahel Bachem, Dorit Brafman, Menachem Ben-Ezra
Summary: Negative symptoms of schizophrenia have been overlooked, and this study found an association between negative symptoms and the risk of dissociative disorder, independently of depression and anxiety symptoms. It is important to consider both negative symptoms and dissociative symptoms in clinical practice to better understand their interaction.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Review
Psychiatry
Roland Mergl, Sarah M. Quaatz, Vanessa Lemke, Antje-Kathrin Allgaier
Summary: Women who have had miscarriages or stillbirths have an increased risk for depressive symptoms and disorders, with a wide range of prevalence rates. However, depressive symptoms tend to diminish over time.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Hai-Yang Wang, Lin Zhang, Bei-Yan Guan, Shi-Yao Wang, Cui-Hong Zhang, Ming-Fei Ni, Yan-Wei Miao, Bing-Wei Zhang
Summary: This study investigates the association between cognitive reappraisal and panic disorder (PD), and finds that PD patients have weakened functional connectivity between the prefrontal cortex (PFC) and the amygdala, which is associated with the severity of PD symptoms. Additionally, cognitive reappraisal is negatively correlated with PD severity, and the PFC-amygdala functional connectivity plays a mediating role in this association.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Yanqiang Tao, Xinyuan Zou, Qihui Tang, Wenxin Hou, Shujian Wang, Zijuan Ma, Gang Liu, Xiangping Liu
Summary: Depression and anxiety are prevalent mental disorders among adolescents. The study utilized network analysis to examine the symptom dimension of depression and anxiety in different age groups of adolescents. The results indicated that different age groups have different key symptoms and bridging symptoms, highlighting the importance of targeting specific symptoms at different stages of adolescence in treatment to alleviate the comorbidity of anxiety and depression.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Philip J. Batterham, Aliza Werner-Seidler, Bridianne O'Dea, Alison L. Calear, Kate Maston, Andrew Mackinnon, Helen Christensen
Summary: Screening for psychological distress in adolescents is important, and the Distress Questionnaire-5 (DQ5) is a reliable measure for this purpose. The study found that DQ5 had good fit to a unidimensional construct, strong criterion and predictive validity, and sensitivity to change. The brevity and ease of interpretation of DQ5 make it suitable for screening in schools.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Xiaoli Liu, Qianqian Chen, Fang Cheng, Wenhao Zhuang, Wenwu Zhang, Yiping Tang, Dongsheng Zhou
Summary: This study found working memory defects in adolescents with major depressive disorder compared to healthy controls based on mean oxy-hemoglobin changes, which can be useful for distinguishing adolescents with MDD from healthy controls.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Anders Nordahl-Hansen, Hugo Cogo-Moreira, Sareh Panjeh, Daniel S. Quintana
Summary: This article aims to determine empirically-derived effect size thresholds associated with psychotherapy for depressive disorders by calculating the effect size distribution. The findings indicate that the observed effect size thresholds are larger than the suggested guidelines, which has implications for interpreting study effects and planning future research.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Guangli Zhao, Liyong Yu, Peixin Chen, Keli Zhu, Lu Yang, Wenting Lin, Yucai Luo, Zeyang Dou, Hao Xu, Pan Zhang, Tianmin Zhu, Siyi Yu
Summary: This study investigated the neural mechanisms underlying emotional attention bias in patients with CID using ERP and rs-FC approaches. The results revealed abnormalities in attention processing and connectivity in the emotion-cognition networks of CID patients. This study provides a neural basis for understanding attention bias in CID.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Seungyeon Lee, Sora Mun, Jiyeong Lee, Hee-Gyoo Kang
Summary: Major depressive disorder is a prevalent condition worldwide, but the proportion of patients receiving treatment has not increased. Biomarkers related to drug-treatment responses can be used to monitor the effectiveness of medication. Serum protein levels were compared among patients with depression who received medication, those who did not, and a control group. Eight biomarkers were identified, which can be used to monitor the effectiveness of drug treatment.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Alfredo L. Sklar, Fang -Cheng Yeh, Mark Curtis, Dylan Seebold, Brian A. Coffman, Dean F. Salisbury
Summary: This study investigated semantic verbal fluency (SVF) impairments in first-episode psychosis patients within the schizophrenia spectrum. The findings revealed disruptions in both functional and structural connectivity in these patients, as well as an association between enhanced connectivity in the right hemisphere and worse SVF performance and longer disease duration.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Maksymilian Rejek, Blazej Misiak
Summary: This study investigates the association of the exposome score (ES) with psychosis risk in a non-clinical population. The results show that the ES is associated with the extended psychosis phenotype, suggesting its potential to identify individuals who may benefit from further psychosis risk assessment.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
