Review
Pharmacology & Pharmacy
Seyyed Mostafa Arabi, Leila Sadat Bahrami, Narges Milkarizi, Mohsen Nematy, Vladislav Kalmykov, Amirhossein Sahebkar
Summary: This study analyzed eight randomized controlled trials and found that walnut consumption can reduce serum triglyceride levels in individuals with metabolic syndrome, but it has no significant effect on other cardiometabolic indices. Further well-designed and large-scale studies are needed to further explore the beneficial effects of walnut consumption on cardiometabolic profile.
PHARMACOLOGICAL RESEARCH
(2022)
Review
Endocrinology & Metabolism
Haiyan Zhu, Xin Wang, Shihao Lu, Kongbo Ou
Summary: Clear cell renal cell carcinoma (ccRCC) is a malignancy characterized by metabolic reprogramming, which provides potential targets for therapeutic interventions. This review summarizes recent discoveries of metabolic alterations in ccRCC, including changes in glucose, lipid, and amino acid metabolism. It also discusses the development of metabolic drugs targeting these pathways and proposes future trends in drug development. Overall, this review highlights the potential for developing new treatments for ccRCC based on metabolic alterations.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Arthur Eumann Mesas, Miriam Garrido-Miguel, Ruben Fernandez-Rodriguez, Sofia Fernandez Franco, Cristina Lugones-Sanchez, Luis Garcia-Ortiz, Vicente Martinez-Vizcaino
Summary: This study examined the relationship between egg consumption and blood lipid parameters and found that higher egg consumption was not associated with total cholesterol, HDL cholesterol, and triglyceride levels, but was associated with lower LDL cholesterol levels and LDL/HDL ratio. In individuals with chronic metabolic disorders, higher egg consumption was not associated with lipid abnormalities, while in individuals without these conditions, those who consumed more eggs had better lipid profiles.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Ewa Blaszczyk, Anna-Mariia Shulhai, Joanna Gieburowska, Kamil Baranski, Aneta Monika Gawlik
Summary: Long-term growth hormone treatment affects the carbohydrate metabolism parameters in girls with Turner syndrome. Blood glucose levels significantly increase in the first five years of therapy, but decrease during treatment. Insulin resistance and carbohydrate metabolism impairment are more prominent during growth hormone therapy.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Clinical Neurology
Andrew T. Nelson, Davide Trotti
Summary: ALS is a devastating neurodegenerative disease that affects motor neurons, causing muscle atrophy, paralysis, and death. Despite progress in research, there are currently no effective treatments available. Alterations to bioenergetic and metabolic homeostasis have been identified as potential therapeutic targets for ALS.
Article
Nutrition & Dietetics
Du Ho Kwon, Young Gyu Cho, Hyun Ah Park, Ho Seok Koo
Summary: Physical activity and muscle strengthening are crucial for preventing and managing metabolic syndrome. This study found that meeting guidelines for aerobic physical activity and muscle strengthening exercise was associated with a lower prevalence of metabolic syndrome. Additionally, individuals who engaged in both aerobic physical activity and muscle strengthening exercise had the lowest prevalence of metabolic syndrome.
Review
Food Science & Technology
Josue Delgado, Diana Ansorena, Thomas Van Hecke, Iciar Astiasaran, Stefaan De Smet, Mario Estevez
Summary: Red and processed meat consumption may increase the risk of cardiovascular diseases through meat lipids, oxidation products, and excessive salt intake. Recent evidence suggests that carnitine in red meat may lead to atherosclerosis, increasing the risk of suffering CVD.
Article
Medicine, General & Internal
Eun Hyo Jin, Yoon Jin Choi, Joo Hyun Lim, Cheol Min Shin, Kyungdo Han, Dong Ho Lee
Summary: Active control of metabolic syndrome (MetS) can reduce the risk of colorectal cancer (CRC). Individuals who recover from MetS have a lower risk of CRC compared to those with persistent MetS. Resolving high blood pressure, abdominal obesity, and blood sugar levels can prevent CRC, while normalizing lipid profile does not independently decrease CRC risk. Therefore, controlling MetS is crucial for CRC prevention.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Leilah K. Grant, Melissa A. St Hilaire, George C. Brainard, Charles A. Czeisler, Steven W. Lockley, Shadab A. Rahman
Summary: Clinical biomarkers of metabolic health are regulated by endogenous circadian rhythms, but their expression is influenced by environmental factors and can be reset.
JOURNAL OF PINEAL RESEARCH
(2021)
Article
Nutrition & Dietetics
Haijing Wang, Yanxiang Wang, Zumin Shi, Lei Zhao, Wenxiu Jian, Ke Li, Ruihua Xu, Yan Wu, Fei Xu, Youfa Wang, Wen Peng
Summary: This study aimed to investigate the longitudinal association between dietary patterns and metabolic disorders in Tibetans living at high altitude areas. The results showed that participants in the third tertile of the urban dietary pattern had a 3.42-fold higher risk of metabolic syndrome compared to those in the first tertile. Moreover, the modern dietary pattern was associated with elevated blood pressure and triglycerides, but inversely associated with high-density lipoprotein cholesterol. The urban dietary pattern was associated with a higher risk of low-density lipoprotein cholesterol, but a lower risk of impaired fasting blood glucose. On the other hand, the pastoral dietary pattern was a risk factor for impaired fasting blood glucose, but protective for central obesity and elevated blood pressure. Altitude was found to modify the associations of the modern and pastoral dietary patterns with metabolic disorders.
Review
Biochemistry & Molecular Biology
Tao Shen, Tingting Wang
Summary: Plenty of research has shown significant changes in metabolism due to COVID-19, leading to the perspective that COVID-19 is a metabolic disease. Reprogramming of amino acid, glucose, cholesterol and fatty acid is a distinctive characteristic of COVID-19 infection, offering new insights into COVID-19 pathophysiology. This metabolic reprogramming provides opportunities for developing novel biomarkers and therapeutic agents for effective adjuvant therapies against COVID-19 infection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Oncology
Ahmad Ali, Ugo Chianese, Chiara Papulino, Antonella Toraldo, Mawada Elmagboul Abdalla Abakar, Eugenia Passaro, Rosario Cennamo, Nunzio Del Gaudio, Lucia Altucci, Rosaria Benedetti
Summary: This article describes the metabolic features of pancreatic ductal adenocarcinoma and discusses how this could be exploited as a weakness for clinical interventions. Metabolism plays a crucial role in the development of PDAC, and interventions on bioenergetic circuits could potentially reduce its aggressiveness.
Review
Urology & Nephrology
Mario Bonomini, Victor Zammit, Jose C. Divino-Filho, Simon J. Davies, Lorenzo Di Liberato, Arduino Arduini, Mark Lambie
Summary: Peritoneal dialysis (PD) is a viable treatment for uremic patients, but concerns about the bio-incompatibility of PD fluids, particularly due to high glucose content, have led to efforts to develop alternative solutions using osmolytes like icodextrin and amino acids. By replacing glucose with these alternative osmotic ingredients, the metabolic impact on patients may be reduced, potentially ameliorating existing co-morbidities such as insulin resistance and type-2 diabetes commonly seen in the dialysis population.
JOURNAL OF NEPHROLOGY
(2021)
Article
Nutrition & Dietetics
Tiago Rodrigues de Lima, David Alejandro Gonzalez-Chica, Eleonora D'Orsi, Xuemei Sui, Diego Augusto Santos Silva
Summary: This study aimed to determine the cut-points for muscle strength based on metabolic syndrome diagnosis. The findings suggest that cut-points derived from ROC analysis have good discriminatory power for metabolic syndrome among adults aged 25 to <50 years but not for adults aged 50+ years. Additionally, the cut-points for muscle strength may assist in the identification of adults at risk for cardiometabolic disease.
APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
(2021)
Review
Plant Sciences
Tia D. Jeffery, Matthew L. Richardson
Summary: The study reviewed the effectiveness of hibiscus in improving biomarkers of metabolic syndrome, finding significant benefits in blood glucose, cholesterol, weight, and blood pressure, and in some cases hibiscus was more effective than pharmaceuticals.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Oncology
Hans C. Lee, Karthik Ramasamy, Katja Weisel, Rafat Abonour, James W. Hardin, Robert M. Rifkin, Sikander Ailawadhi, Howard R. Terebelo, Brian G. M. Durie, Derek Tang, Prashant Joshi, Liang Liu, Ying-Ming Jou, Min Che, Gabriela Hernandez, Mohit Narang, Kathleen Toomey, Cristina Gasparetto, Lynne I. Wagner, Sundar Jagannath
Summary: This study evaluated the treatment patterns, survival, quality of life, and healthcare resource use among patients with triple-class refractory multiple myeloma (TCR MM) in US clinical practice. The findings highlight the substantial burden of TCR MM and the need for more effective treatment options.
CLINICAL LYMPHOMA MYELOMA & LEUKEMIA
(2023)
Article
Public, Environmental & Occupational Health
Melissa J. J. Kottke, Jessica M. M. Sales, Peggy Goedken, Jennifer L. L. Brown, Kendra Hatfield-Timajchy, Emilia H. H. Koumans, James W. W. Hardin, Joan Marie Kraft, Athena P. P. Kourtis
Summary: The 2gether intervention has been shown to be effective in increasing the use of condoms with contraception and reducing the rates of pregnancy and selected STIs among young African American females.
JOURNAL OF WOMENS HEALTH
(2023)
Article
Public, Environmental & Occupational Health
Mohiuddin Ahsanul Kabir Chowdhury, James W. Hardin, Bryan L. Love, Anwar T. Merchant, Suzanne McDermott
Summary: The study examined the association between nonsteroidal anti-inflammatory drug (NSAID) use during pregnancy and autism spectrum disorder (ASD) and intellectual disability (ID) in children. A retrospective cohort study was conducted using multiple datasets in South Carolina between 2010 and 2017. Results showed that NSAID use during pregnancy was associated with ID only, but not with ASD.
JOURNAL OF WOMENS HEALTH
(2023)
Article
Medicine, Research & Experimental
Allison M. Sweeney, Dawn K. Wilson, Nicole Zarrett, Pamela Martin, James W. Hardin, Amanda Fairchild, Sheryl Mitchell, Lindsay Decker
Summary: The TEAM-PA trial aims to test the effectiveness of a group intervention in increasing physical activity among insufficiently active African American women. The trial uses a group cohort design and involves 360 participants. The intervention integrates elements from various theories and focuses on social affiliation to evaluate its impact on physical activity.
CONTEMPORARY CLINICAL TRIALS
(2023)
Letter
Ophthalmology
S. Scott Sutton, Joseph Magagnoli, Tammy H. H. Cummings, James W. W. Hardin, Jayakrishna Ambati
OCULAR IMMUNOLOGY AND INFLAMMATION
(2023)
Article
Ophthalmology
S. Scott Sutton, Joseph Magagnoli, Tammy H. Cummings, James W. Hardin, Jayakrishna Ambati
Summary: By inhibiting xanthine oxidase, allopurinol may reduce the risk of diabetic macular edema (DME) by limiting inflammation and blood-retina barrier breakdown. A retrospective cohort study of type 2 diabetic US veterans found that allopurinol was associated with a 24.6% reduction in the risk of DME. Further research on the effects of allopurinol on DME is warranted.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2023)
Article
Public, Environmental & Occupational Health
Demetrius A. Abshire, Guillermo M. Wippold, Dawn K. Wilson, Bernardine M. Pinto, Janice C. Probst, James W. Hardin
Summary: This study conducted telephone interviews with 23 overweight or obese Black men in rural South Carolina communities to explore the factors that affect their motivation and weight-related behaviors, and to culturally adapt behavioral interventions for this population. Findings revealed that physical health and health behaviors were key determinants of overall health, and social support from family and friends both increased and hindered motivation. Younger participants expressed stronger views on the lack of support for healthy lifestyles in rural environments, along with personal challenges and lack of motivation.
SOCIAL SCIENCE & MEDICINE
(2023)
Article
Chemistry, Medicinal
Joseph Magagnoli, Siddharth Narendran, Felipe Pereira, Tammy H. Cummings, James W. Hardin, S. Scott Sutton, Jayakrishna Ambati
Summary: A retrospective evaluation of cancer patients receiving checkpoint inhibitor therapy found that the combination of fluoxetine and checkpoint inhibitors could improve overall survival (OS).
Article
Public, Environmental & Occupational Health
Wanfang Zhang, Suzanne McDermott, Deborah C. C. Salzberg, NaTasha D. D. Hollis, James Hardin
Summary: This study assessed an educational intervention aimed at reducing the number of emergency department and inpatient stays for cardiovascular diagnoses among South Carolina adult Medicaid members with intellectual and developmental disability and hypertension. The results of the randomized controlled trial showed significant reductions in hospital utilization in the intervention group compared to the control group.
AMERICAN JOURNAL OF HEALTH PROMOTION
(2023)
Article
Clinical Neurology
Souvik Sen, James Curtis, David Hicklin, Cynthia Nichols, Saundra Glover, Anwar T. Merchant, James W. Hardin, Makenzie Logue, Jaclyn Meyer, Emma Mason, David Y. Huang, Cristiano Susin, Kevin Moss, James Beck
Summary: Intensive periodontal disease treatment was not superior to standard treatment in preventing stroke/myocardial infarction/death in patients with recent stroke/transient ischemic attack and periodontal disease. Fewer events were observed in the intensive arm with comparable safety outcomes. The secondary outcome measures showed a trend toward improvement, with significant changes noted in diastolic blood pressure and high-density lipoprotein in both treatment arms.
Article
Psychology, Multidisciplinary
James F. Thrasher, Stuart G. Ferguson, Emily E. Hackworth, Chung-Li Wu, Victoria C. Lambert, Norman Porticella, Minji Kim, James W. Hardin, Jeff Niederdeppe
Summary: Cigarette pack inserts with cessation messages may promote smoking cessation behaviors.
ANNALS OF BEHAVIORAL MEDICINE
(2024)
Correction
Cardiac & Cardiovascular Systems
S. Scott Sutton, Joseph Magagnoli, Tammy H. H. Cummings, Theresa Dettling, Belinda Lovelace, Mary J. J. Christoph, James W. W. Hardin
JOURNAL OF THROMBOSIS AND THROMBOLYSIS
(2023)
Article
Cardiac & Cardiovascular Systems
S. Scott Sutton, Joseph Magagnoli, Tammy H. Cummings, Theresa Dettling, Belinda Lovelace, Mary J. Christoph, James W. Hardin
Summary: Oral factor Xa inhibitors effectively reduce stroke and thromboembolic events in patients with atrial fibrillation or venous thromboembolism. However, due to the lack of a randomized controlled trial comparing andexanet alfa to usual care, non-specific replacement agents, including 4 F-PCC, are still used off-label for managing FXa inhibitor bleeds. A retrospective cohort study of 255 hospitalized patients exposed to oral factor Xa inhibitors and experiencing acute major bleeds found that those treated with andexanet alfa had significantly lower in-hospital and 30-day mortality rates compared to those treated with 4 F-PCC.
JOURNAL OF THROMBOSIS AND THROMBOLYSIS
(2023)
Article
Primary Health Care
S. Scott Sutton, Joseph Magagnoli, Tammy H. Cummings, James W. Hardin
Summary: The objective of this paper was to analyze patient outcomes in gout treatment and determine the differences in serum uric acid measures and treatment adherence among patients in metropolitan, micropolitan, or rural areas. The results showed that there was no significant difference in the proportion of patients achieving the target serum uric acid levels or treatment adherence between urban and rural patients.
JOURNAL OF PRIMARY CARE AND COMMUNITY HEALTH
(2023)
Meeting Abstract
Hematology
S. Scott Sutton, Joe Magagnoli, Tammy H. Cummings, Terry Dettling, James Hardin, Belinda Lovelace
AMERICAN JOURNAL OF HEMATOLOGY
(2023)
