Review
Biochemistry & Molecular Biology
Eri Mukai, Shimpei Fujimoto, Nobuya Inagaki
Summary: The dysfunction of pancreatic beta-cells is crucial in the development of type 2 diabetes mellitus, characterized by impaired glucose stimulation and reduced ATP production. High glucose metabolism leads to the generation of reactive oxygen species in mitochondria, which affects beta-cells due to low expression of antioxidant enzymes. Activating the antioxidant defense factor Nrf2 may improve beta-cell dysfunction caused by ROS.
Review
Biochemistry & Molecular Biology
Masuko Ushio-Fukai, Dipankar Ash, Sheela Nagarkoti, Eric J. Belin de Chantemele, David J. R. Fulton, Tohru Fukai
Summary: Reactive oxygen species (ROS) and reactive nitrogen species (RNS) play important roles as signaling molecules at physiological levels, but excess levels are associated with cardiovascular disease. Cells regulate ROS and RNS levels by controlling metabolic pathways, with implications for disease treatment strategies.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Review
Biochemistry & Molecular Biology
Kozo Nakai, Daisuke Tsuruta
Summary: Oxygen in the atmosphere is vital for human life, but the metabolites ROS, produced in excess, can exacerbate skin aging and inflammation. Excessive exposure to air pollutants and other harmful substances can stimulate the production of ROS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Plant Sciences
Nathan D. Tivendale, Katharina Belt, Oliver Berkowitz, James Whelan, A. Harvey Millar, Shaobai Huang
Summary: Knockdown of SDHAF2 in Arabidopsis thaliana leads to pH-inducible root elongation and auxin hyperaccumulation and hypersensitivity, mediated by altered ROS homeostasis. This observation establishes a cascade of cellular events linking mitochondrial function, auxin, and root growth at different pH values.
PLANT AND CELL PHYSIOLOGY
(2021)
Article
Cell Biology
Joanna Nowaczyk, Barbara Poniedzialek, Piotr Rzymski, Dominika Sikora, Mariola Ropacka-Lesiak
Summary: This study aimed to evaluate platelet parameters in pregnant women with fetal growth restriction (FGR) and their relationship with hemodynamic abnormalities. The study found that FGR patients had impaired oxidative metabolism in platelets, which may lead to oxidative stress and impaired platelet function.
Article
Clinical Neurology
Moinay Kim, Joonho Byun, Yeongu Chung, Si Un Lee, Ji Eun Park, Wonhyoung Park, Jung Cheol Park, Jae Sung Ahn, Seungjoo Lee
Summary: Administering ROS scavengers to patients with acute ICH significantly reduced PHE volume, shortened time to reach target Richmond Agitation Sedation Scale, and reduced length of stay in the intensive care unit.
Article
Medicine, Research & Experimental
Caio Pupin Rosa, Thiago Caetano Andrade Belo, Natalia Cristina de Melo Santos, Evandro Neves Silva, Juciano Gasparotto, Patricia Paiva Corsetti, Leonardo Augusto de Almeida
Summary: Intracellular production of reactive oxygen species (ROS) plays a significant role in both the lethal effects on microorganisms and the regulation of inflammation and metabolism. Various microorganisms have been found to modulate the assembly or disruption of inflammasomes through ROS production. This process is a significant milestone in our understanding of the immunology of intracellular pathogens.
Article
Biochemistry & Molecular Biology
Anton G. Rogov, Tatiana N. Goleva, Khoren K. Epremyan, Igor I. Kireev, Renata A. Zvyagilskaya
Summary: Mitochondria are considered the primary source of ROS in cells, with ROS-induced ROS release triggered in cardiac myocytes under excessive oxidative stress. Using Dipodascus magnusii yeast cells, it was found that prooxidant-induced oxidative stress begins in mitochondria before spreading to the whole cell, with mitochondrial ROS leading to mitochondrial fragmentation.
Article
Engineering, Biomedical
Bijun Zhu, Jiangjiexing Wu, Tong Li, Songtao Liu, Junheng Guo, Yijun Yu, Xinyi Qiu, Yue Zhao, Haoran Peng, Jinli Zhang, Leiying Miao, Hui Wei
Summary: In this study, the use of MVF nanozyme as a precise regulator of ROS in periodontitis is proposed. By selectively eliminating H2O2, the most prominent ROS, MVF contributes to limiting inflammation, regulating immune microenvironment, promoting periodontal regeneration, and stimulating osteogenic differentiation of periodontal stem cells. MVF regulates ROS through the Nrf2/HO-1 pathway and promotes osteogenic differentiation through the PI3K/Akt pathway. Nanozymes have the potential to be an important precision medicine tool in periodontitis therapy.
ADVANCED HEALTHCARE MATERIALS
(2023)
Review
Biochemistry & Molecular Biology
Yang Zhang, Mengqiu Hao, Xuyang Yang, Su Zhang, Junhong Han, Ziqiang Wang, Hai-Ning Chen
Summary: Colorectal cancer often requires adjuvant therapies to reduce tumor burden, and the efficacy of these therapies is significantly influenced by reactive oxygen species (ROS). ROS-mediated colorectal cancer adjuvant therapies involve multiple mechanisms, and preliminary clinical trials have shown the potential of ROS-manipulating therapy in enhancing treatment outcomes.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Review
Biochemistry & Molecular Biology
Yoon-Seok Seo, Jung-Min Park, Jae-Hyeong Kim, Moo-Yeol Lee
Summary: Smoking is a significant risk factor for various diseases due to the production of excessive reactive oxygen species (ROS). This review focuses on how cigarette smoke promotes the formation of ROS and provides key mechanisms involved.
Article
Engineering, Environmental
Steven Lelieveld, Jake Wilson, Eleni Dovrou, Ashmi Mishra, Pascale S. J. Lakey, Manabu Shiraiwa, Ulrich Poeschl, Thomas Berkemeier
Summary: Air pollutants such as aerosols and ozone can cause the generation of reactive oxygen species in the human respiratory tract, leading to oxidative stress and adverse health effects.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Sulagna Dutta, Pallav Sengupta, Sanghamitra Das, Petr Slama, Shubhadeep Roychoudhury
Summary: Reactive nitrogen species (RNS) play important roles in male reproduction, but excessive levels can impair fertility by affecting testicular functions and compromising semen quality. High RNS levels lead to abnormalities in germ cells and gametes, and severely impact maturation and fertilization processes. Conventional semen analyses are not reliable predictors for assisted reproductive technology outcomes in cases of male infertility, highlighting the need for novel assessment and treatment methods.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Prima Buranasin, Hiromi Kominato, Koji Mizutani, Risako Mikami, Natsumi Saito, Kohei Takeda, Takanori Iwata
Summary: Diabetes mellitus is associated with periodontal disease and affects the efficacy of periodontal treatment. Increased reactive oxygen species (ROS) production in periodontal tissues of diabetic patients contributes to insulin resistance and impairs wound healing and tissue repair. Antioxidants and insulin resistance ameliorants may improve wound healing by inhibiting ROS production. This review comprehensively examines the latest evidence on ROS generation in periodontal tissues, particularly related to microbial challenge and diabetes, and discusses the impact of oxidative stress on wound healing in periodontal and dental implant therapies, as well as the potential benefits of administering antioxidants and anti-insulin resistance medications to counteract ROS production and inflammation.
Article
Food Science & Technology
Xin Kang, Zihan Gao, Lingjie Zheng, Xiaoru Zhang, Hao Li
Summary: Co-cultivation of Lactobacillus plantarum with Saccharomyces cerevisiae can reduce intracellular reactive oxygen species levels in yeast cells, increase oxidative tolerance, and promote ATP production.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2021)
Editorial Material
Neurosciences
Consuelo Walss-Bass, Gabriel R. Fries
NEUROPSYCHOPHARMACOLOGY
(2019)
Review
Behavioral Sciences
Gabriel R. Fries, Consuelo Walss-Bass, Moises E. Bauer, Antonio L. Teixeira
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2019)
Article
Neurosciences
Laura Stertz, Jessica Di Re, Guangsheng Pei, Gabriel R. Fries, Emily Mendez, Shenglan Li, Laura Smith-Callahan, Henriette Raventos, Jerricho Tipo, Rohan Cherukuru, Zhongming Zhao, Ying Liu, Peilin Jia, Fernanda Laezza, Consuelo Walss-Bass
Summary: This study utilized human-induced pluripotent stem cells (hiPSCs) derived from schizophrenia (SCZ) patients in the isolated population of the Central Valley of Costa Rica for RNA-sequencing analysis, identifying differentially expressed genes enriched in the phosphoinositide 3-kinase/glycogen synthase kinase 3 (PI3K/GSK3) signaling pathway, and suggesting disruption of the PI3K/GSK3 signaling pathway as a potential risk factor for SCZ.
NEUROPSYCHOPHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Gabriela Chavarria-Soley, Fernanda Francis-Cartin, Fabiola Jimenez-Gonzalez, Alejandro Avila-Aguirre, Maria Jose Castro-Gomez, Lauren Robarts, Anna Middleton, Henriette Raventos
Summary: Most people in Costa Rica are willing to donate their medical and genetic information for research, with higher willingness for nonprofit research and medical professionals compared to for-profit researchers. The main concerns regarding donation of genetic data relate to possible discrimination by health/life insurance companies and employers, according to the first study on attitudes toward genetic data donation in Costa Rica.
PERSONALIZED MEDICINE
(2021)
Article
Neurosciences
Emma E. M. Knowles, Juan M. Peralta, Laura Almasy, Vishwajit Nimgaonkar, Francis J. McMahon, Andrew M. McIntosh, Pippa Thomson, Samuel R. Mathias, Ruben C. Gur, Joanne E. Curran, Henriette Raventos, Javier Contreras, Assen Jablensky, Johanna Badcock, John Blangero, Raquel E. Gur, David C. Glahn
Summary: The study found significant genetic overlap between psychotic disorders and cognitive measures, while the genetic overlap between bipolar disorder and cognition is specific to different ascertainment strategies and ethnicities. Patients with affective disorders show enhanced performance in working and face memory.
BIOLOGICAL PSYCHIATRY
(2021)
Article
Clinical Neurology
Carolina Coto-Vilchez, Jose J. Martinez-Magana, Lara Mora-Villalobos, Daniel Valerio, Alma D. Genis-Mendoza, Jeremy M. Silverman, Humberto Nicolini, Henriette Raventos, Gabriela Chavarria-Soley
Summary: In this study, differential methylated regions (DMRs) in the genomes of cognitively healthy individuals and individuals with LOAD were identified. The study revealed 11 DMRs that contain genes involved in various biological processes. The findings suggest that PM20D1 may play a role in protection against AD. Additionally, the study found that genotypes influence the methylation levels of PM20D1.
Meeting Abstract
Clinical Neurology
Gabriela Chavarria-Soley, Fernanda Francis-Cartin, Fabiola JImenez-Gonzalez, Juan Manuel Peralta, John Blangero, Raquel E. Gur, Laura Almasy, David Glahn, Henriette Raventos
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2021)
Meeting Abstract
Clinical Neurology
Gabriela Chavarria-Soley, Fernanda Francis-Cartin, Gabriel Macaya, Ronald Alfaro, Lauren Robarts, Anna Middleton, Henriette Raventos
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Niamh Ryan, Cathal Ormond, Yi-Chieh Chang, Javier Contreras, Henriette Raventos, Michael Gill, Elizabeth Heron, Carol A. Mathews, Aiden Corvin
Summary: This study investigates the genetic variants associated with Tourette Syndrome (TS) in a Costa Rican family through whole-genome sequencing analysis. The researchers identified rare variants that were not present in controls and were linked with risk haplotypes in the family. These variants are enriched in pathways related to locomotion and signal transduction, suggesting their role in TS risk. The study highlights the importance of investigating both coding and non-coding variants in understanding the genetic basis of TS.
MOLECULAR PSYCHIATRY
(2022)
Article
Multidisciplinary Sciences
Jeffrey Lazarus, Diana Romero, Christopher J. Kopka, Salim Abdool Karim, Laith J. Abu-Raddad, Gisele Almeida, Ricardo Baptista-Leite, Joshua A. Barocas, Mauricio L. Barreto, Yaneer Bar-Yam, Quique Bassat, Carolina Batista, Morgan Bazilian, Shu-Ti Chiou, Carlos del Rio, Gregory J. Dore, George F. Gao, Lawrence O. Gostin, Margaret Hellard, Jose L. Jimenez, Gagandeep Kang, Nancy Lee, Mojca Maticic, Martin McKee, Sabin Nsanzimana, Miquel Oliu-Barton, Bary Pradelski, Oksana Pyzik, Kenneth Rabin, Sunil Raina, Sabina Faiz Rashid, Magdalena Rathe, Rocio Saenz, Sudhvir Singh, Malene Trock-Hempler, Sonia Villapol, Peiling Yap, Agnes Binagwaho, Adeeba Kamarulzaman, Ayman El-Mohandes
Summary: Despite scientific and medical advances, political, socioeconomic, and behavioral factors continue to undermine the response to the COVID-19 pandemic. A Delphi study involving a diverse panel of experts from 112 countries and territories developed a set of recommendations across various domains to address this global threat to public health.
Article
Genetics & Heredity
Diana Garro-Nunez, Maria Jesus Picado-Martinez, Erika Espinoza-Campos, Daniela Ugalde-Araya, Gabriel Macaya, Henriette Raventos, Gabriela Chavarria-Soley
Summary: Psychiatric genetics research with Latin American populations is limited, with most studies conducted in Brazil and Mexico. Lack of local funding and resources for larger studies and the use of participants with a single ancestry restrict the exploration of gene-environment interactions.
AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
(2023)
Meeting Abstract
Medicine, General & Internal
Niamh Ryan, Cathal Ormond, Yi-Chieh Chang, Nelson Freimer, Javier Contreras, Henriette Raventos, Carol A. Mathews, Elizabeth Heron, Michael Gill, Aiden Corvin
IRISH JOURNAL OF MEDICAL SCIENCE
(2022)
Meeting Abstract
Biochemistry & Molecular Biology
G. Chavarria-Soley, M. Francis, F. Jimenez, A. Avila, M. Castro-Gomez, H. Raventos
EUROPEAN JOURNAL OF HUMAN GENETICS
(2020)
Meeting Abstract
Neurosciences
Emma Knowles, Vishwajit Nimgaonkar, Henriette Raventos, Javier Contreras, Andrew McIntosh, Pippa Thomson, Assen Jablensky, Juan Peralta, Seth Ament, Francis McMahon, Ruben Gur, Maja Bucan, Joanne Curran, Laura Almasy, Raquel Gur, John Blangero, David Glahn
NEUROPSYCHOPHARMACOLOGY
(2019)
Meeting Abstract
Clinical Neurology
Gabriela Chavarria-Soley, Javier Contreras, Patricia Bolanos-Palmieri, Daniela Ugalde-Araya, Alejandro Avila-Aguirre, Christopher Mairena-Acuna, Henriette Raventos
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2019)