期刊
JOURNAL OF PROTEOMICS
卷 103, 期 -, 页码 15-22出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jprot.2014.03.020
关键词
Whole saliva; Alpha-defensins; S100 A12; Cystatins; Schizophrenia; Bipolar disorder
资金
- Cagliari University
- Catholic University of Rome
- MIUR
- Italian National Research Council (CNR)
- Regione Sardegna
- Nando Peretti Foundation
The analysis of whole saliva of 32 subjects with diagnosis of schizophrenia (SZ), 17 with diagnosis of bipolar disorder (BD), and 31 healthy subjects divided in non-smokers (HN; n = 19) and smokers (HS; n = 12) using an HPLC ESI-MS top-down platform is reported in this study. Both SZ and BD revealed more than 10 fold mean increase of alpha-defensins 1-4, S100Al2, cystatin A and S-derivatives of cystatin B levels with respect to the HN and HS control groups. No differences of protein levels were observed between SZ and BD groups and between HN and HS groups. Moreover, the correlation coefficients among the different proteins were significantly better in BD group than in SZ group. Biological significance This study on whole saliva confirms a schizophrenia-associated dysregulation of immune pathway of peripheral white blood cells and suggests that the dysregulation of BD group could involve the activation of more specific cell type than that of SZ group. (c) 2014 Elsevier B.V. All rights reserved.
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