Article
Biochemical Research Methods
Gilbert S. Omenn, Lydie Lane, Christopher M. Overall, Charles Pineau, Nicolle H. Packer, Ileana M. Cristea, Cecilia Lindskog, Susan T. Weintraub, Sandra Orchard, Michael H. A. Roehrl, Edouard Nice, Siqi Liu, Nuno Bandeira, Yu-Ju Chen, Tiannan Guo, Ruedi Aebersold, Robert L. Moritz, Eric W. Deutsch
Summary: According to the 2022 metrics of the HUPO Human Proteome Project (HPP), protein expression has been detected for 93.2% of the predicted proteins in the human genome. The number of missing proteins has been reduced, indicating experimental progress and reclassification. Proteomics continues to yield significant findings in biological and clinical studies and integrates with other omics platforms.
JOURNAL OF PROTEOME RESEARCH
(2023)
Article
Biochemical Research Methods
Gilbert S. Omenn, Lydie Lane, Christopher M. Overall, Young-Ki Paik, Ileana M. Cristea, Fernando J. Corrales, Cecilia Lindskog, Susan Weintraub, Michael H. A. Roehrl, Siqi Liu, Nuno Bandeira, Sudhir Srivastava, Yu-Ju Chen, Ruedi Aebersold, Robert L. Moritz, Eric W. Deutsch
Summary: The 2021 Metrics of the HUPO Human Proteome Project (HPP) reveal significant progress in detecting protein expression in the human genome. The number of missing proteins has decreased, and the utilization of proteomics in biological and clinical research continues to expand and integrate effectively with other omics platforms. This represents a promising advancement in understanding the human proteome and its potential applications in healthcare.
JOURNAL OF PROTEOME RESEARCH
(2021)
Review
Multidisciplinary Sciences
Lloyd M. Smith, Jeffrey N. Agar, Julia Chamot-Rooke, Paul O. Danis, Ying Ge, Joseph A. Loo, Ljiljana Pasa-Tolic, Yury O. Tsybin, Neil L. Kelleher
Summary: Understanding the structure and properties of proteins is crucial in deciphering biological functions. The concept of defining the human proteome as a reference set of proteoforms is proposed, with a call for improved technologies in a two-pronged strategy.
Article
Ophthalmology
David J. Taylor Gonzalez, Mak Djulbegovic, Michael Antonietti, Matthew Cordova, Guy W. Dayhoff II, Robby Mattes, Anat Galor, Vladimir N. Uversky, Carol L. Karp
Summary: The purpose of this study was to characterize the proteome of human tears and investigate the presence of intrinsically disordered proteins (IDPs). The findings revealed an abundance of IDPs in tears, indicating their significant role in protein function and interaction networks. These findings have promising implications for disease biomarker identification and drug target development.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2023)
Review
Biochemical Research Methods
Gilbert S. Omenn
Summary: The HUPO Human Proteome Project celebrates its 10th anniversary by achieving the milestone of confident detection of proteins from 90% of predicted protein-coding genes. This global project has influenced data-sharing, quality assurance, and issued stringent guidelines for detecting missing proteins. The project's impact is highlighted in special issues of Nature Communications and Journal of Proteome Research.
MOLECULAR & CELLULAR PROTEOMICS
(2021)
Article
Biochemistry & Molecular Biology
Eva Kocsmar, Marlene Schmid, Miguel Cosenza-Contreras, Ildiko Kocsmar, Melanie Foell, Leah Krey, Balint Andras Barta, Gergely Racz, Andras Kiss, Martin Werner, Oliver Schilling, Gabor Lotz, Peter Bronsert
Summary: Protein expression is a main focus in histological diagnostics and tissue-based research. The post-mortem applicability of protein expression is still unclear. Autopsy tissue specimens provide unique insight into advanced disease states, especially in cancer research. In this study, the maximum post-mortem interval (PMI) suitable for characterizing protein expression patterns was identified. Significant protein degradation was observed in kidneys and livers at 48 hours, while degradation in lungs was detected at 72 hours, suggesting organ-specific degradation kinetics. Proteins with similar post-mortem kinetics are not primarily shared in their biological functions. Structural features may play a role in determining post-mortem stability.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Lili Niu, Philipp E. Geyer, Rajat Gupta, Alberto Santos, Florian Meier, Sophia Doll, Nicolai J. Wewer Albrechtsen, Sabine Klein, Cristina Ortiz, Frank E. Uschner, Robert Schierwagen, Jonel Trebicka, Matthias Mann
Summary: This study quantified protein composition differences among liver cell types and analyzed dynamic proteome changes in primary cell cultures, providing valuable insights for biological and pharmaceutical research.
MOLECULAR SYSTEMS BIOLOGY
(2022)
Article
Engineering, Biomedical
Amish Asthana, Riccardo Tamburrini, Deborah Chaimov, Carlo Gazia, Stephen J. Walker, Mark Van Dyke, Alice Tomei, Sandrine Lablanche, John Robertson, Emmanuel C. Opara, Shay Soker, Giuseppe Orlando
Summary: Interactions between pancreatic ECM and islet cells play a crucial role in islet physiology, and combining engineering approaches with mass spectrometry techniques can provide a more comprehensive analysis of the proteome for creating physiologically relevant pancreatic microenvironments.
Article
Biochemical Research Methods
Deeptarup Biswas, Sanjyot Vinayak Shenoy, Chetanya Chetanya, Mercedes Lachen-Montes, Abhilash Barpanda, Arunachalam Paramasivan Athithyan, Susmita Ghosh, Karina Ausin, Maria Victoria Zelaya, Joaquin Fernandez-Irigoyen, Akash Manna, Sudesh Roy, Arunasu Talukdar, Graham Roy Ball, Enrique Santamaria, Sanjeeva Srivastava
Summary: This study presents the first draft of the human brain interhemispheric proteome, providing comprehensive coverage of 3300 experimentally measured proteins across multiple brain regions. Specific markers were identified in different brain regions, contributing to the understanding of brain disorders and synapse biology. An online portal, IBPM, was developed to facilitate research in neuroproteomics.
JOURNAL OF PROTEOME RESEARCH
(2021)
Article
Cell Biology
Kai-Wen Cheng, Shan Li, Feng Wang, Nallely M. Ruiz-Lopez, Nadia Houerbi, Tsui-Fen Chou
Summary: Research shows that the essential host protein p97 plays a crucial role in supporting human coronavirus replication, with inhibition of p97 showing antiviral activity at early stages of the virus life cycle and protecting cells from virus-induced damage. Additionally, p97 inhibition inhibits viral production in infected cells, indicating p97 as a potential therapeutic target for treating coronavirus infections.
Article
Biochemistry & Molecular Biology
Georg Kustatscher, Martina Hodl, Edward Rullmann, Piotr Grabowski, Emmanuel Fiagbedzi, Anja Groth, Juri Rappsilber
Summary: Operons are transcriptional modules that allow bacteria to adapt to environmental changes by coordinating the expression of relevant genes. In humans, the coordination of entire biological processes is unclear. Using machine-learning on proteomics data, we identified 31 higher-order co-regulation modules, called progulons, which consist of proteins that mediate core cellular functions. Progulon abundance changes are primarily controlled at the level of protein synthesis and degradation. By implementing our approach as a web app, we can search for progulons of specific cellular processes and identify new replication factors.
MOLECULAR SYSTEMS BIOLOGY
(2023)
Article
Biology
Morten Hostrup, Anders Krogh Lemminger, Ben Stocks, Alba Gonzalez-Franquesa, Jeppe Kjaergaard Larsen, Julia Prats Quesada, Martin Thomassen, Brian Tate Weinert, Jens Bangsbo, Atul Shahaji Deshmukh, David E. James
Summary: Exercise is effective in preventing and treating metabolic diseases. High-intensity interval training (HIIT) can induce changes in the proteome and acetylome of human skeletal muscle, leading to metabolic adaptations. Furthermore, HIIT increases the acetylation of mitochondrial proteins.
Article
Cardiac & Cardiovascular Systems
Michael J. Previs, Thomas S. O'Leary, Michael P. Morley, Bradley M. Palmer, Martin LeWinter, Jaime M. Yob, Francis D. Pagani, Christopher Petucci, Min-Soo Kim, Kenneth B. Margulies, Zoltan Arany, Daniel P. Kelly, Sharlene M. Day
Summary: This study identified metabolic reprogramming in human HCM hearts, characterized by deficits in nucleotide availability, reduced capacity for fatty acid oxidation, and increases in ketone bodies and branched chain amino acids. These findings have important therapeutic implications for the future design of metabolic modulators to treat HCM.
CIRCULATION-HEART FAILURE
(2022)
Article
Biochemical Research Methods
Pieter M. Dekker, Sjef Boeren, Johannes B. van Goudoever, Jacques J. M. Vervoort, Kasper A. Hettinga
Summary: The study found significant interindividual variation in proteins and peptides in human milk, and identified distinct characteristics in different protein and peptide clusters through weighted correlation network analysis. Several associations between different data sets and specific sample characteristics were also discovered.
JOURNAL OF PROTEOME RESEARCH
(2022)
Article
Endocrinology & Metabolism
Giuseppe Grande, Ferran Barrachina, Ada Soler-Ventura, Meritxell Jodar, Francesca Mancini, Riccardo Marana, Sabrina Chiloiro, Alfredo Pontecorvi, Rafael Oliva, Domenico Milardi
Summary: This study used proteomic profiling to analyze alterations of sperm protein composition in secondary male hypogonadism. Several differentially expressed proteins were identified and may serve as new targets for infertility treatments due to androgen deficiency.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Immunology
Emanuela Oldoni, Alain van Gool, Laura Garcia Bermejo, Andreas Scherer, Michaela Th Mayrhofer, Francesco Florindi, Jacques Demotes, Christine Kubiak, Anne-Charlotte Fauvel, Florence Bietrix, Anton Ussi, Antonio L. Andreu
Summary: Effectively responding to the COVID-19 pandemic requires a better understanding of virus infection biology and identifying validated biomarker profiles. This can only be achieved through a high level of knowledge and coordination between the public and private sectors within a robust quality framework.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Allergy
Henry Y. Lu, Mehul Sharma, Ashish A. Sharma, Atilano Lacson, Ashley Szpurko, Joanne Luider, Poonam Dharmani-Khan, Afshin Shameli, Peter A. Bell, Gregory M. T. Guilcher, Victor A. Lewis, Marta Rojas Vasquez, Sunil Desai, Lyle McGonigle, Luis Murguia-Favela, Nicola A. M. Wright, Consolato Sergi, Eytan Wine, Christopher M. Overall, Sneha Suresh, Stuart E. Turvey
Summary: This study identified novel pathogenic biallelic loss-of-function variants in CARD11 in two patients with profound CID. The defects in immune signaling pathways resulted in impaired B and T cell development, compromised antibody responses, and abolished MALT1 paracaspase activity. Hematopoietic stem cell transplantations restored the impaired signaling pathways and led to functional normalization.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Review
Medicine, Research & Experimental
David de Gonzalo-Calvo, Monica Marchese, Jan Hellemans, Fay Betsou, Nanna Lond Skov Frisk, Louise Torp Dalgaard, Paivi Lakkisto, Carole Foy, Andreas Scherer, Maria Laura Garcia Bermejo, Yvan Devaux
Summary: Despite the promising findings of qPCR-based tests, their clinical application is limited due to a lack of technical standardization. Guidelines for clinical research assay validation are needed to incorporate qPCR-based tests into the clinic, which would impact the clinical management of patients. However, there is currently a lack of clear assay validation protocols for biomarker investigation in clinical trials using molecular assays.
MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT
(2022)
Article
Multidisciplinary Sciences
Philipp Strauss, Mariell Rivedal, Andreas Scherer, Oystein Eikrem, Sigrid Nakken, Christian Beisland, Leif Bostad, Arnar Flatberg, Eleni Skandalou, Vidar Beisvag, Jessica Furriol, Hans-Peter Marti
Summary: This study investigated the differences in transcriptome, miRNA, and proteomic data in low-risk tumors progressing and non-progressing in clear cell renal cell carcinoma (ccRCC) patients. The researchers identified differentially expressed proteins, mRNAs, and miRNAs between progressing and non-progressing tumors. They developed a classifier using a combination of proteins, genes, and miRNAs that effectively differentiated progressing and non-progressing ccRCC, potentially aiding in the early identification of low-risk patients requiring closer surveillance and treatment adjustments.
SCIENTIFIC REPORTS
(2022)
Article
Peripheral Vascular Disease
Havard Mikkelsen, Bjorn E. Vikse, Oystein Eikrem, Andreas Scherer, Kenneth Finne, Tarig Osman, Hans-Peter Marti
Summary: Based on the proteomic profiling of glomeruli, we identified candidate prognostic markers that can distinguish between progressing and non-progressing hypertensive nephropathy (HN) patients. This study provides a new approach for prognostic evaluation of HN.
HYPERTENSION RESEARCH
(2023)
Article
Biochemical Research Methods
Gilbert S. Omenn, Lydie Lane, Christopher M. Overall, Charles Pineau, Nicolle H. Packer, Ileana M. Cristea, Cecilia Lindskog, Susan T. Weintraub, Sandra Orchard, Michael H. A. Roehrl, Edouard Nice, Siqi Liu, Nuno Bandeira, Yu-Ju Chen, Tiannan Guo, Ruedi Aebersold, Robert L. Moritz, Eric W. Deutsch
Summary: According to the 2022 metrics of the HUPO Human Proteome Project (HPP), protein expression has been detected for 93.2% of the predicted proteins in the human genome. The number of missing proteins has been reduced, indicating experimental progress and reclassification. Proteomics continues to yield significant findings in biological and clinical studies and integrates with other omics platforms.
JOURNAL OF PROTEOME RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Emanuela Oldoni, Gary Saunders, Florence Bietrix, Maria Laura Garcia Bermejo, Anna Niehues, Peter A. C. 't Hoen, Jessica Nordlund, Marian Hajduch, Andreas Scherer, Katja Kivinen, Esa Pitkanen, Tomi Pekka Makela, Ivo Gut, Serena Scollen, Lukasz Kozera, Manel Esteller, Leming Shi, Anton Ussi, Antonio L. Andreu, Alain J. van Gool
Summary: Personalised medicine (PM) offers a great opportunity to enhance individualized healthcare. Advances in -omics technologies have enabled the study of complex human diseases, supporting the development of PM. This article summarizes the outcomes of a workshop that aimed to outline common promises and challenges in multi-omics research, assess the potential of new technologies like artificial intelligence, and foster collaboration between key initiatives.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Editorial Material
Biochemical Research Methods
John R. Yates, Ileana M. Cristea, Meng-Qui Dong, Claire E. Eyers, Joshua LaBaer, Jia V. Li, Jeremy K. Nicholson, Christopher M. Overall, Magnus Palmblad, Nikolai Slavov
JOURNAL OF PROTEOME RESEARCH
(2022)
Article
Multidisciplinary Sciences
Jina Yun, Simon Hansen, Otto Morris, David T. Madden, Clare Peters Libeu, Arjun J. Kumar, Cameron Wehrfritz, Aaron H. Nile, Yingnan Zhang, Lijuan Zhou, Yuxin Liang, Zora Modrusan, Michelle B. Chen, Christopher C. Overall, David Garfield, Judith Campisi, Birgit Schilling, Rami N. Hannoush, Heinrich Jasper
Summary: Cellular senescence and the senescence-associated secretory phenotype (SASP) play a role in aging and age-related diseases. The inflammation caused by SASP is believed to contribute to tissue dysfunction in aging and diseased animals. Research using intestinal organoids as a model has found that SASP factors released by senescent fibroblasts disturb stem cell activity and differentiation, leading to impaired crypt formation. It has been discovered that the N-terminal domain of Ptk7, which is secreted by senescent cells, activates non-canonical Wnt/Ca2+ signaling through FZD7 in intestinal stem cells (ISCs), disrupting symmetry breaking and stem cell differentiation. This study provides insight into the mechanism by which cellular senescence contributes to tissue dysfunction in aging and disease.
NATURE COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Peter A. Bell, Christopher M. Overall
Summary: Proteolytic processing, the most common post-translational modification, has a significant impact on protein function. By reanalyzing shotgun proteomics datasets, we found evidence of proteolytic processing in COVID-19, which provides valuable insights for studying protease function and virus-host interactions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biotechnology & Applied Microbiology
Ying Yu, Wanwan Hou, Yaqing Liu, Haiyan Wang, Lianhua Dong, Yuanbang Mai, Qingwang Chen, Zhihui Li, Shanyue Sun, Jingcheng Yang, Zehui Cao, Peipei Zhang, Yi Zi, Ruimei Liu, Jian Gao, Naixin Zhang, Jingjing Li, Luyao Ren, He Jiang, Jun Shang, Sibo Zhu, Xiaolin Wang, Tao Qing, Ding Bao, Bingying Li, Bin Li, Chen Suo, Yan Pi, Xia Wang, Fangping Dai, Andreas Scherer, Pirkko Mattila, Jinxiong Han, Lijun Zhang, Hui Jiang, Danielle Thierry-Mieg, Jean Thierry-Mieg, Wenming Xiao, Huixiao Hong, Weida Tong, Jing Wang, Jinming Li, Xiang Fang, Li Jin, Joshua Xu, Feng Qian, Rui Zhang, Leming Shi, Yuanting Zheng
Summary: This study established RNA reference materials based on Quartet samples, including four RNA reference materials and ratio-based transcriptome-wide reference datasets between two samples. The results of the study demonstrate that these reference materials can be used to assess and improve the quality of transcriptomic data in clinical and biological settings.
NATURE BIOTECHNOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Yuanting Zheng, Yaqing Liu, Jingcheng Yang, Lianhua Dong, Rui Zhang, Sha Tian, Ying Yu, Luyao Ren, Wanwan Hou, Feng Zhu, Yuanbang Mai, Jinxiong Han, Lijun Zhang, Hui Jiang, Ling Lin, Jingwei Lou, Ruiqiang Li, Jingchao Lin, Huafen Liu, Ziqing Kong, Depeng Wang, Fangping Dai, Ding Bao, Zehui Cao, Qiaochu Chen, Qingwang Chen, Xingdong Chen, Yuechen Gao, He Jiang, Bin Li, Bingying Li, Jingjing Li, Ruimei Liu, Tao Qing, Erfei Shang, Jun Shang, Shanyue Sun, Haiyan Wang, Xiaolin Wang, Naixin Zhang, Peipei Zhang, Ruolan Zhang, Sibo Zhu, Andreas Scherer, Jiucun Wang, Jing Wang, Yinbo Huo, Gang Liu, Chengming Cao, Li Shao, Joshua Xu, Huixiao Hong, Wenming Xiao, Xiaozhen Liang, Daru Lu, Li Jin, Weida Tong, Chen Ding, Jinming Li, Xiang Fang, Leming Shi
Summary: This study develops multi-omics reference materials, including matched DNA, RNA, protein, and metabolites, for feature quantification and data integration. The research identifies the lack of reference for "absolute" feature quantification as the root cause of irreproducibility in multi-omics measurement and data integration. The use of a ratio-based profiling approach produces reproducible and comparable data suitable for integration.
NATURE BIOTECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Aleksander M. Haack, Christopher M. Overall, Ulrich auf dem Keller
Summary: The extracellular matrix (ECM) is composed of proteins secreted by cells and plays a crucial role in maintaining tissue homeostasis and cellular control. Aberrant signaling through the ECM can lead to various pathological conditions. Therefore, characterizing the components of the ECM and developing novel therapeutics are of great importance.
Article
Biochemistry & Molecular Biology
Peter A. Bell, Sophia Scheuermann, Florian Renner, Christina L. Pan, Henry Y. Lu, Stuart E. Turvey, Frederic Bornancin, Catherine H. Regnier, Christopher M. Overall
Summary: Researchers developed a bioinformatics-led substrate discovery workflow to expand the known substrate repertoire of MALT1. They identified seven new MALT1 substrates using their approach and confirmed their functions in NF-κB regulation.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2022)
Article
Biotechnology & Applied Microbiology
Bohu Pan, Luyao Ren, Vitor Onuchic, Meijian Guan, Rebecca Kusko, Steve Bruinsma, Len Trigg, Andreas Scherer, Baitang Ning, Chaoyang Zhang, Christine Glidewell-Kenney, Chunlin Xiao, Eric Donaldson, Fritz J. Sedlazeck, Gary Schroth, Gokhan Yavas, Haiying Grunenwald, Haodong Chen, Heather Meinholz, Joe Meehan, Jing Wang, Jingcheng Yang, Jonathan Foox, Jun Shang, Kelci Miclaus, Lianhua Dong, Leming Shi, Marghoob Mohiyuddin, Mehdi Pirooznia, Ping Gong, Rooz Golshani, Russ Wolfinger, Samir Lababidi, Sayed Mohammad Ebrahim Sahraeian, Steve Sherry, Tao Han, Tao Chen, Tieliu Shi, Wanwan Hou, Weigong Ge, Wen Zou, Wenjing Guo, Wenjun Bao, Wenzhong Xiao, Xiaohui Fan, Yoichi Gondo, Ying Yu, Yongmei Zhao, Zhenqiang Su, Zhichao Liu, Weida Tong, Wenming Xiao, Justin M. Zook, Yuanting Zheng, Huixiao Hong
Summary: This study systematically evaluates the reproducibility of inherited variants with whole genome sequencing (WGS) and identifies the impact of different factors on variant call quality. The findings show that bioinformatics pipelines have a larger impact on reproducibility than WGS platform or library preparation. Single-nucleotide variants (SNVs) are more reproducible than small insertions and deletions (indels), and increasing sequencing coverage improves indel reproducibility but has limited impact on SNVs above 30x.
Article
Biochemical Research Methods
Tanushree Halder, Elke Stroeher, Hui Liu, Yinglong Chen, Guijun Yan, Kadambot H. M. Siddique
Summary: Improving the root system of wheat is crucial for enhancing grain yield and climate resilience. This study identified proteins associated with root length and root mass in wheat using label-free quantitative proteomics. The findings revealed potential biomarkers that could be used for improving the root system of wheat.
JOURNAL OF PROTEOMICS
(2024)
Article
Biochemical Research Methods
Yinhua Pan, Quanqing Zou, Wu Yin, Zhen Huang, Yingzhu Zhao, Zongming Mo, Lihui Li, Jianrong Yang
Summary: A prognostic model of BC based on LNM-related genes was established in this study, providing guidance for prognosis evaluation and precise treatment of BC. The genes related to lymph node metastasis in BC are largely unknown and need further exploration. Searching for potential lymph node metastasis-related genes of BC will provide meaningful biomarkers for BC treatment. Our model, based on TCGA-BRCA data, effectively predicted patient outcomes and classified BC patients. The identified feature genes might have a predictive function in immunotherapy. The results of this study provide a new reference for the prognosis and treatment of BC patients with lymph node metastasis.
JOURNAL OF PROTEOMICS
(2024)
Article
Biochemical Research Methods
Qiushi Liang, Joon M. Pijnenburg, Erikjan Rijkers, Arnold G. Vulto, Ans T. van der Ploeg, Niek P. van Til, Eva C. Vlaar, Jeroen A. A. Demmers, W. W. M. Pim Pijnappel
Summary: Pompe disease is a lysosomal storage disorder characterized by glycogen accumulation in skeletal muscle, leading to profound pathology. This study showed that lentiviral gene therapy with LV-IGF2.GAAco can nearly completely correct disease-associated proteomic changes, supporting its future clinical development as a new treatment option for Pompe disease.
JOURNAL OF PROTEOMICS
(2024)
Article
Biochemical Research Methods
Chuang Liu, Wenjing Zhang, Qianli Dong, Haipeng Liu
Summary: This study fills the knowledge gap about the matrix proteins involved in the formation of mineralized exoskeletons in decapod crustaceans. By comparing with well-studied molluscan biomineralization proteins, it is proposed that decapod crustaceans evolved novel proteins while sharing some proteins with molluscs. This study provides insights into the evolution and adaptation of crustaceans and molluscs in forming their exoskeletons.
JOURNAL OF PROTEOMICS
(2024)
Article
Biochemical Research Methods
Rania D. Baka, Josipa Kules, Angelo Beletic, Vladimir Farkas, Dina Resetar Maslov, Blanka Beer Ljubic, Ivana Rubic, Vladimir Mrljak, Mark McLaughlin, David Eckersall, Zoe Polizopoulou
Summary: This study analyzed serum samples from dogs with epilepsy and identified potential markers of epilepsy, proteins involved in nerve tissue regeneration, and proteins altered by antiepileptic medication. The findings provide insight into the pathogenesis of epilepsy and the effects of medication on extracellular matrix proteins.
JOURNAL OF PROTEOMICS
(2024)
Article
Biochemical Research Methods
Viviane M. Codognoto, Fabiana F. de Souza, Thais R. Cataldi, Carlos A. Labate, Laiza S. de Camargo, Pedro H. Esteves Trindade, Roberto R. da Rosa Filho, Diego J. B. de Oliveira, Eunice Oba
Summary: This study aimed to compare urine proteomics from non- and pregnant buffaloes to identify potential biomarkers of early pregnancy. A total of 798 proteins were reported in the urine considering all groups, and the differential proteins play essential roles during pregnancy.
JOURNAL OF PROTEOMICS
(2024)