Review
Clinical Neurology
Adeel S. S. Zubair, Kevin N. N. Sheth
Summary: Stroke is a major cause of illness and death worldwide, and hemorrhagic transformation is a serious complication of ischemic stroke. Current treatments for acute ischemic stroke, such as endovascular thrombectomy and thrombolytic therapy, increase the risk of hemorrhagic conversion. The timely diagnosis and management of patients with hemorrhagic conversion are crucial for patient outcomes. This review aims to discuss the pathophysiology, risk factors, imaging considerations, and treatment of hemorrhagic conversion in acute ischemic stroke.
Review
Biochemistry & Molecular Biology
Eun Chae Lee, Tae Won Ha, Dong-Hun Lee, Dong-Yong Hong, Sang-Won Park, Ji Young Lee, Man Ryul Lee, Jae Sang Oh
Summary: Stroke is a leading cause of death and neurological disorders globally, but diagnostic techniques and treatments are limited for certain types. Recent studies have focused on the clinical value of utilizing exosome mechanisms and reported changes in diagnostic biomarkers of exosomes after stroke, as well as their potential applications in therapeutics.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Genetics & Heredity
Jia Liang, Hui Li, Chang-Dong Liu, Xiao-Yan Zhou, Yan-Yan Fu, Xiang-Yu Ma, Dan Liu, Yu-Ling Chen, Qian Feng, Zhen Zhang, Xiang-Ru Wen, Guang Zhu, Nan Wang, Yuan-Jian Song
Summary: The study shows that intervention of the interaction between S100b and Rage can treat ischemic stroke. The designed peptide, TAT-W61, can directly bind to S100b, reducing inflammation and improving pathological damage, as well as restoring cognitive and motor functions in animal models.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2023)
Article
Clinical Neurology
Dominic Millenaar, Andreas Ragoschke-Schumm, Tobias Fehlmann, Maximilian Raible, Piergiorgio Lochner, Michael Boehm, Klaus Fassbender, Andreas Keller, Felix Mahfoud, Christian Ukena
Summary: Ischemic stroke is the second leading cause of death worldwide, and its research output shows some clear trends. The United States has the highest number of research publications, followed by China and Germany. Clinical neurology is the most common topic in the research. The scientific landscape is male-dominated, and international collaborations play a significant role in this field.
FRONTIERS IN NEUROLOGY
(2022)
Article
Nutrition & Dietetics
Masahiro Shiozawa, Hidehiro Kaneko, Hidetaka Itoh, Kojiro Morita, Akira Okada, Satoshi Matsuoka, Hiroyuki Kiriyama, Tatsuya Kamon, Katsuhito Fujiu, Nobuaki Michihata, Taisuke Jo, Norifumi Takeda, Hiroyuki Morita, Sunao Nakamura, Koichi Node, Hideo Yasunaga, Issei Komuro
Summary: This study examined the association between body mass index (BMI) and stroke risk, finding that overweight and obesity were associated with a higher incidence of stroke and ischemic stroke in both men and women. Additionally, underweight, overweight, and obesity were linked to a higher risk of hemorrhagic stroke in men, but not in women.
Article
Critical Care Medicine
Charikleia S. Vrettou, Alice G. Vassiliou, Maria Pratikaki, Chrysi Keskinidou, Stamatios Tsipilis, Parisis Gallos, Edison Jahaj, Stylianos E. Orfanos, Anastasia Kotanidou, Ioanna Dimopoulou
Summary: This study aims to investigate the role of neural injury biomarkers and compare them with inflammatory markers in predicting mortality in COVID-19 patients. The results show that among the investigated biomarkers, s100b demonstrated the best predictive ability for death in the intensive care unit. The overall biomarker profile suggests direct involvement of the nervous system by the novel coronavirus.
Article
Biochemistry & Molecular Biology
Francisco Jose Julian-Villaverde, Marta Serrano-Ponz, Enrique Ramalle-Gomara, Alfredo Martinez, Laura Ochoa-Callejero
Summary: This study found that CCL5 levels could serve as a predictive marker for clinical outcomes in stroke patients, especially in distinguishing between ischemic and hemorrhagic strokes and predicting infarct volume outcomes in acute ischemic patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Clinical Neurology
Rosanna Rossi, Andrew Douglas, Sara Molina Gil, Duaa Jabrah, Abhay Pandit, Michael Gilvarry, Ray McCarthy, James Prendergast, Katarina Jood, Petra Redfors, Annika Nordanstig, Erik Ceder, Dennis Dunker, Jeanette Carlqvist, Istvan Szikora, John Thornton, Georgios Tsivgoulis, Klearchos Psychogios, Turgut Tatlisumak, Alexandros Rentzos, Karen M. M. Doyle
Summary: By analyzing 122 thrombi from 80 patients with acute ischemic stroke, it was found that elevated S100b levels were associated with an increased risk of PTIH. Additionally, higher S100b expression, higher NIHSS scores at admission, and a greater number of passes during thrombectomy were all associated with PTIH.
FRONTIERS IN NEUROLOGY
(2023)
Article
Environmental Sciences
Han Wu, Bingyin Zhang, Jing Wei, Zilong Lu, Min Zhao, Wenhui Liu, Pascal Bovet, Xiaolei Guo, Bo Xi
Summary: Short-term exposure to ambient PM1, PM2.5, and PM10 is associated with increased risk of stroke incidence in China. PM1 has a stronger association and larger attributable fraction to stroke than PM2.5 and PM10. Clean air policies should focus on addressing the impact of PM1.
ENVIRONMENTAL RESEARCH
(2022)
Article
Medicine, General & Internal
Emilia Salvadori, Gioele Papi, Greta Insalata, Valentina Rinnoci, Ida Donnini, Monica Martini, Catuscia Falsini, Bahia Hakiki, Annamaria Romoli, Carmen Barbato, Paola Polcaro, Francesca Casamorata, Claudio Macchi, Francesca Cecchi, Anna Poggesi
Summary: Comparison studies on recovery outcomes in ischemic (IS) and hemorrhagic strokes (HS) have shown mixed results. In a retrospective observational study, it was found that HS patients were younger and had more severe clinical deficits compared to IS patients. However, functional status change at discharge did not significantly differ between the two stroke types, with age and initial stroke severity being main prognostic factors.
Review
Medicine, General & Internal
Luis F. Rendon, Stephanie Malta, Jacob Leung, Rafael Badenes, Ala Nozari, Federico Bilotta
Summary: Cocaine consumption has increased, and it can lead to serious neurovascular complications. This systematic review and meta-analysis aimed to describe the clinical features and outcomes of strokes associated with cocaine use. The findings show that cocaine use increases the risk of strokes and leads to worse outcomes such as mortality, vasospasm, and seizures.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Sarah Gelhard, Roxane-Isabelle Kestner, Moritz Armbrust, Helmuth Steinmetz, Christian Foerch, Ferdinand O. Bohmann
Summary: This study evaluated the risk of hemorrhagic transformation (HT) and worsening functional outcome after rt-PA treatment in experimental ischemic stroke, with or without additional hyperglycemia. Hyperglycemia was found to be a risk factor for neurological deterioration after rt-PA treatment.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Hansen Chen, Binghe Guan, Shuang Chen, Dan Yang, Jiangang Shen
Summary: Hyperglycemia exacerbates neuronal damage and poor outcomes in ischemic stroke, and peroxynitrite may play a key role in this process. Targeting peroxynitrite-mediated NLRP3 inflammasome activation could be a promising strategy for treating ischemic stroke with hyperglycemia.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Clinical Neurology
Anas Alrohimi, Brian Buck, Glen Jickling, Ashfaq Shuaib, Sibi Thirunavukkarasu, Ken S. Butcher
Summary: This study aimed to assess the impact of early anticoagulation on hemorrhagic transformation in atrial fibrillation (AF) patients after stroke. The results showed that early apixaban treatment did not lead to symptomatic HT, with all HT being asymptomatic on imaging. Recurrent ischemic events were common and clinically symptomatic.
JOURNAL OF NEUROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Mengyun Huang, Lijun Zhu, Yan Chen, Yuelong Jin, Zhengmei Fang, Yingshui Yao
Summary: The association between zinc levels and stroke risk remains controversial, but a meta-analysis showed no significant difference in zinc levels between the stroke group and control group overall. However, zinc levels were significantly higher in ischemic stroke patients compared to controls, indicating a possible association with increased risk of ischemic stroke.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2022)
Article
Neuroimaging
Jiahui Li, Alejandro Tomasello, Manuel Requena, Pere Canals, Riccardo Tiberi, Inaki Galve, Elisabeth Engel, David F. Kallmes, Oscar Castano, Marc Ribo
Summary: This study aims to provide insight into navigating devices through the vascular anatomy with minimal track forces. The use of microcatheter and stent retriever was found to significantly reduce track forces and improve tracking reliability.
JOURNAL OF NEUROINTERVENTIONAL SURGERY
(2023)
Article
Neuroimaging
Rosalie McDonough, Johanna M. Ospel, Charles B. L. M. Majoie, Jeffrey L. Saver, Philip White, Diederik W. J. Dippel, Scott B. Brown, Andrew M. Demchuk, Tudor G. Jovin, Peter J. Mitchell, Serge Bracard, Bruce C. Campbell, Keith W. Muir, Michael D. Hill, Francis Guillemin, Mayank Goyal
Summary: This study examined the effect of pre-stroke functional levels on the outcome of endovascular therapy. The results showed that patients with mild pre-existing disability/symptoms had worse outcomes compared to those without disability. However, within the subgroup of patients with mild disability/symptoms, endovascular therapy still had a significant benefit.
JOURNAL OF NEUROINTERVENTIONAL SURGERY
(2023)
Article
Neuroimaging
David Cano, Estefania Montiel, Maria Baladas, Esther Sanchez-Gavilan, Carolina Paredes, Marta Rubiera, Manuel Requena, Marian Muchada, Marta Olive Gadea, Alvaro Garcia-Tornel, Carlos A. Molina, Marc Ribo
Summary: This study aimed to evaluate patient-reported outcomes (PROMs) through a smartphone-based communication platform in stroke patients who underwent endovascular treatment (EVT). The study found that the modified Rankin Scale (mRS) score had a ceiling effect and was insufficient for fine-tuning long-term clinical results. The use of PROMs may allow for a better characterization of long-term outcome profiles after EVT.
JOURNAL OF NEUROINTERVENTIONAL SURGERY
(2023)
Article
Clinical Neurology
Manuel Requena, Carlos Pinana, Marta Olive-Gadea, David Hernandez, Sandra Boned, Marta De Dios, Marc Rodrigo, Eila Rivera, Marian Muchada, Jose Luis Cuevas, Marta Rubiera, Alvaro Garcia-Tornel, Laura Ludovica Gramegna, Carlos Molina, Marc Ribo, Alejandro Tomasello
Summary: This study evaluated the effectiveness and safety of a combined MT technique using a stent retriever and REACT catheter in patients with AIS due to LVO. The results showed a high rate of successful recanalization and first pass recanalization, as well as low rates of procedural complications and symptomatic intracranial hemorrhage.
INTERVENTIONAL NEURORADIOLOGY
(2023)
Article
Astronomy & Astrophysics
V. A. Acciari, I. Agudo, T. Aniello, S. Ansoldi, L. A. Antonelli, A. Arbet Engels, M. Artero, K. Asano, D. Baack, A. Babic, A. Baquero, U. Barres de Almeida, J. A. Barrio, I. Batkovic, J. Becerra Gonzalez, W. Bednarek, E. Bernardini, M. Bernardos, A. Berti, J. Besenrieder, W. Bhattacharyya, C. Bigongiari, A. Biland, O. Blanch, H. Boekenkamp, G. Bonnoli, Z. Bosnjak, I. Burelli, G. Busetto, R. Carosi, G. Ceribella, M. Cerruti, Y. Chai, A. Chilingarian, S. Cikota, E. Colombo, J. L. Contreras, J. Cortina, S. Covino, G. D'Amico, V. D'Elia, P. Da Vela, F. Dazzi, A. De Angelis, B. De Lotto, A. Del Popolo, M. Delfino, J. Delgado, C. Delgado Mendez, D. Depaoli, F. Di Pierro, L. Di Venere, E. Do Souto Espineira, D. Dominis Prester, A. Donini, D. Dorner, M. Doro, D. Elsaesser, V. Fallah Ramazani, L. Farina, A. Fattorini, L. Font, C. Fruck, S. Fukami, Y. Fukazawa, R. J. Garcia Lopez, M. Garczarczyk, S. Gasparyan, M. Gaug, N. Giglietto, F. Giordano, P. Gliwny, N. Godinovic, J. G. Green, D. Green, D. Hadasch, A. Hahn, T. Hassan, L. Heckmann, J. Herrera, D. Hrupec, M. Huetten, T. Inada, R. Iotov, K. Ishio, Y. Iwamura, I. Jimenez Martinez, J. Jormanainen, L. Jouvin, D. Kerszberg, Y. Kobayashi, H. Kubo, J. Kushida, A. Lamastra, D. Lelas, F. Leone, E. Lindfors, L. Linhoff, I. Liodakis, S. Lombardi, F. Longo, R. Lopez-Coto, M. Lopez-Moya, A. Lopez-Oramas, S. Loporchio, A. Lorini, B. Machado de Oliveira Fraga, C. Maggio, P. Majumdar, M. Makariev, M. Mallamaci, G. Maneva, M. Manganaro, K. Mannheim, M. Mariotti, M. Martinez, A. Mas Aguilar, D. Mazin, S. Menchiari, S. Mender, S. Micanovic, D. Miceli, T. Miener, J. M. Miranda, R. Mirzoyan, E. Molina, H. A. Mondal, A. Moralejo, D. Morcuende, V. Moreno, E. Moretti, T. Nakamori, C. Nanci, L. Nava, V. Neustroev, M. Nievas Rosillo, C. Nigro, K. Nilsson, K. Nishijima, K. Noda, S. Nozaki, Y. Ohtani, T. Oka, J. Otero-Santos, S. Paiano, M. Palatiello, D. Paneque, R. Paoletti, J. M. Paredes, L. Pavletic, P. Penil, M. Persic, M. Pihet, P. G. Prada Moroni, E. Prandini, C. Priyadarshi, I. Puljak, W. Rhode, M. Ribo, J. Rico, C. Righi, A. Rugliancich, N. Sahakyan, T. Saito, S. Sakurai, K. Satalecka, F. G. Saturni, B. Schleicher, K. Schmidt, F. Schmuckermaier, J. L. Schubert, T. Schweizer, J. Sitarek, I. Snidaric, D. Sobczynska, A. Spolon, A. Stamerra, J. Striskovic, D. Strom, M. Strzys, Y. Suda, T. Suric, M. Takahashi, R. Takeishi, F. Tavecchio, P. Temnikov, T. Terzic, M. Teshima, L. Tosti, S. Truzzi, A. Tutone, S. Ubach, J. van Scherpenberg, G. Vanzo, M. Vazquez Acosta, S. Ventura, V. Verguilov, I. Viale, C. F. Vigorito, V. Vitale, I. Vovk, M. Will, C. Wunderlich, T. Yamamoto, D. Zaric, A. Neronov, D. Semikoz, A. Korochkin
Summary: This study analyzes observations from different telescopes and finds variations in the flux of γ-rays in the TeV energy range, but no variations in the 1-100 GeV energy range. This result provides constraints on the study of cosmological magnetic fields.
ASTRONOMY & ASTROPHYSICS
(2023)
Meeting Abstract
Clinical Neurology
David Rodriguez-Luna, Olalla Pancorbo, Pilar Coscojuela, Prudencio Lozano, Federica Rizzo, Marta Olive-Gadea, Manuel Requena, Alvaro Garcia-Tornel, Noelia Rodriguez-Villatoro, Jesus Juega, Sandra Boned, Marian Muchada, Jorge Pagola, Marta Rubiera, Marc Ribo, Alejandro Tomasello, Carlos A. Molina
Meeting Abstract
Clinical Neurology
Alvaro Garcia-Tornel Garcia-Camba, Prudencio Lozano, Manuel Requena, David Rodriguez-Luna, Noelia Rodriguez-Villatoro, Marta Rubiera, Marian Muchada, Marta Olive-Gadea, Federica Rizzo, Sandra Boned, Marc Ribo
Meeting Abstract
Clinical Neurology
Adnan Mujanovic, Omer Eker, Gaultier Marnat, Daniel Strbian, Petra Ijas, Cecile Preterre, Aude Triquenot, Jean-Francois Albucher, Maxime Gauberti, David Weisenburger-Lile, Marielle Sophie, Omid NIkoubashman, Anastasios Mpotsaris, Benjamin Gory, Vi Tuan Hua, Marc Ribo, David S. Liebeskind, Tomas Dobrocky, Thomas Meinel, Lukas Butikofer, Jan Gralla, Urs Fischer, Johannes Kaesmacher
Article
Medicine, General & Internal
Amrou Sarraj, Ameer E. Hassan, Michael G. Abraham, Santiago Ortega-Gutierrez, Scott E. Kasner, M. Shazam Hussain, Michael Chen, Spiros Blackburn, Clark W. Sitton, Leonid Churilov, Sophia Sundararajan, Yin C. Hu, Nabeel A. Herial, Pascal Jabbour, Daniel Gibson, Adam N. Wallace, Juan F. Arenillas, Jenny P. Tsai, Ronald F. Budzik, William J. Hicks, Osman Kozak, Bernard Yan, Dennis J. Cordato, Nathan W. Manning, Mark W. Parsons, Ricardo A. Hanel, Amin N. Aghaebrahim, Teddy Y. Wu, Pere Cardona-Portela, Natalia Perez de la Ossa, Joanna D. Schaafsma, Jordi Blasco, Navdeep Sangha, Steven Warach, Chirag D. Gandhi, Timothy J. Kleinig, Daniel Sahlein, Lucas Elijovich, Wondwossen Tekle, Edgar A. Samaniego, Laith Maali, M. Ammar Abdulrazzak, Marios N. Psychogios, Ashfaq Shuaib, Deep K. Pujara, Faris Shaker, Hannah Johns, Gagan Sharma, Vignan Yogendrakumar, Felix C. Ng, Mohammad H. Rahbar, Chunyan Cai, Philip Lavori, Scott Hamilton, Thanh Nguyen, Johanna T. Fifi, Stephen Davis, Lawrence Wechsler, Vitor M. Pereira, Maarten G. Lansberg, Michael D. Hill, James C. Grotta, Marc Ribo, Bruce C. Campbell, Gregory W. Albers
Summary: This study is a trial on the efficacy and safety of endovascular thrombectomy in patients with large ischemic strokes. The results show that compared to medical care alone, endovascular thrombectomy can improve functional independence in patients, but it also carries the risk of vascular complications.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Geriatrics & Gerontology
Anna Bonaterra-Pastra, Sonia Benitez, Olalla Pancorbo, David Rodriguez-Luna, Carla Vert, Alex Rovira, M. Mar Freijo, Silvia Tur, Maite Martinez-Zabaleta, Pere Cardona Portela, Rocio Vera, Lucia Lebrato-Hernandez, Juan F. Arenillas, Soledad Perez-Sanchez, Ana Dominguez-Mayoral, Joan Marti Fabregas, Gerard Mauri, Joan Montaner, Jose Luis Sanchez-Quesada, Mar Hernandez-Guillamon
Summary: This study found an association between cerebral amyloid angiopathy (CAA) and single nucleotide polymorphisms (SNPs) associated with Alzheimer's disease (AD). The study also observed a relationship between CAA and lipid metabolism, as well as brain vascular functionality. The levels of ApoJ and ApoE in plasma were found to be associated with CAA-related MRI markers.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Clinical Neurology
Macarena Hernandez-Jimenez, Francisco Abad-Santos, Ian Cotgreave, Jaime Gallego, Bernd Jilma, Alan Flores, Tudor G. Jovin, Jose Vivancos, Carlos A. Molina, Joan Montaner, Joaquin Casariego, Mads Dalsgaard, Maria Hernandez-Perez, David S. Liebeskind, Erik Cobo, Marc Ribo
Summary: In the reperfusion era, the combination of endovascular treatment (EVT) and neuroprotective drugs, such as ApTOLL, is emerging as a promising therapeutic option for patients with acute ischemic stroke (AIS). ApTOLL, a Toll-like receptor 4 (TLR4) antagonist, has shown neuroprotective effects in preclinical models and has a favorable pharmacokinetic and safety profile. This clinical trial, called APRIL, aims to assess the tolerability, safety, pharmacokinetics, and biological effect of ApTOLL in AIS patients eligible for EVT.
FRONTIERS IN NEUROLOGY
(2023)
Article
Plant Sciences
Jennifer Mesa-Marin, Enrique Mateos-Naranjo, Joao Carreiras, Eduardo Feijao, Bernardo Duarte, Ana Rita Matos, Marco Betti, Carmen Del Rio, Marina Romero-Bernal, Joan Montaner, Susana Redondo-Gomez
Summary: In this study, the combined effect of increased temperature and atmospheric CO2, salt and drought stress, and PGPR inoculation on the growth and nutritional parameters of Salicornia ramosissima, an edible halophyte, was investigated. It was found that these stressors led to significant changes in fatty acids, phenols, and oxalate contents of S. ramosissima, which are important compounds for human health. Results suggest that in future climate change scenarios, there will be alterations in the lipid profile and levels of oxalate and phenolic compounds in S. ramosissima due to temperature, CO2, and salt and drought stress. The effect of PGPR inoculation depended on the strains used, with some strains inducing the accumulation of phenols and oxalate. This study highlights the potential for nutritional and economic valorization of S. ramosissima in response to these stressors and environmental conditions.
Review
Clinical Neurology
E. Sanjuan, O. Pancorbo, K. Santana, O. Minarro, V. Sala, M. Muchada, S. Boned, J. M. Juega, J. Pagola, A. Garcia-Tornel, M. Requena, N. Rodriguez-Villatoro, D. Rodriguez-Luna, M. Deck, M. Ribo, C. A. Molina, P. Meler, V. Romero, G. Dalmases, M. T. Rodriguez-Samaniego, L. Calleja, T. Gutierrez, L. Pena, J. C. Gallego, E. Lorenzo, Y. Gonzalez, R. Moreno, M. Rubiera
Summary: This study provides updated, evidence-based recommendations for the management of acute stroke, serving as a reference for nursing care protocols. The available evidence and national and international guidelines were reviewed to establish levels of evidence and degrees of recommendation. The study covers various aspects of acute stroke care, including prehospital care, code stroke protocol, stroke team care, reperfusion treatments, stroke unit admission, nursing care, and discharge from hospital. However, more research is needed for certain aspects of acute stroke management.
Article
Clinical Neurology
Chi P. Nguyen, Maarten M. H. Lahr, Durk-Jouke van der Zee, Henk van Voorst, Marc Ribo, Yvo B. W. M. Roos, Ido van den Wijngaard, Erik Buskens, Maarten Uyttenboogaart
Summary: This study evaluated the cost-effectiveness of the direct transfer of patients with suspected large vessel occlusion (LVO) to the angiography suite (DTAS) strategy compared to the initial transfer to the emergency room (ITER) strategy. The results showed that the DTAS strategy was more cost-effective and resulted in better outcomes compared to the ITER strategy.
Article
Behavioral Sciences
Elena Pala, Anna Penalba, Alejandro Bustamante, Teresa Garcia-Berrocoso, Marcel Lamana-Vallverdu, Christian Meisel, Andreas Meisel, H. Bart van der Worp, Malcolm R. Macleod, Bernd Kallmuenzer, Stefan Schwab, Joan Montaner
Summary: Blood biomarkers, including MMP-3, FABP, and IL-8, showed increased levels over time in relation to therapeutic hypothermia in stroke patients. These changes could serve as surrogate markers to evaluate the efficacy and safety of hypothermia treatment.
BRAIN AND BEHAVIOR
(2023)
Article
Biochemical Research Methods
Tanushree Halder, Elke Stroeher, Hui Liu, Yinglong Chen, Guijun Yan, Kadambot H. M. Siddique
Summary: Improving the root system of wheat is crucial for enhancing grain yield and climate resilience. This study identified proteins associated with root length and root mass in wheat using label-free quantitative proteomics. The findings revealed potential biomarkers that could be used for improving the root system of wheat.
JOURNAL OF PROTEOMICS
(2024)
Article
Biochemical Research Methods
Yinhua Pan, Quanqing Zou, Wu Yin, Zhen Huang, Yingzhu Zhao, Zongming Mo, Lihui Li, Jianrong Yang
Summary: A prognostic model of BC based on LNM-related genes was established in this study, providing guidance for prognosis evaluation and precise treatment of BC. The genes related to lymph node metastasis in BC are largely unknown and need further exploration. Searching for potential lymph node metastasis-related genes of BC will provide meaningful biomarkers for BC treatment. Our model, based on TCGA-BRCA data, effectively predicted patient outcomes and classified BC patients. The identified feature genes might have a predictive function in immunotherapy. The results of this study provide a new reference for the prognosis and treatment of BC patients with lymph node metastasis.
JOURNAL OF PROTEOMICS
(2024)
Article
Biochemical Research Methods
Qiushi Liang, Joon M. Pijnenburg, Erikjan Rijkers, Arnold G. Vulto, Ans T. van der Ploeg, Niek P. van Til, Eva C. Vlaar, Jeroen A. A. Demmers, W. W. M. Pim Pijnappel
Summary: Pompe disease is a lysosomal storage disorder characterized by glycogen accumulation in skeletal muscle, leading to profound pathology. This study showed that lentiviral gene therapy with LV-IGF2.GAAco can nearly completely correct disease-associated proteomic changes, supporting its future clinical development as a new treatment option for Pompe disease.
JOURNAL OF PROTEOMICS
(2024)
Article
Biochemical Research Methods
Chuang Liu, Wenjing Zhang, Qianli Dong, Haipeng Liu
Summary: This study fills the knowledge gap about the matrix proteins involved in the formation of mineralized exoskeletons in decapod crustaceans. By comparing with well-studied molluscan biomineralization proteins, it is proposed that decapod crustaceans evolved novel proteins while sharing some proteins with molluscs. This study provides insights into the evolution and adaptation of crustaceans and molluscs in forming their exoskeletons.
JOURNAL OF PROTEOMICS
(2024)
Article
Biochemical Research Methods
Rania D. Baka, Josipa Kules, Angelo Beletic, Vladimir Farkas, Dina Resetar Maslov, Blanka Beer Ljubic, Ivana Rubic, Vladimir Mrljak, Mark McLaughlin, David Eckersall, Zoe Polizopoulou
Summary: This study analyzed serum samples from dogs with epilepsy and identified potential markers of epilepsy, proteins involved in nerve tissue regeneration, and proteins altered by antiepileptic medication. The findings provide insight into the pathogenesis of epilepsy and the effects of medication on extracellular matrix proteins.
JOURNAL OF PROTEOMICS
(2024)
Article
Biochemical Research Methods
Viviane M. Codognoto, Fabiana F. de Souza, Thais R. Cataldi, Carlos A. Labate, Laiza S. de Camargo, Pedro H. Esteves Trindade, Roberto R. da Rosa Filho, Diego J. B. de Oliveira, Eunice Oba
Summary: This study aimed to compare urine proteomics from non- and pregnant buffaloes to identify potential biomarkers of early pregnancy. A total of 798 proteins were reported in the urine considering all groups, and the differential proteins play essential roles during pregnancy.
JOURNAL OF PROTEOMICS
(2024)