Article
Biochemistry & Molecular Biology
Sungtaek Oh, Yura Jang, Chan Hyun Na
Summary: This study used discovery-based approaches and quantitative comparative analyses to identify differential proteins in the cerebrospinal fluid (CSF) of patients with ALS. They found 15 proteins that showed significant differences between ALS and the control group, providing a foundation for biomarker research in ALS.
Review
Biochemistry & Molecular Biology
Besnik Muqaku, Patrick Oeckl
Summary: Mass spectrometry is an important technique for analyzing biomolecules, especially in the field of neurodegenerative diseases where peptidomics analysis of cerebrospinal fluid samples has played a crucial role.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Geriatrics & Gerontology
Nicolas Delcourt, Alix-Marie Pouget, Alicia Grivaud, Leonor Nogueira, Frederic Larvor, Philippe Marchand, Eric Schmidt, Bruno Le Bizec
Summary: This study found that PFAS compounds, widely used in various products, are present in human cerebrospinal fluid and are associated with clinical and biological markers of Alzheimer's disease.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Review
Cell Biology
Rita Azevedo, Chloe Jacquemin, Nicolas Villain, Francois Fenaille, Foudil Lamari, Francois Becher
Summary: Neurodegenerative diseases are incurable disorders that challenge modern medicine. A deeper understanding of the pathogenesis underlying these diseases is necessary to develop new diagnostic biomarkers and disease-modifying therapy. Mass spectrometry analysis has provided breakthroughs in studying post-translational modifications in neurodegenerative diseases and discovering potential clinical markers.
Article
Cell Biology
Julia Costa, Catherine Hayes, Frederique Lisacek
Summary: Glycosylation is a common post-translational modification of brain proteins, and abnormal glycosylation has been found in central nervous system disorders. A detailed analysis of glycan structures in brain tissues and cerebrospinal fluid has been conducted, creating a dedicated set in the GlyConnect database. The shared molecular composition between cerebrospinal fluid and brain may lead to the discovery of novel glycobiomarkers for neurodegenerative diseases, providing potential therapeutic targets and diagnostic tools.
AGEING RESEARCH REVIEWS
(2023)
Article
Neurosciences
Fan Liu, Yun Bao, Binghui Qiu, Jian Mao, Xixian Liao, Haorun Huang, An Zhang, Guozhong Zhang, Songtao Qi, Fen Mei
Summary: In this study, we identified and validated five cerebrospinal fluid (CSF) biomarkers for cognitive impairment in patients with aneurysmal subarachnoid hemorrhage (aSAH). These biomarkers have important predictive and discriminative potential for cognitive impairment in aSAH and could be potential targets for early disease intervention.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Clinical Neurology
Matthias Schmitz, Anna Villar-Pique, Peter Hermann, Georgia Escaramis, Miguel Calero, Cao Chen, Niels Kruse, Maria Cramm, Ewa Golanska, Beata Sikorska, Pawel P. Liberski, Maurizio Pocchiari, Peter Lange, Christiane Stehmann, Shannon Sarros, Eulalia Marti, Ines Baldeiras, Isabel Santana, Dana Zakova, Eva Mitrova, Xiao-Ping Dong, Steven Collins, Anna Poleggi, Anna Ladogana, Brit Mollenhauer, Gabor G. Kovacs, Michael D. Geschwind, Raquel Sanchez-Valle, Inga Zerr, Franc Llorens
Summary: This study aimed to analyze the diagnostic accuracy of cerebrospinal fluid (CSF) biomarkers used in the clinical diagnosis of genetic prion diseases. The study included 302 symptomatic cases from 11 prion diagnostic centers, encompassing 36 different pathogenic sequence variations. The results showed variations in the accuracy and associations of biomarkers in different genetic prion diseases.
Article
Neurosciences
Virginie Imbault, Chiara Dionisi, Gilles Naeije, David Communi, Massimo Pandolfo
Summary: This study aimed to identify potential biomarkers in FRDA patients by analyzing changes in cerebrospinal fluid (CSF) proteins. The researchers found 172 differentially expressed proteins between FRDA patients and controls, indicating possible involvement of various signaling pathways and pathogenic mechanisms.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Clinical Neurology
Weiwei Liu, Ruze Ma, Chen Sun, Yingxi Xu, Yang Liu, Jiajin Hu, Yanan Ma, Difei Wang, Deliang Wen, Yang Yu
Summary: Neurodegenerative diseases (NDs) affect 15% of the world's population and have become a common cause of morbidity and mortality worldwide. Studies have shown that circadian rhythm disorders (CRDs) are involved in the pathogenic regulation of various neurologic diseases, including Alzheimer's disease, Parkinson's disease, Huntington's disease, multiple sclerosis, and amyotrophic lateral sclerosis. Proteomic technology is useful in identifying treatment targets for CRDs in patients with NDs. This review provides a theoretical and technical reference for the precise study of circadian disorder-mediated regulation of ND pathology.
SLEEP MEDICINE REVIEWS
(2023)
Review
Biochemistry & Molecular Biology
Xin-Yu Ma, Ting-Ting Yang, Lian Liu, Xiao-Chun Peng, Feng Qian, Feng-Ru Tang
Summary: The loss of neurons caused by progressive damage to the nervous system is proposed as the main pathogenesis of neurodegenerative diseases. Ependyma, composed of ciliated ependymal cells, plays a role in the formation of the brain-cerebrospinal fluid barrier (BCB) and the circulation and material exchange of cerebrospinal fluid (CSF) and brain interstitial fluid. Radiation-induced brain injury (RIBI) leads to impairments of the blood-brain barrier (BBB). The vulnerability of ependyma to immune responses may disrupt the integrity of BCB, affecting CSF flow and material exchange, and contributing to the pathogenesis of neurodegenerative diseases.
Article
Biochemistry & Molecular Biology
Nathan Hwangbo, Xinyu Zhang, Daniel Raftery, Haiwei Gu, Shu-Ching Hu, Thomas J. Montine, Joseph F. Quinn, Kathryn A. Chung, Amie L. Hiller, Dongfang Wang, Qiang Fei, Lisa Bettcher, Cyrus P. Zabetian, Elaine R. Peskind, Ge Li, Daniel E. L. Promislow, Marie Y. Davis, Alexander Franks
Summary: Metabolomics has been utilized to analyze human cerebrospinal fluid samples and found strong separation between PD and AD patients and healthy controls in the metabolome. Key metabolites associated with PD and AD classification were identified, along with metabolic pathways linked to these neurodegenerative diseases.
Review
Biochemistry & Molecular Biology
Irina Baichurina, Victor Valiullin, Victoria James, Albert Rizvanov, Yana Mukhamedshina
Summary: Despite extensive research, the molecular mechanisms underlying neurological disorders, especially spinal cord injury and neurodegenerative diseases, remain unclear. microRNAs (miRNAs) in cerebrospinal fluid (CSF) have been proposed as potential biomarkers, but their isolation and detection are technically challenging. This review evaluates recent studies on CSF miRNAs as biomarkers and provides an overview of research methods and possible solutions for studying miRNAs in CSF.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Visesha Kakarla, Scott L. Letendre, Ronald J. Ellis
Summary: Accumulation of soluble proteins and metabolites during wakefulness and their clearance during sleep via the glymphatic system is disturbed in some neurological conditions and has not been evaluated in people with HIV.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Dorota Konickova, Katerina Mensikova, Katerina Klicova, Monika Chudackova, Michaela Kaiserova, Hana Prikrylova, Pavel Otruba, Martin Nevrly, Petr Hlustik, Eva Henykova, Michal Kaleta, David Friedecky, Radoslav Matej, Miroslav Strnad, Ondrej Novak, Lucie Plihalova, Raymond Rosales, Carlo Colosimo, Petr Kanovsky
Summary: Neurodegenerative diseases are a heterogeneous group of diseases that affect the nervous system. Clinical diagnosis of these diseases is challenging due to their variability and overlapping symptoms. This study aimed to identify biomarkers in the cerebrospinal fluid and serum that can aid in the differential diagnosis and differentiation of specific neurodegenerative diseases. The results suggest that the proposed biomarkers can be useful for distinguishing between certain types of neurodegenerative diseases.
JOURNAL OF NEUROCHEMISTRY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Melissa M. Grant, John J. Taylor, Katrin Jaedicke, Andrew Creese, Catherine Gowland, Bernard Burke, Khawla Doudin, Upen Patel, Paul Weston, Michael Milward, Susan M. Bissett, Helen J. Cooper, Gerben Kooijman, Amir Rmaile, Marko de Jager, Philip M. Preshaw, Iain L. C. Chapple
Summary: Differential protein biomarkers in saliva and gingival crevicular fluid can be used to objectively distinguish between periodontal health and disease states.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2022)
Article
Biochemical Research Methods
Tanushree Halder, Elke Stroeher, Hui Liu, Yinglong Chen, Guijun Yan, Kadambot H. M. Siddique
Summary: Improving the root system of wheat is crucial for enhancing grain yield and climate resilience. This study identified proteins associated with root length and root mass in wheat using label-free quantitative proteomics. The findings revealed potential biomarkers that could be used for improving the root system of wheat.
JOURNAL OF PROTEOMICS
(2024)
Article
Biochemical Research Methods
Yinhua Pan, Quanqing Zou, Wu Yin, Zhen Huang, Yingzhu Zhao, Zongming Mo, Lihui Li, Jianrong Yang
Summary: A prognostic model of BC based on LNM-related genes was established in this study, providing guidance for prognosis evaluation and precise treatment of BC. The genes related to lymph node metastasis in BC are largely unknown and need further exploration. Searching for potential lymph node metastasis-related genes of BC will provide meaningful biomarkers for BC treatment. Our model, based on TCGA-BRCA data, effectively predicted patient outcomes and classified BC patients. The identified feature genes might have a predictive function in immunotherapy. The results of this study provide a new reference for the prognosis and treatment of BC patients with lymph node metastasis.
JOURNAL OF PROTEOMICS
(2024)
Article
Biochemical Research Methods
Qiushi Liang, Joon M. Pijnenburg, Erikjan Rijkers, Arnold G. Vulto, Ans T. van der Ploeg, Niek P. van Til, Eva C. Vlaar, Jeroen A. A. Demmers, W. W. M. Pim Pijnappel
Summary: Pompe disease is a lysosomal storage disorder characterized by glycogen accumulation in skeletal muscle, leading to profound pathology. This study showed that lentiviral gene therapy with LV-IGF2.GAAco can nearly completely correct disease-associated proteomic changes, supporting its future clinical development as a new treatment option for Pompe disease.
JOURNAL OF PROTEOMICS
(2024)
Article
Biochemical Research Methods
Chuang Liu, Wenjing Zhang, Qianli Dong, Haipeng Liu
Summary: This study fills the knowledge gap about the matrix proteins involved in the formation of mineralized exoskeletons in decapod crustaceans. By comparing with well-studied molluscan biomineralization proteins, it is proposed that decapod crustaceans evolved novel proteins while sharing some proteins with molluscs. This study provides insights into the evolution and adaptation of crustaceans and molluscs in forming their exoskeletons.
JOURNAL OF PROTEOMICS
(2024)
Article
Biochemical Research Methods
Rania D. Baka, Josipa Kules, Angelo Beletic, Vladimir Farkas, Dina Resetar Maslov, Blanka Beer Ljubic, Ivana Rubic, Vladimir Mrljak, Mark McLaughlin, David Eckersall, Zoe Polizopoulou
Summary: This study analyzed serum samples from dogs with epilepsy and identified potential markers of epilepsy, proteins involved in nerve tissue regeneration, and proteins altered by antiepileptic medication. The findings provide insight into the pathogenesis of epilepsy and the effects of medication on extracellular matrix proteins.
JOURNAL OF PROTEOMICS
(2024)
Article
Biochemical Research Methods
Viviane M. Codognoto, Fabiana F. de Souza, Thais R. Cataldi, Carlos A. Labate, Laiza S. de Camargo, Pedro H. Esteves Trindade, Roberto R. da Rosa Filho, Diego J. B. de Oliveira, Eunice Oba
Summary: This study aimed to compare urine proteomics from non- and pregnant buffaloes to identify potential biomarkers of early pregnancy. A total of 798 proteins were reported in the urine considering all groups, and the differential proteins play essential roles during pregnancy.
JOURNAL OF PROTEOMICS
(2024)
