Article
Cell Biology
Scott Cooper, Phillip A. Wilmarth, Jennifer M. Cunliffe, John Klimek, Jiaqing Pang, Samuel Tassi Yunga, Jessica Minnier, Ashok Reddy, Larry David, Joseph E. Aslan
Summary: By studying the proteomes of platelets from hibernating ground squirrels, it was found that there are significant variations in platelet proteins during hibernation, which may support hemostatic adaptations in torpor.
PHYSIOLOGICAL GENOMICS
(2021)
Review
Cell Biology
Zhi Cai, Junyan Feng, Nian Dong, Pan Zhou, Yuanshuai Huang, Hongwei Zhang
Summary: Platelet-derived extracellular vesicles (PEVs) not only have procoagulant activity but also contain platelet-derived inflammatory factors that mediate inflammatory responses. Studies have shown that platelets are activated during storage to produce large amounts of PEVs, which may have implications for platelet transfusion therapy. Compared to platelets, PEVs have a longer storage time and greater procoagulant activity, making them an ideal alternative to platelets.
Article
Cell Biology
Ujjal Didar Singh Sekhon, Kelsey Swingle, Aditya Girish, Norman Luc, Maria de la Fuente, Jurgis Alvikas, Shannon Haldeman, Adnan Hassoune, Kaisal Shah, Youjoung Kim, Steven Eppell, Jeffrey Capadona, Andrew Shoffstall, Matthew D. Neal, Wei Li, Marvin Nieman, Anirban Sen Gupta
Summary: Platelet-mimicking procoagulant nanoparticles (PPNs) have been created to emulate the functions of platelets and address the challenges of limited availability and contamination risk in the treatment of bleeding disorders. In vitro and in vivo experiments have shown that PPNs can effectively restore and enhance clotting functions, reduce bleeding, and improve survival rates without systemic or off-target thrombotic risks.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Hanqi Zhao, Dana V. Devine
Summary: Cold-stored platelets are gaining attention due to their superior hemostatic effectiveness, reduced bacterial growth, and longer shelf lives. However, further experimental studies are needed before reintroducing them in clinical settings.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Christos Gogos, Konstantinos Stamos, Nikolaos Tsanaxidis, Ioannis Styliadis, Ioanna Koniari, Sophia N. N. Kouni, Cesare de Gregorio, Nicholas G. G. Kounis
Summary: Kounis syndrome is a disease that affects the circulatory system and can result in spasms and blood clot formation. It can occur due to allergic or hypersensitivity reactions and involves the release of inflammatory mediators. The syndrome can affect various arteries, including the coronary arteries.
Article
Medicine, General & Internal
Patou Masika Musumari, Samclide Mutindu Mbikayi, Kriengkrai Srithanaviboonchai, Teeranee Techasrivichien, Arunrat Tangmunkongvorakul, Leon Tshilolo
Summary: Blood transfusion is a life-saving procedure with associated risks, including acute transfusion reactions (ATRs). This study in the DRC documented a 2.6% prevalence of ATRs in blood transfusion recipients, with common symptoms being dyspnea, fever, and rash/hives. The study emphasizes the need for surveillance to detect, prevent, and manage ATRs in this context.
Review
Medicine, General & Internal
Xinyan Wang, Xinxin Wang, Fa Liang, Yun Yu, Ruquan Han
Summary: This study aims to analyze the safety and efficacy of different doses and administration routes of TXA in surgery using the network meta-analysis method. The study will investigate heterogeneity through literature screening, subgroup analysis, and sensitivity analysis, and evaluate the certainty of the evidence.
Article
Medicine, General & Internal
Nanfang Xu, Youyu Zhang, Yun Tian, Baohua Li, Haiqin Qiao, Xiaoqing Zhang, Nan Yang, Wei Li, Chao Zhang, Weishi Li, Wei Fu
Summary: This study aims to investigate the clinical effectiveness of preoperative autologous blood donation (PABD) in patients undergoing lumbar fusion surgery and explore the optimal timing for PABD. A total of 1200 eligible patients will be recruited and randomly assigned to three groups for observation.
Review
Biochemistry & Molecular Biology
Olga Shevchuk, Antonija Jurak Begonja, Stepan Gambaryan, Matthias Totzeck, Tienush Rassaf, Tobias B. Huber, Andreas Greinacher, Thomas Renne, Albert Sickmann
Summary: This review discusses the role of proteomics in understanding the molecular basics of traditional and emerging functions of platelets, as well as the application of proteomic technologies in platelet biogenesis, signaling, and storage. Additionally, the potential of newly appeared trapped ion mobility spectrometry (TIMS) in platelet research is highlighted, along with discussions on the implementation of proteomic methods in platelet transfusion medicine, diagnostics, and prognostics.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemical Research Methods
HanQi Wayne Zhao, Katherine Serrano, Davide Stefanoni, Angelo D'Alessandro, Dana Devine
Summary: The research shows that cold-stored platelets have higher hemostatic functions and can be stored for longer periods, with lower oxidative stress and reduced energy needs.
JOURNAL OF PROTEOME RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Narges Hadjesfandiari, Mona Khorshidfar, Dana V. Devine
Summary: This review article examines the molecular differences impacting the quality of blood components, with a focus on factors affecting the quality of red blood cells and platelets, and emphasizes the importance of donor individual molecular and genetic profile in improving blood component quality.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Medicine, General & Internal
Marius Roman, Oluwatomini Fashina, Sara Tomassini, Riccardo G. Abbasciano, Florence Lai, Toby Richards, Gavin Murphy
Summary: This study examined the effects of declared and undeclared conflicts of interest on patient blood management interventions in randomized controlled trials. The findings suggest that there is reporting bias favoring PBM interventions and that trials with declared conflicts linked to professional advocacy groups had significant reductions in mortality.
Article
Veterinary Sciences
James L. L. Cooper, Claire R. R. Sharp, Corrin J. J. Boyd, Melissa A. A. Claus, Gabriel Rossi
Summary: This study compared the hemostatic characteristics of cold-stored whole blood from non-greyhound dogs and greyhound dogs over 42 days. The results showed that the hemostatic activity of greyhound dogs was generally lower than that of non-greyhound dogs, but most parameters remained above 50% of baseline for more than 14 days.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Review
Biochemistry & Molecular Biology
Angelo D'Alessandro, Alkmini T. Anastasiadi, Vassilis L. Tzounakas, Travis Nemkov, Julie A. Reisz, Anastsios G. Kriebardis, James C. Zimring, Steven L. Spitalnik, Michael P. Busch
Summary: Red blood cells play a central role in oxygen transport in the human body. Recent advancements in omics technologies have revealed the complex proteome and metabolome of red blood cells, leading to a reevaluation of the mechanisms underlying RBC metabolism. These findings have also provided insights into changes that occur during refrigerated storage of RBCs in blood banks, which are crucial for life-saving transfusions worldwide.
Article
Medicine, General & Internal
Ali T. Taher, Khaled M. Musallam, Vip Viprakasit, Antonis Kattamis, Jennifer Lord-Bessen, Aylin Yucel, Shien Guo, Christopher Pelligra, Alan L. Shields, Jeevan K. Shetty, Dimana Miteva, Luciana Moro Bueno, Maria Domenica Cappellini
Summary: The NTDT-PRO questionnaire was developed to assess anaemia-related tiredness/weakness and shortness of breath in patients with NTDT. The psychometric properties of the questionnaire were evaluated using blinded data from the BEYOND trial, and it was found to have adequate reliability and validity.
Article
Biochemical Research Methods
Tanushree Halder, Elke Stroeher, Hui Liu, Yinglong Chen, Guijun Yan, Kadambot H. M. Siddique
Summary: Improving the root system of wheat is crucial for enhancing grain yield and climate resilience. This study identified proteins associated with root length and root mass in wheat using label-free quantitative proteomics. The findings revealed potential biomarkers that could be used for improving the root system of wheat.
JOURNAL OF PROTEOMICS
(2024)
Article
Biochemical Research Methods
Yinhua Pan, Quanqing Zou, Wu Yin, Zhen Huang, Yingzhu Zhao, Zongming Mo, Lihui Li, Jianrong Yang
Summary: A prognostic model of BC based on LNM-related genes was established in this study, providing guidance for prognosis evaluation and precise treatment of BC. The genes related to lymph node metastasis in BC are largely unknown and need further exploration. Searching for potential lymph node metastasis-related genes of BC will provide meaningful biomarkers for BC treatment. Our model, based on TCGA-BRCA data, effectively predicted patient outcomes and classified BC patients. The identified feature genes might have a predictive function in immunotherapy. The results of this study provide a new reference for the prognosis and treatment of BC patients with lymph node metastasis.
JOURNAL OF PROTEOMICS
(2024)
Article
Biochemical Research Methods
Qiushi Liang, Joon M. Pijnenburg, Erikjan Rijkers, Arnold G. Vulto, Ans T. van der Ploeg, Niek P. van Til, Eva C. Vlaar, Jeroen A. A. Demmers, W. W. M. Pim Pijnappel
Summary: Pompe disease is a lysosomal storage disorder characterized by glycogen accumulation in skeletal muscle, leading to profound pathology. This study showed that lentiviral gene therapy with LV-IGF2.GAAco can nearly completely correct disease-associated proteomic changes, supporting its future clinical development as a new treatment option for Pompe disease.
JOURNAL OF PROTEOMICS
(2024)
Article
Biochemical Research Methods
Chuang Liu, Wenjing Zhang, Qianli Dong, Haipeng Liu
Summary: This study fills the knowledge gap about the matrix proteins involved in the formation of mineralized exoskeletons in decapod crustaceans. By comparing with well-studied molluscan biomineralization proteins, it is proposed that decapod crustaceans evolved novel proteins while sharing some proteins with molluscs. This study provides insights into the evolution and adaptation of crustaceans and molluscs in forming their exoskeletons.
JOURNAL OF PROTEOMICS
(2024)
Article
Biochemical Research Methods
Rania D. Baka, Josipa Kules, Angelo Beletic, Vladimir Farkas, Dina Resetar Maslov, Blanka Beer Ljubic, Ivana Rubic, Vladimir Mrljak, Mark McLaughlin, David Eckersall, Zoe Polizopoulou
Summary: This study analyzed serum samples from dogs with epilepsy and identified potential markers of epilepsy, proteins involved in nerve tissue regeneration, and proteins altered by antiepileptic medication. The findings provide insight into the pathogenesis of epilepsy and the effects of medication on extracellular matrix proteins.
JOURNAL OF PROTEOMICS
(2024)
Article
Biochemical Research Methods
Viviane M. Codognoto, Fabiana F. de Souza, Thais R. Cataldi, Carlos A. Labate, Laiza S. de Camargo, Pedro H. Esteves Trindade, Roberto R. da Rosa Filho, Diego J. B. de Oliveira, Eunice Oba
Summary: This study aimed to compare urine proteomics from non- and pregnant buffaloes to identify potential biomarkers of early pregnancy. A total of 798 proteins were reported in the urine considering all groups, and the differential proteins play essential roles during pregnancy.
JOURNAL OF PROTEOMICS
(2024)