期刊
JOURNAL OF PROTEOMICS
卷 73, 期 2, 页码 209-217出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jprot.2009.06.012
关键词
QX disease; Marteilia sydneyi; Proteomics; Saccostrea glomerata; Sydney rock oysters; Superoxide dismutase; Two dimensional electrophoresis
资金
- Australian Fisheries Research and Development Corporation (FRDC) in conjunction with the NSW Department of Primary industries
The Sydney rock oyster, Saccostrea glomerata, is susceptible to infection by the protozoan parasite, Marteilia sydneyi, the causative agent of QX disease. M. sydneyi infection peaks during summer when QX disease can cause up to 95% mortality. The current study takes a proteomic a roach using 2-dimensional electrophoresis and mass spectrometry to identify markers of QX disease resistance among Sydney rock oysters. Proteome maps were developed for QX disease-resistant and -susceptible oysters. Six proteins in those maps were clearly associated with resistance and so were characterized by mass spectrometry. Two of the proteins (p9 and p11) were homologous to superoxide dismutase-like molecules from the Pacific oyster, Crassostrea gigas, and the Eastern oyster, Crassostrea virginica. The remaining S. glomerata proteins had no obvious similarities to known molecules in sequence databases. p9 and p11 are currently being investigated as potential markers for the selective breeding of QX disease-resistant oysters. (C) 2009 Elsevier B.V. All rights reserved.
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