期刊
PHYSIOLOGY & BEHAVIOR
卷 144, 期 -, 页码 1-6出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.physbeh.2015.03.011
关键词
Chronic stress; Unpredicted; Chronic mild stress; Hippocampus; Autophagy; Reverse teaming; Morris water maze
资金
- Science Philosophy Betterment Society (Registered British Virgin Islands)
- Hundred Talents program of Nanjing Normal University
- Qing Lan Project of Nanjing Normal University
- Jiangsu Provincial Natural Science Foundation [BK20140917]
Chronic stress results in hippocampal injury, and impairs learning and memory ability of animals. However the cellular mechanisms underlying cell death within hippocampus remain elusive. The present employed the rat model of chronic unpredicted mild stress (CUMS) and examined the cellular mechanism responsible for learning and memory impairments. The results showed that in correlation to the decreased ability in novelty cognition and reverse learning, CUMS led to loss of CA3 neurons in hippocampus, especially in the right hippocampus. Interestingly, autophagy contributed to the cell loss but was asymmetrical on both sides. This suggested that CUMS resulted in asymmetrical hippocampal injuries, which is not fully determined by autophagy. (C) 2015 Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据