Review
Oncology
Andrew Gold, Fouad Choueiry, Ning Jin, Xiaokui Mo, Jiangjiang Zhu
Summary: Colorectal Cancer (CRC) is a leading cause of cancer-related death in the United States and current diagnosis techniques lack sufficient sensitivity. Metabolomics is a promising technique for identifying CRC biomarkers with high sensitivity and specificity, but it is rarely used in clinical settings. This study conducted a systematic review of recent literature on the detection of CRC biomarkers through metabolomics, identifying dysregulated metabolites across different biospecimens. The study also highlighted the interplay between the gut microbiome and perturbed metabolites in CRC. The findings demonstrate the value of metabolomics as a promising diagnostic technique for CRC.
Review
Biochemistry & Molecular Biology
Atiah H. Almalki
Summary: Lung cancer is the leading cause of cancer-related death worldwide. This review presents recent trends in the analytical techniques used for metabolome mapping of lung cancer, and discusses the potential applications of these techniques in the analysis of biological samples, providing new avenues for treatment strategies and monitoring drug responses.
Article
Biochemistry & Molecular Biology
Katarina Davalieva, Sanja Kiprijanovska, Ognen Ivanovski, Aleksandar Trifunovski, Skender Saidi, Aleksandar Dimovski, Zivko Popov
Summary: The high recurrence rate and invasive diagnostic methods in bladder cancer clinical management require the development of new non-invasive molecular tools for early detection and risk stratification. This study identified potential non-invasive diagnostic and prognostic markers using a new analysis method, expanding the field of bladder cancer research.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Chemistry, Analytical
Muhammad Waris, Engin Kocak, Ekrem Murat Gonulalan, L. Omur Demirezer, Sedef Kir, Emirhan Nemutlu
Summary: Plant-based metabolomics studies aim to discover new active compounds, determine vegetation period, investigate adulteration, evaluate correlation activity and metabolite levels, and monitor quality control of medicinal plants. However, the chemical differences of primary and secondary metabolites in complex natural products present challenges for analysis, ranging from sample collection to preparation, and from analysis to metabolite annotation and quantification. A comprehensive evaluation of current and new trends in plant metabolomics helps researchers in designing their studies holistically.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2022)
Article
Food Science & Technology
Yuling Wu, Zhanming Li, Hui Zhu, Run Zi, Fang Xue, Yue Yu
Summary: Tartary buckwheat has attracted more attention due to its unique chemical composition and higher efficacy in disease prevention. However, counterfeiting and adulteration of Tartary buckwheat with common buckwheat is common, leading to consumer harm and market disruption. This study used metabolomics technology to develop a new and simple identification method for Tartary buckwheat and common buckwheat, revealing differential metabolic pathways between the two. This research has important implications for quality control of related agricultural products.
Article
Biochemistry & Molecular Biology
Dingnian Bi, Mingyang Shi, Qian Hu, Hongling Wang, Didong Lou, Aihua Zhang, Yong Hu
Summary: This study investigated the potential biomarkers and metabolic pathways of arsenic-induced liver injury using a metabolomic approach. The results showed significantly increased levels of arsenic, ALT, ALP, and TBA in the livers of rats treated with arsenic, along with histological evidence of liver damage. Metabolomic analysis identified 109 significantly altered metabolites and several metabolic pathways, providing potential evidence for the early diagnosis and prevention of arsenism.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2022)
Article
Environmental Sciences
Yiyang Li, Nyuk Ling Ma, Huiling Chen, Jiateng Zhong, Dangquan Zhang, Wanxi Peng, Su Shiung Lam, Yafeng Yang, Xiaochen Yue, Lijun Yan, Ting Wang, Bjarne Styrishave, Tomasz Maciej Ciesielski, Christian Sonne
Summary: According to the World Health Organization, breast cancer is a common and serious health issue for women. This study focuses on searching for bioactive compounds from plants for breast cancer treatment. By screening plant extracts from Chinese ancient forests, the researchers identified potent extracts from Amur honeysuckle and Nigaki plants. Further experiments showed that these extracts significantly reduced tumor growth and killed breast cancer cells. The study also found that the extracts target and interact with known breast cancer genes, providing new insights for future cancer treatments.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Chemistry, Applied
Ting Zeng, Baohua Fang, Fenglin Huang, Li Dai, Zhi Tang, Jinglin Tian, Guodong Cao, Xuanlin Meng, Yuanchen Liu, Bo Lei, Minghua Lu, Zongwei Cai
Summary: Through metabolomics analysis, it was found that under cadmium stress, most carbohydrates and amino acids were down-regulated as the cadmium concentration increased in rice grains, except for myoinositol which can prevent cadmium toxicity. D-Mannitol and L-cysteine were up-regulated in low-cadmium-accumulating rice with the increase of cadmium concentration. Organic acids, especially 13-(S)-hydroperoxy-9(Z),11(E),15(Z)-octadecatrienoic acid related to alphalinolenic acid metabolism and jasmonic acid production, were activated.
Review
Chemistry, Analytical
Tengfei Yuan
Summary: Analyzing steroids in different biological matrices helps gain insight into the status of steroids.
MICROCHEMICAL JOURNAL
(2022)
Article
Chemistry, Analytical
Kaijing Guo, Xiao He, Hongyi Zhao, Chen Ma
Summary: This study investigated the stress testing of Tegoprazan under various conditions, including hydrolysis, oxidation, photolysis, and thermal stress. The results showed that Tegoprazan exhibits instability in acidic, alkaline, and oxidative conditions, and eight degradation products were identified. The synthesis and confirmation of DP-1, DP-2, and DP-3 were successfully achieved, and the degradation pathway of Tegoprazan was summarized. To the best of our knowledge, this is the first study on the forced degradation of Tegoprazan.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2023)
Article
Agronomy
Archis Pandya, Bjorn Thiele, Andres Zurita-Silva, Bjorn Usadel, Fabio Fiorani
Summary: The study evaluated saponin content and their corresponding sapogenins in 114 different quinoa accessions, showing considerable variability in saponin content in quinoa. Approximately 75% of the genotypes were classified as low-saponin content lines, which is promising for current and future quinoa breeding programs. Additionally, twelve saponins of the oleanane type were identified, including a previously unreported compound, contributing to the valorization of genetic resources for quinoa.
Review
Medical Laboratory Technology
Stephanie Rankin-Turner, Liam M. Heaney
Summary: Mass spectrometry (MS) has become a powerful and versatile tool in clinical laboratory, with advancements in biomarker detection, protein measurement, therapeutic drug monitoring, and automation leading to potential revolution in clinical testing.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2023)
Article
Environmental Sciences
C. D. Metcalfe, S. Bayen, M. Desrosiers, G. Munoz, S. Sauve, V Yargeau
Summary: Endocrine disrupting chemicals (EDCs) are a diverse group of chemicals that require sensitive and varied analytical methods to monitor their presence in the environment. Only environmental matrixes with a clear link to endocrine effects are included, and emerging methods and advanced instruments for sample preparation are also discussed.
ENVIRONMENTAL RESEARCH
(2022)
Article
Horticulture
Jung-Sung Chung, Hyeong-Cheol Kim, Su-Min Yun, Hyun-Jin Kim, Cheol-Soo Kim, Jeung-Joo Lee
Summary: Sulfur is an essential nutrient for plant growth and metabolism, and significantly affects the growth and metabolites of lettuce. Higher sulfur concentration treatment resulted in increased growth and metabolite content in lettuce compared to lower sulfur concentration treatment.
Article
Pharmacology & Pharmacy
Donghui Lao, Rong Liu, Jianying Liang
Summary: By applying metabolomics, potential biomarkers for AIDS patients have been identified and verified, suggesting their potential role in the diagnosis of HIV/AIDS.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Ziteng Wang, Eleanor Jing Yi Cheong, Pipin Kojodjojo, Eric Chun Yong Chan
Summary: Concurrent use of rivaroxaban and amiodarone increases the risk of bleeding. The study found that human renal organic anion transporter 3 (hOAT3) plays a key role in the renal secretion of rivaroxaban and amiodarone inhibits hOAT3. When prescribed together, a dose reduction of rivaroxaban to 10 mg in elderly people with moderate renal impairment results in persistently higher rivaroxaban peak concentrations. To manage the increased bleeding risk, a further dose reduction of rivaroxaban to 2.5 mg twice daily is recommended.
CARDIOVASCULAR DRUGS AND THERAPY
(2023)
Article
Chemistry, Analytical
Ziteng Wang, Ching Yee Fong, Evelyn Mei Ling Goh, Hooi Yan Moy, Eric Chun Yong Chan
Summary: Concurrent use of synthetic cannabinoids (SCs) and alcohol has been observed among drug abusers. This study investigated the susceptibility of three indazole-3-carboxamide type SCs to transesterification in the presence of ethanol, as well as its potential augmented toxicity. Results showed that all three SCs underwent transesterification to ethyl ester analogs in the presence of ethanol, which was time- and concentration-dependent. The co-abuse of SCs and alcohol could lead to increased toxicity and further research is warranted.
JOURNAL OF ANALYTICAL TOXICOLOGY
(2023)
Article
Biochemical Research Methods
Zhandong Yang, Xuzi Cai, Xiaoxia Xu, Zengmei Xu, Simin Ye, Yan Wang, Yanjun Hong, Baochun Shen, Qiongfeng Liao, Zhiyong Xie, Xuefeng Wang
Summary: This study revealed metabolic disturbances associated with polycystic ovary syndrome (PCOS) using urinary metabolomics. By combining quantitative analysis and enrichment analysis, metabolic pathways related to PCOS, especially glycerophospholipid metabolism and tryptophan metabolism, were identified. Additionally, seven tryptophan-kynurenine metabolites were found to be up-regulated in PCOS and showed significant correlations with PCOS clinical features.
ANALYTICAL BIOCHEMISTRY
(2022)
Article
Cardiac & Cardiovascular Systems
Xin Qin Soh, Doreen Su-Yin Tan, Eric Chun Yong Chan
Summary: This study identifies a potential association between concurrent use of simvastatin and rivaroxaban with bleeding events in Singaporean Asians.
CARDIOVASCULAR DRUGS AND THERAPY
(2023)
Article
Pharmacology & Pharmacy
Lloyd Wei Tat Tang, Guoyi Wu, Eric Chun Yong Chan
Summary: This study found that Infigratinib has a potent competitive inhibition and mechanism-based inactivation effect on CYP2J2, and predicted that its coadministration with rivaroxaban may result in a drug-drug interaction, increasing the risk of major bleeding.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
(2022)
Article
Plant Sciences
Ying Cai, Siju Li, Xiaojun Zhang, Xueqin Cao, Deliang Liu, Yanglu Zhu, Simin Ye, Zengmei Xu, Qiongfeng Liao, Yanjun Hong, Zhiyong Xie
Summary: This study revealed that ZJW could alleviate DSS-induced UC in rats by modulating the interaction between gut microbiota and host cometabolites.
Article
Agriculture, Multidisciplinary
Yuxiang Gu, Haoran Chen, Xing Li, Dan Li, Yue Sun, Lin Yang, Ying Ma, Eric Chun Yong Chan
Summary: This study found that Lactobacillus paracasei IMC 502 can prevent and alleviate type 2 diabetes by mediating the gut microbiota-SCFA-hormone/inflammation pathway.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2023)
Article
Pharmacology & Pharmacy
Jacqueline Wen Hui Leow, Xiao Jun Ang, Eric Chun Yong Chan
Summary: A physiologically based pharmacokinetic (PBPK) model was developed to study the drug-drug interaction between dronedarone and rivaroxaban, and the simulation results showed that reducing the dose of rivaroxaban to at least 15 mg in subjects with mild renal impairment can achieve a better balance of risk and benefit.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Letter
Pharmacology & Pharmacy
Ziteng Wang, Eric Chun Yong Chan
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Urology & Nephrology
Ziting Wang, Kaiying Wang, Han Yang Ong, Woon Chau Tsang, Qing Hui Wu, Edmund Chiong
Summary: This study investigates the impact of 5-alpha reductase inhibitor (5-ARI) therapy on the MRI findings and biopsy yield in patients with suspected prostate cancer. The results show significant differences in imaging and biopsy characteristics between patients receiving and not receiving 5-ARI therapy, suggesting that 5-ARI use may confound MRI findings.
Review
Urology & Nephrology
Chloe S. H. Ong, Terence Y. X. Law, Alex Mok, Kenny S. C. Ho, Ziting Wang, Edmund Chiong, Ho Yee Tiong, Jeremy Y. C. Teoh
Summary: This study aimed to evaluate the impact of body mass index (BMI) on the outcomes of patients who underwent nephrectomy. The results showed that higher BMI was associated with improved long-term oncological survival, while lower BMI was associated with better surgical outcomes.
Article
Pharmacology & Pharmacy
Eleanor Jing Yi Cheong, Sheng Yuan Chin, Zheng Wei Ng, Ting Jian Yap, Ervin Zhi Bin Cheong, Ziteng Wang, Eric Chun Yong Chan
Summary: This study aims to develop a physiologically based pharmacokinetic (PBPK) model for abiraterone to investigate the potential associations between its concentrations and pharmacodynamic consequences, and optimize the dosage to achieve better therapeutic outcomes.
CLINICAL PHARMACOKINETICS
(2023)
Article
Pharmacology & Pharmacy
Jacqueline Wen Hui Leow, Yuxiang Gu, Eric Chun Yong Chan
Summary: This study investigated the inhibitory effects of 16 drugs with intermediate to high risk of torsades de pointes (TdP) on the metabolism of arachidonic acid (AA) to epoxyeicosatrienoic acid (EET) by cardiac cytochrome P450 2J2 (CYP2J2). The results showed that 11 out of the 16 drugs exhibited inhibitory effects on CYP2J2 metabolism of AA. Among the high TdP risk category drugs, vandetanib and bepridil had the highest inhibitory effects. Further research is needed to determine the role of CYP2J2 metabolism in cardiac electrophysiology and the in vivo evidence of drug-AA interactions.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Article
Food Science & Technology
Yuxiang Gu, Xing Li, Eric Chun Yong Chan
Summary: The production of cultured meat involves complex technologies and novel ingredients, which may introduce hazards and risks. Currently, there is a lack of systematic and in-depth risk assessment for cultured meat. Therefore, targeted and effective risk and safety assessment strategies should be adopted, and a harmonized regulatory framework should be established globally.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Lei Hou, Yingying Zhao, Shiyu Zhao, Xuexia Zhang, Xia Yao, Jianjun Yang, Ziteng Wang, Shuaibing Liu
Summary: This study systematically characterized the UGTs enzymes involved in the formation of M4 and the inhibitory effects of ciprofol and its metabolite M4 on P450s enzymes. In vitro-in vivo extrapolation and PBPK simulations were performed to predict potential drug-drug interactions caused by ciprofol.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
