Article
Immunology
Baoying Cheng, Xin Li, Kai Dai, Shengshun Duan, Zhouyi Rong, Yingmin Chen, Liangcheng Lu, Zhaoji Liu, Xiaohua Huang, Huaxi Xu, Yun-Wu Zhang, Honghua Zheng
Summary: TREM2 and CSF1R interact directly in microglia cells, modulating their expression levels. Administration of CSF1 partially restores the survival ability of Trem2-deficient microglia, showing potential therapeutic intervention in TREM2 variant-bearing patients with a high risk of Alzheimer's disease.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
William T. Ralvenius, Jason L. Andresen, Margaret M. Huston, Jay Penney, Julia Maeve Bonner, Owen S. Fenton, Robert Langer, Li-Huei Tsai
Summary: In this study, lipid nanoparticles (LNP) were used to transfect microglia in vitro and to deliver either mRNA or siRNA in vivo. Using these LNP to deliver anti-inflammatory siRNA reduces neuroinflammation in a neurodegeneration model, highlighting the potential of these LNP as therapeutic tools.
ADVANCED MATERIALS
(2023)
Article
Cell Biology
Jiwei Jiang, Wenyi Li, Xiaohong Wang, Zhongli Du, Jinlong Chen, Yaou Liu, Wei Li, Zhonghua Lu, Yanli Wang, Jun Xu
Summary: This study describes two novel heterozygous splicing variants of the CSF1R gene in two unrelated Han Chinese families with CSF1R-microglial encephalopathy. The findings highlight the value of pCASL for early detection of this disease.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Clinical Neurology
Philip W. Tipton, Daniel Kenney-Jung, Beth K. Rush, Erik H. Middlebrooks, David Nascene, Balvindar Singh, Shernan Holtan, Ernesto Ayala, Daniel F. Broderick, Troy Lund, Zbigniew K. Wszolek
Summary: The study found that HSCT treatment for CSF1R-related leukoencephalopathy can stabilize the disease in some patients, but there is variability in patient responsiveness. Therefore, measures of disease heterogeneity and severity should be considered when evaluating a patient's candidacy for transplant.
MOVEMENT DISORDERS
(2021)
Article
Neurosciences
Anna A. Pimenova, Manon Herbinet, Ishaan Gupta, Saima I. Machlovi, Kathryn R. Bowles, Edoardo Marcora, Alison M. Goate
Summary: The study demonstrates that PU.1 expression levels in microglia modulate various microglial responses, with increased expression associated with heightened pro-inflammatory response related to increased cell viability under cytotoxic conditions. On the other hand, low expression of PU.1 leads to increased cell death under cytotoxic conditions and reduced pro-inflammatory signaling, highlighting the protective effect of SPI1 genotype in Alzheimer's disease.
NEUROBIOLOGY OF DISEASE
(2021)
Article
Neurosciences
Dave E. Marzan, Valerie Brugger-Verdon, Brian L. West, Shane Liddelow, Jayshree Samanta, James L. Salzer
Summary: The activated microglia play a crucial role in demyelination, with CSF1 signaling being implicated in these events.
Article
Neurosciences
Mariam Melkumyan, Angela E. Snyder, Sarah S. Bingaman, Amy C. Arnold, Yuval Silberman
Summary: The Central Amygdala is involved in alcohol use disorder, and ethanol can modulate glutamatergic transmission in this region, possibly through the activation of neuroimmune cells, particularly astrocytes. Microglia activation has minimal impact on this modulation. Neuroimmune activation through lipopolysaccharide is also dependent on astrocyte signaling.
Article
Immunology
Katiria Soto-Diaz, Mario Vailati-Riboni, Allison Y. Louie, Daniel B. McKim, H. Rex Gaskins, Rodney W. Johnson, Andrew J. Steelman
Summary: Microglia activation and proliferation are characteristic of many neurodegenerative disorders, and can be regulated by neurons through the secretion of IL-34. Treatment with CSF1R antagonists can lead to microglia death or suppress activation, potentially rendering microglia more susceptible to reactive oxygen and nitrogen species.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, General & Internal
Ling Yan, Yanli Li, Fengmei Fan, Mengzhuang Gou, Fangling Xuan, Wei Feng, Keerthana Chithanathan, Wei Li, Junchao Huang, Hongna Li, Wenjin Chen, Baopeng Tian, Zhiren Wang, Shuping Tan, Alexander Zharkovsky, L. Elliot Hong, Yunlong Tan, Li Tian
Summary: The study found that effector molecules expressed in microglia/brain macrophages were involved in schizophrenia by regulating stress susceptibility. In both patients with first episode schizophrenia and animal models, lower expression levels of CSF1R were associated with higher stress levels and altered brain structure. CSF1R was found to regulate anxiety behaviors and brain angiogenesis through its effects on microglial/macrophagic morphology.
Article
Biochemistry & Molecular Biology
Man Liu, Shan-Shan Zhang, Dong-Ni Liu, Ying-Lin Yang, Yue-Hua Wang, Guan-Hua Du
Summary: Chrysomycin A has anti-neuroinflammatory effects possibly through regulating cytokine responses and immune system processes. KEGG enrichment analysis suggests its mechanisms may involve TNF signaling pathway, cytokine-cytokine receptor interaction, NF-kappa B signaling pathway, IL-17 signaling pathway and NOD-like receptor signaling pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Omkar L. Patkar, Melanie Caruso, Ngari Teakle, Sahar Keshvari, Stephen J. Bush, Clare Pridans, Arnauld Belmer, Kim M. Summers, Katharine M. Irvine, David A. Hume
Summary: Mutations in the human CSF1R gene have been associated with neurodegenerative diseases. Results from rat models with Csf1r mutations show reduced fiber tracts and microglial markers, with minimal impact on other neuronal markers. Defects in dendritic arborization and expression of specific neural cell adhesion molecules were also observed. These findings suggest that microglia may play a significant role in brain development, while CSF1R haploinsufficiency is unlikely to cause leukoencephalopathy.
NEUROBIOLOGY OF DISEASE
(2021)
Article
Biochemistry & Molecular Biology
I-Li Tan, Raquel Duque Nascimento Arifa, Harikrishna Rallapalli, Veronika Kana, Zhimin Lao, Reeti Mayur Sanghrajka, N. Sumru Bayin, Antoine Tanne, Alexandre Wojcinski, Andrey Korshunov, Nina Bhardwaj, Miriam Merad, Daniel H. Turnbull, Juan J. Lafaille, Alexandra L. Joyner
Summary: The immune microenvironment of tumors plays a critical role in tumor progression, with TAMs promoting SHH-MB progression in a mouse model. Inhibiting CSF1R reduces TAMs, prolongs survival, and decreases tumor volume, suggesting therapeutic potential for SHH-MB patients.
Article
Neurosciences
Katharine E. Askew, Joshua Beverley, Emma Sigfridsson, Stefan Szymkowiak, Katherine Emelianova, Owen Dando, Giles E. Hardingham, Jessica Duncombe, Edel Hennessy, Juraj Koudelka, Neshika Samarasekera, Rustam Al-Shahi Salman, Colin Smith, Adriana A. S. Tavares, Diego Gomez-Nicola, Raj N. Kalaria, Barry W. Mccoll, Karen Horsburgh
Summary: White matter abnormalities, related to poor cerebral perfusion, are a core feature of small vessel cerebrovascular disease and critical determinants of vascular cognitive impairment and dementia. Inhibition of microglial proliferation may protect against chronic cerebrovascular white matter pathology and cognitive deficits.
Article
Immunology
Sharmistha Banerjee, Taeyeop Park, Yoo Sun Kim, Hee-Yong Kim
Summary: This study aimed to determine the effects of single-dose acute ethanol exposure and GPR110 activation on neuroinflammation mechanisms. The results showed that single-dose ethanol exposure exacerbated LPS-induced inflammatory responses, while the GPR110 ligand synaptamide mitigated the effects of ethanol by counteracting the cAMP system and regulating the NLRP3 inflammasome.
JOURNAL OF NEUROINFLAMMATION
(2023)
Review
Geriatrics & Gerontology
Yan-Li Wang, Fang-Ze Wang, Runzhi Li, Jiwei Jiang, Xiangrong Liu, Jun Xu
Summary: Colony-stimulating factor-1 receptor-microglial encephalopathy is a rare rapidly progressive dementia caused by CSF1R mutations, primarily expressed in microglia. Current research focuses on exploring pathogenic mechanisms and potential therapeutic strategies, especially the feasibility of microglial replacement therapy.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Biochemical Research Methods
Jennifer Guergues, Jessica Wohlfahrt, Ping Zhang, Bin Liu, Stanley M. Stevens
JOURNAL OF PROTEOMICS
(2020)
Article
Toxicology
Max Russo, Amin Sobh, Ping Zhang, Alex Loguinov, Abderrahmane Tagmount, Chris D. Vulpe, Bin Liu
TOXICOLOGICAL SCIENCES
(2020)
Article
Substance Abuse
Meera Rath, Jennifer Guergues, Joao P. C. Pinho, Ping Zhang, Truc G. Nguyen, Kaley A. MacFadyen, Joanna Peris, Jay P. McLaughlin, Stanley M. Stevens, Bin Liu
ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH
(2020)
Article
Biochemical Research Methods
Crystina L. Kriss, Nalvi Duro, Owen W. Nadeau, Jennifer Guergues, Omar Chavez-Chiang, Ashley E. Culver-Cochran, Dale Chaput, Sameer Varma, Stanley M. Stevens
Summary: Oxidative and nitrative stress play a role in various biological processes and diseases, with nitrotyrosine observed in alcohol-induced liver injury. The nitration of histone proteins may induce chromatin structural changes associated with gene transcription processes in alcohol-induced liver injury.
JOURNAL OF MASS SPECTROMETRY
(2021)
Article
Multidisciplinary Sciences
Ravneet Chhabra, Stephanie Rockfield, Jennifer Guergues, Owen W. Nadeau, Robert Hill, Stanley M. Stevens, Meera Nanjundan
Summary: Malignant transformation of fallopian tube secretory epithelial cells (FTSECs) induced by chronic iron exposure involves increased expression of oncogenic mediators, telomerase transcripts, and growth/migratory potential. Global miRNA and protein alterations in iron-exposed FTSECs may be regulated by genome-wide epigenetic changes, potentially serving as future biomarkers for early ovarian cancer detection and therapeutic targets.
SCIENTIFIC REPORTS
(2021)
Article
Substance Abuse
Meera Rath, Jasmin Tawfic, Aziza Abrorkhujaeva, Sam Sowell, Sara Wu, Shainnel O. Eans, Joanna Peris, Jay P. McLaughlin, Stanley M. Stevens, Bin Liu
Summary: The study successfully modeled acute movement impairments and anxiety-like behaviors in mice after binge ethanol consumption using a modified drinking-in-the-dark model. The individual mice's ethanol intake positively correlated with blood ethanol concentration levels.
Article
Biochemistry & Molecular Biology
Ahmad Jalloh, Antwoine Flowers, Charles Hudson, Dale Chaput, Jennifer Guergues, Stanley M. Stevens, Paula C. Bickford
Summary: Research indicates that microglial activity is a central factor in aging-related dysfunction, with protein signaling cascades playing a key role in altering microglial function. Polyphenols may offer a means of addressing age-related decline, highlighting their potential therapeutic role in age-associated dysfunction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Toxicology
Max Russo, Sara T. Humes, Ariana M. Figueroa, Abderrahmane Tagmount, Ping Zhang, Alex Loguinov, John A. Lednicky, Tara Sabo-Attwood, Chris D. Vulpe, Bin Liu
Summary: Organochlorine pesticides have been shown to negatively impact immune responses. This study found that dieldrin, a type of OCP, can inhibit key genes involved in antiviral responses in neuronal and epithelial cells. The modulation of these genes may be linked to changes in intracellular oxidative status.
TOXICOLOGICAL SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Santiago Rodriguez Ospina, Danielle M. Blazier, Marangelie Criado-Marrero, Lauren A. Gould, Niat T. Gebru, David Beaulieu-Abdelahad, Xinming Wang, Elizabeth Remily-Wood, Dale Chaput, Stanley Stevens, Vladimir N. Uversky, Paula C. Bickford, Chad A. Dickey, Laura J. Blair
Summary: The study found that overexpression of Hsp22 can protect synaptic plasticity and cognition in tauopathic brains, without significantly altering tau phosphorylation levels. Mass spectrometry analysis revealed that Hsp22 overexpression in neurons promotes synaptic plasticity by regulating canonical pathways and upstream regulators related to potential AD markers and synaptogenesis regulators.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemical Research Methods
Ping Zhang, Jennifer Guergues, Amy R. Alleyne, Thomas J. Cirino, Owen Nadeau, Ariana M. Figueroa, Heather M. Stacy, Takayoshi Suzuki, Jay P. McLaughlin, Stanley M. Stevens, Bin Liu
Summary: This study identified specific histone protein modifications associated with chronic pain in microglia, providing critical insight into the contribution of microglia to pain development and maintenance. The findings suggest that targeting these chromatin marks may lead to the development of novel nonopioid therapeutics for chronic pain management.
Article
Biochemical Research Methods
Jennifer Guergues, Jessica Wohlfahrt, Stanley M. Stevens
Summary: This study used TIMS to fractionate ions in the gas phase and combined it with PASEF for protein and peptide analysis. The results showed that TIMS fractionation significantly increased the number of protein and peptide identifications without affecting quantitation precision.
JOURNAL OF PROTEOME RESEARCH
(2022)
