Article
Oncology
Wenqing Hu, Jianghong He, Yu Wang, Lingchi Xu, Ying Zhao, Xinping Hu, Hongmei Shen
Summary: In cultured neurons, ABPPs provide neuroprotection against NMDA-mediated excitotoxicity by modulating NR2A and NR2B subunits differently. ABPPs enhance the function of NR2A subunits and prevent the function of NR2B subunits in mature cultures, while showing an opposite effect in immature cultures.
ANNALS OF TRANSLATIONAL MEDICINE
(2021)
Article
Cell Biology
Can Ozden, Roman Sloutsky, Tomohiro Mitsugi, Nicholas Santos, Emily Agnello, Christl Gaubitz, Joshua Foster, Emily Lapinskas, Edward A. Esposito, Takeo Saneyoshi, Brian A. Kelch, Scott C. Garman, Yasunori Hayashi, Margaret M. Stratton
Summary: This study investigates the activation mechanism of CaMKII using X-ray crystallography, molecular dynamics simulations, and biochemistry. The results show that contrary to the previously believed two distinct sites, activators and substrates actually bind to a single continuous site on the kinase domain. Through kinetic competition with the regulatory segment, high-affinity binding partners sustain the activity of CaMKII, allowing substrate phosphorylation.
Article
Neurosciences
Longjie Zhang, Lan Luo, Lifen Xue, Dongzhi Ran, Fang Yang, Qiang Tang, Wengao Jiang
Summary: NMDA receptors are important in the development of mood disorders induced by chronic stress. The mechanism underlying the disturbance of NMDA receptor subunit expression due to chronic stress is still unclear. This study suggests that the RAGE signaling pathway is involved in the regulation of NMDA receptor subunit expression, which mediates the effects of chronic stress on depressive-like behaviors.
EXPERIMENTAL NEUROLOGY
(2023)
Article
Multidisciplinary Sciences
Maria Vistrup-Parry, Xudong Chen, Thea L. Johansen, Sofie Bach, Sara C. Buch-Larsen, Christian R. O. Bartling, Chenxue Ma, Louise S. Clemmensen, Michael L. Nielsen, Mingjie Zhang, Kristian Stromgaard
Summary: Studies have shown that site-specific phosphorylation of PSD-95 can affect its binding to interaction partners and play a critical role in phase separation of PSD-95 complexes. Two new phosphorylation sites have been identified with opposing effects on phase separation of PSD-95 complexes.
Review
Cell Biology
Fang Du, Tao Tang, Qingzhu Li, Jiaxin Liu
Summary: Ischemic stroke is a common type of stroke that causes disability and death. Fyn, a nonreceptor tyrosine kinase, plays a crucial role in the pathological processes of cerebral ischemia-reperfusion, including energy metabolism disorders, neurotoxicity, and apoptotic gene activation. Fyn also promotes the production of superoxide, contributing to cerebral ischemia-reperfusion injury. Exploring the role of Fyn is important for understanding the mechanisms of cerebral ischemia-reperfusion injury and developing treatment strategies.
MEDIATORS OF INFLAMMATION
(2022)
Article
Biochemistry & Molecular Biology
Birgit Rossner, Maximilian Klingler, Tanja Bulat, Ajinkya Sase, Andrea Zeilinger, Melanie Spitzwieser, Jana Aradska, Margit Cichna-Markl, Gert Lubec
Article
Behavioral Sciences
M. Bezu, B. Shanmugasundaram, G. Lubec, V. Korz
BEHAVIOURAL BRAIN RESEARCH
(2016)
Article
Chemistry, Organic
Ilya V. Efimov, Marsel Z. Shafikov, Nikolai A. Beliaev, Natalia N. Volkova, Tetyana V. Beryozkina, Wim Dehaen, Zhijin Fan, Viktoria V. Grishko, Gert Lubec, Pavel A. Slepukhin, Vasiliy A. Bakulev
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
(2016)
Article
Biochemistry & Molecular Biology
Jose Roberto Aparecido dos Santos-Pinto, Helen Andrade Arcuri, Gert Lubec, Mario Sergio Palma
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
(2016)
Article
Immunology
Balazs A. Gyorffy, Peter Gulyassy, Barbara Gellen, Katalin Volgyi, Dora Madarasi, Viktor Kis, Oliver Ozohanics, Ildiko Papp, Peter Kovacs, Gert Lubec, Arpad Dobolyi, Jozsef Kardos, Laszlo Drahos, Gabor Juhasz, Katalin. A. Kekesi
BRAIN BEHAVIOR AND IMMUNITY
(2016)
Correction
Anatomy & Morphology
Ming-Dong Zhang, Swapnali Barde, Edit Szodorai, Anna Josephson, Nicholas Mitsios, Masahiko Watanabe, Johannes Attems, Gert Lubec, Gabor G. Kovacs, Mathias Uhlen, Jan Mulder, Tibor Harkany, Tomas Hokfelt
BRAIN STRUCTURE & FUNCTION
(2016)
Article
Anatomy & Morphology
Ming-Dong Zhang, Swapnali Barde, Edit Szodorai, Anna Josephson, Nicholas Mitsios, Masahiko Watanabe, Johannes Attems, Gert Lubec, Gabor G. Kovacs, Mathias Uhlen, Jan Mulder, Tibor Harkany, Tomas Hokfelt
BRAIN STRUCTURE & FUNCTION
(2016)
Article
Anatomy & Morphology
Maryam Ghafari, Soheil Keihan Falsafi, Edit Szodorai, Eun-Jung Kim, Lin Li, Harald Hoeger, Johannes Berger, Karoline Fuchs, Werner Sieghart, Gert Lubec
BRAIN STRUCTURE & FUNCTION
(2017)
Article
Neurosciences
Isabella Salzer, Fatma Asli Erdem, Wei-Qiang Chen, Seok Heo, Xaver Koenig, Klaus W. Schicker, Helmut Kubista, Gert Lubec, Stefan Boehm, Jae-Won Yang
JOURNAL OF PHYSIOLOGY-LONDON
(2017)
Article
Biochemical Research Methods
Jose Roberto Aparecido dos Santos-Pinto, Ana Maria Caviquioli Garcia, Helen Andrade Arcuri, Franciele Grego Esteves, Heliana Clara Salles, Gert Lubec, Mario Sergio Palma
JOURNAL OF PROTEOME RESEARCH
(2016)
Article
Biochemical Research Methods
L. Turkovicova, R. Smidak, G. Jung, J. Turna, G. Lubec, J. Aradska
JOURNAL OF PROTEOMICS
(2016)
Article
Multidisciplinary Sciences
Janos Hanics, Edit Szodorai, Giuseppe Tortoriello, Katarzyna Malenczyk, Erik Keimpema, Gert Lubec, Zsofia Hevesi, Mirjam I. Lutz, Mark Kozsurek, Zita Puskar, Zsuzsanna E. Toth, Ludwig Wagner, Gabor G. Kovacs, Tomas G. M. Hoekfelt, Tibor Harkany, Alan Alpar
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2017)
Article
Biochemistry & Molecular Biology
Shima Kouhnavardi, Maureen Cabatic, M. Carmen Manas-Padilla, Marife-Astrid Malabanan, Tarik Smani, Ana Cicvaric, Edison Alejandro Munoz Aranzalez, Xaver Koenig, Ernst Urban, Gert Lubec, Estela Castilla-Ortega, Francisco J. Monje
Summary: Cortisol is a steroid hormone that affects the central nervous system and plays important roles in brain neuronal synaptic plasticity and emotional and behavioral responses. Dysregulation of cortisol is associated with conditions such as Alzheimer's Disease, chronic stress, anxiety, and depression. The effects of cortisol on hippocampal functions and the mechanisms involved in fine-tuning synaptic responses are poorly understood.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Jana Lubec, Ahmed M. Hussein, Predrag Kalaba, Daniel Daba Feyissa, Edgar Arias-Sandoval, Anita Cybulska-Klosowicz, Mekite Bezu, Tamara Stojanovic, Volker Korz, Jovana Malikovic, Nilima Y. Aher, Martin Zehl, Vladimir Dragacevic, Johann Jakob Leban, Claudia Sagheddu, Judith Wackerlig, Marco Pistis, Merce Correa, Thierry Langer, Ernst Urban, Harald Hoeger, Gert Lubec
Summary: The worldwide increase in cognitive decline calls for the search of pharmacological treatment. Current dopamine transporter (DAT) inhibitors have unwanted side effects due to lack of specificity. A highly specific DAT inhibitor, S-CE-123, was synthesized and tested for its potential to enhance cognitive functions in rats. S-CE-123 showed good bioavailability and improved the performance of aged rats.
Article
Biochemistry & Molecular Biology
Predrag Kalaba, Katharina Pacher, Philip John Neill, Vladimir Dragacevic, Martin Zehl, Judith Wackerlig, Michael Kirchhofer, Simone B. Sartori, Hubert Gstach, Shima Kouhnavardi, Anna Fabisikova, Matthias Pillwein, Francisco Monje-Quiroga, Karl Ebner, Alexander Prado-Roller, Nicolas Singewald, Ernst Urban, Thierry Langer, Christian Pifl, Jana Lubec, Johann Jakob Leban, Gert Lubec
Summary: The high structural similarity among dopamine, norepinephrine, and serotonin transporters, especially in transmembrane regions, presents a challenge for specifically targeting individual transporters. Ligand design is limited by chemists' tendency to modify lead compounds in a way that reduces the number of chiral centers, thus limiting the chemical space of synthetic ligands. However, increasing molecular complexity by introducing additional chiral centers has been shown to lead to more selective and potent dopamine reuptake inhibitors. The establishment of a compound library with defined absolute configurations lays the foundation for computational chemists to optimize and design specific monoamine transporter reuptake inhibitors.