Article
Cell & Tissue Engineering
Runfeng Zhang, Jiang Yu, Ningkun Zhang, Wensong Li, Jisheng Wang, Guocai Cai, Yu Chen, Yong Yang, Zhenhong Liu
Summary: The study aimed to evaluate the efficacy and safety of intracoronary autologous bone marrow mesenchymal stem cell (BM-MSC) transplantation in patients with ST-segment elevation myocardial infarction (STEMI). Results showed that BM-MSC transplantation did not significantly promote the recovery of left ventricular function and myocardial viability after acute myocardial infarction.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Medicine, General & Internal
Jing Jiang, Jiaojiao Xin, Wenchao Ding, Dongyan Shi, Suwan Sun, Beibei Guo, Xingping Zhou, Chufan Zheng, Jun Li
Summary: This study identified miRNAs that play important regulatory roles in the differentiation of human bone marrow mesenchymal stem cells (hBMSCs) into hepatocyte-like cells and liver regeneration. Manipulation of these miRNAs significantly improved hepatocyte generation and showed potential for future clinical applications.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2022)
Article
Health Care Sciences & Services
Cheng-Feng Chu, Shih-Hsuan Mao, Victor Bong-Hang Shyu, Chih-Hao Chen, Chien-Tzung Chen
Summary: The study found that allogeneic BMSCs can promote bone regeneration to some extent and gradually match the efficacy of autologous BMSCs after a period of time. In terms of immune response, allogeneic BMSCs caused a weaker immune response in vivo and the bone regeneration effects gradually matched those of autologous BMSCs.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Cell Biology
Ju -Pi Li, Kang-Hsi Wu, Wan-Ru Chao, Yi-Ju Lee, Shun-Fa Yang, Yu-Hua Chao
Summary: Immune-mediated hematopoietic destruction plays a major role in idiopathic severe aplastic anemia. Mesenchymal stem cells (MSCs) have important immunomodulatory functions in the bone marrow niche. Dysfunction of MSCs is believed to be a major cause of immunological changes in SAA bone marrow.
Review
Biochemistry & Molecular Biology
Xing-An Wang, Ju-Pi Li, Kang-Hsi Wu, Shun-Fa Yang, Yu-Hua Chao
Summary: Aplastic anemia is a rare but life-threatening disease characterized by low blood cell count and reduced cellularity in the bone marrow. Mesenchymal stem cell dysfunction is believed to play a role in the development of the disease. This review provides a comprehensive understanding of the involvement of mesenchymal stem cells in acquired idiopathic aplastic anemia and discusses their clinical application. The pathophysiology of the disease, properties of mesenchymal stem cells, and results of mesenchymal stem cell therapy in animal models are also described. The authors anticipate that more patients with aplastic anemia can benefit from mesenchymal stem cell therapy in the future.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Xiaoyu Li, Xue Wang, Chunmei Zhang, Jinsong Wang, Songlin Wang, Lei Hu
Summary: This study investigated the metabolic activity of MSCs and its possible mechanism during aging. The findings suggest that the metabolic function of BMSCs is impaired in aged mice, characterized by decreased oxidative phosphorylation and glycolytic activity, as well as lower mitochondrial membrane potential, NAD+/NADH ratio, and ATP production. FABP4 may play a key role in BMSC senescence caused by fatty acid metabolism disorders. Regulation of metabolic activity could be a potential therapeutic target for enhancing the regenerative functions of BMSCs.
CELL PROLIFERATION
(2022)
Article
Cell & Tissue Engineering
Xuan Zheng, Dirk M. Hermann, Mathias Baehr, Thorsten R. Doeppner
Summary: The heart and brain form a functional axis that is disrupted under ischemic conditions, but stem cell-derived extracellular vesicles show potential for treating ischemic stroke and myocardial infarction, offering hope. Therapeutic actions of EVs in the brain and heart reciprocally influence each other, with EVs playing roles in promoting angiogenesis, parenchymal remodeling, and tissue recovery, and the therapeutic effects are dependent on the cargos within EVs.
Review
Immunology
Yanjing Huang, Mengdi Zhu, Zhuo Liu, Runan Hu, Fan Li, Yufan Song, Yuli Geng, Wenwen Ma, Kunkun Song, Mingmin Zhang
Summary: Premature ovarian failure is a common female reproductive disorder characterized by early menopause, increased gonadotropin levels, and estrogen deficiency. The use of bone marrow mesenchymal stem cells may offer potential for restoring ovarian function and fertility in POF patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Selda Ayhan, Emirhan Nemutlu, Duygu Uckan Cetinkaya, Sedef Kir, Riza Koksal Ozgul
Summary: Using a special harvesting method and comparative 'omics' technologies, this study identified differences in bone marrow niches in two different anatomical regions of the iliac crest in humans, particularly in terms of energy metabolism. The research provides basic data for regenerative medicine in designing appropriate microenvironments and establishing normal reference values for comparison in hematological diseases.
JOURNAL OF CELL SCIENCE
(2021)
Retraction
Biochemistry & Molecular Biology
Sabine Wislet-Gendebien, Emerence Laudet, Virginie Neirinckx, Philippe Alix, Pierre Leprince, Aneta Glejzer, Christophe Poulet, Benoit Hennuy, Lukas Sommer, Olga Shakhova, Bernard Rogister
Summary: A correction to this paper has been published.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Cell & Tissue Engineering
Wei Zhang, Qing Ling, Bin Wang, Kai Wang, Jianbo Pang, Jing Lu, Yan Bi, Dalong Zhu
Summary: Both UC-MSCs and BM-MSCs showed comparable therapeutic effects in improving T1D, with similar results in lowering blood glucose levels and preserving beta-cell function.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Virology
Juliane Kager, Jochen Schneider, Sebastian Rasch, Peter Herhaus, Mareike Verbeek, Carolin Mogler, Albert Heim, Gert Froesner, Dieter Hoffmann, Roland M. Schmid, Tobias Lahmer
Summary: This study retrospectively analyzed three patients with HAdV hepatitis, highlighting the importance of this condition in immunocompromised individuals. Diagnosis could be confirmed through pathology, CT scan, and measurement of transaminase levels. Although there is currently no established treatment, prompt initiation of therapy is crucial to prevent disease dissemination.
Article
Multidisciplinary Sciences
Cheng Su, Xiao Zheng, Yanjin He, Li Long, Wenchuan Chen
Summary: This study identified aberrant expression of circRNAs in hUCMSCs during osteogenic differentiation, constructed competing endogenous RNA networks using bioinformatics tools, elucidated underlying mechanisms, and validated the osteogenic-promoting effect of a specific circRNA.
SCIENTIFIC REPORTS
(2021)
Article
Biotechnology & Applied Microbiology
Yue Ke, Yu Ye, Jintao Wu, Yanxia Ma, Yuxin Fang, Fei Jiang, Jinhua Yu
Summary: A phosphoserine-loaded chitosan membrane was synthesized to improve the osteogenic effect of chitosan membranes. The incorporation of phosphoserine into chitosan membranes was confirmed and the phosphoserine-chitosan membranes significantly stimulated bone regeneration.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Cell & Tissue Engineering
David Brett Erasmus, Nisha Durand, Francisco A. Alvarez, Tathagat Narula, David O. Hodge, Abba C. Zubair
Summary: This study demonstrates the therapeutic effects of intravenous infusion of low-dose bone marrow-derived MSCs in lung transplant patients. The results show that this treatment can slow the progression of chronic lung allograft syndrome in some patients and stabilize lung function decline.
STEM CELLS TRANSLATIONAL MEDICINE
(2022)
Article
Virology
Jian Wu, Mariza Bortolanza, Guanghua Zhai, Anquan Shang, Zongxin Ling, Bin Jiang, Xiaochen Shen, Yiwen Yao, Jiong Yu, Lanjuan Li, Hongcui Cao
Summary: The study found no significant difference in bacterial diversity between patients with acute hepatitis E and healthy controls, but Proteobacteria, Gammaproteobacteria, and Enterobacteriaceae were more abundant in AHE patients. Functional prediction analysis revealed that ribosome, purine metabolism, and two-component system were the top three pathways affected by HEV infection. Furthermore, higher levels of interferon-gamma were associated with increased abundance of certain bacterial taxa in AHE patients, and Gammaproteobacteria abundance was positively correlated with liver enzyme levels.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Cell & Tissue Engineering
Dongdong Wang, Yi Fu, Junfen Fan, Yue Wang, Chao Li, Yi Xu, Hui Chen, Yu Hu, Hongcui Cao, Robert Chunhua Zhao, Wei He, Jianmin Zhang
Summary: This study investigated the immunogenicity of human adipose-derived mesenchymal stromal cells (Ad-MSCs) and identified potential immunogenic molecules. The results showed that allogeneic Ad-MSCs recruited human T cells and were cleared faster in humanized mice compared to non-humanized mice. In vitro experiments demonstrated that co-culture with human Ad-MSCs significantly enhanced T cell proliferation and activation. Several potential immunogenic candidates, including alpha-enolase, were identified.
Article
Virology
Jian Wu, Yanping Xu, Yubao Cui, Mariza Bortolanza, Minjie Wang, Bin Jiang, Meina Yan, Wei Liang, Yiwen Yao, Qiaoling Pan, Jinfeng Yang, Jiong Yu, Dawei Wang, Hongcui Cao, Lanjuan Li
Summary: This study investigates the dynamic changes in metabolites associated with liver disease progression, particularly in predicting the prognosis of hepatitis E virus acute liver failure (HEV-ALF). Ultra-performance liquid chromatography-mass spectroscopy was used to evaluate serum metabolites in healthy controls (HC), acute hepatitis E (AHE) patients, and HEV-ALF patients. Significant differences in metabolite components were observed between AHE patients and HC, as well as between HEV-ALF and AHE patients. Pathway enrichment analysis revealed altered linoleic acid metabolism and phenylalanine, tyrosine, and tryptophan biosynthesis pathways in AHE patients compared to HC. In HEV-ALF, the linoleic acid metabolism and porphyrin and chlorophyll metabolism pathways differed significantly from AHE patients. Differential metabolites such as taurocholic acid, glycocholic acid, glycochenodeoxycholate-3-sulfate, and docosahexaenoic acid showed discriminatory performance in distinguishing HEV-ALF from AHE patients. Serum levels of specific metabolites were associated with the prognosis of HEV-ALF patients. The dynamic changes in serum metabolites were found to be associated with AHE infection and severity, and the identified metabolites have the potential to be used for diagnosis and prognosis prediction of HEV-ALF.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Gastroenterology & Hepatology
Jinjin Luo, Xi Liang, Jiaojiao Xin, Jiaqi Li, Peng Li, Qian Zhou, Shaorui Hao, Huafen Zhang, Yingyan Lu, Tianzhou Wu, Lingling Yang, Jiang Li, Tan Li, Keke Ren, Beibei Guo, Xingping Zhou, Jiaxian Chen, Lulu He, Hui Yang, Wen Hu, Shaoli You, Shaojie Xin, Jing Jiang, Dongyan Shi, Xin Chen, Jun Li
Summary: This study aimed to develop and validate a prognostic score to predict the onset of acute-on-chronic liver failure (ACLF) in patients with hepatitis B virus (HBV)-related chronic liver disease. The study identified four predictors (total bilirubin, international normalized ratio, alanine aminotransferase, and ferritin) that were significantly associated with ACLF onset at 7 days. The newly developed prognostic score showed higher predictive value compared to other existing scores.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Virology
Jiong Yu, Xiaowei Shi, Haiying Yu, Jian Wu, Jing Ma, Siyi Dong, Sen Lu, Shusen Zheng, Lanjuan Li, Xiao Xu, Hongcui Cao
Summary: This study investigated the interaction between chronic hepatitis B virus (HBV) infection, hepatocellular carcinoma (HCC), and the use of HBsAg-positive grafts in liver transplantation. The results showed that the use of HBsAg-positive grafts in HCC recipients was associated with lower patient and graft survival rates, as well as an increased risk of HCC recurrence.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Pharmacology & Pharmacy
Jiahang Zhou, Xudong Feng, Jiaqi Zhu, Bing Feng, Qigu Yao, Qiaoling Pan, Jiong Yu, Jinfeng Yang, Lanjuan Li, Hongcui Cao
Summary: Research shows that MSC treatment can effectively alleviate ALI, regulate the functional changes of MoMF in different periods, and serve as immunotherapeutic targets for ALI.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Cell Biology
Feiyan Lin, Wenyi Chen, Jiahang Zhou, Jiaqi Zhu, Qigu Yao, Bing Feng, Xudong Feng, Xiaowei Shi, Qiaoling Pan, Jiong Yu, Lanjuan Li, Hongcui Cao
Summary: This study investigates the protective effect of mesenchymal stem cells (MSCs) and MSC-derived exosomes (MSC-Exo) on carbon tetrachloride (CCl4)-induced acute liver injury (ALI). It proposes a novel therapeutic strategy for ferroptosis-induced ALI by maintaining the function of SLC7A11 protein.
CELL DEATH & DISEASE
(2022)
Article
Biotechnology & Applied Microbiology
Qian Zhou, Beibei Guo, Deying Chen, Heng Yao, Xi Liang, Jiaojiao Xin, Dongyan Shi, Keke Ren, Hui Yang, Jing Jiang, Jun Li
Summary: This study investigates the dynamic changes of metabolites during the vascularization of decellularized liver scaffolds (DLSs). It identifies three distinct phases and reveals differentially abundant metabolites in these phases. The results suggest that beta-Alanine may serve as a predictor of the patency of vascularized bioengineered livers.
BIOTECHNOLOGY AND BIOENGINEERING
(2022)
Article
Genetics & Heredity
Heng Yao, Peng Li, Jiaojiao Xin, Xi Liang, Jing Jiang, Dongyan Shi, Jiang Li, Hozeifa Mohamed Hassan, Xin Chen, Jun Li
Summary: This study used topological analysis of the miRNA/mRNA network to reveal the association between fibrosis and miR-20a-5p/miR-340-5p in HBV-LC, involving initiating activations of macrophage and HSC.
BMC MEDICAL GENOMICS
(2022)
Review
Oncology
Yiru Zhang, Qigu Yao, Yong Pan, Xinru Fang, Haoying Xu, Tingxiao Zhao, Guangqi Zhu, Tianan Jiang, Shibo Li, Hongcui Cao
Summary: Combination therapy with PD-1/PD-L1 inhibitors and other antitumor therapies can improve patients' objective response rate, disease control rate, and progression-free survival compared to anti-PD-1/PD-L1 monotherapy. However, there is no significant benefit to overall survival and an increased risk of adverse events in combinatorial therapies.
Review
Gastroenterology & Hepatology
Peng Li, Xi Liang, Jinjin Luo, Jun Li
Summary: Acute-on-chronic liver failure (ACLF) is a critical clinical entity characterized by acute decompensation, organ failure, and high mortality in patients with chronic liver disease. The pathophysiology of ACLF involves systemic inflammation, immune-metabolism disorder, mitochondrial dysfunction, and microenvironment imbalance. Omics-based analytical techniques offer novel insights into the mechanisms of ACLF and can identify potential biomarkers and therapeutic targets. This paper reviews the current knowledge and recent advances in ACLF definitions, criteria, prognostic assessments, and the application of omics-based analyses in understanding ACLF biology.
LIVER INTERNATIONAL
(2023)
Article
Biochemistry & Molecular Biology
Qigu Yao, Wenyi Chen, Feiqiong Gao, Yuchen Wu, Lingling Zhou, Haoying Xu, Jong Yu, Xinli Zhu, Lan Wang, Lanjuan Li, Hongcui Cao
Summary: By analyzing the data from The Cancer Genome Atlas database, weighted gene co-expression network analysis identified 61 hub genes that regulated the progression and prognosis of cholangiocarcinoma (CCA). Eight hub genes (VSNL1, TH, PCP4, IGDCC3, RAD51AP2, MUC2, BUB1, and BUB1B) were found to be significantly associated with the tumorigenic mechanism and prognosis of CCA. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis revealed the involvement of the blue and magenta modules in chromosome segregation, mitotic and oocyte meiosis, the cell cycle, and sister chromatid segregation. The validation using GSE119336 cohort data and human tissue samples further confirmed the importance of four hub genes (VSNL1, PCP4, BUB1, and BUB1B) in the progression and prognosis of CCA.
Review
Health Care Sciences & Services
Xinru Fang, Feiqiong Gao, Qigu Yao, Haoying Xu, Jiong Yu, Hongcui Cao, Shibo Li
Summary: Through a pooled analysis of 39 studies, it was found that MSC-derived extracellular vesicle (EV) therapy had significant benefits for liver injury, improving liver function, promoting liver tissue repair, reducing inflammation, and showing comparable effectiveness to MSCs. MSC-EVs have therapeutic potential for acute and chronic liver diseases.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Health Care Sciences & Services
Peng Li, Xi Liang, Jinjin Luo, Jiaqi Li, Jiaojiao Xin, Jing Jiang, Dongyan Shi, Yingyan Lu, Hozeifa Mohamed Hassan, Qian Zhou, Shaorui Hao, Huafen Zhang, Tianzhou Wu, Tan Li, Heng Yao, Keke Ren, Beibei Guo, Xingping Zhou, Jiaxian Chen, Lulu He, Hui Yang, Wen Hu, Shiwen Ma, Bingqi Li, Shaoli You, Shaojie Xin, Yu Chen, Jun Li
Summary: This study aimed to identify an appropriate score for predicting the survival benefit of liver transplantation (LT) in HBV-related acute-on-chronic liver failure (ACLF) patients. The results showed that the COSSH-ACLF IIs score accurately predicted the risk of death on the waitlist and post-LT mortality, and patients with a score of 7-10 derived a higher net survival benefit from LT.
LANCET REGIONAL HEALTH-WESTERN PACIFIC
(2023)
Article
Medicine, General & Internal
Xinyu Sheng, Wenyi Chen, Yanping Xu, Feiyan Lin, Hongcui Cao
Summary: The study found that higher MCHC levels were associated with worse prognosis in HRS patients, indicating that patients with higher MCHC levels had a higher risk of mortality.
AMERICAN JOURNAL OF THE MEDICAL SCIENCES
(2022)