Article
Chemistry, Analytical
Jia Yi, Yueqing Shen, Yi Yang, Chengpin Shen, Baohong Liu, Liang Qiao, Yan Wang
Summary: By characterizing gingival crevicular fluid (GCF) sediments and identifying potential protein biomarkers using mass spectrometry techniques, this study has contributed to the early diagnosis of periodontitis and understanding of its pathogenesis. The identified biomarkers hold potential value for accurate monitoring and can be utilized by non-specialists for widespread screening.
Review
Biochemical Research Methods
Qiuqin Zhou, Annabelle Fueloep, Carsten Hopf
Summary: MALDI-MSI is a rapidly growing technique for visualizing the distribution of biomolecules in tissue sections, with challenges such as sensitivity and specificity. Recent developments in small organic MALDI matrices and on-tissue chemical derivatization reagents play a crucial role in improving image quality and expanding application areas.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2021)
Article
Medicine, General & Internal
Inaki Beguiristain, Lucia Henriquez, Ignacio Sancho, Carmen Martin, Angel Hidalgo-Ovejero, Carmen Ezpeleta, Maria Eugenia Portillo
Summary: The accurate and fast diagnosis of prosthetic joint infection is crucial. This study assesses the role of direct MALDI-TOF MS for early identification of pathogens causing PJI from sonication fluid inoculated in blood culture bottles.
Review
Biochemistry & Molecular Biology
Cristina Herrera-Pariente, Sheyla Montori, Joan Llach, Alex Bofill, Eduardo Albeniz, Leticia Moreira
Summary: Gastric cancer is a common cancer worldwide, with early detection being crucial for improving clinical outcomes. Current screening programs are effective in high-incidence populations but not cost-effective in low-incidence populations, highlighting the need for new noninvasive biomarkers.
Article
Infectious Diseases
Yuliya Zboromyrska, Veronica Rico, Cristina Pitart, Mariana Jose Fernandez-Pittol, Alex Soriano, Jordi Bosch
Summary: The direct identification and rapid detection of ESBL and carbapenemase-producing strains from urine samples is a reliable and useful tool in adjusting empirical antimicrobial treatment.
Article
Multidisciplinary Sciences
Konrad Lehr, Darja Nikitina, Ramiro Vilchez-Vargas, Ruta Steponaitiene, Cosima Thon, Jurgita Skieceviciene, Denny Schanze, Martin Zenker, Peter Malfertheiner, Juozas Kupcinskas, Alexander Link
Summary: Helicobacter pylori (H. pylori) infection is the main cause of gastric cancer, but other bacterial species may also play a role. This study found that the mucosal microbial community in the stomach is associated with the prognosis of gastric cancer. The abundance of Fusobacterium and Prevotella is significantly associated with worse overall survival in gastric cancer patients.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Konrad Lehr, Darja Nikitina, Ramiro Vilchez-Vargas, Ruta Steponaitiene, Cosima Thon, Jurgita Skieceviciene, Denny Schanze, Martin Zenker, Peter Malfertheiner, Juozas Kupcinskas, Alexander Link
Summary: The mucosal microbial community in the stomach is associated with worse overall survival in gastric cancer patients, with the genus Fusobacterium and Prevotella being significantly associated with poor prognosis. The abundance of Fusobacterium nucleatum in tumorous specimens has the strongest negative impact on prognosis.
SCIENTIFIC REPORTS
(2023)
Review
Biotechnology & Applied Microbiology
Kunxiang Liu, Qi Zhao, Bei Li, Xia Zhao
Summary: This article reviews the applications of Raman spectroscopy for in vivo and in vitro diagnosis of gastric cancer, methodology related to spectroscopy data analysis, and presents the limitations of the technique.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Dasheng Liu, Yuejian Shen, Dandan Di, Shenhui Cai, Xueyang Huang, Hongguo Lin, Yalan Huang, Jing Xue, Li Liu, Bin Hu
Summary: Direct mass spectrometry (MS) analysis of human tissue can provide insights into biomarker discovery and disease diagnosis. However, conventional biological and clinical MS methods usually require complex and time-consuming sample preparation processes for tissue samples. To overcome this, the use of direct MS with ambient ionization technique, such as the wooden tip (WT) method described in this work, allows for simple and rapid analysis of biological tissues. The WT-ESI-MS method was successfully applied for the analysis of thyroid tissue samples and the detection of lipids as the main compounds in this type of tissue.
FRONTIERS IN CHEMISTRY
(2023)
Article
Biology
Weiming Hu, Chen Li, Xiaoyan Li, Md Mamunur Rahaman, Jiquan Ma, Yong Zhang, Haoyuan Chen, Wanli Liu, Changhao Sun, Yudong Yao, Hongzan Sun, Marcin Grzegorzek
Summary: This paper presents a publicly available gastric cancer histopathology image database for evaluating the performance of different classifiers. The study shows that there are discrepancies in the methods of different periods on this database. Traditional machine learning and deep learning methods also have variations in accuracy rates for image classification tasks.
COMPUTERS IN BIOLOGY AND MEDICINE
(2022)
Article
Oncology
Ryo Saito, Katsutoshi Shoda, Suguru Maruyama, Atsushi Yamamoto, Koichi Takiguchi, Shinji Furuya, Naohiro Hosomura, Hidenori Akaike, Yoshihiko Kawaguchi, Hidetake Amemiya, Hiromichi Kawaida, Makoto Sudo, Shingo Inoue, Hiroshi Kono, Katsue Suzuki-Inoue, Daisuke Ichikawa
Summary: This study revealed that platelets from gastric cancer patients enhance the malignant behaviors of cancer cells through EMT-related signaling, especially through direct contact with tumor cells.
BRITISH JOURNAL OF CANCER
(2021)
Article
Biochemistry & Molecular Biology
Vanna Denti, Maria K. Andersen, Andrew Smith, Anna Mary Bofin, Anna Nordborg, Fulvio Magni, Siver Andreas Moestue, Marco Giampa
Summary: The study successfully investigated lipid alterations in patient-derived xenograft of breast cancer using MALDI MSI technology, confirming the technical reliability and effectiveness of the method. This research provides strong support for the establishment of a MALDI MSI-based workflow.
Article
Gastroenterology & Hepatology
Michelle R. Ju, Rodrigo E. Alterio, Tarek Sawas, Herbert J. Zeh, Sam C. Wang, Matthew R. Porembka
Summary: This study aimed to quantify the proportion of gastric cancer patients experiencing delays in diagnosis and analyze the contributing barriers of care. The results showed that 23% of gastric cancer patients had delays in diagnosis, with the most common barrier being provider knowledge/skills gaps.
JOURNAL OF GASTROINTESTINAL SURGERY
(2022)
Article
Medicine, General & Internal
Luyao Zhao, Muran Li, Shiwu Zhang, Yandi Liu
Summary: This study evaluated the potential performance of plasma SEPT9 methylation as a noninvasive biomarker for the diagnosis of gastric cancer. The results suggest that mSEPT9 may serve as a useful and noninvasive biomarker for the diagnosis of gastric cancer.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
In-Seob Lee, Jiyoung Ahn, Kwangsoo Kim, Yoshinaga Okugawa, Yuji Toiyama, Hoon Hur, Ajay Goel
Summary: Delayed detection of tumours is detrimental to gastric cancer patients, but the development of a novel 5-gene biomarker panel has shown great promise in noninvasive diagnosis of GC. Validation in two independent serum cohorts demonstrated high accuracy in identifying gastric cancer, regardless of tumor histology, with particularly high performance in detecting early stage cancer.
BRITISH JOURNAL OF CANCER
(2021)
Article
Oncology
Bang Wool Eom, Jun Sik Yu, Keun Won Ryu, Myeong-Cherl Kook, Young-Il Kim, Soo-Jeong Cho, Jong Yeul Lee, Chan Gyoo Kim, Il Ju Choi, Hong Man Yoon, Young-Woo Kim
ANNALS OF SURGICAL ONCOLOGY
(2015)
Article
Oncology
Young-Il Kim, Jun Ho Lee, Myeong-Cherl Kook, Jong Yeul Lee, Chan Gyoo Kim, Keun Won Ryu, Young-Woo Kim, Il Ju Choi
Article
Oncology
Young-Woo Kim, Mi-Jung Kim, Keun Won Ryu, Hyeong-Seok Lim, Jun Ho Lee, Sun-Young Kong, Jong Seok Lee, Il Ju Choi, Chan Gyoo Kim, Jong Yeul Lee, Soo-Jeong Cho, Myeong-Cherl Kook, Young-Iee Park, Seok-Ki Kim, Sook Ryun Park
Article
Gastroenterology & Hepatology
Eun Kyung Lee, So Young Kim, You Jin Lee, Mi Hyang Kwak, Hak Jin Kim, Il Ju Choi, Soo-Jeong Cho, Young Woo Kim, Jong Yeul Lee, Chan Gyoo Kim, Hong Man Yoon, Bang Wool Eom, Sun-Young Kong, Min Kyong Yoo, Jong Hyock Park, Keun Won Ryu
WORLD JOURNAL OF GASTROENTEROLOGY
(2015)
Article
Oncology
Ji Yeon Park, Myeong-Cherl Kook, Bang Wool Eom, Hong Man Yoon, Soo Jin Kim, Ji Yoon Rho, Seok-Ki Kim, Young-Il Kim, Soo-Jeong Cho, Jong Yeul Lee, Chan Gyoo Kim, Il Ju Choi, Young-Woo Kim, Keun Won Ryu
SURGICAL ONCOLOGY-OXFORD
(2016)
Article
Oncology
Young-Il Kim, Soo-Jeong Cho, Jong Yeul Lee, Chan Gyoo Kim, Myeong-Cherl Kook, Keun Won Ryu, Young-Woo Kim, Il Ju Choi
CANCER RESEARCH AND TREATMENT
(2016)
Article
Oncology
Kyung Hee Kim, Chan Gyoo Kim, Young-Woo Kim, Hae Moon, Jee Eun Choi, Soo-Jeong Cho, Jong Yeul Lee, Il Ju Choi
JOURNAL OF GASTRIC CANCER
(2016)
Article
Oncology
Young-Il Kim, Hyoung Sang Kim, Myeong-Cherl Kook, Soo-Jeong Cho, Jong Yeul Lee, Chan Gyoo Kim, Keun Won Ryu, Young-Woo Kim, Il Ju Choi
JOURNAL OF GASTRIC CANCER
(2016)
Article
Gastroenterology & Hepatology
Bang Wool Eom, Young-Il Kim, Kwang Hee Kim, Hong Man Yoon, Soo-Jeong Cho, Jong Yeul Lee, Chan Gyoo Kim, Myeong-Cherl Kook, Young-Woo Kim, Byung-Ho Nam, Keun Won Ryu, Il Ju Choi
GASTROINTESTINAL ENDOSCOPY
(2017)
Article
Oncology
Jun Ho Lee, Il Ju Choi, Hye Seung Han, Young-Woo Kim, Keun Won Ryu, Hong Man Yoon, Bang Wool Eom, Chan Gyoo Kim, Jong Yeul Lee, Soo-Jeong Cho, Young-Il Kim, Byung-Ho Nam, Myeong-Cherl Kook
ANNALS OF SURGICAL ONCOLOGY
(2015)
Article
Oncology
Bang Wool Eom, Chan Gyoo Kim, Myeong-Cherl Kook, Hong Man Yoon, Keun Won Ryu, Young-Woo Kim, Ji Yoon Rho, Young-Il Kim, Jong Yeul Lee, Il Ju Choi
Summary: NESS-EFTR is a newly developed method to prevent tumor exposure, and this study compared its results with laparoscopic and endoscopic cooperative surgery, demonstrating the feasibility of NESS-EFTR for gastric subepithelial tumors.
Article
Medicine, General & Internal
Young Ki Lee, Eun Kyung Lee, You Jin Lee, Bang Wool Eom, Hong Man Yoon, Young-Il Kim, Soo Jeong Cho, Jong Yeul Lee, Chan Gyoo Kim, Sun-Young Kong, Min Kyong Yoo, Yul Hwangbo, Young-Woo Kim, Il Ju Choi, Hak Jin Kim, Mi Hyang Kwak, Keun Won Ryu
Summary: The study evaluated the metabolic effects of gastrectomies and endoscopic submucosal dissections in EGC patients with T2DM, showing that gastrectomy improved glycemic control and various metabolic parameters. There were improvements in insulin resistance and other metabolic parameters as well.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Oncology
Young-Il Kim, Chan Gyoo Kim, Jong Yeul Lee, Il Ju Choi, Bang Wool Eom, Hong Man Yoon, Keun Won Ryu, Young-Woo Kim
Summary: The Niti-S Beta stent is an effective treatment for anastomotic leakage after total or proximal gastrectomy for gastric cancer, allowing for stent maintenance without hospitalization.
Article
Oncology
Hyeon Woo Lim, Tae Hyun Kim, Il Ju Choi, Chan Gyoo Kim, Jong Yeul Lee, Soo Jeong Cho, Hyeon Seok Eom, Sung Ho Moon, Dae Yong Kim
RADIATION ONCOLOGY JOURNAL
(2016)
Article
Gastroenterology & Hepatology
Jong Yeul Lee, Il Ju Choi, Chan Gyoo Kim, Soo-Jeong Cho, Myeong-Cherl Kook, Keun Won Ryu, Young-Woo Kim