期刊
JOURNAL OF PROTEOME RESEARCH
卷 8, 期 2, 页码 860-869出版社
AMER CHEMICAL SOC
DOI: 10.1021/pr800370n
关键词
Metsovo lung; asbestos; tremolite; malignant mesothelioma; pleural calcifications; bronchoalveolar lavage; proteomics; two-dimensional electrophoresis; acid ceramidase
资金
- GlaxoSmithKline
- FIRB [RBRN07BMCT_013]
Inhabitants of Metsovo, NW Greece, have been exposed to an asbestos whitewash, resulting in malignant pleural mesothelioma (MPM) and pleural calcifications (PCs). Interestingly, those with PCs (PC+) are less prone to MPM. They also have lymphocytic alveolitis, and differences in bronchoalveolar lavage (BAL) proteins, compared with those without pleural calcifications (PC-). This may mean a different response to the fiber leading to different susceptibility to neoplasia. To further evaluate this, a proteomic analysis of BAL proteins was performed. Proteomic analysis (2D-electrophoresis/Mass Spectrometry) of BAL in Metsovites nonoccupationally exposed to asbestos revealed increased albumin fragments, alpha 1-antitrypsin, S100-A9 and HSP27, suggesting ongoing inflammation. In those without pleural calcifications, increased expression of acid ceramidase, glutathione-S-transferase and presence of calcyphosin, all involved in cell cycle regulation and death as well as in the detoxification of mutagenic and toxic agents, lend further support to our thesis of possible protection against neoplasia in Metsovites with pleural calcifications.
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