Review
Microbiology
Pallavi Chandra, Steven J. Grigsby, Jennifer A. Philips
Summary: In this Review, the authors discuss the strategies used by Mycobacterium tuberculosis to evade the immune response and exploit the host inflammatory response during different phases of its life cycle. They highlight recent studies, identify gaps in knowledge and emphasize the importance of a detailed molecular understanding for the development of novel therapies, vaccines and diagnostics.
NATURE REVIEWS MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Zunyong Feng, Jing Zhou, Yinhua Liu, Ruixue Xia, Qiang Li, Liang Yan, Qun Chen, Xiaobing Chen, Yuxin Jiang, Gao Chao, Ming Wang, Guoren Zhou, Yijie Zhang, Yongsheng Wang, Hongping Xia
Summary: This study investigated the role of RGS1 in regulating the immunophenotype of different subpopulations of alveolar macrophages, finding that miRNA in exosomes can affect their immune balance, with potential therapeutic effects on ALI/ARDS and PF.
CELL DEATH AND DIFFERENTIATION
(2021)
Review
Biochemistry & Molecular Biology
Tarina Sharma, Anwar Alam, Aquib Ehtram, Anshu Rani, Sonam Grover, Nasreen Z. Ehtesham, Seyed E. Hasnain
Summary: Mycobacterium tuberculosis is a successful pathogen that can survive within host alveolar macrophages and resist immune responses. The PE/PPE/PE_PGRS proteins encoded by the pathogen's genome play multiple roles in enhancing its virulence and modulating immune responses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Guillem Pascual-Pasto, Brendan McIntyre, Rawan Shraim, Samantha N. Buongervino, Amy K. Erbe, Doncho Zhelev, Shakhnozakhon Sadirova, Anna M. Giudice, Daniel Martinez, Laura Garcia-Gerique, Dimiter S. Dimitrov, Paul M. Sondel, Kristopher R. Bosse
Summary: This study characterizes the immunomodulatory properties of a GPC2-targeted ADC and demonstrates the efficacy of combination immunotherapies in diverse neuroblastoma preclinical models.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Immunology
Noemi Rebecca Meier, Thomas M. Sutter, Marc Jacobsen, Tom H. M. Ottenhoff, Julia E. Vogt, Nicole Ritz
Summary: This study aimed to identify optimal antigen-cytokine combinations using machine learning algorithms to improve immunodiagnostic assays for tuberculosis in children. The results revealed that novel Mycobacterium tuberculosis antigens had the potential to enhance the accuracy of diagnostic tests.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Multidisciplinary Sciences
Sadaf Sulman, Saher Shahid, Aasia Khaliq, Atiqa Ambreen, Imran H. Khan, Andrea M. Cooper, Muhammad Waheed Akhtar
Summary: The study demonstrated that the fusion protein TriFu64 increased the sensitivity of TB serodiagnosis and was particularly effective in detecting sputum and culture negative patients. By combining Mtb antigens into fusion proteins, a broad sensitivity across different disease types, gender and age groups in a Pakistani population was achieved.
Article
Biochemistry & Molecular Biology
Asta Luciunaite, Indre Dalgediene, Emilija Vasiliunaite, Milda Norkiene, Indre Kucinskaite-Kodze, Aurelija Zvirbliene, Alma Gedvilaite
Summary: Polyomaviruses are common in humans and animals, and some of them may have potential zoonotic transmission. This study investigated the immunogenic properties of VP1 virus-like particles derived from human polyomaviruses (HPyVs). The results showed that these VP1 particles are highly immunogenic and have antigenic similarities among different polyomaviruses. The study also revealed the interaction between VP1 particles and phagocytes. This research provides important insights into the study of polyomavirus biology and its interaction with the host immune system using VP1 particles.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Ye-yu Li, Han-Mei Liu, Decheng Wang, Yan Lu, Cairong Ding, Li-Shuang Zhou, Xiang-Yang Wu, Zi-Wei Zhou, Shu-qin Xu, Chen Lin, Lian-Hua Qin, Yao Li, Jun Liu, Hai-Peng Liu, Lu Zhang
Summary: The study found that the AG of Mycobacterium can suppress host immune responses and enhance bacterial intracellular proliferation. The arabinose chains of AG have a greater impact on the virulence and pathogenicity of Mycobacterium.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Virology
Mengyuan Cen, Wei Ouyang, Xiuhui Lin, Xiaohong Du, Huiqun Hu, Huidan Lu, Wanying Zhang, Jingyan Xia, Xiaofeng Qin, Feng Xu
Summary: The F-box protein FBXO6 plays a role in inducing apoptosis in alveolar macrophages and modulates macrophage survival and interferon signaling in response to influenza A virus (IAV) infection. FBXO6 deficiency leads to decreased viral replication, reduced inflammation, and improved survival rates in IAV-infected mice. Furthermore, FBXO6 interacts with and promotes the degradation of NLRX1, impairing the survival of alveolar macrophages and the antiviral immunity of the host.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Editorial Material
Hematology
Wen Xuan Zhang, Paul Kubes
Summary: In this study, NOX2-deficient mice were used to investigate the underlying mechanisms of noninfectious inflammatory conditions in patients with CGD. The researchers identified a new population of AMs that exhibited significant inflammatory properties.
Article
Infectious Diseases
Ernest Adankwah, Norman Nausch, Difery Minadzi, Mohammed K. Abass, Kees L. M. C. Franken, Tom H. M. Ottenhoff, Ertan Mayatepek, Richard O. Phillips, Marc Jacobsen
Summary: IL-6 showed the highest sensitivity for detecting tuberculosis patients and asymptomatic contacts. Latency-associated antigens Rv2628 and Rv1733 increased concentrations of IFN gamma, IP-10, and IL-22 in asymptomatic contacts. The combination of IFN gamma induced by Rv2628/Rv1733 and IL-6 induced by IGRA-antigen was optimal for classifying tuberculosis patients and asymptomatic contacts.
JOURNAL OF INFECTION
(2021)
Article
Immunology
Elisa Petruccioli, Linda Petrone, Teresa Chiacchio, Chiara Farroni, Gilda Cuzzi, Assunta Navarra, Valentina Vanini, Umberto Massafra, Marianna Lo Pizzo, Giuliana Guggino, Nadia Caccamo, Fabrizio Cantini, Fabrizio Palmieri, Delia Goletti
Summary: Patients with immune-mediated inflammatory diseases (IMID), such as rheumatoid arthritis (RA), have a higher risk of developing active tuberculosis (TB) compared to the general population. Studying the M. tuberculosis (Mtb) specific T-cell response may help identify immune biomarkers of Mtb burden or clearance in different TB statuses and risk groups.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Elena G. Ufimtseva, Natalya I. Eremeeva, Tatiana V. Umpeleva, Diana V. Vakhrusheva, Sergey N. Skornyakov
Summary: The study compared Mtb loads in different lung lesions of TB patients and identified tuberculoma walls as the main niche for Mtb survival. Understanding the host-pathogen interactions is crucial for developing new therapeutic strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Microbiology
Jessica Luana Chechi, Tiwa Rotchanapreeda, Giselle Souza da Paz, Ana Carolina Prado, Alana Lucena Oliveira, Jose Cavalcante Souza Vieira, Marilia Afonso Rabelo Buzalaf, Anderson Messias Rodrigues, Lucilene Delazari dos Santos, Theerapong Krajaejun, Sandra de Moraes Gimenes Bosco
Summary: Pythiosis, caused by the oomycete Pythium insidiosum, is a life-threatening disease mainly seen in tropical and subtropical countries, affecting various animal species. The difficulty in diagnosis and lack of specific antigens prompted a study that revealed common antigens recognized by horses and humans with pythiosis, which could potentially serve as biomarkers for improved diagnosis and treatment.
Article
Critical Care Medicine
Ines Bendib, Asma Beldi-Ferchiou, Frederic Schlemmer, Mathieu Surenaud, Bernard Maitre, Anne Plonquet, Guillaume Carteaux, Keyvan Razazi, Veronique Godot, Sophie Hue, Armand Mekontso Dessap, Nicolas de Prost
Summary: This study aimed to assess the interrelation of ARDS/sepsis biomarkers in the alveolar and blood compartments and explored their association with clinical outcomes. The study found that IL-8 was the most compartmentalized cytokine and lower BAL fluid-to-serum concentration ratios of IL-1Ra were associated with hospital mortality in patients with pneumonia-associated ARDS.
Article
Multidisciplinary Sciences
Larry E. Taylor, Brandon C. Knott, John O. Baker, P. Markus Alahuhta, Sarah E. Hobdey, Jeffrey G. Linger, Vladimir V. Lunin, Antonella Amore, Venkataramanan Subramanian, Kara Podkaminer, Qi Xu, Todd A. VanderWall, Logan A. Schuster, Yogesh B. Chaudhari, William S. Adney, Michael F. Crowley, Michael E. Himmel, Stephen R. Decker, Gregg T. Beckham
NATURE COMMUNICATIONS
(2018)
Article
Engineering, Environmental
Yoontaek Oh, Ryan Noga, Vesselin Shanov, Hodon Ryu, Harish Chandra, Brijesh Yadav, Jagjit Yadav, Soryong Chae
CHEMICAL ENGINEERING JOURNAL
(2019)
Article
Plant Sciences
Venkataramanan Subramanian, Matt S. A. Wecker, Alida Gerritsen, Marko Boehm, Wei Xiong, Benton Wachter, Alexandra Dubini, David Gonzalez-Ballester, Regina Antonio, Maria L. Ghirardi
Article
Chemistry, Multidisciplinary
Kavita Bhagat, Jyoti Bhagat, Manish Kumar Gupta, Jatinder Vir Singh, Harmandeep Kaur Gulati, Atamjit Singh, Kamalpreet Kaur, Gurinder Kaur, Shally Sharma, Abhineet Rana, Harbinder Singh, Sahil Sharma, Preet Mohinder Singh Bedi
Article
Biochemistry & Molecular Biology
Manish K. Gupta, Vishakha Sharma, Sangram K. Lenka, Viswanathan Chinnusamy
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2020)
Article
Biotechnology & Applied Microbiology
Swati Gupta, Yashwant Pathak, Manish K. Gupta, Suresh P. Vyas
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
(2019)
Article
Chemistry, Analytical
Kiera Gazica, Elizabeth FitzGerald, Gabrielle Dangel, Erin N. Haynes, Jagjit Yadav, Noe T. Alvarez
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2020)
Article
Multidisciplinary Sciences
Carlos del Cerro, Erika Erickson, Tao Dong, Allison R. Wong, Elizabeth K. Eder, Samuel O. Purvine, Hugh D. Mitchell, Karl K. Weitz, Lye Meng Markillie, Meagan C. Burnet, David W. Hoyt, Rosalie K. Chu, Jan-Fang Cheng, Kelsey J. Ramirez, Rui Katahira, Wei Xiong, Michael E. Himmel, Venkataramanan Subramanian, Jeffrey G. Linger, Davinia Salvachua
Summary: Research shows that two white-rot fungi can utilize lignin as a carbon source and funnel carbon from lignin-derived aromatic compounds into central carbon metabolism via intracellular catabolic pathways. These insights into global carbon cycling and the foundation for a sustainable bioeconomy highlight the importance of simultaneous lignin depolymerization and bioconversion by white-rot fungi.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biology
Alison M. Pecquet, Andrew Maier, Susan Kasper, Saulius Sumanas, Jagjit Yadav
BMC RESEARCH NOTES
(2020)
Article
Biotechnology & Applied Microbiology
Venkataramanan Subramanian, Vladimir V. Lunin, Samuel J. Farmer, Markus Alahuhta, Kyle T. Moore, Angela Ho, Yogesh B. Chaudhari, Min Zhang, Michael E. Himmel, Stephen R. Decker
BIOTECHNOLOGY FOR BIOFUELS
(2020)
Meeting Abstract
Chemistry, Multidisciplinary
Yoontaek Oh, Ryan Noga, Vesselin Shanov, Hodon Ryu, Jagjit Yadav, Soryong Chae
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2019)
Article
Biochemistry & Molecular Biology
Jatinder V. Singh, Gurbachan Mal, Gurleen Kaur, Manish K. Gupta, Amritpal Singh, Kunal Nepali, Harbinder Singh, Sahil Sharma, Preet Mohinder S. Bedi
Correction
Biochemistry & Molecular Biology
Jatinder V. Singh, Gurbachan Mal, Gurleen Kaur, Manish K. Gupta, Amrit Pal Singh, Kunal Nepali, Harbinder Singh, Sahil Sharma, Preet Mohinder S. Bedi
Review
Microbiology
Sunil K. Deshmukh, Manish K. Gupta, Ved Prakash, M. Sudhakara Reddy
Article
Chemistry, Medicinal
Subhajit Roy, Bawneet K. Narang, Manish K. Gupta, Vikrant Abbot, Virender Singh, Ravindra K. Rawal