Article
Environmental Sciences
Yi Sun, Wenchang Zhang, Yuchen Li, Jianlin Zhu, Chenchen Liu, Lingfeng Luo, Jin Liu, Chenyun Zhang
Summary: This study investigates the effects of paternal cadmium exposure on offspring ovarian granulosa cell apoptosis and multigenerational genetic effects. Male Sprague-Dawley rats were exposed to varying concentrations of CdCl2, and subsequent generations were assessed for apoptotic rates, gene expression, and miRNA changes. Paternal cadmium exposure was found to induce ovarian granulosa cell apoptosis in F1 and F2 generations, along with alterations in apoptosis-related gene expression and miRNA profiles.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Pharmacology & Pharmacy
Z. Pandelides, M. C. Sturgis, C. Thornton, N. Aluru, K. L. Willett
Summary: The study investigated the sex-dependent multigenerational effects of preconceptional exposure to BaP. The results showed that parental dietary BaP exposure significantly affected the offspring's behavior and development, especially in the adult generation and subsequent generations. In addition, BaP also caused changes in gene expression and DNA methylation levels in the offspring.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2023)
Article
Biology
Georges Raad, Fabrizio Serra, Luc Martin, Marie-Alix Derieppe, Jerome Gilleron, Vera L. Costa, Didier F. Pisani, Ez-Zoubir Amri, Michele Trabucchi, Valerie Grandjean
Summary: Research shows that maintaining a paternal Western diet feeding for five consecutive generations in mice leads to an increase in fat mass and related metabolic diseases over generations, but progenies from these multigenerational Western-diet-fed males develop a healthy overweight phenotype characterized by normal glucose metabolism and without fatty liver, which persists for four subsequent generations. Sperm RNA is suggested to be sufficient for the establishment but not for long-term maintenance of epigenetic inheritance of metabolic pathologies.
Article
Biochemistry & Molecular Biology
Iala Milene Bertasso, Egberto Gaspar de Moura, Carla Bruna Pietrobon, Suelen Silva Cabral, George Eduardo Gabriel Kluck, Georgia Correa Atella, Alex Christian Manhaes, Patricia Cristina Lisboa
Summary: Maternal protein-restricted diet during lactation may affect hepatic metabolism in offspring without inducing hepatic lipid accumulation. Female offspring showed normal hepatic morphology, while male offspring had no liver steatosis.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Article
Veterinary Sciences
Dian G. M. Zijlmans, Annemiek Maaskant, Annet L. Louwerse, Elisabeth H. M. Sterck, Jan A. M. Langermans
Summary: This study investigates the effects of mild caloric restriction on multigenerational long-tailed macaque breeding groups. The results show that caloric restriction can effectively reduce the weight of overweight adult macaques, with no adverse effects on immature growth, veterinary consultations, and reproductive success.
VETERINARY SCIENCES
(2022)
Article
Multidisciplinary Sciences
Liana Fasching, Yeongjun Jang, Simone Tomasi, Jeremy Schreiner, Livia Tomasini, Melanie Brady, Taejeong Bae, Vivekananda Sarangi, Nikolaos Vasmatzis, Yifan Wang, Anna Szekely, Thomas Fernandez, James F. Leckman, Alexej Abyzov, Flora M. Vaccarino
Summary: The study found that mosaic mutations can help track cell lineages in humans, with different efficiencies of DNA repair potentially contributing to lineage imbalances. By analyzing cell lineages, insights into cell division, tissue formation, and disease development can be gained.
Article
Biochemistry & Molecular Biology
Lin Ma, Yanhua Du, Yi Hui, Nan Li, Beibei Fan, Xiaojie Zhang, Xiaocui Li, Wei Hong, Zhiping Wu, Shuwei Zhang, Shanshan Zhou, Xiangjie Xu, Zhongshu Zhou, Cizhong Jiang, Ling Liu, Xiaoqing Zhang
Summary: The dorsal and ventral regions of the human telencephalon contain different neuronal subtypes, generated from radial glial cells (RGs) through intermediate progenitor cells (IPCs_div) and early postmitotic neuroblasts (eNBs), with the transcription factor ASCL1 playing a key role in this developmental process. These findings suggest a general developmental scheme for human telencephalic progenitors, with neuronal diversity being shaped during neurogenesis and neural circuit integration.
Article
Cell Biology
Kara N. N. Thomas, Katherine N. N. Zimmel, Alison Basel, Alexis N. N. Roach, Nicole A. A. Mehta, Kelly R. R. Thomas, Luke J. J. Dotson, Yudhishtar S. S. Bedi, Michael C. C. Golding
Summary: This study shows that chronic preconception paternal alcohol exposures can program nonlinear, dose-dependent changes in offspring fetoplacental growth, which may help explain the variation in fetal alcohol spectrum disorder (FASD) phenotypes and incidence.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Plant Sciences
Soon-Ki Han, June M. Kwak, Xingyun Qi
Summary: Stomatal development plays a critical role in plant survival and growth under varying environmental conditions, with signaling cascades, transcriptional networks, and environmental cues all influencing proper stomatal patterning, density, and polarity. Recent findings highlight the complexity of the developmental program governing stomatal lineage cells, providing insights for improving crop plant photosynthesis and water-stress resilience in the face of climate change.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Ecology
Elizabeth M. L. Duxbury, Hanne Carlsson, Kris Sales, Zahida Sultanova, Simone Immler, Tracey Chapman, Alexei A. Maklakov
Summary: Adulthood-only downregulation of insulin/IGF-1 signaling can increase lifespan without affecting reproduction in nematodes. The long-term effects of reduced signaling remain unexplored, but our study suggests that reducing insulin/IGF-1 signaling can actually benefit fitness, particularly under stressful conditions.
Article
Nutrition & Dietetics
Thalles de Freitas Castro, Natalia Alves de Matos, Ana Beatriz Farias de Souza, Guilherme de Paula Costa, Luiza Oliveira Perucci, Andre Talvani, Silvia Dantas Cangussu, Rodrigo Cunha Alvim de Menezes, Frank Silva Bezerra
Summary: Maternal protein restriction during pregnancy has adverse effects on the lungs of offspring, including decreased body weight, inflammation and oxidative stress, and simplification of lung structure.
Article
Multidisciplinary Sciences
Sara K. Jones, Deirdre M. Mccarthy, Gregg D. Stanwood, Christopher Schatschneider, Pradeep G. Bhide
Summary: Environmental exposures can lead to heritable traits that have long-term effects on the population. For example, consuming substances like artificial sweeteners daily, without proper evaluation of their genetic effects, can result in cognitive deficits. These deficits can be passed down through the paternal lineage, highlighting the need to consider heritable effects in regulatory evaluations of substances like artificial sweeteners.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Pengfei Gong, Danielle Bailbe, Lola Bianchi, Gaelle Pommier, Junjun Liu, Stefania Tolu, Maria G. Stathopoulou, Bernard Portha, Valerie Grandjean, Jamileh Movassat
Summary: The study found that paternal high-protein diet has a sex-specific impact on the metabolic health of offspring, particularly affecting male descendants.
Article
Environmental Sciences
Min-Chen Wang, Fumiya Furukawa, Ching-Wei Wang, Hui-Wen Peng, Ching-Chun Lin, Tzu-Hao Lin, Yung-Che Tseng
Summary: This study explores the transgenerational plasticity in tilapia under global warming scenario and finds that parental cold-experience may affect energy provision during reproduction and early life stages of the offspring. Metabolomics-based profiling reveals potential metabolic traits that help tilapia cope with temperature perturbations. The study also applies feature rescaling and UMAP to visualize metabolic dynamics.
ENVIRONMENTAL POLLUTION
(2022)
Article
Biology
Florent Ailloud, Wilhelm Gottschall, Sebastian Suerbaum
Summary: An extensive dataset of Helicobacter pylori methylome suggests that natural selection can regulate the epigenetic landscape by configuring methyltransferases and their recognition sequences. The frequency and abundance of methyltransferases and their recognition sequences were influenced by phylogeographic structure, with some type II methyltransferases showing positive or negative correlation. The study also revealed that methylation patterns can be enriched by positive selection and specific sites have important functions in methylation-dependent phenotypes.
COMMUNICATIONS BIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Sergio De los Santos, Ramon Mauricio Coral-Vazquez, Marta Menjivar, Maria de los Angeles Granados-Silvestre, Sebastian De la Rosa, Luis Antonio Reyes-Castro, Juan Pablo Mendez, Elena Zambrano, Patricia Canto
Summary: Both maternal obesity and high-fat diet have negative effects on the offspring, but treatment with epicatechin can reverse these effects. In male rats descended from obese mothers and fed a high-fat diet, epicatechin reduced fat mass and increased lean mass, but did not fully restore body mineral density.
FUNDAMENTAL & CLINICAL PHARMACOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Amita Bansal, Giselle A. Abruzzese, Erandi Hewawasam, Kyoko Hasebe, Hirotaka Hamada, Zahra Hoodbhoy, Hanna Diounou, Carlos A. Ibanez, Rosiane A. Miranda, Thea N. Golden, Kozeta Miliku, Carmen R. Isasi
Summary: The COVID-19 pandemic has had a significant impact on the careers and research progress of research trainees and early career researchers worldwide. The International DOHaD ECR committee formed a special interest group to understand the effects of the pandemic and to discuss ways to strengthen collaborative work based on shared experiences.
JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE
(2022)
Article
Energy & Fuels
German Buendia Rodriguez, Diego Alfredo Cardoso Carmona, Mona M. Y. Elghandour, Abdelfattah Z. M. Salem, Hector Reyes Soto, Ricardo Ruiz Sanchez, Moyosore J. Adegbeye
Summary: The addition of sodium butyrate to milk replacement for Holstein calves improved their productive performance, energy metabolism, and rumen microbiota. The best results were observed with the addition of 5 grams of sodium butyrate.
BIOMASS CONVERSION AND BIOREFINERY
(2022)
Article
Developmental Biology
Clarissa A. Moura, Fernanda C. Cagni, Layse Rf Costa, Pamella Rf Tiago, Mikael Croyal, Audrey Aguesse, Luis A. Reyes-Castro, Elena Zambrano, Francisco Bolanos-Jimenez, Elaine Cristina Gavioli
Summary: Maternal stress during pregnancy can affect the behavior and brain metabolism of offspring, and this effect is influenced by sex. This study found that maternal stress leads to emotional disorders in adult offspring, with females showing depressive-like behaviors and males showing anxiety-like behaviors.
DEVELOPMENTAL NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Guadalupe L. Rodriguez-Gonzalez, Lilia Vargas-Hernandez, Luis A. Reyes-Castro, Carlos A. Ibanez, Claudia J. Bautista, Consuelo Lomas-Soria, Nozomi Itani, Guadalupe Estrada-Gutierrez, Aurora Espejel-Nunez, Arturo Flores-Pliego, Araceli Montoya-Estrada, Enrique Reyes-Munoz, Paul D. Taylor, Peter W. Nathanielsz, Elena Zambrano
Summary: Maternal obesity leads to oxidative stress and metabolic dysfunction. Supplementation of obese mothers with resveratrol improves maternal metabolic alterations and reduces oxidative stress in the placenta and maternal and fetal liver, with a sex-dependent effect.
Article
Nutrition & Dietetics
Guadalupe L. L. Rodriguez-Gonzalez, Sergio De Los Santos, Dayana Mendez-Sanchez, Luis A. A. Reyes-Castro, Carlos A. A. Ibanez, Patricia Canto, Elena Zambrano
Summary: Offspring of obese mothers develop obesity and metabolic alterations in adulthood. In addition, poor postnatal dietary patterns exacerbate these health issues. Our study found that a high-fat diet consumed by the offspring of obese mothers worsens body fat accumulation, metabolic abnormalities, and adipocyte size distribution.
BRITISH JOURNAL OF NUTRITION
(2023)
Article
Endocrinology & Metabolism
Carla Elena Mezo-Gonzalez, Juan Antonio Garcia Santillan, Luis A. Reyes-Castro, Mathilde Gourdel, Mikael Croyal, Francisco Bolanos-Jimenez
Summary: Obesity is associated with impaired learning, and it is unclear how this cognitive dysfunction occurs. The role of sex differences in obesity-induced learning deficits is also controversial. Estrogens are believed to protect females from cognitive decline by enhancing the expression of tryptophan hydroxylase-2 (TPH-2), which is involved in the conversion of tryptophan into serotonin. However, other compounds derived from tryptophan metabolism through the kynurenine pathway (KP) also play a role in learning and memory. This study aimed to investigate the involvement of the KP in learning regulation in control and obese female rats and found that the impairments in learning caused by obesity are closely related to the estrous cycle and the kynurenine pathway of tryptophan metabolism.
NEUROENDOCRINOLOGY
(2023)
Article
Nutrition & Dietetics
Carlos A. Ibanez, Gabriela Lira-Leon, Luis A. A. Reyes-Castro, Guadalupe L. Rodriguez-Gonzalez, Consuelo Lomas-Soria, Alejandra Hernandez-Rojas, Eyerahi Bravo-Flores, Juan Mario Solis-Paredes, Guadalupe Estrada-Gutierrez, Elena Zambrano
Summary: We investigated the effects of maternal obesity on adipocyte size distribution and gene expression in offspring. It was found that retroperitoneal adipose tissue expansion and metabolic dysfunction differed between male and female offspring. The expression of pro-adipogenic genes and insulin signaling were reduced in males, while lipid mobilization-related genes were reduced in females.
Article
Biology
Consuelo Lomas-Soria, Guadalupe L. Rodriguez-Gonzalez, Carlos A. Ibanez, Luis A. Reyes-Castro, Peter W. Nathanielsz, Elena Zambrano
Summary: The present study explored the impact of maternal obesity on hepatic mitochondrial function in male and female offspring at different ages. The findings suggest that maternal obesity accelerates the age-related down-regulation of electron transport chain (ETC) gene expression, leading to oxidative stress, premature aging, and metabolic dysfunction in male offspring. These effects were not observed in female offspring until later in life. The study highlights the importance of mitochondria in the development of fatty liver and provides insights into the mechanisms underlying sexual dimorphism in aging.
Article
Biology
Erika Chavira-Suarez, Carlos Alberto Ibanez, Diana Catalina Castro-Rodriguez, Luis Antonio Reyes-Castro, Marina Gisela Ramirez-Leal, Lucia Alba Martinez-Mota, Elena Zambrano
Summary: Maternal obesity has negative effects on the metabolic function of offspring, and its impact on skeletal muscle programming and aging has been poorly studied. This study evaluated the effects of maternal obesity on muscle strength, adiposity, and metabolism in offspring from a rat model. The results showed that maternal obesity can lead to metabolic dysfunctions in male offspring during aging, while adiposity-related muscle strength loss and fatty acid alterations were observed in female offspring.
JOURNAL OF BIOSCIENCES
(2023)
Article
Psychology, Biological
Umit Yilmaz, Kevser Tanbek
Summary: This study investigated the effects of intracerebroventricular administration of Spexin on the hypothalamus-pituitary-thyroid axis and energy expenditure in rats. The results showed that Spexin reduced food consumption and body weight, increased thyroid hormones, and enhanced energy metabolism.
PHYSIOLOGY & BEHAVIOR
(2024)
Article
Psychology, Biological
Kuei-Yu Chien, Yun-Ju Chen, Kuo-Jen Hsu, Chiao-Nan Chen
Summary: This study investigated the effects of a high-protein diet and high-intensity interval training on appetite and weight loss in obese middle-aged individuals. The results showed that consuming a high-protein drink and following a high-protein diet after exercise can reduce post-exercise appetite and the frequency of late-night snacking.
PHYSIOLOGY & BEHAVIOR
(2024)
Review
Psychology, Biological
Melissa Alves Braga Oliveira, Ana Carolina Odebrecht Vergne de Abreu, Debora Barroggi Constantino, Andre C. Tonon, Antoni Diez-Noguera, Fernanda Gaspar Amaral, Maria Paz Hidalgo
Summary: Biological processes in living organisms exhibit strong rhythmicity and are regulated by internal timing systems. Understanding the influence of biological rhythms is crucial for experimental design and reporting.
PHYSIOLOGY & BEHAVIOR
(2024)
Article
Psychology, Biological
Yanqun Cao, Hao Chen, Yinna Tan, Xu-Dong Yu, Chuli Xiao, Yin Li, James Reilly, Zhiming He, Xinhua Shu
Summary: There is evidence to suggest that chronic stress impacts neurochemical homeostasis and contributes to mental disorders. This study investigates the therapeutic potential of p-coumaric acid (p-CA), a natural compound found in vegetables and fruits, against stress-associated mental disorders. The findings suggest that p-CA could alleviate cognitive deficits and depression-like behavior in mice exposed to chronic restraint stress (CRS) by regulating the PKA-CREB-BDNF signaling pathway.
PHYSIOLOGY & BEHAVIOR
(2024)
Article
Psychology, Biological
Mai O. Spaulding, Jessica R. Hoffman, Grace C. Madu, Magen N. Lord, Caroline Soares Iizuka, Kevin P. Myers, Emily E. Noble
Summary: Food insecurity is associated with obesity and disordered eating behaviors. Studying a rodent model, researchers found that adolescent food insecurity may increase susceptibility to obesity and altered eating behaviors during adulthood.
PHYSIOLOGY & BEHAVIOR
(2024)
Article
Psychology, Biological
K. Oberman, B. L. van Leeuwen, M. Nabben, J. E. Villafranca, R. G. Schoemaker
Summary: The present study investigated the post-operative complications and therapeutic potential of J147 in male Zucker rats, and found that J147 treatment had positive effects on behavioral and metabolic parameters, but did not affect neuroinflammation. The results suggest that a combination of acute and chronic J147 treatment may be optimal for treatment.
PHYSIOLOGY & BEHAVIOR
(2024)
Review
Psychology, Biological
Mathieu Cournoyer, Alice Maldera, Alexandre-Charles Gauthier, Fabien Dal Maso, Marie-Eve Mathieu
Summary: This article provides a comprehensive view of the literature on the effect of different odors on physical activity through a systematic review. It was found that pleasant odors have a positive impact on participants' physical activity. However, better methodological consistency is needed in studies to produce more meaningful results.
PHYSIOLOGY & BEHAVIOR
(2024)
Article
Psychology, Biological
Gabriel R. Gilmore, Jeff Dyche
Summary: This study examined sleep, sleep/wake regularity, and cognition in college students diagnosed with depression and using serotonergic antidepressants, comparing them to those without a depression diagnosis. The results showed that students using antidepressants had slightly longer wake after sleep onset and lower sleep efficiency, but these differences were likely not noticed by the participants. There were no differences in sleep regularity or cognition between the two groups.
PHYSIOLOGY & BEHAVIOR
(2024)
Article
Psychology, Biological
Erica A. Cross, Kim L. Huhman, H. Elliott Albers
Summary: Social stress plays a significant role in the development of neuropsychiatric disorders and can lead to behavioral deficits such as social withdrawal. This study investigates the impact of social stress on social reward in Syrian hamsters. The results show that subordinate and socially defeated males have reduced motivation for social interactions compared to dominant males. Additionally, winning males exhibit greater activation in the mesolimbic dopamine system compared to losers. In females, there were no differences in social entries between winners and losers, but winning females display more activation in the NAc shell.
PHYSIOLOGY & BEHAVIOR
(2024)
Article
Psychology, Biological
Daniel A. R. Cabral, Maria L. M. Rego, Eduardo B. Fontes, Vagner D. O. Tavares
Summary: This study examined the association between body mass index (BMI) and negative emotional states (NES) in men with substance use disorders (SUD) undergoing treatment. The findings showed a positive correlation between BMI and stress, anxiety, and depression. These results suggest that reducing body fat accumulation may contribute to improving mental health in individuals with SUD during recovery.
PHYSIOLOGY & BEHAVIOR
(2024)
Review
Psychology, Biological
Elizabeth Agbor Epse Muluh, Jessica C. McCormack, Yunfan Mo, Michael Garratt, Mei Peng
Summary: This PROSPERO pre-registered systematic review and meta-analysis evaluated the olfactory and gustatory changes in pregnant individuals. The meta-analysis revealed that pregnant individuals performed poorer in odour identification, rated olfactory stimuli to be more intense during the second and third trimester, and had increased pleasantness for sweet taste in the first trimester. No major difference was observed in terms of gustatory functions between pregnant and non-pregnant subjects.
PHYSIOLOGY & BEHAVIOR
(2024)
Article
Psychology, Biological
Renee Spiteri Douglas, Mackenzie R. Hartley, J. Renee Yang, Tamara B. Franklin
Summary: The expression of Hdac2 in the hippocampus is associated with social status, while the expression of closely related genes Hdac1 and HDAC2 protein is not associated with social rank in the hippocampus.
PHYSIOLOGY & BEHAVIOR
(2024)