期刊
JOURNAL OF PROTEOME RESEARCH
卷 8, 期 1, 页码 72-81出版社
AMER CHEMICAL SOC
DOI: 10.1021/pr800638w
关键词
premature neonates; enteral formula feeding; necrotizing enterocolitis; 2-DE; mass spectrometry; temporal study
资金
- University of Hong Kong
- Danish Research Councils
Necrotizing enterocolitis (NEC), a serious gastrointestinal inflammatory disease, frequently occurs in preterm neonates that fail to adapt to enteral nutrition. A temporal gel-based proteomics study was performed on porcine intestine with NEC lesions induced by enteral formula feeding. Functional assignment of the differentially expressed proteins revealed that important cellular functions, such as the heat shock response, protein processing; and purine, nitrogen, energy metabolism, were possible involved in the early progression of NEC.
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