期刊
JOURNAL OF PROTEOME RESEARCH
卷 7, 期 11, 页码 4904-4913出版社
AMER CHEMICAL SOC
DOI: 10.1021/pr800551m
关键词
hyaloid vascular system; vasa hyaloidea propria; tunica vasculosa lentis; proteomic analysis; kininogen; angiogenic factors; antiangiogenic factors; vessel regression
资金
- S. Elizabeth O'Brien Trust
- NIH [EY10101, P30-001792, EY14048]
- Research to Prevent Blindness (New York, NY)
We describe a proteomic approach to investigate the differential protein expression patterns and identify the physiologically relevant angiogenic and antiangiogenic factors involved in the hyaloid vascular system regression. Differentially expressed proteins were identified using two-dimensional gel electrophoresis followed by nanoflow chromatography coupled with tandem mass spectrometry. These proteins are expected to provide insight as to their function in the early maintenance and eventual regression of the hyaloid vascular system.
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