Review
Immunology
Ruozhu Yang, Yi Han, Wenjun Yi, Qian Long
Summary: Breast cancer is a common and significant public health issue for women worldwide. Mammography, the main screening method for breast cancer, has limitations in terms of accuracy, especially for patients with small tumors and dense breasts. Recent research has found that autoantibodies in peripheral blood can serve as noninvasive, presymptomatic, and low-cost biomarkers, providing a potential supplementary method for breast cancer screening and prognosis classification.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Qianyu Zhu, Pingping He, Cuiling Zheng, Zhibin Chen, Saiping Qi, Donghu Zhou, Yanmeng Li, Qin Ouyang, Huaduan Zi, Hengcheng Tang, Jie Xing, Yibin Xie, Shengtao Zhu, Jiansong Ren, Jian Huang
Summary: In this study, novel serum autoantibody-based biomarkers for precancerous lesion and early gastric cancer were identified. The identified autoantibodies showed higher levels in patients compared with healthy individuals and had good potential for differentiating between different stages of gastric cancer. Predictive models incorporating these autoantibodies improved the diagnostic efficiency for early detection of gastric cancer and precancerous lesion.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Medicine, General & Internal
Young Joo Shin, Eunbi Kim, Bobby Kwanghoon Han, Kayoung Yi
Summary: This study evaluated biomarkers for glaucoma diagnosis in Korea and found that serum MBP level was higher and serum anti-alpha-fodrin antibody level was lower in the glaucoma group compared to the control group. NTG group showed higher anti-SSA and anti-SSB levels and lower anti-alpha-fodrin IgG/IgA levels than HTG group. These biomarkers were useful for diagnosing and discriminating between different types of patients with glaucoma.
Article
Oncology
Chao-Qun Hong, Xue-Fen Weng, Xu-Chun Huang, Ling-Yu Chu, Lai-Feng Wei, Yi-Wei Lin, Liu-Yi Chen, Can-Tong Liu, Yi-Wei Xu, Yu-Hui Peng
Summary: A panel of autoantibodies targeting BMI-1, HSP70, NY-ESO-1, and p53 showed potential in detecting early stage breast cancer with high sensitivity and specificity.
Article
Oncology
Xuan Zou, Tiansong Xia, Minghui Li, Tongshan Wang, Ping Liu, Xin Zhou, Zebo Huang, Wei Zhu
Summary: A signature of 12 serum miRNAs was identified in this study, showing potential for non-invasive diagnosis of BC.
Article
Biochemistry & Molecular Biology
Yangyang Sun, Chengxi Liu, Huidong Zhong, Chenguang Wang, Haibo Xu, Wei Chen
Summary: In this study, the researchers identified high expression of certain autoantibodies in serum of renal cancer patients using the human proteome microarray technology, suggesting their potential as biomarkers for renal cancer.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2022)
Article
Medical Laboratory Technology
Ramtin Omid-Shafaat, Hassan Moayeri, Karim Rahimi, Mohammad-Nazir Menbari, Zakaria Vahabzadeh, Mohammad-Saied Hakhamaneshi, Bijan Nouri, Bayazid Ghaderi, Mohammad Abdi
Summary: In this study, the diagnostic efficiency of combined circRNAs panel including Circ-ELP3 and Circ-FAF1 as a non-invasive marker for detecting breast carcinomas was shown to be high. The combined use of these circRNAs resulted in better diagnostic accuracy compared to using them separately.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2021)
Review
Immunology
Maheswari Muruganandam, Angie Ariza-Hutchinson, Rosemina A. Patel, Wilmer L. Sibbitt
Summary: Systemic sclerosis is a complex autoimmune disease characterized by vascular damage, inflammation, and fibrosis. Biomarkers play an important role in understanding the disease process and potential therapeutic targets. Anti-nuclear antibodies are classical biomarkers, while other proteins and pathways are also implicated. The use of biomarker panels combined with advanced analysis techniques can help determine disease activity and treatment response.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Article
Medicine, General & Internal
Zuhu Yu, Chong Lu, Yongqing Lai
Summary: In this study, the expression profiles of miRNAs in serum samples of bladder cancer patients and healthy controls were detected, and five differentially expressed miRNAs were identified. A three-miRNA signature consisting of miR-27b-3p, miR-381-3p, and miR-451a was constructed with a high diagnostic efficiency for bladder cancer. This three-miRNA signature may serve as a promising non-invasive biomarker for early diagnosis of bladder cancer.
ANNALS OF MEDICINE
(2023)
Article
Immunology
Hongqin You, Guanglei Dang, Bichao Lu, Siya Zhang, Chen Li, Lun Wang, Yu Hu, Hui Chen, Jianmin Zhang, Wei He
Summary: The study identified the serum anti-Sp17 autoantibody as a specific biomarker in patients with SAPHO syndrome. Levels of the anti-Sp17 autoantibody were significantly elevated in patients with active SAPHO and correlated with other biochemical markers. Treatment with pamidronate disodium decreased the levels of the autoantibody, along with levels of inflammatory markers, in patients with active SAPHO. This suggests that the anti-Sp17 autoantibody may serve as a specific biomarker for diagnosis or disease monitoring in SAPHO syndrome.
JOURNAL OF CLINICAL IMMUNOLOGY
(2021)
Article
Biology
Sinan U. Umu, Hilde Langseth, Verena Zuber, Aslaug Helland, Robert Lyle, Trine B. Rounge
Summary: This study showed that lung cancer can be detected years before diagnosis through serum RNA levels, regardless of histological subtype. The strongest models successfully predicted the occurrence of non-small cell lung cancer and small cell lung cancer within specific time intervals, with different types of RNA serving as important separators.
Article
Chemistry, Analytical
A. N. Stephen, S. R. Dennison, M. A. Holden, S. M. Reddy
Summary: Rapid detection of biologicals is important for various applications, and this study investigates the use of electropolymerized molecularly imprinted polymers (E-MIPs) as alternative biosensors with high selectivity and sensitivity. The results show that E-MIPs can rapidly and selectively recognize target proteins, and the sensitivity depends on the nature of the electrode surface area.
Article
Oncology
Pei-Chun Hsueh, Kai-Ping Chang, Hao-Ping Liu, Wei-Fan Chiang, Xiu-Ya Chan, Chu-Mi Hung, Lichieh Julie Chu, Chih-Ching Wu
Summary: This study evaluated the performance of nine salivary autoantibodies as biomarkers for oral cavity squamous cell carcinoma (OSCC). A panel of four autoantibodies achieved high sensitivity and specificity for early diagnosis of OSCC. This multiplex autoantibody platform shows clinical applicability for OSCC screening.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Sara D. Alharthi, Hemalatha Kanniyappan, Soundarya Prithweeraj, Divya Bijukumar, Mathew T. Mathew
Summary: Breast cancer is the second leading cause of cancer-related mortality in women worldwide and in the United States. Early detection using a cost-effective, rapid, and highly sensitive approach such as an electrochemical biosensor is crucial for better treatment outcomes. Our research focuses on using the ECM1 biomarker with higher expression in synthetic urine to develop such a biosensor for breast cancer detection.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Oncology
Zhe Cao, Kristin Delfino, Vivek Tiwari, Xin Wang, Abdul Hannan, Fawwad Zaidi, Andrew McClintock, Kathy Robinson, Yun Zhu, John Gao, Deliang Cao, Krishna Rao
Summary: This case-controlled pilot study found that serum AKR1B10 was significantly elevated in breast cancer patients, and it was correlated with its expression in tumor tissues. After surgical removal of primary tumors, the serum AKR1B10 levels rapidly decreased and became similar to those of healthy individuals. ROC curve analysis suggested that serum AKR1B10 could serve as a biomarker for breast cancer.
FRONTIERS IN ONCOLOGY
(2022)
