Article
Limnology
Claudia Patriarca, Vicente T. Sedano-Nunez, Sarahi L. Garcia, Jonas Bergquist, Stefan Bertilsson, Per J. R. Sjoberg, Lars J. Tranvik, Jeffrey A. Hawkes
Summary: Autotrophic dissolved organic matter (DOM) plays a significant role in the carbon biogeochemistry of aquatic systems, yet its complexity has not been thoroughly studied. This study used high-resolution mass spectrometry to investigate the DOM produced by the cyanobacteria Microcystis aeruginosa, revealing that this autotroph-derived DOM is highly susceptible to removal by heterotrophic bacteria, resulting in low concentrations in natural settings.
LIMNOLOGY AND OCEANOGRAPHY
(2021)
Article
Obstetrics & Gynecology
Ragnheidur Valdimarsdottir, Anna-Karin Wikstrom, Theodora Kunovac Kallak, Evangelia Elenis, Ove Axelsson, Hubert Preissl, S. J. Kumari A. Ubhayasekera, Jonas Bergquist, Inger Sundstrom Poromaa
Summary: Women with PCOS have higher testosterone levels during pregnancy than women without PCOS. High maternal testosterone levels in early second trimester are associated with an increased risk of developing preeclampsia in women with PCOS.
REPRODUCTIVE BIOMEDICINE ONLINE
(2021)
Article
Public, Environmental & Occupational Health
Oskar Karlsson, Joacim Rocklov, Alizee P. Lehoux, Jonas Bergquist, Anna Rutgersson, Martin J. Blunt, Linda S. Birnbaum
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2021)
Article
Clinical Neurology
Valter Niemela, Anne-Marie Landtblom, Dag Nyholm, Maria Kneider, Radu Constantinescu, Martin Paucar, Per Svenningsson, Sandy Abujrais, Joachim Burman, Ganna Shevchenko, Jonas Bergquist, Jimmy Sundblom
Summary: Identifying molecular changes in Huntington's disease is crucial for therapy development. Mass-spectrometry analysis revealed differences in protein expression between HD patients and controls, with PENK levels potentially serving as a marker for the state of medium spiny neurons in HD.
MOVEMENT DISORDERS
(2021)
Article
Pharmacology & Pharmacy
Daiane Cattani, Nona Struyf, Vivien Steffensen, Jonas Bergquist, Ariane Zamoner, Eva Brittebo, Malin Andersson
Summary: Using MALDI IMS, this study examined persistent changes in peptide expression in the substantia nigra (SN) of adult male Wistar rats following perinatal exposure to glyphosate-based herbicide (GBH), revealing significant alterations in peptidergic signaling in the SN. The findings suggest that perinatal GBH exposure may perturb critical neurodevelopmental processes, leading to long-term changes in the SN and hippocampus.
Article
Multidisciplinary Sciences
Christine Olander, Jesper Edvardsson Rasmussen, Per Olof Eriksson, Goran Laurell, Helge Rask-Andersen, Jonas Bergquist
Summary: This study analyzed the proteomics of the endolymphatic sac using a refined sampling technique, identifying a total of 1656 non-redundant proteins, with 110 proteins unique to the endolymphatic sac. The results validate a strategy for in vivo and in situ human sampling during surgery and may form a platform for further investigations into the function of this intriguing part of the inner ear.
SCIENTIFIC REPORTS
(2021)
Article
Genetics & Heredity
Sergey Nikulin, Galina Zakharova, Andrey Poloznikov, Maria Raigorodskaya, Daniel Wicklein, Udo Schumacher, Stepan Nersisyan, Jonas Bergquist, Georgy Bakalkin, Lidiia Astakhova, Alexander Tonevitsky
Summary: Knocking down ELOVL5 and IGFBP6 genes in breast cancer cells leads to a significant increase in the expression of MMP1 and a decrease in the expression of genes involved in intercellular adhesion, ultimately affecting the invasive potential of tumor cells.
FRONTIERS IN GENETICS
(2021)
Article
Oncology
Ariadna Lara Gutierrez, Julia Hedlund Lindberg, Ganna Shevchenko, Inger Gustavsson, Jonas Bergquist, Ulf Gyllensten, Stefan Enroth
Summary: Cervical cancer is the fourth most common cancer among women worldwide, and screening programs increase its detection rate and survivability. Molecular screening for the presence of HPV as an alternative to physical examinations offers cost-efficient solutions, and our study found that protein biomarkers can aid in the detection of cervical cancer pre-stages.
Article
Biochemistry & Molecular Biology
Henrik Hill, Andris Elksnis, Per Lundkvist, Kumari Ubhayasekera, Jonas Bergquist, Bryndis Birnir, Per-Ola Carlsson, Daniel Espes
Summary: Gamma-aminobutyric acid (GABA) is an important inhibitory neurotransmitter found in the central nervous system and immune cells. Research has shown that GABA has immune-modulatory and beta-cell stimulatory effects and could potentially be used to treat type 1 diabetes. However, a study measuring the levels of GABA in T1D patients found that the levels were unchanged compared to healthy controls, suggesting that GABA secretion from beta-cells has minimal impact on systemic levels. The study also found correlations between GABA levels and certain cytokines and GAD-autoantibodies, indicating potential alterations in local GABA levels within pancreatic islets.
Article
Biochemistry & Molecular Biology
Wei Hu, Yaorui Hu, Yao Pei, Rongrong Li, Fuyi Xu, Xiaodong Chi, Jia Mi, Jonas Bergquist, Lu Lu, Luping Zhang, Chunhua Yang
Summary: A study found that there were 46 differentially expressed proteins between cervical carcinoma (CC) and normal tissues, with Integrin beta 6, PPP1CB, TMPO, PTGES3, and DTX3L significantly upregulated in CC, while Desmin was significantly downregulated. Silencing DTX3L could suppress CC cell proliferation, migration, invasion, and tumorigenesis, and enhance cell apoptosis. Furthermore, DTX3L silencing inhibited the activity of the PI3K/AKT/mTOR signaling pathway. These findings suggest that DTX3L may regulate CC progression through the PI3K/AKT/mTOR signaling pathway and could serve as a potential biomarker and therapeutic target for CC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Sofia Persson, Kumari A. Ubhayasekera, Jonas Bergquist, Sahruh Turkmen, Inger Sundstroem Poromaa, Evangelia Elenis
Summary: Polycystic ovary syndrome (PCOS) is a common endocrine disorder among women, and hyperandrogenism can cause psychological morbidity and impaired quality of life. This study aimed to investigate whether hyperandrogenism persists into midlife and its impact on quality of life.
Article
Food Science & Technology
Julio Cesar Espana Amortegui, Heidi Pekar, Mark Dennis Chico Retrato, Malin Persson, Bengt Karlson, Jonas Bergquist, Aida Zuberovic-Muratovic
Summary: A LC-MS/MS method was developed for the simultaneous identification and quantification of cyanotoxins in edible bivalves. The method successfully detected and resolved two previously detected cyanotoxin congeners separately. The method showed limitations for certain cyanotoxins but overall was specific and robust for the parameters investigated. The method was applied to analyze mussel and oyster samples collected along the Swedish coast, and the results can contribute to future regulatory monitoring for cyanotoxins to ensure seafood safety.
Article
Infectious Diseases
Anja Naas, Peng Li, Clas Ahlm, Elisabeth Aurelius, Josef D. Jarhult, Silvia Schliamser, Marie Studahl, Wenzhong Xiao, Jonas Bergquist, Gabriel Westman
Summary: This study investigated the temporal changes of the CSF proteome in patients with herpes simplex encephalitis (HSE) and its association with factors such as anti-NMDAR serostatus, corticosteroid treatment, brain MRI, and neurocognitive performance. The results showed that the composition and activation pathways of CSF proteins vary at different stages of the disease. Additionally, it was found that several proteins were less abundant in patients with anti-NMDAR seropositivity compared to seronegativity.
INFECTIOUS DISEASES
(2023)
Article
Chemistry, Analytical
Mark Dennis Chico Retrato, Siyuan Qiu, Anna Lundquist, Aida Zuberovic Muratovic, Farshid Mashayekhy Rad, S. J. Kumari A. Ubhayasekera, Jonas Bergquist
Summary: This study describes a simple and robust method for the identification and quantification of 22 fatty acids in TPN components using gas chromatography-mass spectrometry. The method was evaluated according to the guidelines from FDA, EMA, and ICH, and demonstrated good methodological performance. The developed method has potential applications for quality assurance and control of TPN products.
ANALYTICAL METHODS
(2023)
Article
Medicine, General & Internal
Luis Nacul, Francois Jerome Authier, Carmen Scheibenbogen, Lorenzo Lorusso, Ingrid Bergliot Helland, Jose Alegre Martin, Carmen Adella Sirbu, Anne Marit Mengshoel, Olli Polo, Uta Behrends, Henrik Nielsen, Patricia Grabowski, Slobodan Sekulic, Nuno Sepulveda, Fernando Estevez-Lopez, Pawel Zalewski, Derek F. H. Pheby, Jesus Castro-Marrero, Giorgos K. Sakkas, Enrica Capelli, Ivan Brundsdlund, John Cullinan, Angelika Krumina, Jonas Bergquist, Modra Murovska, Ruud C. W. Vermuelen, Eliana M. Lacerda
Summary: EUROMENE, funded by COST from 2016 to 2020, aims to assess healthcare delivery for individuals with ME/CFS in European countries. The network consists of clinicians, researchers, and health professionals from 22 countries working to improve care for people with ME/CFS.
MEDICINA-LITHUANIA
(2021)