期刊
JOURNAL OF POSTGRADUATE MEDICINE
卷 58, 期 2, 页码 140-146出版社
WOLTERS KLUWER MEDKNOW PUBLICATIONS
DOI: 10.4103/0022-3859.97177
关键词
Regadenoson; A(2A) adenosine receptor agonist; myocardial perfusion imaging
Single-photon emission computerized tomography for myocardial perfusion imaging (MPI) is a non-invasive technique. MPI is performed by subjecting the patient to exercise or by using a pharmacological stress agent. Regadenoson is a selective A(2A) adenosine receptor agonist used when MPI with exercise is contraindicated. It binds to the A(2A) receptor and stimulates adenylate cyclase, resulting in increased cAMP, which phosphorylates protein kinase A thereby opening the ATP-dependant potassium channels leading to hyperpolarization in the coronary vascular smooth muscle. After a single bolus dose of regadenoson 400 mu g, a peak plasma concentration (C-max) of 13.6 ng/mL is attained in 1-4 min, with a terminal half-life of 2 h. It has a quick onset, short duration sufficient enough for hyperemic response, with comparable efficacy to adenosine, but with fewer side-effects. The adverse effects of this drug are dyspnea, headache, flushing, chest pain and atrioventricular block. Regadenoson is used for MPI in patients with co-morbid conditions like mild-to-moderate reactive airway disease, obstructive lung disease and renal impairment.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据