Article
Chemistry, Multidisciplinary
Nikhil Srivastava, Hyun-Joon Ha
Summary: Aziridine displays different regioselective ring-opening reactions depending on the functional group of its alkyl substituents. This reaction can efficiently generate various substituted heterocycles.
FRONTIERS IN CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Jieun Choi, Taehwan Yu, Hyun-Joon Ha
Summary: The highly strained three-membered aziridine ring was activated as an aziridinium ion through alkylation of the ring nitrogen and subsequent ring opening with external nucleophiles. This method provides an easy route for synthesizing various N-alkylated amine-containing molecules with the introduction of external nucleophiles at either the alpha or beta position.
Article
Chemistry, Applied
Linlin Zhu, Qinyong Chen, Ying Wang, Huishan Huang, Wenyi Luo, Zhunxuan Li, Zhen Zhang, Nikos Hadjichristidis
Summary: A facile and effective method involving ring-opening copolymerization of N-sulfonyl aziridines towards cellulose has been developed for efficient oil/water separation. The modified cellulose paper material showed promising properties for efficient oil/water separations, with a grafting ratio ranging from 96 to 150% and a contact angle over 127°.
CARBOHYDRATE POLYMERS
(2021)
Article
Chemistry, Applied
Jan Doubsky, Stanislav Radl, Josef Cinibulk, Robert Klvana
Summary: An efficient and scalable synthesis method for fingolimod hydrochloride has been developed, using the aziridine regioselective ring-opening reaction as a key step. The method is industrially applicable and has been successfully applied to 500 g scales of the target product.
ORGANIC PROCESS RESEARCH & DEVELOPMENT
(2022)
Article
Environmental Sciences
Quyen Kim Thi Doan, Kung Yuh Chiang
Summary: Cellulose nanocrystal (CNC)/silica hybrid aerogel (CSA) was synthesized via a one-step sol-gel method, and polyethyleneimine (PEI) was impregnated on CSA-1 to improve CO2 adsorption performance. The optimized adsorbent (CSA-PEI50) exhibited a high CO2 adsorption capacity of 2.35 mmol g(-1) at 70 & DEG;C and a PEI concentration of 50 wt%. The adsorption mechanism of CSA-PEI50 was elucidated using the Avrami kinetic model, which showed fractional reaction orders and identified film diffusion and intraparticle diffusion resistance as controlling factors.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Engineering, Chemical
Haitao Shi, Jiajia Yang, Zia Ahmad, Haijun Zhang, Jiping Chen
Summary: A novel CO2 capture material, MCF@G-35.6 %PEI, was developed by co-grafting polyethyleneimine (PEI) on mesocellular silica foam (MCF). The material showed excellent CO2 adsorption capacity, fast adsorption kinetics, and long-term stability. It also exhibited outstanding CO2 adsorption capabilities over a wide temperature and concentration range.
SEPARATION AND PURIFICATION TECHNOLOGY
(2023)
Article
Polymer Science
Peng-Duo Song, Lei Xia, Xuan Nie, Guang Chen, Fei Wang, Ze Zhang, Chun-Yan Hong, Ye-Zi You
Summary: In this study, a ring-opening copolymerization method is reported to synthesize poly(thioester sulfonamide)s with highly alternative structures, high yields, and controlled molecular weights. This method combines the advantages of thioesters and amides, and can also be used to produce novel block copolymers.
MACROMOLECULAR RAPID COMMUNICATIONS
(2022)
Article
Polymer Science
Rui Chen, Ying Wang, Linlin Zhu, Zhen Zhang
Summary: An ultrafast method for controlled synthesis of polysulfonamides through organocatalytic anionic ring-opening polymerization (ROP) in the melt has been established. Using N,N,N',N'',N''-pentamethyldiethylenetriamine (PMDETA) as catalyst, poly(2-methyl-N-tosylaziridine) with molecular weight over 100 kg/mol can be synthesized in less than 90 s. Various initiators can be applied to achieve molecular weight and end-group controlled polymers under open-flask conditions.
JOURNAL OF POLYMER SCIENCE
(2021)
Article
Chemistry, Organic
Santa Mondal, Shilpi Sarkar, Siddhartha S. Ghosh, Abu Taleb Khan
Summary: Regioselective ring-opening reactions were successfully used for the synthesis of beta-hydroxysulfides and beta-N-tosylaminosulfides, showing high selectivity, broad substrate compatibility, and mild reaction conditions. The newly synthesized compounds exhibited antiproliferative activity and anti-cancer properties.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Organic
Jaehee Lee, Xuan Ju, Miseon Lee, Qi Jiang, Hwanjong Jang, Wan Shin Kim, Linglin Wu, Suja Williams, Xiao-Jun Wang, Xingzhong Zeng, Jenna Payne, Zhengxu S. Han
Summary: The copper-catalyzed regioselective and stereospecific coupling between aziridines and in situ generated pyridine Grignard reagents is reported in this study. This method enables the synthesis of beta-pyridylethylamines with diverse structures and functionalities, which are potential scaffolds for the synthesis of biologically active compounds commonly found in pharmaceuticals. Additionally, the synthesis of challenging chiral dihydroazaindoles was achieved through mild one-pot reaction conditions involving aziridine opening and nucleophilic cyclization.
Article
Polymer Science
Chandan Giri, Jen-Yu Chang, Pierre Canisius Mbarushimana, Paul A. Rupar
Summary: In this study, the polymerization of tert-butyl aziridine-1-carboxylate (BocAz) was reported. The introduction of a tert-butyloxycarbonyl (BOC) group effectively activated the anionic-ring-opening polymerization of aziridines, leading to the synthesis of low-molecular-weight poly(BocAz) chains.
Article
Chemistry, Multidisciplinary
Qilei Song, Hong Qiu, Lijun Liu, Guangzhao Zhang, Frederic Peruch, Stephane Carlotti, Junpeng Zhao
Summary: One-step sequence-selective block copolymerization requires strict catalytic control of monomer activity and enchainment order, especially for A(n)B(m)-type block copolymers from simple binary monomer mixtures. In this study, ethylene oxide (EO) and N-sulfonyl aziridine (Az) form a valid pair with a bicomponent metal-free catalyst. The optimal Lewis acid/base ratio allows the two monomers to block-copolymerize strictly in a reverse order (EO-first) compared to the conventional anionic route (Az-first). The livingness of the copolymerization enables the one-pot synthesis of multiblock copolymers by adding mixed monomers in batches. Calculation results suggest that the Janus effect of Lewis acid on the two monomers is crucial for enlarging the activity difference and reversing the enchainment order.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Organic
Hannah M. Holst, Jack T. Floreancig, Casey B. Ritts, Nicholas J. Race
Summary: This study demonstrates the synthesis of beta-phenethylamine products through the treatment of unsymmetrical 2,3-disubstituted aziridines with TiCl4, involving the intermediacy of a phenonium ion. Computational analysis provides insight into the reaction mechanism, especially the selectivity of phenonium opening.
Article
Chemistry, Physical
Kai Wu, Qing Ye, Lanyang Wang, Fanwei Meng, Hongxing Dai
Summary: By loading PEI and LDH onto the surface of SBA-15, the composite material with an ordered porous structure showed excellent CO2 adsorption performance, which was attributed to its high BET surface area, abundant basic sites, and fast adsorption kinetics.
APPLIED CLAY SCIENCE
(2022)
Review
Chemistry, Organic
Du Qingfeng, Zhang Lu, Gao Feng, Wang Le, Zhang Wanbin
Summary: Epoxides and aziridines are important three-membered cyclic compounds and their asymmetric ring-opening reactions catalyzed by transition metals are efficient for constructing chiral molecules. This review focuses on the recent progress in this field, including the influence of catalysts, nucleophiles, and ligands, as well as discussing the possible reaction mechanisms, applications, and future development.
CHINESE JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Electrochemistry
Edurne Jaime-Barquero, Yan Zhang, Nicholas E. Drewett, Pedro Lopez-Aranguren, Ekaitz Zulueta, Emilie Bekaert
Summary: Solid-state batteries are a promising technology for high-energy-density and safe storage systems. Understanding defect formation within these batteries is crucial for future development, and nondestructive analytical tools are needed for characterizing key components. In this study, defocused micro-SORS was used to analyze typical components of solid-state batteries, allowing for depth profiling spectra to be obtained and demonstrating the technique's potential for nondestructive chemical analysis.
Article
Food Science & Technology
Thom Romers, Javier Saurina, Sonia Sentellas, Oscar Nunez
Summary: In order to prevent tea fraud, a HPLC-UV method was proposed to classify and authenticate tea samples. By measuring the content of polyphenolic and phenolic acid compounds in tea and using principal component analysis and partial least squares-discriminant analysis, tea samples were effectively distinguished from adulterants like chicory. Furthermore, this method could be used to detect and quantify adulteration of different tea varieties, with high accuracy and stability.
Editorial Material
Chemistry, Analytical
Javier Saurina
Article
Biotechnology & Applied Microbiology
Eleonora Oliva, Aina Mir-Cerda, Manuel Sergi, Sonia Sentellas, Javier Saurina
Summary: Polyphenols, natural phytochemicals found in wines, have attracted significant interest in the scientific community due to their health benefits, as well as their role in identifying wine qualities, such as origin and grape variety. This study aims to obtain valuable chemical and oenological information by processing a large amount of data using appropriate chemometric methods. The concentrations of polyphenols in wines and related samples were determined using HPLC-UV-MS/MS, and the resulting data were used for characterization purposes. Principal component analysis revealed discrimination of samples based on variety and quality issues, and classification models were established to assign unknown samples to their respective classes, achieving an excellent classification rate.
FERMENTATION-BASEL
(2023)
Review
Critical Care Medicine
Aina Areny-Balaguero, Anna Sole-Porta, Marta Camprubi-Rimblas, Elena Campana-Duel, Adrian Ceccato, Anna Roig, Daniel Closa, Antonio Artigas
Summary: Sepsis is a complex syndrome caused by infection that often leads to death in infectious diseases. Personalized management is necessary due to the complexity and heterogeneity of sepsis. Extracellular vesicles (EVs) have the potential to tailor sepsis treatment and diagnosis, and advancements in EV-based therapies are discussed in this article. The use of hybrid and fully synthetic nanocarriers that mimic EVs is also explored. Pre-clinical and clinical studies are reviewed to provide an overview of the current and future perspectives of EV-based sepsis diagnosis and treatment.
INTENSIVE CARE MEDICINE EXPERIMENTAL
(2023)
Review
Food Science & Technology
Sonia Sentellas, Javier Saurina
Summary: Cocoa and its derivative products, particularly chocolate, are highly valued for their qualities and considered as delicacies. However, there is a need for strategies to authenticate their attributes due to the risk of adulteration. Profiling and fingerprinting approaches using analytical techniques such as chromatography and mass spectrometry provide valuable information for authentication purposes. This review discusses the state of the art of cocoa and chocolate authentication, including the pros and cons of different approaches and the relevance of these methods in quality control and sample analysis.
Article
Nanoscience & Nanotechnology
Wid Mekseriwattana, Witthawat Phanchai, Tipparat Thiangtrongjit, Onrapak Reamtong, Theerapong Puangmali, Patompon Wongtrakoongate, Anna Roig, Kanlaya Prapainop Katewongsa
Summary: This study investigated the interactions of SPIONs with ariboflavin (Rf)-citrate ligand with proteins in human serum, as well as the interactions with riboflavin carrier protein (RCP). The results showed that citrate-coated SPIONs exhibited stronger binding to RCP, while Rf-coated SPIONs had lower binding affinity to serum proteins. These findings are important for improving the functionality of Rf ligand, enhancing specific cellular interactions, and improving the Rf-SPIONs as MRI contrast agents for breast cancer.
ACS APPLIED NANO MATERIALS
(2023)
Article
Nanoscience & Nanotechnology
Nanthilde Malandain, Hector Sanz-Fraile, Ramon Farre, Jorge Otero, Anna Roig, Anna Laromaine
Summary: There is a growing interest in developing natural hydrogel-based scaffolds for three-dimensional cell culture. In this study, type I collagen was mixed with bacterial nanocellulose fibers (BCf) to create reinforced scaffolds with improved mechanical properties. The composite hydrogels showed increased stiffness compared to collagen hydrogels alone, while maintaining the same viscoelastic response.
ACS APPLIED BIO MATERIALS
(2023)
Article
Chemistry, Physical
Pedram Ghorbanzade, Arianna Pesce, Kerman Gomez, Grazia Accardo, Shanmukaraj Devaraj, Pedro Lopez-Aranguren, Juan Miguel Lopez del Amo
Summary: In this study, the chemical evolution and phase transitions of LLZO during heat treatment were investigated using solid state NMR, Raman, and XRD diffraction techniques. The results showed that the activation energy for Li jumps decreased after heat treatment, indicating improved Li dynamics. Furthermore, the pretreatment of powders was found to be an effective method for obtaining garnet-rich composite electrolytes with better flexibility and garnet-polymer interphases, enhancing the prospects of this material for processing.
JOURNAL OF MATERIALS CHEMISTRY A
(2023)
Article
Chemistry, Multidisciplinary
Johanna van Gent, Anna Roig
Summary: Bacterial cellulose (BC) is a biopolymer with multiple applications in the biomedical field. By functionalizing BC with CeO2 NPs, a composite material with self-regenerating antioxidant properties is achieved. Low-temperature in situ syntheses of CeO2 NPs in BC enables the formation of BC-CeO2 composites that exhibit enhanced antioxidant performance due to the incorporation of zirconium.
Article
Chemistry, Physical
A. G. Sabato, M. Nunez Eroles, S. Anelli, C. D. Sierra, J. C. Gonzalez-Rosillo, M. Torrell, A. Pesce, G. Accardo, M. Casas-Cabanas, P. Lopez-Aranguren, A. Morata, A. Tarancon
Summary: Additive manufacturing techniques with advanced functional materials are gaining attention in the field of all solid-state lithium batteries (ASSBs) for their potential to produce cheaper, safer, and customizable batteries with high energy density. This study explores the use of stereolithography (SLA) to fabricate complex-shaped Li1.5Al0.5Ge1.5P3O12 (LAGP) full-ceramic electrolytes. The printed electrolytes demonstrated comparable ionic conductivity to conventionally fabricated LAGP. Additionally, 3D printed LAGP membranes with increased interfacial area showed reduced area specific resistance. Symmetrical cells with LAGP printed electrolytes coated with a germanium protective interlayer exhibited stable cycling performance. This innovative approach opens up new possibilities for manufacturing full ceramic electrolytes with complex shapes for the next generation of ASSBs based on LAGP.
JOURNAL OF MATERIALS CHEMISTRY A
(2023)
Article
Nanoscience & Nanotechnology
Khizar Hayat, Daniel Bahamon, Lourdes F. Vega, Ahmed AlHajaj
Summary: In this study, the potential of hierarchical zeolite-templated carbon (ZTC) structures as novel electrodes for high-capacity lithium-oxygen batteries was investigated. It was found that the hierarchical RHO-type ZTC electrode exhibited enhanced mass transfer and improved discharge performance compared to conventional microporous ZTC electrodes.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Engineering, Chemical
Safique Anwer, Ismail I. I. Alkhatib, Hassan A. Salih, Lourdes F. Vega, Inas Alnashef
Summary: This study investigates the effect of water on novel amine-based deep eutectic solvents (DES) for CO2 capture. Experimental results show that water reduces the viscosity of the solvents, affects CO2 solubility and heat of absorption, and optimal water content is identified for best performance. Molecular models are developed to predict the solvents' properties at various conditions.
SEPARATION AND PURIFICATION TECHNOLOGY
(2024)
Article
Green & Sustainable Science & Technology
C. G. Alba, I. I. I. Alkhatib, F. Llovell, L. F. Vega
Summary: This study presents an integrated approach for the rational design of low-GWP refrigerant blends to replace high-GWP HFCs used in refrigeration systems. Through thermodynamic modeling and multiple evaluation criteria, seven promising alternatives were identified.
RENEWABLE & SUSTAINABLE ENERGY REVIEWS
(2023)
Article
Chemistry, Multidisciplinary
Lorenzo Fallarino, Uzair Naveed Chishti, Arianna Pesce, Grazia Accardo, Amna Rafique, Montserrat Casas-Cabanas, Pedro Lopez-Aranguren
Summary: This study demonstrates the feasibility of designing nanoscale bilayers to enable the efficient cycling of lithium-free solid-state batteries, by effectively controlling Li deposition on LLZO without the need for extra external pressure.
CHEMICAL COMMUNICATIONS
(2023)
