Article
Polymer Science
Ozgun Daglar, Emrah Cakmakci, Ufuk Saim Gunay, Gurkan Hizal, Umit Tunca, Hakan Durmaz
Summary: The study focused on developing innovative routes for hybrid polymer nanocomposite preparation using click chemistry reactions. Modified silica nanoparticles showed uniform dispersion in the polymer matrix, leading to enhancements in modulus and T-g values in the prepared hybrid nanocomposites. The gel content of the hybrid nanocomposites reached nearly 88%, confirming their successful formation.
EUROPEAN POLYMER JOURNAL
(2021)
Article
Chemistry, Inorganic & Nuclear
Sana Nayab, Vanessa Trouillet, Hartmut Gliemann, Peter G. Weidler, Iqra Azeem, Saadia R. Tariq, Anja S. Goldmann, Christopher Barner-Kowollik, Basit Yameen
Summary: This study presents multiple approaches for the tandem postsynthetic modification of various metal-organic frameworks, showcasing the use of dienophile and phosphoryl dithioester groups to achieve chemically switchable properties. Additionally, Michael addition reactions were utilized to introduce different molecules into the MOF lattice, expanding the functionality of the MOF materials.
INORGANIC CHEMISTRY
(2021)
Review
Chemistry, Multidisciplinary
Dominik Schauenburg, Tanja Weil
Summary: In vivo chemistry refers to chemical reactions taking place within living systems, such as cells, tissues, or the entire organism, while in vitro reactions occur in artificial environments outside living organisms, like test tubes. It is essential to understand which reactions can efficiently occur without producing by-products and how product formation can be characterized in complex living environments. In vivo chemistry offers potential applications in synthesizing drug molecules within cells and enhancing the understanding of living systems and therapeutic strategies. Two guiding principles in this field are identifying translatable chemical reactions from the laboratory to living systems and selecting suitable methods to study reactions and structure formation in complex living environments.
Article
Biochemistry & Molecular Biology
Ciara Buckley, Therese R. Montgomery, Tomasz Szank, Brian A. Murray, Cormac Quigley, Ian Major
Summary: This research presents a method for modifying hyaluronic acid to generate a new photo-crosslinkable polymer with improved physicochemical properties and biocompatibility. The addition of thiol to HA increases the crosslinking and biocompatibility, and enhances the degradability of methacrylated HA. The novel hydrogel system could have numerous bioengineering applications due to its enhanced properties.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Chemistry, Multidisciplinary
Madonna M. A. Mitry, Francesca Greco, Helen M. I. Osborn
Summary: Bioorthogonal chemistry involves selective biocompatible reactions between functional groups that are not normally present in biology. It has been used to probe biomolecules in living systems, and has advanced biomedical strategies such as diagnostics and therapeutics. This review discusses challenges and opportunities in translating in vitro bioorthogonal approaches to in vivo settings, focusing on methods to deliver the bioorthogonal reaction components, and critically appraises the suitability of these reactions for in vivo applications.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Chemistry, Applied
Huan Liang, Dongmei Yin, Lina Shi, Yihuan Liu, Xin Hu, Ning Zhu, Kai Guo
Summary: Functionalized cellulose has gained research interests for its potential in highly functional and environmentally friendly materials. Surface modification of cellulose via photo-induced click reaction integrates the advantages of photochemistry, click reaction, and surface modification. In this review, recent progress in cellulose surface modification using photo-induced click reactions is summarized. Different click reactions, such as thiol-X and cycloaddition reactions, are compared and their applications in cellulose modification are discussed. The challenges and outlook of photo-induced click reaction in cellulose surface modification are also addressed.
CARBOHYDRATE POLYMERS
(2023)
Article
Chemistry, Physical
Belma Gjergjizi Nallbani, Memet Vezir Kahraman, Isa Degirmenci
Summary: Computational approaches were used to elucidate radical-mediated thiol-epoxy reactions and solve the overlap problem in thiol-ene/thiol-epoxy systems. The study evaluated nine epoxy model molecules to mimic industrial epoxy molecules and proposed a thiol-ene-like mechanism for radical-mediated thiol-epoxide reactions. The findings highlighted the importance of temperature control and the use of specific thiols to avoid curing step overlap.
JOURNAL OF PHYSICAL CHEMISTRY A
(2023)
Article
Chemistry, Physical
Kiho Matsubara, Li-Chieh Chou, Hideki Amii, Ryohei Kakuchi
Summary: This study provides a computational guideline for activated ester-amine chemistry in postpolymerization modification reactions. The analysis explains the experimental reactivity and offers a new approach for reaction profiling in large molecular systems. The research also allows for preliminary assessment and visualization of the polymer effect during the modification process.
MOLECULAR SYSTEMS DESIGN & ENGINEERING
(2022)
Article
Chemistry, Multidisciplinary
Eric S. Yang, Alex Mapp, Andrew Taylor, Paul D. Beer, Jose M. Goicoechea
Summary: Several examples of the cyaphide-azide 1,3-dipolar cycloaddition reaction to produce metallo-triazaphospholes were reported. Gold(I), magnesium(II) and germanium(II) triazaphospholes can be obtained easily and in good yields. Furthermore, these metallo-triazaphospholes can be used as precursors to carbon-functionalized species.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Xueting Wu, Jiajie Deng, Guiling Guo, Yuanqin Zheng, Qin Xiong, Tingting Zheng, Xiaohu Zhao, Zhipeng Yu
Summary: A set of photo-switchable monopeptides have been designed and synthesized, capable of forming multifunctional supramolecules in a hydrophobic phospholipid bilayer environment with high affinity and rapid optimization of self-assembly strength. This enrichment of monopeptides in lipid phase allows for bioorthogonal chemical handles on live cell membranes, enabling high resolution fluorescence labeling of single cell membranes for studies on cell membrane dynamics.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Review
Biotechnology & Applied Microbiology
Priyank Purohit, Akanksha Bhatt, Ravi K. Mittal, Magda H. Abdellattif, Thoraya A. Farghaly
Summary: Polymer grafting is a technique to improve the morphology and properties of polymers. By creating copolymers or grafting, the physicochemical properties of polymers can be further modified. This review discusses various chemical approaches for polymer grafting, such as free radical reactions, click reactions, amide formation, and alkylation. The review also covers the importance of the graft-to approaches and their application in different fields.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Karine Porte, Maxime Riberaud, Remi Chatre, Davide Audisio, Sebastien Papot, Frederic Taran
Summary: The advent of bioorthogonal chemistry has enabled ambitious applications of unnatural chemical reactions within living organisms, a long-sought goal in chemical biology. This review highlights the progress in understanding fundamental biological processes and the development of novel imaging and therapeutic strategies using bioorthogonal chemistry in animal models.
Review
Chemistry, Multidisciplinary
Oleksandr S. Liashuk, Vladyslav A. Andriashvili, Andriy O. Tolmachev, Oleksandr O. Grygorenko
Summary: The chemoselective transformations of functionalized sulfonyl fluorides and chlorides have been comprehensively surveyed. Sulfonyl fluorides show excellent selectivity control in their reactions, while sulfonyl chlorides typically react at the SO2Cl moiety except for a few exceptions.
Article
Chemistry, Multidisciplinary
Nicole Houszka, Hannes Mikula, Dennis Svatunek
Summary: 1,2,4,5-Tetrazines are widely used in bioorthogonal chemistry for their high reactivity in Diels-Alder reactions. The substituents in the 3- and 6-positions of the tetrazine scaffold significantly affect the rate of cycloadditions, but this is not explained by frontier molecular orbital interactions. Instead, the high reactivity of mono-substituted tetrazines is due to decreased Pauli repulsion, leading to a more asynchronous approach and reduced distortion energy. Additionally, ethylene is not a good model compound for other alkenes in Diels-Alder reactions.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Review
Nanoscience & Nanotechnology
Ting Wu, Christopher M. Fitchett, Paula A. Brooksby, Alison J. Downard
Summary: Aryldiazonium ions are widely used for surface modification due to their wide substrate compatibility, formation of stable covalent bonding, simple modification methods, and commercial availability of aniline precursors. This method allows for further on-surface chemistry and broadens the range of species that can be immobilized. The resulting materials have been applied in various fields such as chemical sensors, biosensors, catalysis, optoelectronics, composite materials, and energy conversion and storage.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Polymer Science
Huseyin Cem Kiliclar, Gorkem Yilmaz, Yusuf Yagci
Summary: A new visible light induced step-growth polymerization of dibromoxylene and diols using dimanganese decacarbonyl and diphenyliodonium salt is described, resulting in the formation of polyether-based block copolymers. The polymerization proceeds through a substitution reaction between dixylenium cations formed upon visible light irradiation in the presence of dimanganese decacarbonyl and diphenyl iodonium salt, with halide groups at chain ends allowing for subsequent free radical and free radical promoted cationic reactions.
MACROMOLECULAR RAPID COMMUNICATIONS
(2021)
Article
Chemistry, Applied
Ali Suerkan, Ecem Aydan Alkan, Kerem Kaya, Yasemin Arslan Udum, Levent Toppare, Yusuf Yagci
Summary: This study introduces a new visible and near-infrared light photoinitiator system using highly conjugated thiophenes in combination with alkyl iodide compounds for free radical and cationic polymerizations. The radicals and Bronsted acid formed through electron transfer reactions can initiate the polymerization of appropriate monomers.
PROGRESS IN ORGANIC COATINGS
(2021)
Review
Chemistry, Multidisciplinary
Cansu Aydogan, Gorkem Yilmaz, Ataulla Shegiwal, David M. Haddleton, Yusuf Yagci
Summary: The application of photochemistry in polymer synthesis offers unique advantages compared to thermochemistry, allowing for precise control over macromolecular structure and chain length while also being environmentally friendly. Recent research has focused on utilizing photocontrolled living radical and cationic polymerizations for polymer synthesis.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Polymer Science
Kerem Kaya, Ecem Aydan Alkan, Mustafa Yasa, Ali Suerkan, Yasemin Arslan Udum, Levent Toppare, Yusuf Yagci
Summary: Two new donor-acceptor-donor (DAD) polymers with near-infrared absorbing properties were designed and synthesized via light induced step-growth polymerization, investigating the impact of different acceptor groups on the electrochemical and optical properties. The synthesized polymers show promising features for application in various optoelectronic devices.
EUROPEAN POLYMER JOURNAL
(2021)
Article
Polymer Science
Zeynep Deliballi, Rezan Demir-Cakan, Baris Kiskan, Yusuf Yagci
Summary: A new approach to vulcanize commercial PVC at room temperature using elemental sulfur and an initiator is reported. The obtained crosslinked polymer with polysulfide linkages shows potential for recycling/self-healing and as cathode material for Li-S battery.
MACROMOLECULAR CHEMISTRY AND PHYSICS
(2023)
Article
Polymer Science
Huseyin Cem Kiliclar, Emirhan Gencosman, Yusuf Yagci
Summary: This study presents a novel visible light induced step-growth polymerization mechanism and demonstrates the potential for grafting onto polymers containing epoxide at their side chains. By changing the molar ratios of the monomers, higher molecular weight polymers can be obtained, showing the effectiveness of the chain-growth condensation polymerization mechanism.
MACROMOLECULAR RAPID COMMUNICATIONS
(2022)
Article
Polymer Science
Bahar T. Ercan, Sirin S. Gultekin, Tamer Yesil, Haluk Dincalp, Sermet Koyuncu, Yusuf Yagci, Ceylan Zafer
Summary: This study reports the photoinitiated cationic polymerization of epoxy resins using four new chromophoric dyes and diphenyliodonium hexafluorophosphate under sunlight. It is shown that ISOVIII and TPDC6, which have carbazole groups, exhibited higher initiation efficiency.
POLYMER INTERNATIONAL
(2022)
Article
Polymer Science
Cansu Aydogan, F. Simal Aykac, Gorkem Yilmaz, Ye Qiu Chew, Atsushi Goto, Yusuf Yagci
Summary: A versatile strategy for the fabrication of block copolymers using a combination of two discrete living polymerization techniques has been reported. The strategy involves reversible complexation mediated living radical polymerization (RCMP) and photoinduced radical oxidation addition deactivation (PROAD) processes. The formation of the block copolymers was confirmed through various characterization techniques.
Article
Polymer Science
Mehmet Bilgehan Bilgic, Kerem Kaya, Nermin Orakdogen, Yusuf Yagci
Summary: Hydrogels, with high water absorption, biocompatibility, and non-toxic characteristics, are important polymers for various technologies. In this study, a facile synthesis of clickable polyacrylamide hydrogel was reported using photopolymerization. The gel's properties were affected by the irradiation time.
EUROPEAN POLYMER JOURNAL
(2022)
Article
Chemistry, Analytical
Tugba Celiker, Faezeh Ghorbanizamani, Hichem Moulahoum, Emine Guler Celik, Kerem Tok, Figen Zihnioglu, Candan Cicek, Ruchan Sertoz, Bilgin Arda, Tuncay Goksel, Kutsal Turhan, Suna Timur, Yusuf Yagci
Summary: A rapid and easy immunofluorescence bioassay for SARS-CoV-2 detection was developed using a one-pot synthetic approach for the production of a graft fluorescent copolymer PPy-g-PCL. The assay showed a detection range of 6.03-8.7 LOG viral copy mL(-1) and a high correlation with RT-PCR data. This study provides new insights for simplified synthesis procedures of reporter molecules and their potential applications in sensing and diagnosis.
Article
Chemistry, Multidisciplinary
Azra Kocaarslan, Kerem Kaya, Steffen Jockusch, Yusuf Yagci
Summary: In this study, a single component near UV-responsive photopolymerization system using phenacyl bromide (PAB) is reported for step-growth polymerization of N-methylpyrrole (MPyr) and N-methylindole (MIn). The polymerization process proceeds through photoinduced cleavage of PAB, followed by electron transfer, proton release, and coupling processes. Chain growth continues even after photolysis in daylight or dark.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Polymer Science
Cansin Birsen Buldum, Sevinc Gulyuz, Yusuf Yagci, Baris Kiskan
Summary: Siloxane bearing benzoxazines derived from renewable phenolics such as vanillin and coumarin have been prepared and reacted with glycerol to form processable, soft, and curable bio-hybrid gels. The presence of hydroxyl groups on glycerol moieties facilitates curing, resulting in bio-hybrid polybenzoxazines at temperatures below 200°C.
EUROPEAN POLYMER JOURNAL
(2022)
Article
Materials Science, Multidisciplinary
Armin Asghari Alamdari, Mahshid Hashemkhani, Saman Hendessi, Pinar Tatar Guner, Havva Yagci Acar, Ibrahim Halil Kavakli, Ugur Unal, Amir Motallebzadeh
Summary: The study developed and evaluated antibacterial and biocompatible refractory high-entropy alloy (RHEAs) films using RF magnetron sputtering technique. The results showed that the Ag nanoparticle doped RHEA film exhibited strong antibacterial activity and promising biocompatibility.
Article
Biochemistry & Molecular Biology
Zehra Gul Coban, Huseyin Cem Kiliclar, Yusuf Yagci
Summary: Photochemical techniques have seen a revival due to their adaptability and ability to produce complex macromolecular structures, although their application in the polymerization of cyclic siloxane monomers has been limited. This study investigated the cationic ring-opening polymerization of Octamethylcyclotetrasiloxane (D4) using diphenyl iodonium hexafluorophosphate (DPI) as the initiator. Both direct and indirect initiation systems were examined, using benzophenone and pyrene to generate photochemically induced protonic acids and silylium cations for the polymerization. Kinetics of the polymerization were monitored using viscosimetry and GPC analysis. This approach has potential industrial importance for polysiloxane fabrication due to its ability to overcome challenges associated with conventional methods.
Article
Polymer Science
Sevinc Gulyuz, Yusuf Yagci, Baris Kiskan
Summary: A new strategy for the synthesis of self-healable/recyclable polybenzoxazine networks by exploiting dynamic B-O bond exchanges is presented in this work. The obtained films exhibit good self-healing properties and hydrolysis stability under mild conditions.
