Article
Dermatology
Feng Shang, Yan-Hua Lu, Jian Gao, Qiang Hou
Summary: This study found that in severely burned patients, artificial dermis combined with autologous split-thickness skin grafting showed better therapeutic outcomes compared to autologous intermediate-thickness skin grafting, with reduced healing time of donor skin, decreased scar formation, improved psychological recovery, and possibly enhanced functional reconstruction.
INTERNATIONAL WOUND JOURNAL
(2021)
Article
Fisheries
Lene Sveen, Gerrit Timmerhaus, Lill-Heidi Johansen, Elisabeth Ytteborg
Summary: An AI model was trained to detect multi-class segmentation of skin from Atlantic salmon and produced reliable spatial measurements of all the successive skin layers. The results were highly correlated to manual measurements and showed variations in skin tissue abundance at different body sites. The AI model was further used to evaluate skin samples from commercially farmed Atlantic salmon, revealing dynamic behavior of the skin related to time, life stage, and operational events.
Article
Surgery
Maria Chicco, Hsu-Tang Cheng
Summary: Reconstructive surgery following skin cancer resection in octogenarian patients can be challenging, often requiring local or free flap coverage with potential physical and emotional impairment. Few reports have been published on managing these complex craniofacial defects. Two octogenarian patients underwent wide excision and reconstruction with fenestrated-type artificial dermis, both recovering uneventfully with wound healing by secondary intention without skin grafting.
JOURNAL OF CRANIOFACIAL SURGERY
(2021)
Letter
Cell & Tissue Engineering
Ryushiro Sugimoto, Hiroki Yamanaka, Itaru Tsuge, Yasuhiro Katayama, Motoki Katsube, Michiharu Sakamoto, Naoki Morimoto
Summary: This retrospective case series investigated the use of bFGF-impregnated artificial dermis for two-stage skin grafting and the impact of a shorter waiting period on surgical outcomes. The results showed that bFGF-impregnated artificial dermis has the potential to shorten the waiting period without decreasing the success rate of skin grafting.
REGENERATIVE THERAPY
(2022)
Article
Surgery
V Holmdahl, B. Stark, L. Clay, U. Gunnarsson, K. Strigard
Summary: The study compared the use of FTSG and conventional SM in the repair of giant incisional hernia. Results showed that at the 3-year follow-up, there were 5 recurrences in the FTSG group and 3 in the SM group, but the difference was not significant. Both groups showed significant improvements in the physical, emotional, and mental domains of the SF-36 questionnaire.
Article
Oncology
Yingyi Zhang, Chuanqi Liu, Shiyou Wei, Guonian Zhu, Zhengyong Li
Summary: The study introduced a modified Zhuang's ear reconstruction technique for microtia patients, which resulted in better aesthetic outcomes, fewer hypertrophic scar cases, shorter therapy and hospital duration compared to Zhuang's method.
ANNALS OF TRANSLATIONAL MEDICINE
(2021)
Article
Dermatology
Je Yeon Byeon, Yong Seon Hwang, Hwan Jun Choi, Jun Hyuk Kim, Da Woon Lee
Summary: Micronized acellular dermal matrix (ADM) treatment has shown positive results in treating diabetic foot ulcers (DFU) that have invaded ligaments or bones, with a low recurrence rate. Close follow-up of weight bearing areas allows for early identification and treatment of recurrence.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Surgery
Ivan R. Almeida, Adriana C. Gonqalves, Fernanda B. Correa, Julio C. D. Castro, Elaine C. O. Guirro, Jayme A. Farina Jr, Pedro S. Coltro
Summary: The aim of this study was to compare clinical and biomechanical features of scars resulting from the treatment of burn contractures using different acellular dermal matrices. The results suggest that there is no significant difference in the quality of the scar when using acellular dermal matrices compared to only split-thickness skin graft.
Article
Cell & Tissue Engineering
Motoki Katsube, Natsuko Utsunomiya, Yasuhiro Katayama, Hiroki Yamanaka, Itaru Tsuge, Yoshihiro Sowa, Michiharu Sakamoto, Naoki Morimoto
Summary: This study demonstrates that the use of bFGF-CGS in primary palatoplasty can significantly reduce the occurrence of post-operative oronasal fistulas.
REGENERATIVE THERAPY
(2023)
Article
Oncology
Makoto Shiraishi, Yoshihiro Sowa, Itaru Tsuge, Akiko Shiraishi, Naoki Inafuku, Ichiro Nakayama, Naoki Morimoto
Summary: This study identified a psychotic or neurological history and a history of chemotherapy and/or hormone therapy as risk factors for chronic pain after breast surgery, while the type of operation was not associated with chronic pain.
Review
Engineering, Biomedical
Zhizhong Shen, Lei Sun, Zixian Liu, Meng Li, Yanyan Cao, Lu Han, Jianming Wang, Xunwei Wu, Shengbo Sang
Summary: This review summarizes recent research advances in understanding the structural features, function, morphogenesis, influencing factors, and reconstruction strategies pertaining to rete ridges (RRs). It also discusses the preparation methods and limitations of tissue-engineered skin with RRs. The review serves as a valuable reference for transferring tissue-engineered skin with RR structure from the laboratory to clinical applications in skin repair.
ACTA BIOMATERIALIA
(2023)
Article
Engineering, Biomedical
John Toaquiza Tubon, Vivek D. Sree, Jordanna Payne, Luis Solorio, Adrian Buganza Tepole
Summary: This article focuses on the biomechanical properties of porcine skin and the damage mechanisms during drug delivery. Mechanical tests and imaging techniques were used to validate the findings. The study shows that the stiffness of porcine skin is influenced by anatomical location, and there is energy dissipation and softening in the stress-stretch response.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2023)
Review
Rheumatology
Fiona L. Coath, Chetan Mukhtyar
Summary: The study shows that Colour Doppler ultrasonography is an effective tool for objective assessment of giant cell arteritis, with good reliability and validity in determining ultrasonographic changes. Although not well-defined in follow-up, it has potential value in diagnosis.
Article
Materials Science, Multidisciplinary
Donghui Bian, Yan Wu, Guodong Song
Summary: It is discovered that the extracellular matrix (ECM) plays a crucial role in organizing the in vivo signaling of growth factors (GFs) by precisely releasing them and modulating their intracellular signaling. This has motivated researchers to develop effective GF delivery systems. Particularly, basic fibroblast growth factor (bFGF) integrated into ECM-based mimetic systems has shown great potential in skin bioengineering by promoting re-epithelialization, neovascularization, skin regeneration, and wound healing. This review focuses on current advances in bFGF-loaded ECM-mimetic delivery systems for wound healing enhancement, including scaffolds, hydrogels, and artificial dermis, and highlights the role of ECM as a regulator of GF signaling and the significance of bFGF in wound healing. The integration of bFGF and ECM mimetic delivery systems is speculated to have a significant impact on future skin tissue regeneration in the clinical setting.
MATERIALS TODAY COMMUNICATIONS
(2023)
Article
Surgery
Pengfei Sun, Shanbaga Zhao, Changchen Wang, Bo Pan
Summary: In auricle reconstruction using tissue expanders, combining with skin grafting can effectively reduce the incidence of postoperative complications, but may result in skin necrosis and expander leakage/exposure. On the other hand, without skin grafting can improve the satisfaction rate and reduce the incidence of postoperative complications. There is no significant difference in the treatment effect between the two surgical methods.
JOURNAL OF CRANIOFACIAL SURGERY
(2022)
Article
Cell & Tissue Engineering
Shuichi Ogino, Michiharu Sakamoto, Sunghee Lee, Hiroki Yamanaka, Itaru Tsuge, Jun Arata, Yuki Sakamoto, Yusuke Kambe, Tetsuji Yamaoka, Naoki Morimoto
JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2020)
Article
Biotechnology & Applied Microbiology
Toshihito Mitsui, Naoki Morimoto, Atsushi Mahara, Sharon Claudia Notodihardjo, Tien Minh Le, Maria Chiara Munisso, Natsuko Kakudo, Tetsuji Yamaoka, Kenji Kusumoto
BIOMED RESEARCH INTERNATIONAL
(2020)
Article
Multidisciplinary Sciences
Michiharu Sakamoto, Shuichi Ogino, Yoshihiro Shimizu, Masukazu Inoie, Sunghee Lee, Hiroki Yamanaka, Itaru Tsuge, Susumu Saito, Naoki Morimoto
Review
Pediatrics
Motoki Katsube, Shigehito Yamada, Natsuko Utsunomiya, Naoki Morimoto
Summary: The face is a small complex three-dimensional structure composed of various bones and essential organs. Geometric morphometrics (GM) uses shape configurations to retain geometric information and help visualize results, making it advantageous in morphometric studies of congenital facial anomalies.
CONGENITAL ANOMALIES
(2022)
Article
Cell & Tissue Engineering
A. Shoji-Pietraszkiewicz, M. Sakamoto, M. Katsube, S. Ogino, I Tsuge, H. Yamanaka, J. Arata, N. Morimoto
Summary: In this study, cultured epithelial autografts (CEA) were applied after curettage or abrasion of giant congenital melanocytic nevi (GCMN). The results showed successful growth of CEA on wounds and improvement in lesion color. Histopathological examination revealed regenerated dermis without nevus cells.
REGENERATIVE THERAPY
(2021)
Article
Cell & Tissue Engineering
Naoki Morimoto, Toshihito Mitsui, Yasuhiro Katayama, Natsuko Kakudo, Shuichi Ogino, Itaru Tsuge, Michiharu Sakamoto, Masakatsu Hihara, Kenji Kusumoto
Summary: CEA appears to accelerate epithelization after curettage or ablation of CMN, and can significantly improve the color of CMN when applied initially. The color of the target nevus improved significantly in both the Curettage group and non-Curettage group with initial treatment, with no significant differences in epithelization period or incidence of hypertrophic scars among the groups.
REGENERATIVE THERAPY
(2021)
Article
Cell & Tissue Engineering
Yuanjiaozi Li, Eiichi Sawaragi, Michiharu Sakamoto, Takashi Nakano, Hiroki Yamanaka, Itaru Tsuge, Kumiko Matsuno, Yasuhiko Tabata, Naoki Morimoto
Summary: The study concluded that Genocel (R) can serve as an equivalent skin substitute for wound healing, demonstrating comparable performance to conventional substitutes. Additionally, Genocel (R) exhibited the ability to accelerate capillary formation, making it a more suitable treatment option for chronic skin ulcers such as diabetic ulcers.
REGENERATIVE THERAPY
(2022)
Article
Cell & Tissue Engineering
Takashi Nakano, Michiharu Sakamoto, Yasuhiro Katayama, Yoshihiro Shimizu, Masukazu Inoie, Yuanjiaozi Li, Hiroki Yamanaka, Itaru Tsuge, Susumu Saito, Naoki Morimoto
Summary: Autologous cultured epidermis (CE) is an effective approach for treating extensive burns, but its production time is too long. Allogeneic CE can be prepared in advance and used as a wound dressing to promote wound healing. Dried CE, prepared by removing all water and viable cells, accelerates wound healing and may be a new therapeutic strategy. This study evaluated the safety and efficacy of dried CE in wound healing using a miniature swine model.
REGENERATIVE THERAPY
(2023)
Article
Surgery
Shinsuke Akita, Hiraku Kumamaru, Hisashi Motomura, Nobuyuki Mitsukawa, Naoki Morimoto, Minoru Sakuraba
Summary: This study analyzed data from 19,482 free-flap surgeries performed at 407 facilities in Japan and found that free-flap surgeries performed at institutions with a low average annual number of procedures had a higher risk of total necrosis. It is recommended to either aggregate cases into high-volume centers or improve management at low-volume centers.
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
(2023)
Letter
Surgery
Itaru Tsuge, Nobuyuki Mitsukawa, Takane Suzuki, Shinsuke Akita, Yoshimichi Imai, Koichi Omori, Naoki Morimoto
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
(2023)
Article
Surgery
Itaru Tsuge, Maria Chiara Munisso, Tomoko Kosaka, Ayako Takaya, Yoshihiro Sowa, Chang Liu, Goshiro Yamamoto, Susumu Saito, Naoki Morimoto
Summary: This study successfully visualized subcutaneous arteries using photoacoustic tomography and compared the results with intraoperative fluorescence angiography, with a matching rate of 71.3-82.1%. The results of this study demonstrate that photoacoustic tomography can aid in selecting perforators for abdominal flap surgery.
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
(2023)
Article
Cell & Tissue Engineering
Takashi Nakano, Hiroki Yamanaka, Michiharu Sakamoto, Itaru Tsuge, Yasuhiro Katayama, Susumu Saito, Jiro Ono, Tetsuji Yamaoka, Naoki Morimoto
Summary: This study successfully developed a self-assembled, cell-based dermal substitute derived from human dermal fibroblasts through long-term three-dimensional culture. The scaffold-free cultured dermis exhibited superior properties, such as sufficient tensile strength, high biocompatibility, and efficacy in promoting wound healing when compared to the collagen-based artificial dermis.
TISSUE ENGINEERING PART A
(2023)
Article
Cell & Tissue Engineering
Qiannan Zhao, Shuichi Ogino, Sunghee Lee, Yuki Kato, Yuanjiaozi Li, Michiharu Sakamoto, Hiroki Yamanaka, Takashi Nakano, Eiichi Sawaragi, Naoki Morimoto
Summary: Poly-L-lactic acid (PLLA) mesh implants combined with collagen sponge (CS) were replaced with autologous adipose tissue for regeneration. The study compared different combinations of external frames (P (LA/CL), PLLA, LMWPLLA) and internal fillings (PGA nanosheets, CS) and found that PLLA served as a promising external frame material while PGA nanosheets were an effective alternative internal filling material for adipose tissue regeneration.
REGENERATIVE THERAPY
(2023)
Article
Cell & Tissue Engineering
Motoki Katsube, Natsuko Utsunomiya, Yasuhiro Katayama, Hiroki Yamanaka, Itaru Tsuge, Yoshihiro Sowa, Michiharu Sakamoto, Naoki Morimoto
Summary: This study demonstrates that the use of bFGF-CGS in primary palatoplasty can significantly reduce the occurrence of post-operative oronasal fistulas.
REGENERATIVE THERAPY
(2023)
Article
Cell & Tissue Engineering
Tien Minh Le, Naoki Morimoto, Nhung Thi My Ly, Toshihito Mitsui, Sharon Claudia Notodihardjo, Shuichi Ogino, Jun Arata, Natsuko Kakudo, Kenji Kusumoto
Summary: MSCs have become a focus of attention in tissue repair and wound healing. Recent studies have shown the importance of apoptosis in MSC-mediated immunomodulation. High hydrostatic pressure treatment induced complete apoptosis in MSCs, offering potential for manipulated products in cell-based therapies.
STEM CELL REVIEWS AND REPORTS
(2021)
Letter
Surgery
Arif Tri Prasetyo, Lisa Y. Hasibuan, Kevin Leonard Suryadinata
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
(2024)
Article
Surgery
Peter J. Nicksic, D'Andrea T. Donnelly, Weifeng Zeng, Allison J. Seitz, Samuel O. Poore, Aaron J. Suminski, Aaron M. Dingle
Summary: The study demonstrates that trigeminal nerve stimulation (TNS) or peripheral nerve stimulation (PNS) can improve functional outcomes of peripheral nerve injury in rats. This finding is important in translating the therapy as a non-invasive treatment for high, mixed nerve injuries in humans.
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
(2024)
Article
Surgery
K. Can Bayezid, Suat Morkuzu, Erdem Karabulut, Adam Bajus, Libor Streit
Summary: This study compared the spontaneity outcomes of the most preferred neurotization methods in facial reanimation surgery. The results showed that dual innervation and contralateral facial nerve-driven strategies achieved the most promising outcomes, while motor nerve to the masseter had lower potential to elicit spontaneous smile.
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
(2024)
Letter
Surgery
Hinpetch Daungsupawong, Viroj Wiwanitkit
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
(2024)
Article
Surgery
Zidi Yu, Ziwei Zhang, Xiancheng Wang, Dandan Song, Quanding Yan, Yang Sun, Xiang Xiong, Xianxi Meng, Wenbo Li, Zhongjie Yi
Summary: Pathological psychologies such as anxiety, depression, and body dysmorphic disorder (BDD) are common in female patients scheduled to undergo rhinoplasty. BDD is more likely to be associated with depression. Rhinoplasty has little psychological impact on patients, but female patients with BDD are more likely to be dissatisfied with the surgery.
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
(2024)
Article
Surgery
Lei Wang, Qian Zhu, Yuanyuan Zhang, Yulin Miao, Huan Liu, Fengli Gao
Summary: This comparative observational study found that microscopic varicocoelectomy had higher sperm motility and showed significant improvements in certain postoperative parameters compared to laparoscopic varicocoelectomy. Neither group experienced testicular atrophy.
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
(2024)
Article
Surgery
Mohamed Dalmar, Mohamed El Sheikh, Richard Baker, Rajan Uppal
Summary: This study analyzed complications following cosmetic surgeries managed by plastic surgery services at Heatherwood and Wexham Park hospitals in 2022, including procedures performed internationally. The majority of complications were related to breast cosmetic surgery and abdominoplasties, with the most common complications being wound dehiscence, post-operative infection, and seromas. Turkey was the most popular country selected for surgery, and there is a need to increase public awareness of the risks involved in seeking international options and how to choose suitable clinics.
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
(2024)
Editorial Material
Surgery
Rohun Gupta, Lawson E. Spence, Peter K. Firouzbakht, Brian A. Mailey
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
(2024)
Article
Surgery
Alexandre Mendonca Munhoz, Ary de Azevedo Marques Neto, Joao Maximiliano, Murillo Fraga
Summary: This study investigated the outcomes of silicone implants in breast augmentation and found that ergonomic style implants can achieve favorable results with lower complication rates.
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
(2024)
Article
Surgery
Lee H. Kilmer, Allan A. Weidman, Brent R. Degeorge, John T. Stranix, Chris A. Campbell
Summary: The study aims to compare the oncologic, medical, and surgical outcomes of lumpectomy and oncoplastic breast reduction surgery (OBRS) on a national scale. A database was used to analyze patient data and match them based on various factors. The results showed that lumpectomy patients had higher rates of repeat lumpectomy or subsequent mastectomy, while OBRS patients had higher rates of surgical complications but fewer medical complications. Logistic regression analysis revealed that OBRS was associated with a decreased likelihood of repeat lumpectomy. Although OBRS was associated with increased wound complications, medical complications were found to occur less frequently.
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
(2024)
Review
Surgery
M. Guiotto, C. M. Oranges, M. Cherubino, M. Maruccia, P. Tedeschi, D. F. Kalbermatten, W. Raffoul, P. G. di Summa
Summary: This study evaluated different surgical approaches for neoumbilicoplasty and correlated them with specific surgical needs. The results showed that direct suture, single flap, and multiple flap techniques can achieve overall satisfactory cosmetic outcomes with a low rate of surgical complications. Different surgical techniques are suitable for different patient populations and surgical scenarios.
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
(2024)
Review
Surgery
Samuel Knoedler, Giuseppe Sofo, Barbara Kern, Konstantin Frank, Sebastian Cotofana, Sarah von Isenburg, Soren Konneker, Francesco Mazzarone, Amir H. Dorafshar, Leonard Knoedler, Michael Alfertshofer
Summary: This study compared real patient feedback with ChatGPT-generated reviews for the top five US plastic surgery procedures. It found that analyzing the emotional tone and review length can help differentiate real from fake reviews, and ChatGPT-generated reviews can convincingly deceive commercial AI detection software.
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
(2024)
Article
Surgery
Gerlya Asirova, Jan Wynands, Sergey Frolov, Diana Almeida, Pavel Davydenko, Salem Madina
Summary: By assessing the development and growth of costal cartilage, the optimal age for ear reconstruction surgery in the Russian population was determined to be 10 years and older.
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
(2024)
Letter
Surgery
S. Curran, E. Heffernan, S. Connolly, K. Levins, K. Cronin, R. Dolan
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
(2024)
Article
Surgery
Soo Min Cha, Ashwin Pai, Hyun Jong Lee, Hyun Dae Shin
Summary: In this retrospective case series, we found that non-vascularized iliac bone graft longer than 3 cm had satisfactory clinical outcomes in the treatment of non-union of the upper extremities.
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
(2024)