Article
Biochemistry & Molecular Biology
Valentina Dzreyan, Moez Eid, Stanislav Rodkin, Maria Pitinova, Svetlana Demyanenko
Summary: This study investigated the expression and localization of E2F1 after axonal injury and found that axotomy increased the expression of E2F1 in neurons. The study also suggested that E2F1 and downstream targets could be potential molecular targets for the development of neuroprotective agents.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Lina Huang, Dilip Sharma, Xiaozhou Feng, Zhiqiang Pan, Shaogen Wu, Daisy Munoz, Alex Bekker, Huijuan Hu, Yuan-Xiang Tao
Summary: The study found that RALY, an RNA-binding protein, plays a role in nerve trauma-induced nociceptive hypersensitivity by regulating the expression of translation initiation factor Eif4g2 in dorsal root ganglion neurons. Interventions targeting RALY expression levels could alleviate the development and maintenance of pain hypersensitivity.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Kjeld Morten Mohr, Lone Tjener Pallesen, Mette Richner, Christian Bjerggaard Vaegter
Summary: Satellite glial cells (SGCs) surrounding neuronal somas are sensitive to neuronal stressors and exhibit induced gliosis, however, GFAP may not be a universally suitable marker for SGC reactivity across species and experimental models.
Article
Immunology
James M. Nichols, Caitlin Crelli, Lu Liu, Hoang Vu Pham, Jelena M. Janjic, Andrew J. Shepherd
Summary: This study introduces a novel fluorescently labeled perfluorocarbon nanoemulsion for monitoring phagocytic macrophages in diabetic neuropathy. In vitro experiments showed high stability and uptake of the nanoemulsion by macrophages. In vivo tracking revealed distribution to macrophages in tissues, with reduced distribution in Lepr(db/db) mice.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Cell Biology
Bin Pan, Di Guo, Li Jing, Ke Li, Xin Li, Gen Li, Xiao Gao, Zhi-Wen Li, Wei Zhao, Hu Feng, Meng-Han Cao
Summary: This study reveals the role of lncRNA Pvt1 in the repair of peripheral nerve injury and highlights it as a potential treatment target. The findings show that Pvt1 increases c-Jun expression through sponging miRNA-214, enhancing the proliferation and migration of Schwann cells, and improving the regeneration of injured sciatic nerves and locomotor function in mice.
NEURAL REGENERATION RESEARCH
(2023)
Article
Chemistry, Physical
Linliang Wu, Tiantian Zheng, Wenchao Guan, Qi Han, Huizhao Su, Ningling Wu, Linhui Zhang, Guicai Li
Summary: This study fabricated an anisotropic CS micropatterning containing Me functionalized CTO NPs to regulate DRG behavior. The results showed that Me-PDA-CTO-CS significantly promoted axon extension, providing a new strategy for repairing peripheral nerve injury.
SURFACES AND INTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Dekel Rosenfeld, Hannah Field, Ye Ji Kim, Karen Ka Lam Pang, Keisuke Nagao, Florian Koehler, Polina Anikeeva
Summary: Nerve injuries are common and current treatment methods have limitations. Researchers have discovered that thermal activation of a heat sensitive ion channel TRPV1 can promote axonal growth without invasive surgeries. This finding may become a minimally invasive approach to accelerate nerve regeneration in the future.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Neurosciences
V. A. Dzreyan, S. V. Rodkin, M. A. Pitinova, Anatoly B. Uzdensky
Summary: The study found that the expression of HDAC1 in the dorsal root ganglion is related to neuronal and glial cell damage after nerve injury. Administration of sodium valproate significantly reduces apoptosis and accumulation of nerve injury markers, demonstrating neuroprotective activity in the axotomized ganglion.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Neurosciences
Zheng Wang, Dong Zhang, Xin Zeyu Yi, Yong Zhao, Aixi Yu
Summary: The study demonstrates that RPNI can prevent neuronal loss after peripheral nerve axotomy, and the neuroprotective effect is related to the upregulation of neurotrophins in DRGs, such as NGF, NT-3, BDNF, and GDNF.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Agriculture, Dairy & Animal Science
Eiji Naito, Kohei Nakata, Yukiko Nakano, Yuta Nozue, Shintaro Kimura, Hiroki Sakai, Osamu Yamato, Md Shafiqul Islam, Sadatoshi Maeda, Hiroaki Kamishina
Summary: Canine degenerative myelopathy (DM) is a chronic, progressive, and fatal neurodegenerative disease that results in atrophy of the dorsal root ganglion (DRG). Water-excitation MRI was used to visualize and measure the volume of DRG, which was found to be significantly lower in dogs with DM compared to control dogs and dogs with intervertebral disc herniation. This study suggests that DRG volumetry by water-excitation MRI could serve as a clinical biomarker for DM.
Article
Biochemistry & Molecular Biology
Valentina Dzreyan, Stanislav Rodkin, Viktor Nikul, Maria Pitinova, Anatoly Uzdensky
Summary: Neurotrauma is a major cause of human disability and death, affecting not only neurons but also satellite glial cells. In a rat study, the dynamics of proapoptotic proteins expression in DRG after sciatic nerve transection were examined, revealing early overexpression of E2F1 followed by p53 induction and caspase 3 cleavage. Glial cells were found to be more vulnerable to axotomy than DRG neurons, highlighting E2F1 and p53 as potential molecular targets for neuroprotective agents.
JOURNAL OF MOLECULAR NEUROSCIENCE
(2021)
Article
Anesthesiology
Dongman Chao, Christina M. Mecca, Guoliang Yu, Ian Segel, Michael S. Gold, Quinn H. Hogan, Bin Pan
Summary: Dorsal root ganglion field stimulation can relieve neuropathic pain by blocking spontaneous activity in injured neurons, leading to reduced pain behavior and ongoing pain. The effects are more significant in injured neurons, affecting both pain behavior and ongoing pain.
Article
Neurosciences
Long He, Jing Cao, Bao-Chun Jiang, Jian-Jun Yang, Yuan-Xiang Tao, Yanqiu Ai
Summary: In this study, it was found that spinal nerve ligation upregulated CCAAT/enhancer-binding protein-beta (C/EBP beta) expression in injured dorsal root ganglion, leading to the upregulation of toll-like receptor 7 (TLR7). The activation of TLR7 was associated with cold/thermal hyperalgesia and mechanical allodynia. Mechanistically, an increased binding of C/EBP beta to T1r7 promoter was observed. These findings highlight the importance of C/EBP beta in nerve trauma-induced TLR7 upregulation.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Qianqian Chen, Yang Miao, Zhipeng Xu, Ruirui Zhang, Sheng Yi
Summary: Schwann cells play a crucial role in nerve regeneration and are commonly used in tissue engineering. Identifying Schwann cells with enhanced migration ability is important for improving recovery effects. This study compared Schwann cells from different anatomical locations and found that dorsal root ganglia (DRG) Schwann cells have faster migration speed than sciatic nerve (SN) Schwann cells.
JOURNAL OF NEUROCHEMISTRY
(2023)
Article
Orthopedics
D. Chao, H. Tran, Q. H. Hogan, B. Pan
Summary: GFS produces analgesia in MIA-OA rats at least in part by producing blockade of afferent inputs, possibly also by blocking efferent activity from the dorsal horn.
OSTEOARTHRITIS AND CARTILAGE
(2022)
Article
Oncology
Matteo Scampa, Enrico Tessitore, Dennis E. Dominguez, Didier Hannouche, Nicolas C. Buchs, Daniel F. Kalbermatten, Carlo M. Oranges
Summary: This study analyzed the demographic and clinicopathological characteristics of 442 sacral chordoma patients and evaluated their impact on survival outcomes. The results showed that surgery was the mainstay treatment and age and stage at diagnosis significantly affected survival outcomes.
ANTICANCER RESEARCH
(2022)
Article
Medicine, Research & Experimental
Wenjin Wang, Yizuo Cai, Carlo M. Oranges, Daniel F. Kalbermatten, Dirk J. Schaefer, Chuan Yang, Wei Li
Summary: The long-term outcome and complications of sternocleidomastoid muscle (SCM) flap for facial reanimation were analyzed in this retrospective study. The results showed that the surgery significantly improved facial muscle function and oral commissure excursion with minimal donor site morbidity.
Article
Medicine, General & Internal
Matteo Scampa, Daniel F. Kalbermatten, Carlo M. Oranges
Summary: Vulvar squamous cell carcinoma is the most frequent vulvar neoplasia, and surgery is associated with the best overall survival. Age, pathological grade, stage at diagnosis, treatment sequence, and chemotherapy are identified as independent prognostic factors.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Oncology
Andre S. Alves, Vincent Tan, Matteo Scampa, Daniel F. Kalbermatten, Carlo M. Oranges
Summary: This study analyzed the optimal timing for deep inferior epigastric perforator flap (DIEP) breast reconstruction. The results showed that immediate breast reconstruction surgery has fewer delayed wound healing issues, while there were no significant differences in other complications.
Review
Oncology
Vladimir Megevand, Matteo Scampa, Helen McEvoy, Daniel F. Kalbermatten, Carlo M. Oranges
Summary: Breast cancer is a major problem in modern society, particularly among women. Implant-based breast reconstruction is an effective method to restore quality of life and aesthetic recovery for patients. A meta-analysis was conducted to compare the outcomes of prepectoral and subpectoral breast reconstruction. The results showed higher pain scores in patients with subpectoral implants, while rates of postoperative complications were similar between the two groups. It is important for surgeons to discuss the risks and benefits of each procedure with patients and make informed decisions.
Article
Cell Biology
Ilias G. Petrou, Sofia Nikou, Srinivas Madduri, Martha Nifora, Vasiliki Bravou, Daniel F. Kalbermatten
Summary: This study found that the deregulation of Hippo signaling and Integrin-linked kinase (ILK) are closely associated with the formation of hypertrophic scars and keloids.
Review
Surgery
Carlo M. Oranges, Vendela Grufman, Pietro G. di Summa, Elmar Fritsche, Daniel F. Kalbermatten
Summary: This study conducted a systematic literature review to analyze the outcomes and complications associated with different chin augmentation techniques. All techniques achieved satisfactory cosmetic outcomes, but caution is needed to avoid nerve injuries and overcorrection or undercorrection.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2023)
Article
Oncology
Matteo Scampa, Vladimir Megevand, Juan A. Viscardi, Salvatore Giordano, Daniel F. Kalbermatten, Carlo M. Oranges
Summary: Male gender, tumor ulceration, high mitotic rate, or nodular subtype are negative prognostic factors for scalp melanoma survival. Margins over 2 cm do not provide survival benefit. For a Breslow thickness between 1.1 and 2 mm, there is no significant difference in overall survival between <1 cm margins and 1 to 2 cm margins.
Article
Oncology
Andre S. Alves, Matteo Scampa, Jerome Martineau, Salvatore Giordano, Daniel F. Kalbermatten, Carlo M. Oranges
Summary: Merkel Cell Carcinoma (MCC) is a neuroendocrine skin tumor that primarily affects the external ear, with higher incidence in older men. Surgical excision is the main treatment option, and gross and wide margins provide the best overall survival rates for patients.
Article
Medicine, General & Internal
Matteo Scampa, Daniel F. Kalbermatten, Carlo M. Oranges
Summary: Merkel cell carcinoma is an aggressive malignant skin tumor with high recurrence and low survival. Lymph nodal metastases are associated with a worse overall prognosis. Factors such as increasing age, tumor size, and truncal location are associated with higher positive lymph node rates.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Jerome Martineau, Solange N. Walz, Matteo Scampa, Salvatore Giordano, Daniel F. Kalbermatten, Carlo M. Oranges
Summary: This study analyzed the demographic and pathological characteristics, treatment patterns, and survival outcomes of patients with spiradenocarcinoma. The results showed that spiradenocarcinoma affects males and females equally, with low rates of regional and distant invasion. Surgical excision is the main treatment modality, and the overall and disease-specific survival rates are high for patients with spiradenocarcinoma.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Oncology
Solange N. Walz, Jerome Martineau, Matteo Scampa, Daniel F. Kalbermatten, Carlo M. Oranges
Summary: Melanoma is a common and potentially life-threatening skin cancer that can occur on any part of the body, with the upper limbs and shoulders being frequent locations. Risk of melanoma varies by gender and age, with factors such as disease stage and histologic subtypes also influencing survival outcomes.
Article
Biotechnology & Applied Microbiology
Alois Hopf, Lina Al-Bayati, Dirk J. Schaefer, Daniel F. Kalbermatten, Raphael Guzman, Srinivas Madduri
Summary: This study aimed to develop a new method of decellularizing large-diameter nerves suitable for human transplantation. The optimized method effectively removed immunogenic material and preserved the extracellular structure, showing potential for cell culture studies and clinical trials.
BIOENGINEERING-BASEL
(2022)
Article
Oncology
Ilias G. Petrou, Celine Thomet, Omid Jamei, Ali Modarressi, Daniel F. Kalbermatten, Brigitte Pittet-Cuenod
Summary: This study compared the patient satisfaction and objective outcomes of three common breast reconstruction techniques. The results showed that DIEP reconstruction obtained higher scores in terms of aesthetic outcome, immediate reconstruction impact, and overall satisfaction. Implant-based reconstruction had the best results in the somatosensory evaluation. The study suggests that despite its complexity, DIEP reconstruction is the most satisfactory and best experienced method for patients.
BREAST CANCER-BASIC AND CLINICAL RESEARCH
(2022)
Article
Surgery
Julie C. Triolo, Nicolas C. Buchs, Enrico Tessitore, Didier Hannouche, Dennis E. Dominguez, Daniel F. Kalbermatten, Carlo M. Oranges
Summary: Various reconstructive approaches have been used for sacral chordoma resections. In this case, an acellular dermal matrix and double pedicled muscle gracilis flap were utilized for pelvic floor reconstruction, with a unilateral gluteal fasciocutaneous rotation flap used for soft tissue defect reconstruction. The combined flap reconstruction with a dermal matrix provided reliable results and minimizes morbidity.
PLASTIC AND RECONSTRUCTIVE SURGERY-GLOBAL OPEN
(2022)
Letter
Surgery
Arif Tri Prasetyo, Lisa Y. Hasibuan, Kevin Leonard Suryadinata
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
(2024)
Article
Surgery
Peter J. Nicksic, D'Andrea T. Donnelly, Weifeng Zeng, Allison J. Seitz, Samuel O. Poore, Aaron J. Suminski, Aaron M. Dingle
Summary: The study demonstrates that trigeminal nerve stimulation (TNS) or peripheral nerve stimulation (PNS) can improve functional outcomes of peripheral nerve injury in rats. This finding is important in translating the therapy as a non-invasive treatment for high, mixed nerve injuries in humans.
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
(2024)
Article
Surgery
K. Can Bayezid, Suat Morkuzu, Erdem Karabulut, Adam Bajus, Libor Streit
Summary: This study compared the spontaneity outcomes of the most preferred neurotization methods in facial reanimation surgery. The results showed that dual innervation and contralateral facial nerve-driven strategies achieved the most promising outcomes, while motor nerve to the masseter had lower potential to elicit spontaneous smile.
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
(2024)
Letter
Surgery
Hinpetch Daungsupawong, Viroj Wiwanitkit
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
(2024)
Article
Surgery
Zidi Yu, Ziwei Zhang, Xiancheng Wang, Dandan Song, Quanding Yan, Yang Sun, Xiang Xiong, Xianxi Meng, Wenbo Li, Zhongjie Yi
Summary: Pathological psychologies such as anxiety, depression, and body dysmorphic disorder (BDD) are common in female patients scheduled to undergo rhinoplasty. BDD is more likely to be associated with depression. Rhinoplasty has little psychological impact on patients, but female patients with BDD are more likely to be dissatisfied with the surgery.
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
(2024)
Article
Surgery
Lei Wang, Qian Zhu, Yuanyuan Zhang, Yulin Miao, Huan Liu, Fengli Gao
Summary: This comparative observational study found that microscopic varicocoelectomy had higher sperm motility and showed significant improvements in certain postoperative parameters compared to laparoscopic varicocoelectomy. Neither group experienced testicular atrophy.
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
(2024)
Article
Surgery
Mohamed Dalmar, Mohamed El Sheikh, Richard Baker, Rajan Uppal
Summary: This study analyzed complications following cosmetic surgeries managed by plastic surgery services at Heatherwood and Wexham Park hospitals in 2022, including procedures performed internationally. The majority of complications were related to breast cosmetic surgery and abdominoplasties, with the most common complications being wound dehiscence, post-operative infection, and seromas. Turkey was the most popular country selected for surgery, and there is a need to increase public awareness of the risks involved in seeking international options and how to choose suitable clinics.
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
(2024)
Editorial Material
Surgery
Rohun Gupta, Lawson E. Spence, Peter K. Firouzbakht, Brian A. Mailey
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
(2024)
Article
Surgery
Alexandre Mendonca Munhoz, Ary de Azevedo Marques Neto, Joao Maximiliano, Murillo Fraga
Summary: This study investigated the outcomes of silicone implants in breast augmentation and found that ergonomic style implants can achieve favorable results with lower complication rates.
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
(2024)
Article
Surgery
Lee H. Kilmer, Allan A. Weidman, Brent R. Degeorge, John T. Stranix, Chris A. Campbell
Summary: The study aims to compare the oncologic, medical, and surgical outcomes of lumpectomy and oncoplastic breast reduction surgery (OBRS) on a national scale. A database was used to analyze patient data and match them based on various factors. The results showed that lumpectomy patients had higher rates of repeat lumpectomy or subsequent mastectomy, while OBRS patients had higher rates of surgical complications but fewer medical complications. Logistic regression analysis revealed that OBRS was associated with a decreased likelihood of repeat lumpectomy. Although OBRS was associated with increased wound complications, medical complications were found to occur less frequently.
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
(2024)
Review
Surgery
M. Guiotto, C. M. Oranges, M. Cherubino, M. Maruccia, P. Tedeschi, D. F. Kalbermatten, W. Raffoul, P. G. di Summa
Summary: This study evaluated different surgical approaches for neoumbilicoplasty and correlated them with specific surgical needs. The results showed that direct suture, single flap, and multiple flap techniques can achieve overall satisfactory cosmetic outcomes with a low rate of surgical complications. Different surgical techniques are suitable for different patient populations and surgical scenarios.
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
(2024)
Review
Surgery
Samuel Knoedler, Giuseppe Sofo, Barbara Kern, Konstantin Frank, Sebastian Cotofana, Sarah von Isenburg, Soren Konneker, Francesco Mazzarone, Amir H. Dorafshar, Leonard Knoedler, Michael Alfertshofer
Summary: This study compared real patient feedback with ChatGPT-generated reviews for the top five US plastic surgery procedures. It found that analyzing the emotional tone and review length can help differentiate real from fake reviews, and ChatGPT-generated reviews can convincingly deceive commercial AI detection software.
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
(2024)
Article
Surgery
Gerlya Asirova, Jan Wynands, Sergey Frolov, Diana Almeida, Pavel Davydenko, Salem Madina
Summary: By assessing the development and growth of costal cartilage, the optimal age for ear reconstruction surgery in the Russian population was determined to be 10 years and older.
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
(2024)
Letter
Surgery
S. Curran, E. Heffernan, S. Connolly, K. Levins, K. Cronin, R. Dolan
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
(2024)
Article
Surgery
Soo Min Cha, Ashwin Pai, Hyun Jong Lee, Hyun Dae Shin
Summary: In this retrospective case series, we found that non-vascularized iliac bone graft longer than 3 cm had satisfactory clinical outcomes in the treatment of non-union of the upper extremities.
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
(2024)