Review
Oncology
Xiazhen Nong, Caiyun Zhang, Junmin Wang, Peilun Ding, Guang Ji, Tao Wu
Summary: This article reviews the role and mechanism of BCAT in different diseases, as well as the recent biomedical research progress, providing new research ideas for the treatment, prognosis, and prevention of certain diseases.
FRONTIERS IN ONCOLOGY
(2022)
Review
Genetics & Heredity
Can Chen, Hassan Naveed, Keping Chen
Summary: This article introduces the important role of branched-chain amino acid aminotransferases in cellular metabolism, summarizes the related research in animals, plants, microorganisms, and humans, and analyzes the molecular mechanism. It has been found that disorders in branched-chain amino acid metabolism are closely related to various diseases, especially tumor development.
FRONTIERS IN GENETICS
(2023)
Article
Nutrition & Dietetics
Katarzyna Paczkowska, Dominik Rachon, Andrzej Berg, Jacek Rybka, Katarzyna Kapczynska, Marek Bolanowski, Jacek Daroszewski
Summary: Polycystic ovary syndrome (PCOS) is a common endocrine disorder that predisposes women to metabolic disturbances. Recent research suggests that alterations in amino acid profiles may be indicative of metabolic disorders. This study found elevated levels of aromatic amino acids in PCOS women, and significant differences in amino acid concentrations between metabolically healthy and unhealthy obesity subgroups of PCOS women.
Review
Cell Biology
Michaela E. Trautman, Nicole E. Richardson, Dudley W. Lamming
Summary: The proportion of people suffering from age-related diseases is increasing worldwide. Recent research has shown that low protein diets, particularly those low in branched-chain amino acids (BCAAs), can reduce mortality and promote metabolic health and extended lifespan in both humans and rodents. This article discusses the emerging evidence that BCAAs play a crucial role in healthy metabolism and longevity, and explores the physiological and molecular mechanisms behind the benefits of restricting dietary BCAAs. The findings suggest that the quality of protein, specifically the composition of dietary protein, may be a previously overlooked factor in metabolic dysfunction and reducing dietary BCAAs could be a promising new approach to delaying and preventing age-related diseases.
Article
Pharmacology & Pharmacy
Tiangang Wu, Mengling Wang, Fengling Ning, Shilin Zhou, Xuetao Hu, Hong Xin, Svetlana Reilly, Xuemei Zhang
Summary: Fibrosis, characterized by excessive production of extracellular matrix, is a common pathological feature of organ diseases. Metabolic alterations, especially in the regulation of branched-chain amino acids (BCAAs), have been found to play significant roles in fibrogenesis. Dysregulation of BCAAs metabolism has been implicated in various diseases. This review summarizes the metabolic regulation of fibrosis, changes in BCAAs metabolism associated with fibrosis, and the effects and mechanisms of BCAAs intervention in hepatic, renal, and cardiac fibrosis, with a focus on liver fibrosis and associated hepatocellular carcinoma.
PHARMACOLOGICAL RESEARCH
(2023)
Review
Nutrition & Dietetics
Chuang Du, Wen-Jie Liu, Jing Yang, Shan-Shan Zhao, Hui-Xin Liu
Summary: This article introduces the importance of branched-chain amino acids in human physiology and their association with various metabolic disorders. It also discusses the relationship between the alteration of the branched-chain amino acid catabolism enzyme BCKDK and related diseases. Additionally, the article highlights the interaction between branched-chain amino acids and the gut microbiota.
FRONTIERS IN NUTRITION
(2022)
Review
Biotechnology & Applied Microbiology
Yoichi Toyokawa, Jirasin Koonthongkaew, Hiroshi Takagi
Summary: BCAT catalyzes transamination between BCAAs and BCKAs in the cell. Eukaryotic cells have mitochondrial BCAT (BCATm) and cytosolic BCAT (BCATc) isozymes, which have similar enzymatic functions but differences in physiological functions and regulatory mechanisms. The variations of BCAT could have significant implications for research into the relationship between their primary structures and protein functions.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2021)
Article
Endocrinology & Metabolism
Ninghua Li, Jing Li, Hui Wang, Jinnan Liu, Weiqin Li, Kai Yang, Xiaoxu Huo, Junhong Leng, Zhijie Yu, Gang Hu, Zhongze Fang, Xilin Yang
Summary: BCAAs in early pregnancy are positively associated with the risk of GDM, and high levels of leucine and isoleucine enhance the risk association of high SFA16:0 with GDM, independent of LPCs.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Nutrition & Dietetics
Huan Xu, Xuanyang Wang, Xiaoqing Xu, Lin Liu, Yuntao Zhang, Xuemin Yan, Yingfeng Zhang, Keke Dang, Ying Li
Summary: This study using Mendelian randomization analysis found that increased circulating levels of BCAAs were associated with an increased risk of squamous cell lung cancer, but no causal link was found between BCAAs and other types of cancer.
CLINICAL NUTRITION
(2023)
Article
Nutrition & Dietetics
Imran Ramzan, Moira Taylor, Beth Phillips, Daniel Wilkinson, Kenneth Smith, Kate Hession, Iskandar Idris, Philip Atherton
Summary: The study successfully designed and evaluated a diet aimed at reducing circulating branched-chain amino acids (BCAAs) in humans, achieving a 50% reduction while maintaining energy balance and overall energy/protein intake.
Article
Nutrition & Dietetics
Yuyan Liu, Chengwen Zhang, Yuan Zhang, Xuheng Jiang, Yuanhong Liang, Huan Wang, Yongfang Li, Guifan Sun
Summary: This study aimed to investigate the relationship between dietary intake of branched-chain amino acids (BCAAs) and hypertension risk in the Chinese population. The findings showed that dietary BCAAs intake was positively associated with both systolic and diastolic blood pressure values, as well as an increased risk of hypertension.
Review
Immunology
Berkay Yahsi, Gurcan Gunaydin
Summary: Immunometabolism, especially in terms of augmenting anti-tumor immune responses, has been extensively researched. Regulatory T cells (Tregs) are known for their immunosuppressive roles in anti-tumor immune responses. Targeting Tregs specifically in the tumor microenvironment (TME) is crucial for successful and specific treatment. Recent studies have shown an association between Tregs and isoleucine, which may play a major role in affecting Tregs. Targeting the immunometabolic pathways of Tregs could be a rational approach for treatment.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Paola Cuomo, Rosanna Capparelli, Antonio Iannelli, Domenico Iannelli
Summary: Branched-chain amino acids (BCAAs) play an important role in human health. High levels of BCAAs are associated with various metabolic diseases, while low levels are beneficial for metabolic health. However, the exact mechanisms underlying the dysregulation caused by high levels of BCAAs are still under debate.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Daniel Ferguson, Sophie J. Eichler, Nicole K. H. Yiew, Jerry R. Colca, Kevin Cho, Gary J. Patti, Trevor M. Shew, Andrew J. Lutkewitte, Sandip Mukherjee, Kyle S. McCommis, Natalie M. Niemi, Brian N. Finck
Summary: The study evaluated the effects of MPC inhibitors (MPCi) on branched chain amino acid (BCAA) metabolism and found that MPCi can lower plasma BCAA concentrations and activate AMPK and mTOR signaling pathways. However, the effects on glucose homeostasis may be separate from BCAA concentrations.
MOLECULAR METABOLISM
(2023)
Article
Microbiology
Soumita Dutta, Ileana D. Corsi, Naomi Bier, Theresa M. Koehler
Summary: Research has shown that branched-chain amino acid synthesis is not sufficient for the robust growth of Bacillus anthracis; access to branched-chain amino acids is necessary for the proliferation of the pathogen in culture and during infection in a murine model. B. anthracis produces a large repertoire of branched-chain amino acid-related transporters, with three isoleucine/valine transporters identified with partial functional redundancy. Deletion of one of these transporters, BrnQ3, led to attenuated virulence. A mutant deficient in branched-chain amino acid biosynthesis grew well in medium containing these amino acids, but was also attenuated in virulence. These findings suggest that branched-chain amino acids are limited in multiple niches during infection and contribute to understanding the nutritional requirements of this important pathogen.
Correction
Plant Sciences
Paula da Fonseca-Pereira, Paulo V. L. Souza, Alisdair R. Fernie, Stefan Timm, Danilo M. Daloso, Wagner L. Araujo
JOURNAL OF EXPERIMENTAL BOTANY
(2022)
Article
Agronomy
Ismael de Oliveira Pinto, Maira Ignacio Sarmento, Auxiliadora Oliveira Martins, Joao Pedro Laurindo Rocha, Gloria Pinto, Wagner L. Araujo, Amadeu M. V. M. Soares, Renato Almeida Sarmento
Summary: This study investigated the changes in primary metabolism and cell death around oviposition sites in two hybrid clones of Eucalyptus with different resistance levels to Leptocybe invasa. The resistant clone exhibited higher amino acid, organic acid, and putrescine content, while the susceptible clone had higher sugar and pyruvate organic acid content. Furthermore, the resistant clone developed larger necrotic areas over time compared to the susceptible clone, indicating a potential defense response against L. invasa.
PEST MANAGEMENT SCIENCE
(2022)
Review
Forestry
Alice Pita-Barbosa, Leonardo Araujo Oliveira, Nairam Felix de Barros, Barbara Elias Reis Hodecker, Franciele S. Oliveira, Wagner L. Araujo, Samuel C. Martins
Summary: Climate change causes worldwide water crisis, affecting plant growth and yield, particularly in planted forests mainly composed of Eucalyptus species. Selecting genotypes capable of growing under water scarcity is crucial for eucalypt cultivation in drought-prone areas. This review summarizes recent advances in identifying potential indicators of drought tolerance in Eucalyptus and discusses their importance for developing drought-tolerant eucalypt varieties.
Review
Plant Sciences
Yasmin Vercosa Kramer, Charles Roland Clement, Josiane Celerino de Carvalho, Andreia Varmes Fernandes, Carlos Vinicius Azevedo da Silva, Hector Henrique Ferreira Koolen, Jaime Paiva Lopes Aguiar, Adriano Nunes-Nesi, Marcio Viana Ramos, Wagner L. Araujo, Jose Francisco de Carvalho Goncalves
Summary: The extraction and commercialization of palm hearts is highly profitable, but the consumption of peach palm fruits is limited to Amazonian communities. The focus on germplasm banks has hindered the development of high-performance varieties, resulting in limited production and consumption. With the fragmentation of the Amazonian rainforest, wild populations of peach palm are at risk of extinction. Further research is needed to understand the impact of climate change on plant performance. Exploiting the full potential of peach palm is crucial for expanding plantations and promoting its market expansion as a fruit crop.
Article
Plant Sciences
Paula da Fonseca-Pereira, Rita de Cassia Monteiro-Batista, Wagner L. Araujo, Adriano Nunes-Nesi
Summary: Cofactors play a fundamental role in enzyme catalytic activity. Plants are a critical source of cofactors, including vitamin precursors, for human nutrition. Numerous studies have explored the metabolism of coenzymes and vitamins in plants, revealing their significant impact on plant development, metabolism, and stress responses.
Article
Biotechnology & Applied Microbiology
Allan Victor M. Almeida, Marcelo Gomes Marcal Vieira Vaz, Naira Valle de Castro, Diego Bonaldo Genuario, Jean Coutinho Oder, Pedro Augusto Marazzo de Souza, Sandy Bastos Martins, Mariana Machado, Adriano Nunes-Nesi, Wagner L. Araujo
Summary: In this study, the diversity within Desmonostoc was investigated using morphological, molecular, metabolic, and physiological characteristics. The results showed that Desmonostoc has high species diversity, with a large metabolic diversity and great biotechnological potential.
SYSTEMATIC AND APPLIED MICROBIOLOGY
(2023)
Review
Plant Sciences
Joao AntonioS Iqueira, Agustin Zsogon, Alisdair R. Fernie, Adriano Nunes-Nesi, Wagner L. Araujo
Summary: This article discusses the regulatory role of day length and circadian rhythms in the uptake and usage of nutrients and the modulation of responses to toxic elements. The authors suggest that knowledge in this area might assist in developing next-generation crops with improved nutrient use efficiency.
TRENDS IN PLANT SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Roberto Neri-Silva, Rita de Cassia Monteiro-Batista, Paula da Fonseca-Pereira, Mateus Dias Nunes, Ana Luiza Viana-Silva, Tamara Palhares Ribeiro, Jorge L. Perez-Diaz, David B. Medeiros, Wagner L. Araujo, Alisdair R. Fernie, Adriano Nunes-Nesi
Summary: Among the adenylate carriers in Arabidopsis thaliana, increased expression of the AMP/ATP transporter ADNT1 is observed in roots under waterlogging stress conditions. The reduced expression of ADNT1 leads to decreased maximum quantum yield of PSII electron transport and higher levels of AMP in roots under nonstress condition. ADNT1-deficient plants exhibit differential expression of hypoxia-related genes and metabolic reprogramming associated with early induction of the fermentative pathway.
Article
Plant Sciences
Josiane C. de Carvalho, Katharine D. Goncalves, Elmer Goncalves, Pedro Paulo dos Santos, Manoel de Jesus de S. Miranda, Adamir da R. Nina Junior, Adriano Nunes-Nesi, Wagner L. Araujo, Jose Francisco de. C. Goncalves
Summary: We investigated the morphophysiological changes related to germination and initial growth of wild and cultivated genotypes of Hevea spp., aiming to add value to new clones. Sterilized seeds from six genotypes were studied for imbibition curve, germination parameters, and initial seedling growth. Morphological differences in seeds/embryos, imbibition process, emergence, and seedling growth were observed. Seed coat patterns, imbibition, growth, and development processes can be used as markers for genotype identification and selection. This is the first morphophysiological study of Hevea spp. seeds and seedlings. Phenotypic variability in seed and seedling morphophysiology can be explored in rubber tree breeding programs.
Article
Plant Sciences
Greice Leal Pereira, Vitor L. Nascimento, Rebeca Patricia Omena-Garcia, Beatriz Costa O. Q. Souza, Jose Francisco de Carvalho Goncalves, Dimas Mendes Ribeiro, Adriano Nunes-Nesi, Wagner L. Araujo
Summary: Boron stress affects physiological parameters in tomato plants and stimulates ethylene biosynthesis, leading to toxicity symptoms in roots and leaves.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Editorial Material
Plant Sciences
Joao Antonio Siqueira, Youjun Zhang, Adrian Nunes-Nesi, Alisdain R. Fernie, Wagner L. Araujo
Summary: The elucidation and removal of photorespiratory metabolic constraints are crucial for improving crop yield in the next agricultural revolution. Fu et al. found that serine is the major export in the photorespiratory pathway, while dynamic changes in glycine pools play a key role in CO2 assimilation during the induction and relaxation of photorespiration.
TRENDS IN PLANT SCIENCE
(2023)
Article
Forestry
Joao Pedro Laurindo Rocha, Thomas Vieira Nunes, Jovielly Neves Rodrigues, Nivea Maria Pereira Lima, Pedro Augusto Laurindo Rocha, Ismael de Oliveira Pinto, Maira Ignacio Sarmento, Wagner L. L. Araujo, Cristiano Bueno de Moraes, Renato Almeida Sarmento
Summary: This study explored the ability of the entomopathogenic fungus B. bassiana to control the galling insect L. invasa. The results showed that inoculating eucalyptus plants with B. bassiana improved their resistance to L. invasa and had positive effects on their morphometric responses and gas exchange.
Article
Multidisciplinary Sciences
Josiane C. De Carvalho, Gleisson De O. Nascimento, Ana Claudia L. Da Silva, Maria Das Gracas R. Ferreira, Wagner L. Araujo, Jose Francisco De C. Goncalves
Summary: This study examined the effect of growth regulators on the germination and seedling establishment of Hevea brasiliensis. The results showed that different genotypes responded differently to the growth regulators, and the protein profiles of the seedlings varied in the presence of different growth regulators.
ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS
(2022)
Article
Forestry
Leonardo A. Oliveira, Amanda A. Cardoso, Moab T. Andrade, Talitha S. Pereira, Wagner L. Araujo, Gleison A. Santos, Fabio M. Damatta, Samuel C. Martins
Summary: The ongoing changes in climate and the resulting mortality of forests emphasize the need to understand plant traits that contribute to drought tolerance. This study assessed key foliar traits in three commercial Eucalyptus hybrids, highlighting the importance of xylem resistance to embolism in drought tolerance.
Review
Engineering, Environmental
Joao Antonio Siqueira, Marcelle Ferreira Silva, Thiago Wakin, Adriano Nunes-Nesi, Wagner L. Araujo
Summary: Acidic soils limit food production in developing countries. High concentrations of aluminum ions inhibit plant growth and damage biomolecules such as DNA. Mitochondrial organic acids play a key role in neutralizing aluminum ions. Understanding these interactions can help develop crops that are more tolerant to aluminum toxicity.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
