Review
Biochemistry & Molecular Biology
Zhuo-Tao Liang, Chao-Feng Guo, Jiong Li, Hong-Qi Zhang
Summary: Adolescent idiopathic scoliosis (AIS) is a common spinal deformity that occurs during puberty, with a higher prevalence in females. Abnormal levels of hormones such as estrogen, melatonin, growth hormone, leptin, adiponectin, and ghrelin may be related to the occurrence and development of AIS. Research aims to provide a better understanding of the role of endocrine hormones in the pathogenesis of AIS.
Article
Cell Biology
Ming Luo, Huiliang Yang, Diwei Wu, Xuanhe You, Shishu Huang, Yueming Song
Summary: This study found that the AIS susceptibility gene Tent5a is differentially expressed in AIS paravertebral muscles. Knockdown of Tent5a inhibited the proliferation and migration of myoblasts and suppressed muscle fiber maturation, potentially involving in the pathogenesis of AIS by regulating the formation of type I muscle fibers.
CELL PROLIFERATION
(2022)
Article
Cell Biology
Hao Tang, Jiong Li, Jia-Ke Li, Si-Han He, Gang Xiang, Rong Rong, Zhuo-Tao Liang, Hong-Qi Zhang
Summary: This study reveals that BMP6 is a key gene regulating the abnormal osteogenic differentiation of BMSCs in AIS. CAP1-217 is identified as a potential upstream regulatory molecule of BMP6. The findings suggest that BMP6 functions via the CAP1-217/BMP6/RUNX2 axis to regulate the abnormal osteogenic differentiation of BMSCs in AIS.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Review
Cell Biology
Meng-Jun Li, Zhuo-Tao Liang, Yang Sun, Jiong Li, Hong-Qi Zhang, Ang Deng
Summary: Adolescent idiopathic scoliosis (AIS) is a common spinal deformity in young women, and its pathogenesis involves genetics, abnormal bone metabolism, and endocrine factors. Bone marrow stem cells (BMSCs) play a crucial role in the development of AIS. Noncoding RNAs (ncRNAs) are also involved in the pathogenesis of AIS and their role in regulating BMSCs in patients with AIS needs further evaluation.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Article
Clinical Neurology
Cesare Faldini, Francesca Barile, Fabrizio Perna, Stefano Pasini, Michele Fiore, Giovanni Viroli, Alberto Di Martino, Alberto Ruffilli
Summary: This article presents an original surgical technique for the treatment of rigid Adult Idiopathic Scoliosis (AdIS) and evaluates the results in a cohort of 40 patients. The surgical technique, Hi-PoAD, proved to be safe and effective in correcting spinal deformity and improving clinical outcomes.
EUROPEAN SPINE JOURNAL
(2021)
Review
Genetics & Heredity
Duan Sun, Zihao Ding, Yong Hai, Yunzhong Cheng
Summary: Scoliosis, a three-dimensional deformity of the spine, is closely related to genetic, hormonal, and environmental factors. Epigenetic alterations in scoliosis have been studied but a comprehensive review is lacking. We analyzed 25 studies on DNA methylation, non-coding RNAs, histone modifications, and chromatin remodeling in scoliosis. DNA methylation and non-coding RNAs are well-researched, providing insights into prevention and treatment strategies. However, there is limited research on histone modifications and chromatin remodeling in scoliosis. Further exploration is needed to understand the overall effects of epigenetics in scoliosis.
FRONTIERS IN GENETICS
(2023)
Article
Surgery
Giuseppe Gargano, Francesco Oliva, Filippo Migliorini, Nicola Maffulli
Summary: This study systematically investigates the role of melatonin in the pathophysiology of adolescent idiopathic scoliosis. The results indicate that the concentration and rhythm of melatonin secretion play an important role in the occurrence of this disease.
SURGEON-JOURNAL OF THE ROYAL COLLEGES OF SURGEONS OF EDINBURGH AND IRELAND
(2022)
Article
Clinical Neurology
Jean-Francois Catanzariti, Alexandre Rimetz, Florence Genevieve, Gemma Renaud, Natacha Mounet
Summary: This study aims to verify the link between obesity and adolescent idiopathic scoliosis (AIS). By conducting X-ray measurements on obese adolescents, it was found that the prevalence of AIS in this population is twice as high as in the general population.
EUROPEAN SPINE JOURNAL
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Chao Wu, Gedong Meng, Jie Lian, Jingxu Xu, Mingjie Gao, Chencui Huang, Shu Zhang, Yunfeng Zhang, Yizhou Yu, Haiyan Wang, Yujie He, Xiaohe Li, Zhijun Li
Summary: This study developed a deep learning algorithm to automatically evaluate and diagnose scoliosis on full spinal X-ray images. The model achieved high sensitivity and accuracy for parameters such as the Cobb angle, apical vertebrae, and demonstrated potential to improve diagnostic efficiency for radiologists.
EUROPEAN RADIOLOGY
(2022)
Article
Pediatrics
Alexandru Herdea, Mihai-Codrut Dragomirescu, Alexandru Ulici, Claudiu N. Lungu, Adham Charkaoui
Summary: Idiopathic scoliosis has a severe impact on children, but supplementation with vitamin D, calcium, and melatonin may have a positive effect on the progression of the disease.
Article
Clinical Neurology
Benjamin Sherman, Peymon Madi, Afshin Aminian
Summary: The study found that performing thoracoplasty with posterior spinal fusion for adolescent idiopathic scoliosis did not increase immediate post-operative pain, narcotic use or oxygen consumption. Additionally, patients showed improved self-image scores after thoracoplasty.
EUROPEAN SPINE JOURNAL
(2021)
Article
Orthopedics
Mingzheng Zhang, Wenxuan Chen, Shengru Wang, You Du, Jianguo Zhang, Fang Pu
Summary: The study aimed to assess whether supine flexibility can predict postoperative correction in adolescent idiopathic scoliosis (AIS) patients. The results showed a significant correlation between supine flexibility and postoperative correction, which can be expressed by linear regression models. Therefore, supine radiographs can be used in clinical practice instead of current flexibility test techniques.
BMC MUSCULOSKELETAL DISORDERS
(2023)
Review
Health Care Sciences & Services
Nicola Montemurro, Luca Ricciardi, Alba Scerrati, Giorgio Ippolito, Giorgio Lofrese, Sokol Trungu, Andrea Stoccoro
Summary: This study found that approximately 35.1% of individuals with 22q11.2 deletion syndrome develop scoliosis. By studying miRNAs in both 22q11.2DS and AIS, two shared miRNAs were identified, supporting the hypothesis of common molecular alterations in these two diseases.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Medicine, General & Internal
Sung Cheol Park, Sei Wook Son, Jae Hyuk Yang, Dong-Gune Chang, Seung Woo Suh, Yunjin Nam, Hong Jin Kim
Summary: This article introduces a novel surgical technique called the coin-hole technique or minimally invasive scoliosis surgery (MISS) for adolescent idiopathic scoliosis (AIS). Compared to conventional open surgery, MISS has advantages such as a smaller incision, less blood loss and postoperative pain, and lower infection rates. However, complications have been reported in the initial stages of using MISS for AIS.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Clinical Neurology
Sandra M. O'Malley, James O. Sanders, Susan E. Nelson, Paul T. Rubery, Natasha T. O'Malley, Christopher T. Aquina
Summary: Following Adolescent Idiopathic Scoliosis (AIS) surgery, there is significant variation in perioperative blood transfusion practices across surgeons and hospitals. The use of autologous blood transfusion and implementation of institutional transfusion protocols may reduce unwarranted variation and potentially decrease infectious complication rates. Surgeon and hospital characteristics explain a significant portion of surgeon variation but only a small amount of hospital variation in transfusion practices.
Review
Food Science & Technology
Xiaoyan Chen, Gene Chi Wai Man, Sze Wan Hung, Tao Zhang, Linda Wen Ying Fung, Chun Wai Cheung, Jacqueline Pui Wah Chung, Tin Chiu Li, Chi Chiu Wang
Summary: Endometriosis, a chronic disorder affecting many women, is currently difficult to treat effectively. However, recent studies have shown that green tea, with its bioactive component EGCG, may have potential therapeutic effects on endometriosis by inhibiting various molecular and cellular mechanisms.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Orthopedics
Cham Kit Wong, Gene Chi Wai Man, Xin He, Jonathan Patrick Ng, Alex Wing Hung Ng, Michael Tim Yun Ong, Patrick Shu Hang Yung
Summary: This study suggests that a large lateral tibial slope (LTS) and a large difference in LTS-MTS are risk factors for poorer functional and radiological outcomes for posterolateral meniscus root tear (PLRT) repair in patients after anterior cruciate ligament reconstruction (ACLR). Closer monitoring and a more stringent rehabilitation plan are recommended for patients with LTS >= 6 degrees or LTS-MTS >= 3 degrees.
BMC MUSCULOSKELETAL DISORDERS
(2022)
Review
Health Care Sciences & Services
Mei Po Tsang, Gene Chi Wai Man, He Xin, Yau Chun Chong, Michael Tim-Yun Ong, Patrick Shu-Hang Yung
Summary: This study aimed to compare the effectiveness of telerehabilitation with conventional in-person rehabilitation in patients who underwent total knee replacement. The results showed that telerehabilitation was comparable to conventional in-person rehabilitation in improving pain and functional outcomes. Additionally, telerehabilitation was associated with lower utilization of hospital resources and costs compared to in-person rehabilitation.
JOURNAL OF TELEMEDICINE AND TELECARE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Zongshan Hu, Claudio Vergari, Laurent Gajny, Gene Chi-Wai Man, Kwong-Hang Yeung, Zhen Liu, Tsz-Ping Lam, Zezhang Zhu, Yong Qiu, Winnie Chiu-Wing Chu, Jack Chun-Yiu Cheng, Wafa Skalli
Summary: The study identified determinants of the 3D OD-HA angle in maintaining global spinopelvic balance in a large Chinese adult cohort, with significant correlations with age, gender, and physiological parameters. The OD-HA angle demonstrated stability in maintaining the head above the pelvis within a cone of stability.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2022)
Article
Orthopedics
Ashley Ying-Ying Wong, Gene Chi-Wai Man, Yuen-Man Wu, Hiu-Wun Wong, Michael Tim-Yun Ong, Patrick Shu-Hang Yung
Summary: This study provides a comprehensive review on the epidemiological profile and the risk for surgery among athletes attending a sports injuries clinic in Hong Kong. The findings suggest that less experienced athletes, particularly those in the 18-29 age group, are more prone to injuries requiring surgery, with soccer and basketball being the most common sports associated with injuries. Strengthening the knee region through preventive measures is important in reducing sports-related injuries and surgeries.
JOURNAL OF ORTHOPAEDICS TRAUMA AND REHABILITATION
(2022)
Article
Orthopedics
Kwong Hang Yeung, Gene Chi Wai Man, Min Deng, Tsz Ping Lam, Jack Chun Yiu Cheng, Ka Chi Chan, Winnie Chiu Wing Chu
Summary: This study aimed to evaluate the morphological and pathological changes of intervertebral discs (IVD) and vertebral bodies (VB) in adolescent idiopathic scoliosis (AIS) girls. The results showed significant morphological changes in VB and IVD, as well as reduced volume of nucleus pulposus (NP) in severe-AIS patients.
BMC MUSCULOSKELETAL DISORDERS
(2022)
Review
Pharmacology & Pharmacy
Sze Wan Hung, Yiran Li, Xiaoyan Chen, Kai On Chu, Yiwei Zhao, Yingyu Liu, Xi Guo, Gene Chi-Wai Man, Chi Chiu Wang
Summary: Green tea, with its main component EGCG, shows potential in suppressing reproductive cancers by regulating autophagy and other cellular processes.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Michael Tim-Yun Ong, Gene Chi-Wai Man, Lawrence Chun-Man Lau, Xin He, Jihong Qiu, Qianwen Wang, Matthew Chun-Sing Chow, Ben Chi-Yin Choi, Mingqian Yu, Patrick Shu-Hang Yung
Summary: This study aims to evaluate the effects of PEMF treatment on quadriceps muscle recovery after ACL reconstruction. Quadriceps muscle atrophy is one of the key determinants for a patient's successful return-to-play. By conducting assessments and collecting samples, this study aims to fill the research gap and provide scientific support for the use of PEMF treatment as part of rehabilitation.
Review
Nutrition & Dietetics
Yiran Li, Sze-Wan Hung, Ruizhe Zhang, Gene Chi-Wai Man, Tao Zhang, Jacqueline Pui-Wah Chung, Lanlan Fang, Chi-Chiu Wang
Summary: This article summarizes the role and therapeutic potential of melatonin in endometriosis, highlighting the need for further clinical trials to confirm its effects and safety.
Article
Pharmacology & Pharmacy
Kai On Chu, Gene Chi Wai Man, Sze Wan Hung, Tak Hang Chan, Wai Yip Thomas Lee, Kwok Ping Chan, Chi Pui Pang, Chi Chiu Wang
Summary: A method for analyzing plasma pro-EGCG and its metabolites has been developed using UPLC-Qtof-MS, which is robust, rapid, and sensitive. The pharmacokinetic profiles of pro-EGCG and its metabolites have been reported for the first time.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Abdukahar Kiram, Zongshan Hu, Gene Chi-Wai Man, Hongru Ma, Jie Li, Yanjie Xu, Zhikai Qian, Zezhang Zhu, Zhen Liu, Yong Qiu
Summary: This study aims to investigate the relationship between paraspinal muscle degeneration and coronal imbalance in patients with degenerative scoliosis (DS). The study found that patients with coronal imbalance demonstrated worse paraspinal muscle degeneration compared to those without coronal imbalance, and paraspinal muscle degeneration strongly correlated with coronal imbalance.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2022)
Article
Orthopedics
Lawrence Chun Man Lau, Elvis Chun Sing Chui, Gene Chi Wai Man, Ye Xin, Kevin Ki Wai Ho, Kyle Ka Kwan Mak, Michael Tim Yun Ong, Sheung Wai Law, Wing Hoi Cheung, Patrick Shu Hang Yung
Summary: The image-based machine learning model developed in this study can accurately and predictably detect loosening in knee arthroplasty, with the class activation heatmap assisting surgeons in identifying the loosening sites.
JOURNAL OF ORTHOPAEDIC TRANSLATION
(2022)
Article
Orthopedics
Michael Tim-yun Ong, Gene Chi-wai Man, Xin He, Mingqian Yu, Lawrence Chun-man Lau, Jihong Qiu, Qianwen Wang, Jeremy Ho-pak, Ben Chi-yin Choi, Jonathan Patrick Ng, Patrick Shu-hang Yung
Summary: In this study, it was found that patients with persistent anterior knee pain after ACLR had increased stiffness and atrophy in the vastus medialis and vastus lateralis muscles. Additionally, these patients tended to shift more of their body weight towards the non-injured limb, leading to abnormal loading on the patellofemoral joint. These findings suggest that persistent quadriceps weakness may contribute to the early development of patellofemoral joint pain.
BMC MUSCULOSKELETAL DISORDERS
(2023)
Article
Surgery
Dennis King-Hang Yee, Jonathan Patrick Ng, Cyrus Tsun-Kit Lau, Kevin Ki-Wai Ho, Gene Chi-Wai Man, Vikki Wing-Shan Chu, Tsz Lung Choi, Gloria Yan Ting Lam, Michael Tim-Yun Ong, Patrick Shu-Hang Yung
Summary: This study compared the accuracy of achieving proper lower limb alignment and component positions after total knee replacement (TKR) with image-free and image-based robotic-assisted TKR. The results showed that there were significant differences between the two robotic systems in the alignment of the femoral and tibial components. The image-free system was more varus, while the image-based system was more valgus in the coronal alignment. The image-based system also had a larger deviation from the planned posterior slope in the sagittal alignment of the tibial component.
INTERNATIONAL JOURNAL OF MEDICAL ROBOTICS AND COMPUTER ASSISTED SURGERY
(2023)
Review
Clinical Neurology
Jocelyn Sze-wing Ho, Koko Shaau-yiu Ko, Sheung Wai Law, Gene Chi-wai Man
Summary: This review examined the effectiveness of robotic therapy (RT) in improving upper limb function for individuals with cervical spinal cord injuries (cSCI), showing mixed evidence. Although RT was found to be safe, feasible, and reduce therapist time, further research is needed to evaluate its long-term effects.
FRONTIERS IN NEUROLOGY
(2023)