Review
Biochemistry & Molecular Biology
Michael Gyorfi, Adam Rupp, Alaa Abd-Elsayed
Summary: This article examines the biological, genetic, and environmental factors that may impact the pathogenesis of fibromyalgia. It discusses abnormalities in pain inhibition, changes in sensory input processing, genetics, exposure to stressors, and abnormal reactions in the autonomic nervous system. The article concludes that further research will improve our understanding of the pathophysiology of fibromyalgia and lead to better treatment options for patients.
Article
Multidisciplinary Sciences
Johannes J. Rasker, Frederick Wolfe, Ewa G. Klaver-Krol, Machiel J. Zwarts, Peter M. ten Klooster
Summary: The study investigated the association between fibromyalgia and self-reported seizures in rheumatoid arthritis patients. Results showed a significant link between FM diagnostic variables, FM-related symptoms, and self-reported seizures, indicating a complex relationship between multi-symptom comorbidity and seizures. Future studies are needed to confirm these findings using validated FM criteria assessments and clinically verified diagnoses of epileptic and psychogenic seizures.
Article
Multidisciplinary Sciences
Justyna Swidrak, Ana Arias, Edgar Rodriguez de la Calle, Antonio Collado Cruz, Maria V. Sanchez-Vives
Summary: Chronic pain alters bodily perception and affects the ownership of a body. The study examined whether women with fibromyalgia are receptive to virtual bodily illusions and what factors influence this experience. The findings showed that patients with FM can experience virtual embodiment and their reactions vary depending on affective responses, cognitive body distortions, and symptom intensity. It is important to consider individual differences among patients in future VR-based interventions.
SCIENTIFIC REPORTS
(2023)
Article
Medicine, General & Internal
Teemu Zetterman, Ritva Markkula, Eija Kalso
Summary: Fibromyalgia patients showed higher glycaemic response to glucose intake, which may not be directly attributed to fibromyalgia but rather lifestyle factors. Body mass index and smoking rates were higher in fibromyalgia patients, while levels of pyruvate and lactate were similar between the two groups.
Article
Rheumatology
Luis F. Vidal, Osvaldo Messina, Tamara Rodriguez, Maritza Vidal, Carlos Pineda, Rasec Morales, Antonio Collado
Summary: The definition of treatment-refractory fibromyalgia is complex and requires proper diagnosis, exclusion of other diseases, and review of treatment response, but a consensus definition has not been reached yet.
CLINICAL RHEUMATOLOGY
(2021)
Article
Biology
Maria Mendoza-Munoz, Jesus Morenas-Martin, Miguel Rodal, Judith Garcia-Matador, Miguel Angel Garcia-Gordillo, Jose Ignacio Calzada-Rodriguez
Summary: The study evaluated the level of knowledge about fibromyalgia among patients in Extremadura, finding that most patients had a medium to high level of understanding. The research showed a weak relationship between the knowledge of physical activity in fibromyalgia and health-related quality of life, but no significant association was found with the actual practice of physical activity.
Article
Rheumatology
F. Atzeni, A. Alciati, L. Bazzichi, M. Govoni, G. Biasi, M. Di Franco, F. Mozzani, E. Gremese, L. Dagna, A. Batticciotto, F. Fischetti, R. Giacomelli, S. Guiducci, G. Guggino, M. Bentivegna, R. Gerli, C. Salvarani, G. Bajocchi, M. Ghini, F. Iannone, V Giorgi, M. Di Carlo, S. Farah, S. Bonazza, S. Barbagli, C. Gioia, N. G. Marino, A. Capacci, G. Cavalli, F. Carubbi, F. Nacci, I Riccucci, M. Cutolo, L. Sinigaglia, P. Sarzi-Puttini, F. Salaffi
Summary: This study aimed to evaluate the relationships between sociodemographic and clinical factors and the severity of FM symptoms. The results showed that being male and separated/divorced were associated with higher severity of FM symptoms, and lower educational level was also related to more severe symptoms.
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2022)
Review
Medicine, General & Internal
Kevin Hackshaw
Summary: Fibromyalgia, a common pain amplification syndrome, has significant societal impact. Early diagnosis can improve patient outlook and redirect valuable healthcare resources. The ongoing search for biomarkers is aimed at improving diagnostic accuracy and verification of this condition.
Review
Nutrition & Dietetics
Fatma Z. Kadayifci, Madelyn J. Bradley, Ahmet M. Onat, Hai Ning Shi, Shasha Zheng
Summary: Nutritional therapy has shown to be beneficial in alleviating symptoms of fibromyalgia (FM), with a focus on high-antioxidant and high-fiber foods, low processed foods, high-quality proteins, and healthy fats. Studies have also highlighted the importance of weight control and nutritional supplementation in the treatment of FM.
Article
Medicine, General & Internal
Ramon Martin-Brufau, Manuel Nombela Gomez, Leyre Sanchez-Sanchez-Rojas, Cristina Nombela
Summary: The study revealed that patients with fibromyalgia (FM) exhibit lower levels of brain activity and connectivity at rest compared to controls, with a distinct neurophysiological pattern fitting the clinical features of the disease.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Myrella Paschali, Asimina Lazaridou, Theodoros Paschalis, Vitaly Napadow, Robert R. Edwards
Summary: By examining the relationships between pain, mindfulness, and catastrophizing in fibromyalgia patients, it was found that pain intensity, catastrophizing, and mindfulness all play a role in affecting functioning. Patients with higher levels of pain and catastrophizing, and lower levels of mindfulness, are more likely to experience impaired functioning. Reducing catastrophizing through treatments like cognitive behavioral therapy is likely to directly improve functioning.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Rheumatology
P. Sarzi-Puttini, V Giorgi, F. Atzeni, R. Gorla, E. Kosek, E. H. Choy, L. Bazzichi, W. Hauser, J. N. Ablin, V Aloush, D. Buskila, H. Amital, J. A. P. Da Silva, S. Perrot, B. Morlion, E. Polati, V Schweiger, S. Coaccioli, G. Varrassi, M. Di Franco, R. Torta, K. M. Oien Forseth, K. Mannerkorpi, F. Salaffi, M. Di Carlo, G. Cassisi, A. Batticciotto
Summary: Fibromyalgia syndrome is a common cause of chronic widespread pain with clinical diagnosis due to lack of biomarkers. Current controversies include defining fibromyalgia, assessing severity, and determining the appropriate treatment approach.
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Soline Philippe, Marine Delay, Nicolas Macian, Veronique Morel, Marie-Eva Pickering
Summary: A significant clinical association between osteoporosis (OP) and fibromyalgia (FM) has been identified. Shared miRNAs, especially those involved in the Wnt pathway and cholinergic system, may offer potential targets for future OP and FM prevention and treatment. Further studies are needed to explore this relationship and to confirm the shared miRNAs through method harmonization.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Rosalba Siracusa, Rosanna Di Paola, Salvatore Cuzzocrea, Daniela Impellizzeri
Summary: Fibromyalgia is a complex syndrome characterized by chronic and widespread musculoskeletal pain, along with other symptoms such as fatigue and intestinal disorders. The exact cause of fibromyalgia remains unknown, but it is believed to be associated with various factors including neurology, inflammation, and immune responses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Carmen M. Galvez-Sanchez, Pablo de la Coba, Jose M. Colmenero, Gustavo A. Reyes del Paso, Stefan Duschek
Summary: The study compared attentional performance between patients with FMS and RA, finding that FMS patients exhibited longer reaction times and more errors in attention tests compared to RA patients and healthy individuals. The differences in performance did not vary by experimental conditions, suggesting a general attentional deficit in FMS rather than specific impairments in different attention domains.
