☆ 4.0 Article

Circadian biomarkers, circadian genes and bipolar disorders

JOURNAL OF PHYSIOLOGY-PARIS (2011)

期刊

JOURNAL OF PHYSIOLOGY-PARIS

卷 105, 期 4-6, 页码 183-189

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ELSEVIER SCI LTD

DOI: 10.1016/j.jphysparis.2011.07.002

关键词

Bipolar disorders; Circadian rhythms; Chronotype; Circadian genes; Trait marker; Melatonin

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Neurosciences Physiology

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摘要

Bipolar disorders are associated with circadian deregulations both during acute mood episodes and during euthymic periods, suggesting that these circadian rhythms may represent trait markers of the disease. Several arguments demonstrate that deregulations of circadian rhythms may be part of the pathophysiology of bipolar disorders. Abnormal quantitative and qualitative circadian disturbances have been repeatedly showed in bipolar patients, both during euthymic periods and acute phases, using different assessment tools such as actigraphy, polysomnography, and blood melatonin monitoring. In addition, many circadian physiological functions have been demonstrated to be altered in bipolar patients, such as secretion of hormones and other endogenous substances, core temperature, and fibroblasts activity. Furthermore, mood stabilizers efficiency could partially be explained by their impact on the regulation of the circadian rhythms. The implication of genetic vulnerability factors has long been demonstrated in bipolar disorders and several circadian genes have been tested for association in bipolar disorders. Although preliminary, interesting results have been obtained in several independent studies. (C) 2011 Elsevier Ltd. All rights reserved.

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Evolution of Cognitive Impairments in Treatment-Resistant Depression: Results from the Longitudinal French Centers of Expertise for Treatment-Resistant Depression (FACE-DR) Cohort

Alexis Vancappel, Yecodji Dansou, Ophelia Godin, Emmanuel Haffen, Antoine Yrondi, Florian Stephan, Raphaelle Marie Richieri, Fanny Moliere, Jerome Holtzmann, Mathilde Horn, Etienne Allauze, Jean Baptiste Genty, Alex Bouvard, Jean-Michel Dorey, Vincent Hennion, Vincent Camus, Guillaume Fond, Barbara Peran, Michel Walter, Loic Anguill, Charlotte Scotto D'apolina, Estelle Vila, Benjamin Fredembach, Jean Petrucci, Romain Rey, Anne Sophie Nguon, Bruno Etain, Mathilde Carminati, Philippe Courtet, Guillaume Vaiva, Pierre Michel Llorca, Marion Leboyer, Bruno Aouizerate, Djamila Bennabi, Wissam El Hage

Summary: This study examines the relationship between cognitive impairments and treatment response in patients with treatment-resistant depression. The findings suggest that cognitive scores improve after therapeutic response, with greater improvement observed in patients with better treatment response. Therefore, cognitive remediation should be provided after therapeutic response to enhance patients' daily functioning.

BRAIN SCIENCES (2023)

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Article Psychology, Clinical

An ecological study of objective rest-activity markers of lithium response in bipolar-I-disorder

Jan Scott, Vincent Hennion, Manon Meyrel, Frank Bellivier, Bruno Etain

Summary: This study reveals the relationship between rest-activity rhythms and lithium response, suggesting that rest-activity rhythms can serve as predictors of lithium treatment response in bipolar disorder patients. The study suggests that more stable circadian rhythms and lower sleep variability may be associated with a good response to lithium.

PSYCHOLOGICAL MEDICINE (2022)

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