Article
Neurosciences
Panos Zanos, Kyle A. Brown, Polymnia Georgiou, Peixiong Yuan, Carlos A. Zarate Jr, Scott M. Thompson, Todd D. Gould
Summary: Ketamine, a well-known NMDA receptor antagonist, exerts rapid antidepressant effects by enhancing excitatory synaptic strength. These findings suggest that promoting NMDA receptor activation or enhancing NMDA receptor-dependent synaptic potentiation may be an effective strategy for antidepressant treatment.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Neurosciences
S. Murat Durakoglugil, R. Catherine Wasser, H. Connie Wong, Theresa Pohlkamp, Xunde Xian, Courtney Lane-Donovan, Katja Fritschle, Lea Naestle, Joachim Herz
Summary: Alzheimer's disease is characterized by the accumulation of Aβ plaques and neurofibrillary tangles, leading to synaptic dysfunction. Reelin protects synapses against Aβ toxicity through ApoE receptors. Experiments showed that Reelin modulates mGluR-LTD, potentially impacting memory consolidation or neurodegeneration.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Biology
Remy A. Yovanno, Tsung Han Chou, Sarah J. Brantley, Hiro Furukawa, Albert Y. Lau
Summary: This study investigated the mechanisms of D-serine in receptor activation and found that D-serine competes with glutamate for binding to GluN2A. The inhibitory effect of D-serine at high concentrations was confirmed through electrophysiology experiments.
Article
Biochemistry & Molecular Biology
Takeshi Hayashi, Lay Katoh, Fumiyo Ozoe, Yoshihisa Ozoe
Summary: Studies on 13 heterocyclic OAR agonists suggest structure-dependent receptor subtype selectivity and G protein subtype preference, emphasizing the importance of determining which subtype and signaling pathway mediates toxicologically relevant effects. Insecticidal assays using B. mori larvae indicate that the activation of signal transduction pathways via alpha-ALOARs may be primarily responsible for the toxicological effects of heterocycles.
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
(2021)
Article
Neurosciences
Yifei Bao, Xin Yang, Yi Fu, Zhengyan Li, Ru Gong, Wei Lu
Summary: The chronic suppression of glutamate reuptake leads to accumulation of ambient glutamate, which can diffuse to the soma and elevate cell excitability. Somatic potentiation of synaptic inputs may represent a novel amplification mechanism that contributes to neuronal hyperactivity in Alzheimer's disease initiated by impaired glutamate reuptake.
TRANSLATIONAL NEURODEGENERATION
(2021)
Article
Pharmacology & Pharmacy
Yulia D. Stepanenko, Dmitry A. Sibarov, Natalia N. Shestakova, Sergei M. Antonov
Summary: N-methyl-D-aspartate receptors (NMDARs) are essential targets for the analgetic action of tricyclic antidepressants (TCAs). The study revealed that the action of TCAs on NMDARs is mainly through the open-channel block. However, at therapeutic blood concentrations, the action of TCAs on NMDARs is insufficient to cause open-channel block. The study also showed that desipramine (DES) demonstrates a profound Ca2+-dependent inhibition, while clomipramine (CLO) has weak effects on NMDARs.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Giulia Murtas, Loredano Pollegioni, Gianluca Molla, Silvia Sacchi
Summary: The gene G72 has been associated with susceptibility to schizophrenia. The protein encoded by this gene, pLG72, plays a role in binding and inactivating d-amino acid oxidase, an enzyme involved in the catabolism of d-serine. pLG72 may also affect mitochondrial functions. However, the detection of pLG72 in the human body is challenging, and its potential as a marker for Alzheimer's disease progression requires further investigation.
Article
Neurosciences
Shao-Rui Chen, Hong Chen, Daozhong Jin, Hui-Lin Pan
Summary: Treatment with opioids not only inhibits nociceptive transmission but also elicits a rebound and persistent increase in primary afferent input to the spinal cord. Opioid-elicited long-term potentiation (LTP) from TRPV1-expressing primary afferents plays a major role in opioid-induced hyperalgesia and analgesic tolerance. The study found that opioid-elicited LTP occurs in VGluT2 neurons in the spinal dorsal horn, and not in VGAT neurons, with underlying signaling mechanisms.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Psychiatry
Courtney J. Wright, Katherine M. Rentschler, Nathan T. J. Wagner, Ashley M. Lewis, Sarah Beggiato, Ana Pocivavsek
Summary: Hypofunction of glutamatergic signaling is linked to neurodevelopmental disorders such as schizophrenia and bipolar disorder, with KYNA playing a potential role in the cognitive dysfunction experienced by patients. The EKyn paradigm induced prenatal KYNA elevation in rats to investigate its effects, showing potential sex- and time-dependent changes in hippocampal neuromodulation. This research sheds light on how prenatal insults may influence behavioral phenotypes related to psychotic disorders.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Pharmacology & Pharmacy
Yoki Nakamura, Ayako Fukuta, Keita Miyashita, Fang Fang Zhang, Dengli Wang, Keyue Liu, Hidenori Wake, Kazue Hisaoka-Nakashima, Masahiro Nishibori, Norimitsu Morioka
Summary: The study demonstrates that increased HMGB1 around the injured sciatic nerve may induce nociceptive hypersensitivity through the activation of spinal microglia.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Behavioral Sciences
Qian-Mei Zhu, Lin-Xin Wu, Bo Zhang, Yan-Peng Dong, Li Sun
Summary: This study demonstrated that donepezil can attenuate morphine-induced tolerance by downregulating the expressions of NMDAR, PKC, and CaMKII pathways. Co-administration of donepezil with morphine prolonged the occurrence of analgesic tolerance in rats. Specifically, morphine upregulated NR1, PKC gamma, and CaMKII alpha in certain brain regions, while downregulating these proteins with donepezil treatment.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2021)
Article
Oncology
Kevin Yijun Fan, Rania Chehade, Maleeha Qazi, Veronika Moravan, Sharon Nofech-Mozes, Katarzyna J. Jerzak
Summary: We evaluated the expression of androgen receptor (AR) in breast cancer brain metastases (BrM). AR was expressed in the majority of BrM and its expression varied across breast cancer subtypes. AR-positive status did not have a significant impact on overall survival, brain-specific progression-free survival, or time from breast cancer diagnosis to BrM diagnosis. AR represents a potential therapeutic target in breast cancer BrM.
Article
Chemistry, Multidisciplinary
Jinggang Lan, Vladimir V. Rybkin, Alfredo Pasquarello
Summary: Using mixed quantum-classical simulations and machine learning techniques, we accurately describe the temperature-dependent properties of the aqueous electron under various thermodynamic conditions. Our work reveals that the red shift of the absorption maximum, in the presence of cavity formation, is due to an increasing gyration radius with temperature, rather than global density variations as previously suggested.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Biochemistry & Molecular Biology
Yves-Henri Sanejouand
Summary: Xenon can induce general anesthesia by interacting with the glycine binding domain of the N-methyl-D-aspartate receptor. Three different xenon binding sites were found, one of them being adjacent to the glycine binding site. This explains why certain mutations can prevent xenon from competitively inhibiting the receptor without affecting glycine binding.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2022)
Article
Biology
Sayali Gore, Eric J. James, Lin-chien Huang, Jenn J. Park, Andrea Berghella, Adrian C. Thompson, Hollis T. Cline, Carlos D. Aizenman
Summary: The study found that chronically elevated MMP-9 activity during early neurodevelopment is associated with neural circuit hyperconnectivity and neurodevelopmental disorders. Overexpression of MMP-9 in Xenopus tadpoles mimics the effects of VPA on synaptic connectivity, while blocking MMP-9 activity can reverse the physiological and behavioral effects of VPA.
Article
Cell Biology
Mengfei Chen, Shenghe Tian, Nathan G. Glasgow, Gregory Gibson, Xiaoling Yang, Christen E. Shiber, James Funderburgh, Simon Watkins, Jon W. Johnson, Joel S. Schuman, Hongjun Liu
Article
Pharmacology & Pharmacy
Jon W. Johnson, Nathan G. Glasgow, Nadezhda V. Povysheva
CURRENT OPINION IN PHARMACOLOGY
(2015)
Article
Neurosciences
Nathan G. Glasgow, Nadezhda V. Povysheva, Andrea M. Azofeifa, Jon W. Johnson
JOURNAL OF NEUROSCIENCE
(2017)
Article
Neurosciences
Christopher B. Divito, Jenna E. Borowski, Nathan G. Glasgow, Aneysis D. Gonzalez-Suarez, Delany Torres-Salazar, Jon W. Johnson, Susan G. Amara
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2017)
Article
Neurosciences
Nathan G. Glasgow, Madeleine R. Wilcox, Jon W. Johnson
Article
Neurosciences
Richard J. Clarke, Nathan G. Glasgow, Jon W. Johnson
JOURNAL OF NEUROSCIENCE
(2013)