Article
Biology
Yu-Ling Lin, Zhu-Sen Yang, Wai-Yi Wong, Shih-Che Lin, Shuu-Jiun Wang, Shih-Pin Chen, Jen-Kun Cheng, Hui Lu, Cheng-Chang Lien
Summary: This study investigates the cellular and synaptic alterations in the central nucleus of the amygdala (CeA) in a mouse model of chronic muscle pain. They found that targeting the somatostatin-expressing CeA (CeA-SST) neurons during the priming phase can prevent the development of chronic pain. Furthermore, they discovered that the CeA-SST neurons have increased excitatory synaptic drive and enhanced neuronal excitability in the chronic pain states. Chemogenetic inactivation of these neurons or suppression of nociceptive afferents from the brainstem to the CeA-SST neurons can alleviate chronic pain and anxiety-depressive symptoms.
Review
Neurosciences
Dheeraj S. Roy, Ying Zhang, Michael M. Halassa, Guoping Feng
Summary: Recent studies using advanced expression profiling have revealed gene expression gradients within and across thalamic nuclei, redefining functional units of the thalamus. Thalamic subnetworks, defined by the intersection of genetics, connectivity, and computation, provide a more appropriate level of functional description.
NATURE NEUROSCIENCE
(2022)
Article
Cell Biology
Elisabetta Iavarone, Jane Simko, Ying Shi, Marine Bertschy, Maria Garcia-Amado, Polina Litvak, Anna-Kristin Kaufmann, Christian O'Reilly, Oren Amsalem, Marwan Abdellah, Grigori Chevtchenko, Benoit Coste, Jean-Denis Courcol, Andras Ecker, Cyrille Favreau, Adrien Christian Fleury, Werner Van Geit, Michael Gevaert, Nadir Roman Guerrero, Joni Herttuainen, Genrich Ivaska, Samuel Kerrien, James G. King, Pramod Kumbhar, Patrycja Lurie, Ioannis Magkanaris, Vignayanandam Ravindernath Muddapu, Jayakrishnan Nair, Fernando L. Pereira, Rodrigo Perin, Fabien Petitjean, Rajnish Ranjan, Michael Reimann, Liviu Soltuzu, Mohameth Francois Sy, M. Anil Tuncel, Alexander Ulbrich, Matthias Wolf, Francisco Clasca, Henry Markram, Sean L. Hill
Summary: A detailed computational model of mouse somatosensory thalamus and thalamic reticular nucleus has been developed to simulate the biological connectivity of over 14,000 neurons and reproduce experimental findings in different brain states. The model suggests that inhibitory rebound enhances thalamic responses to specific frequencies during wakefulness and thalamic interactions are responsible for the characteristic changes in spindle oscillations. Changes in thalamic excitability control spindle frequency and incidence. The openly available model provides a new tool for studying the function and dysfunction of the thalamoreticular circuitry in various brain states.
Article
Neurosciences
Courtney Michelle Whilden, Maxime Chevee, Seong Yeol An, Solange Pezon Brown
Summary: The study focused on the synaptic inputs and different functional regions within the thalamic reticular nucleus of different types of L6 CThNs in the somatosensory cortex, revealing that VPM/POm L6 CThNs received more inputs from other cortical areas, higher order thalamic nuclei, and subcortical structures.
JOURNAL OF COMPARATIVE NEUROLOGY
(2021)
Article
Behavioral Sciences
M. Wolff, S. Morceau, R. Folkard, J. Martin-Cortecero, A. Groh
Summary: Adapting to dynamic environments requires tracking multiple signals and integrating communication between sensory and cognitive brain circuits, with thalamic nuclei acting as a crucial bridge in this process. Thalamus plays a key role in linking perception, cognition, and potentially affective processes.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Neurosciences
Frhan I. Alanazi, Suneil K. Kalia, Mojgan Hodaie, Adriana Lopez L. Rios, Andres M. Lozano, Luka Milosevic, William D. Hutchison
Summary: The neurophysiology of selective attention in visual and auditory systems was studied in animal models and recorded neuronal activity in human patients with parkinsonian and non-parkinsonian tremors. The results showed that the firing rate of neurons decreased during the auditory oddball task, specifically related to auditory attention. The study also found that dopamine modulates thalamic beta oscillations for selective attention in Parkinson's disease patients.
NPJ PARKINSONS DISEASE
(2023)
Article
Neurosciences
Patrick A. Cody, Thanos Tzounopoulos
Summary: Neural adaptation allows the brain to efficiently process sensory signals despite changes in background noise. In the auditory pathway, contrast in background sound levels leads to different neural responses, but mean firing-rates in auditory cortex remain unaffected by sound level contrast. The neuromodulatory mechanisms behind these phenomena are still unknown.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Jing Liu, Dan-Hua Chen, Xiao-Shuang Li, Chuan-Ying Xu, Tao Hu
Summary: Previous studies have shown the importance of thalamic reticular nucleus (TRN) and its sub-nuclei in pain sensation. This study found that activating the parvalbumin-positive (PV+) neurons in the ventral sector of TRN can alleviate pathological pain and reduce pain sensitivity in mice.
Article
Neurosciences
Perez -Ramirez Maria-Belen, Parada Isabel, Prince David
Summary: Status epilepticus (SE) is a life-threatening emergency that can lead to the development or worsening of epilepsy. The study found that neocortical focal status epilepticus (FSE) can induce structural and functional changes in the thalamus, which may contribute to hyperexcitability in thalamocortical circuit. These changes include cell loss in the ventrobasal nucleus (VB) and increased excitatory synapses in intra-thalamic and cortico-thalamic networks.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Yanjun Liu, Bing Chen, Yirong Cai, Yuan Han, Ying Xia, Nanqi Li, Bingqian Fan, Tianjie Yuan, Junli Jiang, P. O. Gao, Weifeng Yu, Yingfu Jiao, Wenxian Li
Summary: The neural activity of the anterior TRN is suppressed during propofol anesthesia but robustly activated during recovery. Activation of anterior TRN neurons shortens emergency time without changing induction time, while inhibition leads to delayed recovery. Anterior TRN is crucial for behavioral arousal during propofol anesthesia, independent of induction time.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2021)
Article
Neurosciences
Vladimir Visocky, Brian J. Morris, John Dunlop, Nick Brandon, Shuzo Sakata, Judith A. Pratt
Summary: Using optogenetics and electrophysiology in C57BL/6 mice, we found that the caudal and rostral subpopulations of the thalamic reticular nucleus (TRN) have distinct effects on cortical alpha and delta oscillations and sleep stability. Silencing the rostral TRN prolongs sleep episodes, while silencing the caudal TRN fragments sleep. These findings demonstrate the different roles exerted by the rostral and caudal TRN in sleep regulation and oscillatory activity.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2023)
Article
Neurosciences
Nicole F. Wong, Matthew A. Xu-Friedman
Summary: This study examines the time course of activity-dependent changes in auditory nerve synapses in mice after noise exposure and conductive hearing loss. The researchers found that EPSC amplitude and synaptic depression decrease shortly after noise exposure, followed by a gradual increase. Occlusion of the ear canal leads to a rapid decrease in EPSC amplitude, followed by an increase. Recovery to normal sound levels takes 1-2 days. Repeated exposure to noise for as little as 8 hours a day causes synaptic changes after 7 days. These findings suggest the presence of three activity-dependent mechanisms in auditory nerve synapses.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Kuang-Yi Ma, Xin-Yu Cai, Xin-Tai Wang, Zhao-Xiang Wang, Wan-Meng Huang, Zhi-Ying Wu, Zhou-Yan Feng, Ying Shen
Summary: The cerebellum is believed to be a processor of complex movements and plays a role in cognitive and emotional behaviors. This study investigated the output of the cerebellar interposed nucleus to thalamic nuclei and found heterogeneity in recipient zones in the thalamus, suggesting differential control of thalamo-cortical networks by the cerebellum.
NEUROSCIENCE BULLETIN
(2021)
Article
Multidisciplinary Sciences
Tristano Pancani, Michelle Day, Tatiana Tkatch, David L. L. Wokosin, Patricia Gonzalez-Rodriguez, Jyothisri Kondapalli, Zhong Xie, Yu Chen, Vahri Beaumont, D. James Surmeier
Summary: Using a mouse model of Huntington's disease, the authors found increased connectivity in the corticostriatal pathway due to deficient cholinergic transmission. Lowering mutant huntingtin specifically in striatal cholinergic interneurons normalized the connectivity, providing evidence for a key node in the network underlying corticostriatal pathophysiology in Huntington's disease.
NATURE COMMUNICATIONS
(2023)
Article
Neurosciences
Jenya Kolpakova, Vincent van der Vinne, Pablo Gimenez-Gomez, Timmy Le, Gilles E. Martin
Summary: Animal studies support the important role of striatal cholinergic interneurons in basal ganglia function, particularly in associative learning, reward processing, and motor control. ChIs regulate synaptic excitability of medium spiny neurons by modulating dopamine, glutamate, and GABA neurotransmission. The effect of ChIs on dopamine D1- and D2 receptor-expressing neurons differs, and is altered after binge alcohol drinking.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Neurosciences
Yan-Gang Sun, Vanessa Rupprecht, Li Zhou, Rajan Dasgupta, Frederik Seibt, Michael Beierlein
JOURNAL OF NEUROSCIENCE
(2016)
Article
Chemistry, Multidisciplinary
Flavia Vitale, Daniel G. Vercosa, Alexander V. Rodriguez, Sushma Sri Parnulapati, Frederik Seibt, Eric Lewis, J. Stephen Yan, Krishna Badhiwala, Mohammed Adnan, Gianni Royer-Carfagni, Michael Beierlein, Caleb Kemere, Matteo Pasquali, Jacob T. Robinson
Article
Anatomy & Morphology
Albert J. Hunt, Rajan Dasgupta, Shivakumar Rajamanickam, Zhiying Jiang, Michael Beierlein, C. Savio Chan, Nicholas J. Justice
BRAIN STRUCTURE & FUNCTION
(2018)
Article
Neurosciences
Rajan Dasgupta, Frederik Seibt, Michael Beierlein
JOURNAL OF NEUROSCIENCE
(2018)
Article
Neurosciences
Yan-Gang Sun, Michael Beierlein
JOURNAL OF NEUROPHYSIOLOGY
(2011)
Article
Neurosciences
Michael H. Myoga, Michael Beierlein, Wade G. Regehr
JOURNAL OF NEUROSCIENCE
(2009)
Article
Neurosciences
Yan-Gang Sun, Chia-Shan Wu, Hui-Chen Lu, Michael Beierlein
JOURNAL OF NEUROSCIENCE
(2011)
Article
Neurosciences
Yan-Gang Sun, Juan D. Pita-Almenar, Chia-Shan Wu, John J. Renger, Victor N. Uebele, Hui-Chen Lu, Michael Beierlein
JOURNAL OF NEUROSCIENCE
(2013)
Article
Neurosciences
Juan Diego Pita-Almenar, Dinghui Yu, Hui-Chen Lu, Michael Beierlein
JOURNAL OF NEUROSCIENCE
(2014)
Editorial Material
Neurosciences
Michael Beierlein
JOURNAL OF PHYSIOLOGY-LONDON
(2014)
Article
Neurosciences
John J. O'Malley, Frederik Seibt, Jeannie Chin, Michael Beierlein
JOURNAL OF NEUROSCIENCE
(2020)
Article
Neurosciences
Amanda Singer, Shayok Dutta, Eric Lewis, Ziying Chen, Joshua C. Chen, Nishant Verma, Benjamin Avants, Ariel K. Feldman, John O'Malley, Michael Beierlein, Caleb Kemere, Jacob T. Robinson
Article
Multidisciplinary Sciences
D. S. Engelke, X. O. Zhang, J. J. O'Malley, J. A. Fernandez-Leon, S. Li, G. J. Kirouac, M. Beierlein, F. H. Do-Monte
Summary: The study reveals that specific CRF-positive neurons in the paraventricular thalamus of rats are crucial in mediating defensive behaviors during conflicts between seeking rewards and avoiding threats. These neurons project to the nucleus accumbens, impacting food seeking and avoidance behaviors. Furthermore, the interaction between the ventromedial hypothalamus and aPVT neurons plays a key role in the modulation of defensive responses during conflicts.
NATURE COMMUNICATIONS
(2021)
Article
Cell Biology
Rohan Jagirdar, Chia-Hsuan Fu, Jin Park, Brian F. Corbett, Frederik M. Seibt, Michael Beierlein, Jeannie Chin
Summary: The study found that activating the thalamic reticular nucleus can improve sleep maintenance and reduce symptoms associated with Alzheimer's disease. Enhancing TRN activity may be a promising therapeutic strategy for AD.
SCIENCE TRANSLATIONAL MEDICINE
(2021)