Article
Biochemical Research Methods
Zoya J. R. Bastany, Shahbaz Askari, Guy A. Dumont, Christoph Kellinghaus, Baran Askari, Kurosh Gharagozli, Ali Gorji
Summary: Ionic currents in the brain generate voltage oscillations, including ultra-low frequency electroencephalograms (DC-EEG) and conventional clinical electroencephalograms (AC-EEG). Recent studies suggest that DC-EEG, which is often censored during conventional EEG recordings, can provide valuable information for analyzing epileptiform discharges. This study describes a novel technique to extend the frequency bandwidth of surface EEG to record signals associated with spreading depression (SD), which may be linked to epileptiform discharges.
JOURNAL OF NEUROSCIENCE METHODS
(2023)
Article
Biophysics
Nipuni D. Nagahawatte, Niranchan Paskaranandavadivel, Timothy R. Angeli-Gordon, Leo K. Cheng, Recep Avci
Summary: This study successfully captured and quantified the bioelectrical activity across the wall of the GI tract using a needle-based microelectrode array. Differences in slow wave characteristics between transmural and serosal layers were observed in terms of period, amplitude, and signal to noise ratio. Additionally, four different slow wave morphologies were identified across the transmural layers, with Type 1 and Type 2 being the most prevalent.
PHYSIOLOGICAL MEASUREMENT
(2021)
Article
Neurosciences
Merve Ilhan-Bayrakci, Yuranny Cabral-Calderin, Til Ole Bergmann, Oliver Tuscher, Albrecht Stroh
Summary: This study analyzed simultaneous EEG-fMRI data during human non-REM sleep and found a direct relationship between slow wave events (SWEs) and BOLD activation patterns in the brain. The spatial extent of BOLD activation patterns and the amplitude of the BOLD response were found to be correlated with the number of SWEs.
Review
Gastroenterology & Hepatology
Fan Ding, Run Guo, Zheng-Yu Cui, Hai Hu, Gang Zhao
Summary: This article reviews the research progress in the characteristics and propagation of slow waves in the gastrointestinal tract and explores the mechanisms underlying GI dysfunction. Various electromyography techniques and clinical applications of GI electrical stimulation therapy are discussed.
WORLD JOURNAL OF GASTROINTESTINAL SURGERY
(2022)
Article
Clinical Neurology
Brice McConnell, Eugene Kronberg, Peter D. Teale, Stefan H. Sillau, Grace M. Fishback, Rini Kaplan, Angela J. Fought, A. Ranjitha Dhanasekaran, Brian D. Berman, Alberto R. Ramos, Rachel L. McClure, Brianne M. Bettcher
Summary: This study identified different subtypes of spindles within slow wave upstates and found that stages N2 and N3 sleep contain a mixture of discrete subtypes of slow waves. The relative contribution of coupling subtypes shifts across the human lifespan, with a deeper sleep phenotype prevailing with increasing age. These findings support the development of coupling-based biomarkers in age-associated neurological disease.
Article
Engineering, Biomedical
Romeo R. Racz, Mihaly Kollo, Gabriella Racz, Ciprian Bulz, Tobias Ackels, Tom Warner, William Wray, Nikolai Kiskin, Chi Chen, Zhiwen Ye, Livia de Hoz, Ede Rancz, Andreas T. Schaefer
Summary: In this study, continuously drawn SiO2-insulated ultra-microelectrode fibers were used to address the issue of damage to vasculature and circuit function during probe insertion. The results showed that these ultra-low impedance electrodes can effectively record and stimulate neuronal activity in both superficial and deep structures of the mouse brain.
JOURNAL OF NEURAL ENGINEERING
(2022)
Article
Neurosciences
Brice V. McConnell, Eugene Kronberg, Lindsey M. Medenblik, Vitaly O. Kheyfets, Alberto R. Ramos, Stefan H. Sillau, Rachelle L. Pulver, Brianne M. Bettcher
Summary: This study aimed to investigate the neurobiological properties and composition of slow wave activity (SWA) during non-rapid-eye-movement (NREM) sleep. The study found that different types of slow waves and spindle subtypes have distinct features and distribution patterns during NREM sleep cycles. Older adults produce a different composition of SWA, with a shift toward the frontal subtype associated with N3 sleep, which becomes increasingly predominant during NREM sleep cycles. These findings are important for understanding the impact of slow wave sleep on memory and neurological diseases.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Health Care Sciences & Services
Adrian D. Wood, Gillian D. Edward, Kirsten Cumming, Mohannad W. Kafri, Roy L. Soiza, Lee Hooper, John F. Potter, Phyo K. Myint
Summary: Dehydration in hospitalized patients, particularly the elderly, is associated with higher morbidity and mortality. A study comparing ICW/ECW ratio and BUN/Cr ratio in predicting poor outcomes found that a low ICW/ECW ratio was associated with unfavorable discharge destination, while the BUN/Cr ratio did not show significant relationship with prolonged hospitalization or discharge destination. Utilizing BIA in conjunction with biochemical measurements could provide valuable information for patient prognosis.
Article
Pediatrics
Hannah Parker, Ethan T. T. Hunt, Keith Brazendale, Lauren von Klinggraeff, Alexis Jones, Sarah Burkart, Roddrick Dugger, Bridget Armstrong, Michael W. W. Beets, R. Glenn Weaver
Summary: This study quantified the accuracy and precision of bioelectrical impedance (BIA)-estimated percent body fat (%BF) using different devices and measurement times. The results showed that the new BIA device Tanita DC-430U underestimated %BF but correctly ranked children in terms of %BF. Measurements taken at different times within a day were less precise compared to measurements taken at different days.
Article
Engineering, Biomedical
Robert Bestel, Ursula van Rienen, Christiane Thielemann, Revathi Appali
Summary: This study investigates the mechanisms underlying the diversity of signal shapes in neuronal cell activity recordings by proposing a computational model based on the finite element method. The results suggest that the geometry and structure of neurons, as well as the pathways of input potentials, significantly affect the shape of extracellular electrode recordings, providing valuable insights into the electrical activity of neuronal networks.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2021)
Article
Gastroenterology & Hepatology
Amir Javan-Khoshkholgh, Joseph C. C. Sassoon, Jennifer Behbodikhah, Wenchen Dai, Senayt Alemu, Saad Quadri, Mohnish Singh, Olga V. V. Savinova, Aydin Farajidavar
Summary: This study established a method to capture and analyze slow waves (SW) in the small intestine of mice with heart failure (HF). The results suggest that HF may be associated with reduced high-frequency SW activity.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Review
Oncology
Yang Ge, Fengyuan Sun, Bo Zhao, Fanyang Kong, Zhaoshen Li, Xiangyu Kong
Summary: Extracellular vesicles, especially Outer Membrane Vesicles (OMVs) produced by Gram-negative bacteria, have been found to play crucial roles in microbial interactions, pathogenesis promotion, stress responses, and biofilm formation. In recent years, there has been increasing research on the potential applications of EVs in bioengineering, such as antibacterial therapy, cancer drugs, and immunoadjuvants, with promising efficacy shown in clinical trials. However, the limited understanding of the sources, membrane structures, and biogenesis mechanisms of EVs hinders the progress of clinical applications. This review summarizes the latest findings of EVs in gastrointestinal tract tumors to provide a comprehensive introduction to the role of EVs in tumorigenesis and therapeutics.
FRONTIERS IN ONCOLOGY
(2023)
Letter
Surgery
Jinghua Dai, Zhaoxia Yang, Chunmei Wu
Summary: The study evaluated the reliability, validity, and predictive validity of Scott Triggers for gastrointestinal surgery patients in China. The results showed good performance of Scott Triggers in assessing the risk of pressure injuries in surgical patients. The study suggests further consideration of body mass index in future research.
ASIAN JOURNAL OF SURGERY
(2021)
Article
Neurosciences
Anna Castelnovo, Althea Lividini, Brady A. Riedner, Giulia Avvenuti, Stephanie G. Jones, Silvia Miano, Giulio Tononi, Mauro Manconi, Giulio Bernardi
Summary: The study aimed to characterize the characteristics of individual slow waves, including origin, synchronization, and cortical propagation, between children and adults. The study found that slow waves in children were larger, steeper, and less widespread compared to adults, mainly originating from and spreading over more posterior brain areas. The slow waves of children also tended to involve and originate more from the right hemisphere compared to adults. The analysis of slow waves with high and low synchronization efficiency showed distinct maturation patterns, suggesting different generation and synchronization mechanisms.
Article
Engineering, Electrical & Electronic
Chen Zhao, Shuo Tian, Wangqi Liu, Xiaoyi Liao, Xiaoxing Fang, Shaomeng Wang
Summary: This article investigates the operation principle and dispersion properties of the co-planar slow wave structure (SWS). The SWS is analyzed using an equivalent circuit model, and the theoretical calculation results are in good agreement with the simulations. Particle-in-cell (PIC) simulation and measurements validate the tunable frequency range and high power output characteristics of the proposed SWS, making it suitable for millimeter-wave BWO applications.
IEEE TRANSACTIONS ON ELECTRON DEVICES
(2023)
Review
Gastroenterology & Hepatology
Nipuni D. Nagahawatte, Leo K. Cheng, Recep Avci, Timothy R. Angeli-Gordon, Niranchan Paskaranandavadivel
Summary: Small intestine pacing has therapeutic potential in treating disorders such as short bowel syndrome and obesity. This systematic review proposes standardized protocols to maximize research outcomes and aims to translate research findings to human clinical validation.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Article
Gastroenterology & Hepatology
William Xu, Cameron I. Wells, Matthew McGuinness, Chris Varghese, Celia Keane, Chen Liu, Gregory O'Grady, Ian P. Bissett, Christopher Harmston
Summary: This study examined the readmission rates after colorectal cancer surgery in New Zealand and identified the risk factors and clinical reasons for unplanned readmissions. The rates of readmission were high and did not significantly improve over time, mainly due to comorbidities, advanced disease, and postoperative complications.
COLORECTAL DISEASE
(2023)
Article
Gastroenterology & Hepatology
Nipuni D. Nagahawatte, Recep Avci, Niranchan Paskaranandavadivel, Timothy R. Angeli-Gordon, Leo K. Cheng
Summary: The study presents a high-resolution framework for simultaneous pacing and response mapping of the small intestine. A novel surface-contact electrode array was developed and applied in vivo on pigs, achieving successful pacing and mapping of the pacing response. The study identified effective pacing parameters for slow-wave entrainment in the jejunum and showed no tissue damage from the pacing.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2023)
Article
Biology
Nipuni D. Nagahawatte, Niranchan Paskaranandavadivel, Laura R. Bear, Recep Avci, Leo K. Cheng
Summary: Electroceuticals offer clinical solutions for various disorders and a new signal processing framework has been developed to isolate and suppress stimulation artifacts in bio-electrical recordings. The autoregression method showed superior artifact removal in experimental recordings compared to linear interpolation and weighted mean approaches.
COMPUTERS IN BIOLOGY AND MEDICINE
(2023)
Article
Engineering, Biomedical
Chad E. Drake, Leo K. Cheng, Niranchan Paskaranandavadivel, Saeed Alighaleh, Timothy R. Angeli-Gordon, Peng Du, Leonard A. Bradshaw, Recep Avci
Summary: Bioelectric slow waves regulate gastrointestinal motility, and disordered activity is linked to motility disorders. A method for reconstructing 3D stomach geometry from coil localization was developed and validated using anatomically realistic models and in-vivo pig studies. The proposed method could enable investigation of novel analysis techniques.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2023)
Article
Surgery
Brodie P. Elliott, Ian Bissett, Christopher Harmston, STRATA Collaborative
Summary: This study investigates the impact of prehospital factors on the severity of pediatric appendicitis in New Zealand. The study found that prehospital delay and differential access to healthcare resources are associated with increased severity of pediatric appendicitis. Specifically, complications were more common in rural areas and among minority children, and were directly related to prehospital delay.
ANZ JOURNAL OF SURGERY
(2023)
Article
Gastroenterology & Hepatology
Chris Varghese, Xavier Harvey, Armen A. Gharibans, Peng Du, Rowan Collinson, Ian P. Bissett, Cathy M. Stinear, Greg O'Grady, Niranchan Paskaranandavadivel
Summary: By developing a high-density electromyography (HD-EMG) probe in conjunction with trans-sacral magnetic stimulation (TSMS), we have created a novel diagnostic tool for assessing anorectal function. The spatiotemporal evaluation of magnetically stimulated motor-evoked potentials correlated well with symptoms, offering a feasible, safe, and patient-tolerable method for evaluating pudendal nerve and external anal sphincter function.
COLORECTAL DISEASE
(2023)
Article
Gastroenterology & Hepatology
Leanora Gomes, Chris Varghese, Rowan J. Collinson, Julian L. Hayes, Bryan R. Parry, David Milne, Ian P. Bissett
Summary: This study analyzed the impact of defecating proctogram (DP) on treatment decision-making for pelvic floor disorders. The results showed that the addition of DP improved agreement among clinicians and increased confidence in treatment decisions. Intra-anal rectal prolapse was identified as a significant factor in treatment decision-making.
COLORECTAL DISEASE
(2023)
Article
Biology
Chad E. Drake, Leo K. Cheng, Nicole D. Muszynski, Suseela Somarajan, Niranchan Paskaranandavadivel, Timothy R. Angeli-Gordon, Peng Du, Leonard A. Bradshaw, Recep Avci
Summary: This article introduces a novel method for measuring gastric motility using bioelectric slow waves and biomagnetic slow waves. The feasibility of the method was verified by conducting experiments on two anesthetized pigs, which showed that the method enables quantitative spatial co-registration of gastric activity and analysis based on anatomical structures.
COMPUTERS IN BIOLOGY AND MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Ashton Matthee, Zahra Aghababaie, Sam Simmonds, Jarrah M. Dowrick, Linley A. Nisbet, Gregory B. Sands, Timothy R. Angeli-Gordon
Summary: Power-controlled, irrigated radio-frequency ablation is effective in creating larger and deeper lesions on the serosal surface of the stomach at reduced temperatures compared to temperature-controlled ablation.
DIGESTIVE DISEASES AND SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Jarrah M. Dowrick, Lisa Jungbauer Nikolas, Sarah J. Offutt, Peter Tremain, Jonathan C. Erickson, Timothy R. Angeli-Gordon
Summary: Existing cardiac monitors may provide an efficient solution for long-term monitoring of gastric slow waves. A study was carried out using an existing implantable cardiac monitor (Reveal LINQ) placed next to a validated extracellular electrical recording device (FPC array) on the serosal surface of a pig stomach. The recorded signals from these devices were compared and found to have comparable periods and signal-to-noise ratios.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)