Bridging the genotype-phenotype gap: what does it take?

Multiscale Modeling and Data Integration in the Virtual Physiological Rat Project

(2012) Daniel A. Beard et al.   ANNALS OF BIOMEDICAL ENGINEERING

Multiscale Systems Analysis of Root Growth and Development: Modeling Beyond the Network and Cellular Scales

(2012) Leah R. Band et al.   PLANT CELL

Parameters in Dynamic Models of Complex Traits are Containers of Missing Heritability

(2012) Yunpeng Wang et al.   PLoS Computational Biology

A theory of biological relativity: no privileged level of causation

(2011) D. Noble   Interface Focus

Epistasis in a Model of Molecular Signal Transduction

(2011) Alain Pumir et al.   PLoS Computational Biology

Beyond Missing Heritability: Prediction of Complex Traits

(2011) Robert Makowsky et al.   PLoS Genetics

Modeling formalisms in Systems Biology

(2011) Daniel Machado et al.   AMB Express

A mathematical model of the murine ventricular myocyte: a data-driven biophysically based approach applied to mice overexpressing the canine NCX isoform

(2010) L. Li et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

A Survey on Methods for Modeling and Analyzing Integrated Biological Networks

(2010) N Tenazinha et al.   IEEE-ACM Transactions on Computational Biology and Bioinformatics

Dissecting spatio-temporal protein networks driving human heart development and related disorders

(2010) Kasper Lage et al.   Molecular Systems Biology

A computational model of teeth and the developmental origins of morphological variation

(2010) Isaac Salazar-Ciudad et al.   NATURE

Hundreds of variants clustered in genomic loci and biological pathways affect human height

(2010) Hana Lango Allen et al.   NATURE

Estimation of effect size distribution from genome-wide association studies and implications for future discoveries

(2010) Ju-Hyun Park et al.   NATURE GENETICS

Phenomics: the next challenge

(2010) David Houle et al.   NATURE REVIEWS GENETICS

Missing heritability and strategies for finding the underlying causes of complex disease

(2010) Evan E. Eichler et al.   NATURE REVIEWS GENETICS

Genotype-phenotype mapping and the end of the 'genes as blueprint' metaphor

(2010) M. Pigliucci   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Allele Interaction – Single Locus Genetics Meets Regulatory Biology

(2010) Arne B. Gjuvsland et al.   PLoS One

Cardiac cell modelling: Observations from the heart of the cardiac physiome project

(2010) Martin Fink et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

A unique micromechanocalorimeter for simultaneous measurement of heat rate and force production of cardiac trabeculae carneae

(2009) June-Chiew Han et al.   JOURNAL OF APPLIED PHYSIOLOGY

Finding the missing heritability of complex diseases

(2009) Teri A. Manolio et al.   NATURE

Stochastic modelling for quantitative description of heterogeneous biological systems

(2009) Darren J. Wilkinson   NATURE REVIEWS GENETICS

Computational analysis of flowering in pea (Pisum sativum)

(2009) Bénédicte Wenden et al.   NEW PHYTOLOGIST

A multiscale model linking ion-channel molecular dynamics and electrostatics to the cardiac action potential

(2009) J. R. Silva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epistasis in a quantitative trait captured by a molecular model of transcription factor interactions

(2009) Jason Gertz et al.   THEORETICAL POPULATION BIOLOGY

When Parameters in Dynamic Models Become Phenotypes: A Case Study on Flesh Pigmentation in the Chinook Salmon ( Oncorhynchus tshawytscha )

(2008) Hannah Rajasingh et al.   GENETICS

Personal genomes: The case of the missing heritability

(2008) Brendan Maher   NATURE