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Biochemistry & Molecular Biology
Rostislav A. Sokolov, Irina V. Mukhina
Summary: Calcium is a crucial intracellular messenger in the brain that regulates various cell processes. In this study, the researchers used a fluorescent probe to investigate spontaneous Ca2+ events (SCEs) in neurons during culture maturation. They found that SCEs exhibited three different amplitude distributions and were dependent on extracellular Ca2+, neuronal network activity, and specific receptors and channels.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2022)
Article
Biochemistry & Molecular Biology
Denis P. Laryushkin, Sergei A. Maiorov, Valery P. Zinchenko, Valentina N. Mal'tseva, Sergei G. Gaidin, Artem M. Kosenkov
Summary: This study investigates the role of ionotropic glutamate receptors (iGluRs) in the generation of paroxysmal depolarization shift (PDS) and the dependence of PDS pattern on neuronal membrane potential. The results show that external stimuli play a crucial role in PDS induction. AMPA receptors are necessary for PDS generation, while NMDA and kainate receptors modulate paroxysmal activity. Agonists of G(i)-coupled receptors suppress PDS generation, suggesting a potential approach for epilepsy pharmacotherapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Jenni Harvey
Summary: It has been well established that leptin plays a crucial role in controlling energy homeostasis by signaling to specific hypothalamic nuclei. However, recent studies have revealed that leptin also acts on hippocampal synapses and significantly impacts cognitive processes, particularly hippocampal-dependent learning and memory.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ahmed Eltokhi, Miguel A. Gonzalez-Lozano, Lars-Lennart Oettl, Andrey Rozov, Claudia Pitzer, Ralph Roth, Simone Berkel, Markus Huser, Aliona Harten, Wolfgang Kelsch, August B. Smit, Gudrun A. Rappold, Rolf Sprengel
Summary: Research shows that mutations in SHANK2 have a significant impact on social behavior, indicating that pre- and postsynaptic SHANK2 actions cooperate for normal neuronal function, and an imbalance between these functions may lead to different neuropsychiatric disorders.
MOLECULAR PSYCHIATRY
(2021)
Article
Neurosciences
Charlotte Gustorff, Till Scheuer, Thomas Schmitz, Christoph Buehrer, Stefanie Endesfelder
Summary: GABA and its receptors play important roles in brain development during fetal and postnatal stages. Inhibitors of GABA receptors affect neurogenesis in newborn rats, with GABA(B) receptor blockade decreasing the expression of transcription factors and neurotrophins. Overall, GABAergic signaling, particularly through the GABA(B) receptor, is crucial for hippocampal neurogenesis during rapid brain growth and postnatal brain development.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Neurosciences
Alexandra Dolgetta, Megan Johnson, Kate Fruitman, Luke Siegel, Yan Zhou, Bruce S. McEwen, Mary Jeanne Kreek, Teresa A. Milner
Summary: Glutamate receptors play a key role in opioid addiction. This study investigates the impact of sex and chronic immobilization stress (CIS) on the redistribution of GluN1 and GluA1 in the hippocampal cells of rats following oxycodone conditioned place preference (CPP). The findings suggest that changes in GluN1 and GluA1 distribution may contribute to increased sensitivity to glutamate excitation and reduced capacity to acquire Oxy CPP in males subjected to CIS.
NEUROBIOLOGY OF STRESS
(2022)
Article
Biochemistry & Molecular Biology
Jessica Marie Perez, Stefano Berto, Kelly Gleason, Subroto Ghose, Chunfeng Tan, Tae-Kyung Kim, Genevieve Konopka, Carol A. Tamminga
Summary: The study demonstrates unique molecular changes in hippocampal subfields of individuals with schizophrenia, suggesting different biological functions in each subfield which may help identify potential hippocampal-based therapeutic targets for schizophrenia.
MOLECULAR PSYCHIATRY
(2021)
Article
Clinical Neurology
Jianhui Jin, Ruirui Wang, Qing Lin
Summary: The study revealed that GluN2B subunits in immature neurons play a significant role in compensatory increases in NMDAR-mediated currents after Ketamine exposure. This indicates that the neonatal brain is particularly vulnerable to the neurotoxic effects of Ketamine.
JOURNAL OF PAIN RESEARCH
(2021)
Article
Multidisciplinary Sciences
Donald J. Joseph, Markus Von Deimling, Yuiko Hasegawa, Ana G. Cristancho, Rebecca C. Ahrens-Nicklas, Stephanie L. Rogers, Rashmi Risbud, Almedia J. McCoy, Eric D. Marsh
Summary: The transcription factor Aristaless-related X-linked gene (Arx) plays a key role in early onset epileptic encephalopathies and early brain development. Postnatal Arx expression in parvalbumin interneurons controls neural circuits, and dysfunction in these roles alone may cause network abnormalities similar to EOEE.
Article
Behavioral Sciences
Irena Smaga, Kinga Gawlinska, Dawid Gawlinski, Paulina Surowka, Malgorzata Filip
Summary: Maternal high-fat diet during pregnancy and lactation disrupts short-term memory in adolescent and young adult females, likely due to dysregulation of glutamatergic system in the hippocampus. Changes in glutamatergic transporters and NMDA receptor subunits, AMPA receptor subunits, as well as BDNF levels may contribute to the behavioral changes observed in offspring.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Neurosciences
Kenichi Miyazaki, William N. Ross
Summary: Accurate assessment of postsynaptic currents in dendritic spines is crucial for understanding synaptic signaling. In this study, new experimental techniques were used to measure spine parameters, revealing that synaptically activated Na+ currents are mainly through AMPA receptors, while Ca2+ changes are primarily due to NMDA receptor activation following Mg2+ block relief.
Article
Cell Biology
Luca Franchini, Jennifer Stanic, Marta Barzasi, Elisa Zianni, Daniela Mauceri, Monica Diluca, Fabrizio Gardoni
Summary: This study demonstrates a key role for Rph3A in the modulation of structural synaptic plasticity at hippocampal synapses, which correlates with its interactions with both NMDARs and AMPARs.
Article
Neurosciences
Carla Alvarez-Ferradas, Mario Wellmann, Koyam Morales, Marco Fuenzalida, Waldo Cerpa, Nibaldo C. Inestrosa, Christian Bonansco
Summary: The activation of the Wnt-5a pathway can convert silent synapses into functional synapses, enhancing the transmission of glutamatergic synapses. This has significant implications for brain circuit development and plasticity.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Xian-Dong Liu, Peng-Hui Ai, Xiao-Na Zhu, Yuan-Bo Pan, Michael M. Halford, Mark Henkemeyer, Dong-Fu Feng, Tian-Le Xu, Suya Sun, Nan-Jie Xu
Summary: The research identifies a specific PDZ scaffold protein, Lnx1, expressed in the hippocampal CA3 region that is critical for initial social behavior. Deficiency of Lnx1 leads to neuronal activity disorders and social memory impairments, along with cognitive defects, in mice. It is found that Lnx1 deletion causes NMDA receptor hypofunction, disrupting the Lnx1-NMDAR-EphB2 complex and affecting synaptic function and social memory.
MOLECULAR PSYCHIATRY
(2021)
Review
Neurosciences
Juliana E. Shaw, Anthony J. Koleske
Summary: Synapses are enriched in the cytoskeletal protein actin, which plays a crucial role in determining synaptic shape, organizing neurotransmitter release machinery, and supporting the activity of neurotransmitter receptors and ion channels. Actin binding proteins serve as molecular linkages between the actin cytoskeleton and various receptors, contributing to the regulation of receptor trafficking and localization at the synapse. Recent advancements in imaging techniques are expected to aid in further understanding the molecular mechanisms by which actin regulates NMDARs.
JOURNAL OF PHYSIOLOGY-LONDON
(2021)
Article
Biochemistry & Molecular Biology
B. Oettinghaus, J. M. Schulz, L. M. Restelli, M. Licci, C. Savoia, A. Schmidt, K. Schmitt, A. Grimm, L. More, J. Hench, M. Tolnay, A. Eckert, P. D'Adamo, P. Franken, N. Ishihara, K. Mihara, J. Bischofberger, L. Scorrano, S. Frank
CELL DEATH AND DIFFERENTIATION
(2016)
Article
Neurosciences
Sebastien Sultan, Liyi Li, Jonathan Moss, Francesco Petrelli, Frederic Casse, Elias Gebara, Jan Lopatar, Frank W. Pfrieger, Paola Bezzi, Josef Bischofberger, Nicolas Toni
Article
Neurosciences
Stefanie Heigele, Sebastien Sultan, Nicolas Toni, Josef Bischofberger
NATURE NEUROSCIENCE
(2016)
Article
Multidisciplinary Sciences
Yoko Iijima, Katharina Behr, Takatoshi Iijima, Barbara Biemans, Josef Bischofberger, Peter Scheiffele
SCIENTIFIC REPORTS
(2016)
Article
Cell Biology
Veronica Costa, Stefan Aigner, Mirko Vukcevic, Evelyn Sauter, Katharina Behr, Martin Ebeling, Tom Dunkley, Arno Friedlein, Sannah Zoffmann, Claas A. Meyer, Frederic Knoflach, Sebastian Lugert, Christoph Patsch, Fatiha Fjeldskaar, Laurie Chicha-Gaudimier, Anna Kiialainen, Paolo Piraino, Marc Bedoucha, Martin Graf, Sebastian Jessberger, Anirvan Ghosh, Josef Bischofberger, Ravi Jagasia
Article
Biology
Liyi Li, Sebastien Sultan, Stefanie Heigele, Charlotte Schmidt-Salzmann, Nicolas Toni, Josef Bischofberger
Article
Neurosciences
Claus Normann, Sibylle Frase, Verena Haug, Gregor von Wolff, Kristin Clark, Patrick Muenzer, Alexandra Dorner, Jonas Scholliers, Max Horn, Tanja Vo Van, Gabriel Seifert, Tsvetan Serchov, Knut Biber, Christoph Nissen, Norbert Klugbauer, Josef Bischofberger
BIOLOGICAL PSYCHIATRY
(2018)
Article
Developmental Biology
Claudio Giachino, Michael Barz, Jan S. Tchorz, Mercedes Tome, Martin Gassmann, Josef Bischofberger, Bernhard Bettler, Verdon Taylor
Article
Neurosciences
Joerg Pohle, Josef Bischofberger
JOURNAL OF PHYSIOLOGY-LONDON
(2014)
Article
Multidisciplinary Sciences
Inga Herpfer, Henning Hezel, Wilfried Reichardt, Kristin Clark, Julia Geiger, Claus M. Gross, Andrea Heyer, Valentin Neagu, Harsharan Bhatia, Hasan C. Atas, Bernd L. Fiebich, Josef Bischofberger, Carola A. Haas, Klaus Lieb, Claus Normann
Article
Neurosciences
Guilherme Lepski, Cinthia E. Jannes, Guido Nikkhah, Josef Bischofberger
FRONTIERS IN CELLULAR NEUROSCIENCE
(2013)
Article
Multidisciplinary Sciences
Jan M. Schulz, Frederic Knoflach, Maria-Clemencia Hernandez, Josef Bischofberger
NATURE COMMUNICATIONS
(2018)
Article
Multidisciplinary Sciences
Stefania Fedele, Ginetta Collo, Katharina Behr, Josef Bischofberger, Stephan Mueller, Tilo Kunath, Klaus Christensen, Anna Lisa Guendner, Martin Graf, Ravi Jagasia, Verdon Taylor
SCIENTIFIC REPORTS
(2017)
Article
Neurosciences
Jan M. Schulz, Frederic Knoflach, Maria-Clemencia Hernandez, Josef Bischofberger
JOURNAL OF NEUROSCIENCE
(2019)