The Mother of All Battles 20 years on: is LTP expressed pre- or postsynaptically?

The early 1990s saw an intense debate over the locus of expression of NMDA receptor-dependent LTP. This provided an impetus for intense research into the mechanisms of modulation and trafficking of glutamate receptors and presynaptic vesicles. As new forms of LTP are discovered at different synapses, a simple resolution of the pre- versus postsynaptic debate seems increasingly remote.