Review
Biochemistry & Molecular Biology
Jian-Xiu Shang, Xiaoying Li, Chuanling Li, Liqun Zhao
Summary: Gas nitric oxide plays a crucial role in plants, especially in alleviating salt stress effects by interacting with signaling molecules and plant hormones, thus enhancing plant salt tolerance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Kevin O'Gallagher, Ryan E. Rosentreter, Jan Elaine Soriano, Ali Roomi, Saqib Saleem, Tyler Lam, Roman Roy, Grant R. Gordon, Satish R. Raj, Philip J. Chowienczyk, Ajay M. Shah, Aaron A. Phillips
Summary: This study investigates the effects of nNOS inhibition on neurovascular coupling (NVC) in humans. It found that nNOS plays a role in dynamic cerebral blood flow control in healthy adults, particularly the rapidity of the NVC response to visual stimulation.
CIRCULATION RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Amir Asgari, Paul Jurasz
Summary: Megakaryocytes are important members of the hematopoietic system, responsible for regulating vascular homeostasis through platelets. The process of megakaryopoiesis generates mature megakaryocytes which release proplatelets into blood vessels. Nitric oxide (NO) plays a modulatory role in hematopoiesis and hemostasis. This review summarizes the effect of NO and its signaling on megakaryopoiesis and thrombopoiesis under physiological and pathophysiological conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Elena Grossini, Divya Garhwal, Sakthipriyan Venkatesan, Daniela Ferrante, Angelica Mele, Massimo Saraceno, Ada Scognamiglio, Jessica Mandrioli, Amedeo Amedei, Fabiola De Marchi, Letizia Mazzini
Summary: This study analyzed the plasma redox system and nitric oxide levels in ALS patients and investigated the effects of plasma on mitochondrial function in endothelial vascular cells and astrocytes. The results showed that oxidative stress and neurovascular unit changes play a central role in ALS, and unknown plasma factors may be involved in the disease pathogenesis.
Article
Clinical Neurology
Jason P. Appleton, Saoirse E. O'Sullivan, Amanda Hedstrom, Jane A. May, Richard Donnelly, Nikola Sprigg, Philip M. Bath, Timothy J. England
Summary: Remote ischaemic per-conditioning reduced SAP and TNF-alpha levels from pre- to post-intervention. Increases in plasma levels of SAP were associated with worse clinical outcomes after ischaemic stroke.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Review
Neurosciences
Samantha Schaeffer, Costantino Iadecola
Summary: Schaeffer and Iadecola reviewed the heterogeneity of the neurovasculature and discussed the limitations of the neurovascular unit concept and the molecular diversity of cerebrovascular cells. They proposed the concept of a 'neurovascular complex' composed of segmentally diverse functional modules that implement coordinated vascular responses to central and peripheral signals.
NATURE NEUROSCIENCE
(2021)
Article
Environmental Sciences
M. Iqbal R. Khan, Badar Jahan, Mohamed F. AlAjmi, Md Tabish Rehman, Noushina Iqbal, Mohammad Irfan, Zebus Sehar, Nafees A. Khan
Summary: Under arsenic stress, the use of salicylic acid can promote photosynthesis and growth of plants by improving plant defense systems and reducing oxidative stress.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Review
Biochemistry & Molecular Biology
Jinghua Chen, Lulu Liu, Weiwei Wang, Haichun Gao
Summary: This article discusses the important role of nitric oxide in the microbe-driven nitrogen biogeochemical cycle, as well as its significance in medicine and the biological sciences. The article explores the importance of nitric oxide in early energy generation and its effects on various biological processes within bacterial physiology.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Maria Rosaria Melis, Antonio Argiolas
Summary: Nitric oxide plays a crucial role in the central nervous system, regulating erectile function and sexual behavior by interacting with neurotransmitters. It acts not only in specific areas of the hypothalamus, but also in extrahypothalamic brain regions, contributing to a neural circuit controlling both consummatory and appetitive components of sexual behavior through interplay with various neurotransmitters.
Article
Veterinary Sciences
Nicole Verhaar, Nicole de Buhr, Maren von Koeckritz-Blickwede, Marion Hewicker-Trautwein, Christiane Pfarrer, Gemma Mazzuoli-Weber, Henri Schulte, Sabine Kaestner
Summary: The study found a reduced apoptotic cell count in the group subjected to Ischaemic postconditioning (IPoC), but none of the other tested variables were significantly affected by IPoC. The clinical relevance and possible protective mechanism of IPoC in equine intestinal ischaemia remain unclear, highlighting the need for further research on its mechanism of action and effects in clinical cases of strangulating colic.
BMC VETERINARY RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Adjanie Patabendige, Ayesha Singh, Stuart Jenkins, Jon Sen, Ruoli Chen
Summary: Ischaemic stroke can cause damage to the neurovasculature, leading to long-term motor and cognitive deficits. Current neuroprotective therapies are lacking, with many studies focusing on neurons and neglecting the important roles of other cells in the neurovascular unit, such as astrocytes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Thomas P. Buters, Pieter Hameeteman, Iris M. E. Jansen, Floris C. van Hindevoort, Wouter ten Voorde, Hendrika W. Grievink, Mascha Schoonakker, Marieke L. de Kam, Derek W. Gilroy, Gary Feiss, Robert Rissmann, Manon A. A. Jansen, Jacobus Burggraaf, Matthijs Moerland
Summary: In this study, the inhibitory effects of oral and topical corticosteroid treatment on intradermal lipopolysaccharide (LPS) responses were evaluated. The results showed that corticosteroids significantly suppressed the clinical inflammatory response and reduced the secretion of inflammatory mediators. This experimental model is effective in evaluating the effects of anti-inflammatory drugs.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Cell Biology
Giuseppe Gagliano, Anita Monteverdi, Stefano Casali, Umberto Laforenza, Claudia A. M. Gandini Wheeler-Kingshott, Egidio D'Angelo, Lisa Mapelli
Summary: This study investigates the relationship between neurovascular coupling (NVC) and neuronal activity (NA) using acute mouse cerebellar slices. The findings suggest that NVC involves a balance between the NMDAR-NO pathway and the mGluRs-20HETE pathway, with the latter playing a role at intermediate frequencies. This has important implications for interpreting fMRI signals.
Review
Physiology
T. C. Stevenson Keller, Christophe Lechauve, Alexander S. Keller, Steven Brooks, Mitchell J. Weiss, Linda Columbus, Hans Ackerman, Miriam M. Cortese-Krott, Brant E. Isakson
Summary: Globin proteins exist in various cell types of the vasculature and have the ability to interact with molecular oxygen and nitric oxide. They play important roles in regulating vascular contraction, tissue perfusion, and vascular reactivity. Understanding the impact of globin proteins on vascular physiology is of great significance for further research on their functions.
PHYSIOLOGICAL REVIEWS
(2022)
Article
Engineering, Electrical & Electronic
Ye Chen, Bingyan Yang, Yuqing Liu, Lixin Xu, Zhongfang Shi, Yixiao Liu, Ruoyu Han, Fang Yuan, Jiting Ouyang, Xu Yan, Kostya (Ken) Ostrikov
Summary: This study found that treatment with atmospheric pressure plasma jet (APPJ) could improve neurological function, enhance blood flow, reduce brain infarction, and decrease brain cell apoptosis in a rat model of ischemic stroke (IS). These findings provide a novel potential strategy for IS treatment using atmospheric pressure plasma inhalation.
Article
Biochemistry & Molecular Biology
Prashant Donthamsetti, Eduardo F. Gallo, David C. Buck, Edward L. Stahl, Ying Zhu, J. Robert Lane, Laura M. Bohn, Kim A. Neve, Christoph Kellendonk, Jonathan A. Javitch
MOLECULAR PSYCHIATRY
(2020)
Review
Medicine, Research & Experimental
Costantino Iadecolar, Marion S. Buckwalter, Josef Anrather
JOURNAL OF CLINICAL INVESTIGATION
(2020)
Editorial Material
Neurosciences
Costantino Iadecola
NATURE NEUROSCIENCE
(2020)
Article
Immunology
David Brea, Carrie Poon, Corinne Benakis, Gabrielle Lubitz, Michelle Murphy, Costantino Iadecola, Josef Anrather
Summary: This study showed that stroke increased immune cell trafficking from the small intestine to peripheral lymphoid organs and the central nervous system, especially at 3 days after stroke. These immune cells may contribute to post-stroke inflammation.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Immunology
Lidia Garcia-Bonilla, Rose Sciortino, Ziasmin Shahanoor, Gianfranco Racchumi, Mathangi Janakiraman, Joan Montaner, Ping Zhou, Josef Anrather, Costantino Iadecola
Summary: The study shows that CD36 is involved in the acute inflammatory response to cerebral ischemia through multiple mechanisms, modulating the production of inflammasomes and IL-1 beta in microglia and endothelial cells, respectively. This highlights CD36 in microglia and endothelium as critical components in the pathogenesis of ischemic brain injury, offering new insights into the understanding of the underlying mechanisms and potential therapeutic targets.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Review
Biochemistry & Molecular Biology
Eleanor H. Simpson, Eduardo F. Gallo, Peter D. Balsam, Jonathan A. Javitch, Christoph Kellendonk
Summary: Research suggests that the etiology of schizophrenia involves overstimulation of dopamine receptors, particularly the D2 receptors. Animal models have shown that alterations in D2 receptor levels can affect the manifestation of schizophrenia symptoms, especially in terms of striatal circuit function and motivated behavior.
MOLECULAR PSYCHIATRY
(2022)
Review
Neurosciences
Samantha Schaeffer, Costantino Iadecola
Summary: Schaeffer and Iadecola reviewed the heterogeneity of the neurovasculature and discussed the limitations of the neurovascular unit concept and the molecular diversity of cerebrovascular cells. They proposed the concept of a 'neurovascular complex' composed of segmentally diverse functional modules that implement coordinated vascular responses to central and peripheral signals.
NATURE NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Eduardo F. Gallo, Julia Greenwald, Jenna Yeisley, Eric Teboul, Kelly M. Martyniuk, Joseph M. Villarin, Yulong Li, Jonathan A. Javitch, Peter D. Balsam, Christoph Kellendonk
Summary: Cholinergic interneurons in the striatum respond to salient stimuli with a pause in activity, which is regulated by dopamine D2 receptors. Upregulation of D2Rs in these neurons leads to a prolonged pause in activity and an enhanced decrease in acetylcholine levels during behavior, resulting in a deficit in learning inhibitory responses. This study highlights the important role of CIN D2Rs in modulating responses to salient stimuli and their impact on inhibitory learning.
MOLECULAR PSYCHIATRY
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Costantino Iadecola, Marc Fisher, Ralph L. Sacco
CIRCULATION RESEARCH
(2022)
Article
Clinical Neurology
Sarah C. Parauda, Cenai Zhang, Setareh Salehi Omran, Andrew D. Schweitzer, Santosh B. Murthy, Alexander E. Merkler, Babak B. Navi, Costantino Iadecola, Hooman Kamel, Neal S. Parikh
Summary: Patients with posterior reversible encephalopathy syndrome (PRES) have an elevated risk of stroke compared to patients with renal colic, but a lower risk compared to patients with transient ischemic attack (TIA). Additionally, PRES is associated with hemorrhagic stroke.
Review
Peripheral Vascular Disease
Monica M. Santisteban, Costantino Iadecola, Daniela Carnevale
Summary: Hypertension is a significant risk factor for vascular cognitive impairment and late-life dementia. It induces various harmful effects on cerebral vasculature and can disrupt blood-brain barrier integrity, leading to cognitive impairment.
Review
Radiology, Nuclear Medicine & Medical Imaging
Nivedita Agarwal, Laura D. Lewis, Lydiane Hirschler, Leonardo Rivera Rivera, Shinji Naganawa, Swati Rane Levendovszky, Geir Ringstad, Marijan Klarica, Joanna Wardlaw, Costantino Iadecola, Cheryl Hawkes, Roxana Octavia Carare, Jack Wells, Erik N. T. P. Bakker, Vartan Kurtcuoglu, Lynne Bilston, Maiken Nedergaard, Yuki Mori, Marcus Stoodley, Noam Alperin, Mony de Leon, Matthias J. P. van Osch
Summary: Neurofluids refer to all fluids in the brain and spine, including blood, cerebrospinal fluid, and interstitial fluid. Neuroscientists have identified various fluid environments that interact harmoniously to support optimal brain function. Animal studies have been crucial in understanding the dynamics of neurofluids, while human studies are limited due to the lack of noninvasive imaging techniques. The future development of noninvasive MRI techniques holds promise in imaging neurofluid dynamics and identifying pathological processes.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Clinical Neurology
Jens Witsch, David Roh, Stephanie Oh, Costantino Iadecola, Ramon Diaz-Arrastia, Scott E. Kasner, Stephan A. Mayer, Santosh B. Murthy
Summary: Neutrophil-mediated inflammation exacerbates intracerebral hemorrhage (ICH) outcomes. This study aimed to investigate the association between serum levels of sICAM-1 and poor outcomes after ICH. After adjustment, sICAM-1 was found to be associated with mortality, poor outcome, and hematoma expansion.
Letter
Cardiac & Cardiovascular Systems
Luisa Rubinelli, Lidia Garcia-Bonilla, Linda Sasset, Anna Cantalupo, Benjamin Goya, James E. Ip, Josef Anrather, Costantino Iadecola, Giuseppe Faraco, Annarita Di Lorenzo
CIRCULATION RESEARCH
(2023)
Article
Clinical Neurology
Marialaura Simonetto, Kevin N. Sheth, Wendy C. Ziai, Costantino Iadecola, Cenai Zhang, Santosh B. Murthy
Summary: Non-Hispanic Black and Hispanic patients with intracerebral hemorrhage (ICH) have a higher risk of ischemic stroke compared with non-Hispanic White patients.