Article
Endocrinology & Metabolism
Fangfang Di, Danfeng Gao, Lihua Yao, Runjie Zhang, Jin Qiu, Liwen Song
Summary: Polycystic ovary syndrome (PCOS) often coexists with a metabolic disorder, and dysfunction of adipose tissue, especially abdominal adipose tissue, can worsen reproductive and metabolic problems in PCOS patients. The study used LC-MS/MS to analyze adipose samples from PCOS patients, and identified PCOS biomarkers engaged in inflammatory diseases and mitochondrial beta-oxidation. In vitro experiments showed that isoleucine could ameliorate the effects of hyperandrogenism on granulosa cells and related metabolic disorders. GC-MS/MS analysis revealed significantly decreased levels of isoleucine in PCOS patients. The findings suggest that metabolome alterations could be a novel therapeutic target for PCOS treatment.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Claire Falzarano, Taylor Lofton, Adjoa Osei-Ntansah, Trinitee Oliver, Taylor Southward, Salim Stewart, Stanley Andrisse
Summary: Recent research has shown a high prevalence of nonalcoholic fatty liver disease (NAFLD) in women with polycystic ovary syndrome (PCOS). Women with normal weight can also develop NAFLD. The majority of studies focus on adult, premenopausal women and little attention has been given to young and adolescent women with NAFLD. Future research should include more diverse populations and study the contribution of excess androgens and insulin resistance to NAFLD risk in women with PCOS of varying weights, ages, and ethnicities.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Biology
Angelo Ascani, Sara Torstensson, Sanjiv Risal, Haojiang Lu, Gustaw Eriksson, Congru Li, Sabrina Teschl, Joana Menezes, Katalin Sandor, Claes Ohlsson, Camilla I. Svensson, Mikael C. I. Karlsson, Martin Helmut Stradner, Barbara Obermayer-Pietsch, Elisabet Stener-Victorin
Summary: This study found that variations in B cell numbers are associated with polycystic ovary syndrome (PCOS), but B cells are not central mediators of PCOS pathology. Hyperandrogenic women with PCOS have increased frequencies of specific types of B cells and higher levels of circulating immunoglobulin M (IgM), but transferring their serum to mice only leads to weight gain. Further experiments demonstrated that co-treatment with an androgen receptor antagonist can prevent PCOS-like phenotypes and alterations of B cell frequencies induced by dihydrotestosterone (DHT) in wild-type mice. B cell-deficient mice exposed to DHT still develop PCOS-like phenotypes.
Article
Endocrinology & Metabolism
Iris Lee, Julia Vresilovic, Maryam Irfan, Robert Gallop, Anuja Dokras
Summary: The study found that there is a difference in the risk of metabolic syndrome in women with polycystic ovary syndrome between Black and White women, with Black women having a higher incidence rate. In addition to early cardiometabolic screening at the time of diagnosis, this population also requires ongoing and frequent screening.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Haiyan Yang, Jie Lin, He Li, Zhangwei Liu, Xia Chen, Qianqian Chen
Summary: The study revealed that infertile women with PCOS have lower serum PRL levels within the normal range, which are associated with a higher incidence of insulin resistance and beta-cell dysfunction. Additionally, serum PRL levels were positively correlated with HDL-C and negatively correlated with various anthropometric parameters, sex hormones, fasting lipids, and hepatic biological parameters. Multiple linear regression analysis showed that LH, LH/FSH, E-2, FINS, HOMA-IR, and HOMA-beta were negatively associated with serum PRL after adjusting for age and BMI.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Izabela Chudzicka-Strugala, Anna Kubiak, Beata Banaszewska, Barbara Zwozdziak, Martyna Siakowska, Leszek Pawelczyk, Antoni J. Duleba
Summary: The study demonstrated that in women with PCOS, lifestyle modifications combined with synbiotic supplementation can significantly decrease body weight, waist circumference, hip circumference, and thigh circumference, as well as lead to a significant reduction in serum testosterone levels.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Izabela Chudzicka-Strugala, Anna Kubiak, Beata Banaszewska, Barbara Zwozdziak, Martyna Siakowska, Leszek Pawelczyk, Antoni J. Duleba
Summary: The study found that synbiotic supplementation can enhance the effects of lifestyle modifications on weight and testosterone levels in patients with PCOS, leading to significant improvements.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Review
Biochemistry & Molecular Biology
Nathalie di Clemente, Chrystele Racine, Rodolfo A. Rey
Summary: This article reviews the main findings on anti-Mullerian hormone (AMH) and its involvement in the pathogenesis of polycystic ovary syndrome (PCOS) and its male equivalent. AMH has important roles in ovarian reserve, follicular development, and the differentiation of the genital tract. It is also used to assess Sertoli cell function in children and has potential implications for male fertility.
Article
Cell Biology
Pernille B. Udesen, Anja E. Sorensen, Rikke Svendsen, Nanna L. S. Frisk, Anne L. Hess, Mubeena Aziz, Marie Louise M. Wissing, Anne Lis M. Englund, Louise T. Dalgaard
Summary: In a 6-year follow-up study, it was found that the levels of certain miRNAs in women with PCOS changed, indicating a shift towards a less hyperandrogenic profile. These findings contribute to our understanding of PCOS and provide potential biomarkers for future research.
Article
Obstetrics & Gynecology
Xiao Jiang, Jingyu Li, Bingqian Zhang, Jingmei Hu, Jinlong Ma, Linlin Cui, Zi-Jiang Chen
Summary: This study investigated the different expression profiles of plasma exosomal miRNAs in PCOS patients and controls, and their potential roles in PCOS pathogenesis. Through sequencing and analysis, differentially expressed miRNAs were identified, which may contribute to the understanding of PCOS pathophysiology. The expression of certain miRNAs correlated with clinical features of PCOS and could help distinguish PCOS patients from controls.
FERTILITY AND STERILITY
(2021)
Article
Nutrition & Dietetics
Anna Bizon, Sylwia Placzkowska, Justyna Niepsuj, Marta Czwojdzinska, Marcin Lesniewski, Artur Nowak, Dagmara Pluta, Pawel Madej, Agnieszka Piwowar, Grzegorz Franik
Summary: This study found that women with Polycystic Ovary Syndrome (PCOS) did not show significant differences in body composition parameters compared to those without PCOS, but they had higher hormone concentrations, with sex hormone binding globulin and free testosterone correlating with all investigated body composition parameters only in the PCOS group. Additionally, logistic regression identified that the concentration of Anti-Mullerian hormones and body mass index could be useful parameters in differentiating women with PCOS from those with other disorders.ROC analysis further confirmed the concentration of Anti-Mullerian hormones as a powerful parameter for categorizing women as suffering from PCOS.
Article
Endocrinology & Metabolism
Ali Abbara, Maria Phylactou, Pei Chia Eng, Sophie A. Clarke, Toan D. Pham, Tuong M. Ho, Kah Yan Ng, Edouard G. Mills, Kate Purugganan, Tia Hunjan, Rehan Salim, Alexander N. Comninos, Lan N. Vuong, Waljit S. Dhillo
Summary: This study compared the endocrine response to triptorelin in women with different reproductive conditions. It found that women with PCOS had a lesser increase in FSH levels compared to healthy women and HA women after triptorelin administration. Additionally, women with polycystic ovaries had lower FSH levels after triptorelin, both with and without ovarian stimulation.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Biochemistry & Molecular Biology
Alexandra E. Butler, Abu Saleh Md Moin, Thozhukat Sathyapalan, Stephen L. Atkin
Summary: In this study, the complement system in polycystic ovary syndrome (PCOS) was comprehensively evaluated. The results showed an upregulation of complement system components, which was offset by the concurrent upregulation of its inhibitors. These changes were partially explained by BMI, hyperandrogenemia, and insulin resistance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Siyu Wang, Liangshan Mu, Chunmei Zhang, Xiaoyu Long, Yurong Zhang, Rong Li, Yue Zhao, Jie Qiao
Summary: This study found that the tryptophan-kynurenine pathway was abnormally activated in patients with polycystic ovary syndrome (PCOS).
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Alexandra E. Butler, Abu Saleh Md Moin, Zeljko Reiner, Thozhukat Sathyapalan, Tannaz Jamialahmadi, Amirhossein Sahebkar, Stephen L. Atkin
Summary: Proteomic analysis was conducted to investigate the mechanism of dyslipidemia in women with polycystic ovary syndrome (PCOS), and whether it is related to obesity and insulin resistance (IR) or intrinsic to PCOS. The analysis revealed altered levels of certain proteins associated with lipid metabolism in PCOS women, suggesting increased cardiovascular risk even in the absence of obesity and IR.
FRONTIERS IN ENDOCRINOLOGY
(2023)