Article
Multidisciplinary Sciences
Asako Noguchi, Roman Huszar, Shota Morikawa, Gyorgy Buzsaki, Yuji Ikegaya
Summary: The activation of inhibitory neurons prior to hippocampal sharp-wave ripples regulates the order of spikes, which is crucial for memory storage.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Balint Kiraly, Andor Domonkos, Marta Jelitai, Vitor Lopes-dos-Santos, Sergio Martinez-Bellver, Barnabas Kocsis, Daniel Schlingloff, Abhilasha Joshi, Minas Salib, Richard Fiath, Peter Bartho, Istvan Ulbert, Tamas F. Freund, Tim J. Viney, David Dupret, Viktor Varga, Balazs Hangya
Summary: The medial septum orchestrates hippocampal network activity at multiple temporal scales likely mediating memory encoding and retrieval.
NATURE COMMUNICATIONS
(2023)
Article
Neurosciences
Barna Dudok, Miklos Szoboszlay, Anirban Paul, Peter M. Klein, Zhenrui Liao, Ernie Hwaun, Gergely G. Szabo, Tristan Geiller, Bert Vancura, Bor-Shuen Wang, Sam McKenzie, Jesslyn Homidan, Lianne M. F. Klaver, Daniel F. English, Z. Josh Huang, Gyorgy Buzsaki, Attila Losonczy, Ivan Soltesz
Summary: The research discovered that the axon initial segment of hippocampal pyramidal cells is under GABAergic control by chandelieror axo-axonic cells (AACs). It was found that AACs in mice are synchronously activated during episodes of locomotion or whisking, and intervention experiments showed that AACs inhibit CA1 pyramidal cells.
Article
Cell Biology
Anna R. Chambers, Christoffer Nerland Berge, Koen Vervaeke
Summary: The hippocampus conveys memory-related neural patterns during high-frequency oscillations called sharp-wave ripples (SWRs). The study found that before SWRs, there is a decrease in superficial inhibition and thalamocortical input in the retrosplenial cortex (RSC). This may aid in communication between the hippocampus and neocortex and promote the strengthening of memory-related connections.
Article
Biochemistry & Molecular Biology
Laurel Watkins de Jong, Mohammadreza Mohagheghi Nejad, Euisik Yoon, Sen Cheng, Kamran Diba
Summary: Recurrent connectivity and feedback inhibition from inhibitory neurons play crucial roles in determining the dynamics and computational properties of neuronal circuits. Through optogenetic manipulations and large-scale unit recordings, paradoxical responses were observed in both CA1 and CA3 regions of the hippocampus, where subsets of cells increased firing during photoinhibition while others decreased firing during photoexcitation. These paradoxical responses were more prominent in CA3 and simulations confirmed that both CA1 and CA3 hippocampal regions exhibit inhibition-stabilized networks with strong recurrent excitation.
Article
Immunology
Jiangong Wang, Bin Liu, Fengjiao Sun, Yong Xu, Haiyun Luan, Meizi Yang, Chaoyun Wang, Tiantian Zhang, Zhenyu Zhou, Haijing Yan
Summary: This study found that inhibition of H3R reduced microglia activity and promoted a shift from pro-inflammatory M1 phenotype to anti-inflammatory M2 phenotype in microglia, thereby attenuating lipopolysaccharide-induced neuroinflammation in mice. Additionally, inhibition of H3R rescued the impairments of neurogenesis and cognitive function caused by neuroinflammation. Mechanistically, the neuroprotective effects of H3R inhibition were mediated by histamine-dependent activation of H2R and reinforcement of CREB-CBP interaction, which led to increased release of anti-inflammatory cytokines and brain-derived neurotrophic factor, as well as decreased release of pro-inflammatory cytokines.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Biochemical Research Methods
Alina A. Studenova, Arno Villringer, Vadim V. Nikulin
Summary: Ongoing oscillations and evoked responses in neuronal activity may be closely related, with non-zero mean neuronal oscillations potentially contributing to the generation of evoked responses. This mechanism was validated using computational modeling and analysis of EEG data. Empirical EEG recordings also supported the presence of non-zero mean oscillations. These findings have important implications for inferring changes in evoked responses related to cognitive conditions, age, or neuropathologies.
PLOS COMPUTATIONAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Xuansheng Xiao, Xiaotong Wang, Ke Zhu, Lijuan Li, Ying He, Jinglan Zhang, Linying Li, Hanning Hu, Yanqiu Cui, Jianliang Zhang, Yan Zheng
Summary: BACE1 is a key enzyme involved in the production of β-amyloid, and is considered a major drug target for Alzheimer's disease. However, BACE1 inhibitors have failed in clinical trials, and may actually worsen cognitive function, suggesting that BACE1 may play a role in regulating cognition-relevant neural circuits.
MOLECULAR PSYCHIATRY
(2023)
Review
Neurosciences
Hugo Balleza-Tapia, Luis Enrique Arroyo-Garcia, Arturo G. Isla, Raul Loera-Valencia, Andre Fisahn
Summary: Gamma oscillations in the hippocampal area CA3 are crucial for memory function. Recent studies have found that pyramidal cells (PCs) in CA3 are organized into different functional subpopulations, which play important roles in cognition-related network dynamics.
PROGRESS IN NEUROBIOLOGY
(2022)
Article
Neurosciences
Ron Refaeli, Adi Doron, Aviya Benmelech-Chovav, Maya Groysman, Tirzah Kreisel, Yonatan Loewenstein, Inbal Goshen
Summary: The study utilized CLARITY technology to conduct large-scale detection of 3D astrocytic domains, revealing different distributions of neuronal content in CA1 and BLA astrocytic domains. SST neurons were found to be located in close proximity to neighboring astrocytes, relative to PV and VIP neurons.
Article
Cell Biology
Niccolo P. Pampaloni, Irene Riva, Anna L. Carbone, Andrew J. R. Plested
Summary: The study shows that in addition to the previously known fast-acting AMPA receptors, slow AMPA receptors with prolonged activity are also expressed in the hippocampal CA1 region. These slow AMPA receptors may play a significant role in synaptic transmission, short-term potentiation, and triggering of action potentials.
Article
Biology
Lingjun Ding, Giuseppe Balsamo, Hongbiao Chen, Eduardo Blanco-Hernandez, Ioannis S. Zouridis, Robert Naumann, Patricia Preston-Ferrer, Andrea Burgalossi
Summary: Neural circuits are composed of diverse neuronal cell types, and this diversity plays a crucial role in brain function during natural behavior. In this study, the combination of juxtacellular recording, labeling, and optogenetics enabled the investigation of molecularly defined cell classes in freely moving mice, revealing the weaker spatial modulation and information transmission of Calbindin-positive CA1 pyramidal cells.
Article
Multidisciplinary Sciences
Laura Green, David Tingley, John Rinzel, Gyorgy Buzsaki
Summary: This study investigates the role of action in the neuronal organization of the hippocampus through a behavioral experiment of training rats to jump a gap. The results indicate that jumping induces consistent electrophysiological patterns in the hippocampus, while the theta spike phase versus animal position relationship remains unchanged.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Multidisciplinary Sciences
Jordan S. Farrell, Matthew Lovett-Barron, Peter M. Klein, Fraser T. Sparks, Tilo Gschwind, Anna L. Ortiz, Biafra Ahanonu, Susanna Bradbury, Satoshi Terada, Mikko Oijala, Ernie Hwaun, Barna Dudok, Gergely Szabo, Mark J. Schnitzer, Karl Deisseroth, Attila Losoncz, Ivan Soltesz
Summary: Research has identified neurons in the supramammillary nucleus (SuM) that are highly correlated with future locomotor speed and reliably drive locomotion. Specifically, Tac1-expressing neurons in the SuM were found to control the activity of speed-modulated hippocampal neurons. These findings suggest that the SuM not only regulates basic locomotor activity but also selectively shapes hippocampal neural activity in a way that may support spatial navigation.
Article
Pharmacology & Pharmacy
Ying Zhang, Hai-Yan Yin, Patrizia Rubini, Peter Illes, Yong Tang
Summary: There is a dispute about whether CNS neurons possess ATP-sensitive P2X7 receptors. By genetically deleting P2X7 receptors in astrocytes and oligodendrocytes, it was found that these receptors indirectly modulate the neuronal input to neighboring neurons.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Neurosciences
Richard Andersson, Dagmar Galter, Daniela Papadia, Andre Fisahn
Article
Psychiatry
Thomas Demuyser, Lauren Deneyer, Eduard Bentea, Giulia Albertini, Teresa Femenia, Laura Walrave, Hideyo Sato, Niels C. Danbolt, Dimitri De Bundel, Alex Michotte, Maria Lindskog, Ann Massie, Ilse Smolders
WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY
(2019)
Review
Clinical Neurology
Johan Soderlund, Maria Lindskog
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
(2018)
Article
Neurosciences
Evgeny E. Akkuratov, Linda Westin, Erika Vazquez-Juarez, Minttu de Marothy, Aleksandra K. Melnikova, Hans Blom, Maria Lindskog, Hjalmar Brismar, Anita Aperia
MOLECULAR NEUROBIOLOGY
(2020)
Article
Cell & Tissue Engineering
Chenhong Lin, Cinzia Calzarossa, Teresa Fernandez-Zafra, Jia Liu, Xiaofei Li, Asa Ekblad-Nordberg, Erika Vazquez-Juarez, Simone Codeluppi, Lena Holmberg, Maria Lindskog, Per Uhlen, Elisabet Akesson
STEM CELL RESEARCH & THERAPY
(2020)
Article
Cell Biology
Ipsit Srivastava, Erika Vazquez-Juarez, Lukas Henning, Marta Gomez-Galan, Maria Lindskog
Correction
Cell & Tissue Engineering
Chenhong Lin, Cinzia Calzarossa, Teresa Fernandez-Zafra, Jia Liu, Xiaofei Li, Asa Ekblad-Nordberg, Erika Vazquez-Juarez, Simone Codeluppi, Lena Holmberg, Maria Lindskog, Per Uhlen, Elisabet Akesson
STEM CELL RESEARCH & THERAPY
(2020)
Review
Biochemistry & Molecular Biology
Dasiel O. Borroto-Escuela, Patrizia Ambrogini, Barbara Chruscicka, Maria Lindskog, Minerva Crespo-Ramirez, Juan C. Hernandez-Mondragon, Miguel Perez de la Mora, Harriet Schellekens, Kjell Fuxe
Summary: Communication through serotonin mainly occurs in the extracellular space and cerebrospinal fluid, with disturbances in receptor-receptor interactions potentially contributing to major depression. Oxytocin receptors play a significant role in modulating social and cognitive behaviors, and their dysfunction may lead to psychiatric diseases like depression. Targeting 5-HTR heterocomplexes could be a novel approach for treating major depression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Raul Loera-Valencia, Erika Vazquez-Juarez, Alberto Munoz, Gorka Gerenu, Marta Gomez-Galan, Maria Lindskog, Javier DeFelipe, Angel Cedazo-Minguez, Paula Merino-Serrais
Summary: Elevated levels of 27-hydroxycholesterol (27-OH) enhance long-term potentiation (LTP) in Schaffer collateral-CA1 synapses and lead to abnormally large dendritic spines in the stratum radiatum. Cyp27Tg mice show a significantly higher density of synaptopodin-positive puncta in CA1. High 27-OH levels may alter synaptic potentiation and disrupt fine-tuned processing of information in hippocampal circuits, potentially causing cognitive impairment.
SCIENTIFIC REPORTS
(2021)
Article
Cell Biology
Marta Dahlstrom, Nather Madjid, Gunnar Nordvall, Magnus M. Halldin, Erika Vazquez-Juarez, Maria Lindskog, Johan Sandin, Bengt Winblad, Maria Eriksdotter, Pontus Forsell
Summary: The research team has identified a novel mechanism to modulate the activity of Trk receptors, and demonstrated that ACD855 and ACD856 act as cognitive enhancers in various behavioral models, showing significant effects on 18-month-old mice and potentially having implications for the treatment of Alzheimer's disease and other cognitive impairment diseases.
Article
Biochemistry & Molecular Biology
Sofia Ygberg, Evgeny E. Akkuratov, Rebecca J. Howard, Fulya Taylan, Daniel C. Jans, Dhani R. Mahato, Adriana Katz, Paula F. Kinoshita, Benjamin Portal, Inger Nennesmo, Maria Lindskog, Steven J. D. Karlish, Magnus Andersson, Anna Lindstrand, Hjalmar Brismar, Anita Aperia
Summary: The Trp931Arg mutation of the Na+,K+-ATPase catalytic alpha 1 subunit described in this study led to reduced membrane expression of the mutant protein, loss of ion pumping activity, and formation of water-filled pores in the plasma membrane. This resulted in depolarization of neurons, a lowered threshold for epileptic seizures, and destabilization of the ion-binding sites. These findings suggest that Na+,K+-ATPase plays a significant role in diseases associated with epilepsy and loss of plasma membrane integrity.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Neurosciences
Giacomo Dentoni, Luana Naia, Benjamin Portal, Nuno Santos Leal, Per Nilsson, Maria Lindskog, Maria Ankarcrona
Summary: This study characterizes mature primary cortical neurons derived from homozygous App(NL-F) embryos and identifies early mitochondrial alterations in this model. The results show that App(NL-F) neurons display overexpression of A beta, abnormal mitochondrial functions, and increased mitochondrial-ER contacts.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Immunology
Evangelos Konstantinidis, Benjamin Portal, Tobias Mothes, Chiara Beretta, Maria Lindskog, Anna Erlandsson
Summary: This study reveals that astrocytes in Alzheimer's disease (AD) are not only associated with the pathology but also play a crucial role in maintaining brain homeostasis and synaptic function. The accumulation of aggregated amyloid-beta (A beta) in astrocytes affects their interaction with neurons, leading to synaptic dysfunction and neuronal apoptosis. These findings are important for understanding the involvement of astrocytes in AD-related synaptic dysfunction.
JOURNAL OF NEUROINFLAMMATION
(2023)
Article
Immunology
Marlena Zysk, Chiara Beretta, Luana Naia, Abdulkhalek Dakhel, Linnea Pavenius, Hjalmar Brismar, Maria Lindskog, Maria Ankarcrona, Anna Erlandsson
Summary: This study investigates the effect of amyloid-beta (A beta) on astrocyte mitochondria functionality and overall energy metabolism. The results demonstrate that A beta leads to abnormal fusion and excessive fission of astrocyte mitochondria, as well as mitochondrial swelling and increased phosphorylated DRP-1 levels. These changes result in altered energy metabolism.
JOURNAL OF NEUROINFLAMMATION
(2023)
Article
Neurosciences
Ipsit Srivastava, Erika Vazquez-Juarez, Maria Lindskog
FRONTIERS IN SYNAPTIC NEUROSCIENCE
(2020)