Article
Multidisciplinary Sciences
Takeshi Ogawa, Jun Koike, Yuka Hirano
Summary: The study found that wearing a cloth face mask increased respiratory muscle effort, decreased ventilatory volume, and slightly reduced exercise tolerance. However, there was no significant impact on peak oxygen uptake.
SCIENTIFIC REPORTS
(2022)
Article
Sport Sciences
Andre L. Teixeira, Ayesha Gangat, Julian C. C. Bommarito, Jamie F. F. Burr, Philip J. J. Millar
Summary: Ischemic preconditioning has a sex-specific effect on functional sympatholysis, which may contribute to the beneficial effects of ischemic preconditioning on exercise performance in humans.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2023)
Article
Medicine, General & Internal
Karsten Keller, Katharina Hartung, Luis del Castillo Carillo, Julia Treiber, Florian Stock, Chantal Schroeder, Florian Hugenschmidt, Birgit Friedmann-Bette
Summary: The definition of exaggerated blood pressure response (EBPR) during exercise testing is not well defined, and there are differing blood pressure thresholds recommended in various guidelines. This study found that the prevalence of EBPR varied depending on the guidelines used, with the highest prevalence using the European Society of Cardiology (ESC) guidelines and the lowest prevalence using the American College of Sports Medicine (ACSM) guidelines. In adult athletes, only the American Heart Association (AHA) guidelines and the systolic blood pressure/MET slope method were predictive of left ventricular hypertrophy (LVH), independent of age and sex.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Nutrition & Dietetics
Adriano E. Lima-Silva, Gislaine Cristina-Souza, Marcos D. Silva-Cavalcante, Romulo Bertuzzi, David J. Bishop
Summary: Caffeine is widely consumed as an ergogenic aid for exercise performance, with its stimulatory effect on the central nervous system being a key mechanism. However, caffeine may also have direct effects on other physiological systems like the pulmonary, cardiovascular, and muscular systems during high-intensity whole-body exercise. Understanding these multiple effects of caffeine could potentially expand its use in different sporting contexts and aid in the treatment of certain diseases.
Review
Orthopedics
Ryan J. Wortman, Symone M. Brown, Ian Savage-Elliott, Zachary J. Finley, Mary K. Mulcahey
Summary: The study indicates that blood flow restriction (BFR) training can improve strength, muscle size, and markers of sports performance in healthy athletes. Combining traditional resistance training with BFR may help athletes maximize athletic performance and maintain good health. Further research is needed to determine the optimal occlusive pressure for maximizing training improvements.
AMERICAN JOURNAL OF SPORTS MEDICINE
(2021)
Article
Multidisciplinary Sciences
Jessica D. Cavalcanti, Guilherme Augusto F. Fregonezi, Antonio J. Sarmento, Thiago Bezerra, Lucien P. Gualdi, Francesca Pennati, Andrea Aliverti, Vanessa R. Resqueti
Summary: Increased work of breathing during exercise can lead to greater activation and fatigue of respiratory muscles, as well as lower limb muscle dysfunctions in individuals with obstructive respiratory diseases. This study assessed the electrical activity and fatigue of respiratory and locomotor muscles during the Incremental Shuttle Walking Test (ISWT) in individuals with obstructive respiratory diseases compared to healthy individuals.
Article
Neurosciences
Rebecca L. Scalzo, Irene E. Schauer, Deirdre Rafferty, Leslie A. Knaub, Nina Kvaratskhelia, Taro Kaelix Johnson, Gregory B. Pott, Layla A. Abushamat, Mary O. Whipple, Amy G. Huebschmann, Melanie Cree-Green, Jane E. B. Reusch, Judith G. Regensteiner
Summary: The study showed that single-leg exercise training can improve impaired skeletal muscle oxidative flux in people with type 2 diabetes, leading to increased skeletal muscle vasculature and oxygen delivery efficiency. This type of training is effective in improving cardiorespiratory fitness in individuals with type 2 diabetes.
JOURNAL OF PHYSIOLOGY-LONDON
(2022)
Article
Physiology
Thomas Losnegard, Sondre Skarli, Joar Hansen, Stian Roterud, Ida S. Svendsen, Bent R. Ronnestad, Goran Paulsen
Summary: The study found a strong relationship between RPE and heart rate, oxygen uptake, and blood lactate concentrations, with exercise mode and sex affecting RPE, particularly at lower exercise intensities. Women showed slightly higher %HR and %VO2 than men at the same RPE level.
INTERNATIONAL JOURNAL OF SPORTS PHYSIOLOGY AND PERFORMANCE
(2021)
Article
Multidisciplinary Sciences
Robert Trybulski, Marta Bichowska, Rafal Piwowar, Anna Pisz, Michal Krzysztofik, Aleksandra Filip-Stachnik, Krzysztof Fostiak, Piotr Makar, Michal Wilk
Summary: The study aimed to evaluate the effects of ischemia on maximal number of repetitions, time under tension, and bar velocity during bench press exercise. The results showed that ischemia significantly decreased the time under tension. Therefore, exercising with ischemia does not enhance strength-endurance performance and bar velocity.
Article
Respiratory System
Hiroki Nishine, Takehiko Hiramoto, Hiroshi Handa, Takeo Inoue, Keiko Wakahara, Hideo Saka, Teruomi Miyazawa, Masamichi Mineshita
Summary: Physiological assessment of extensive airway obstruction using point-by-point P-lat measurement can identify the location of maximal obstruction and guide the need for additional procedures in real time.
Article
Neurosciences
Frederic Stucky, Barbara Uva, Bengt Kayser, Andrea Aliverti
Summary: During submaximal exercise, external expiratory flow limitation (EFLe) can amplify the respiratory pump mechanism and result in blood pooling in the trunk.
JOURNAL OF PHYSIOLOGY-LONDON
(2023)
Article
Respiratory System
Sophie E. Collins, Devin B. Phillips, Andrew R. Brotto, Zahrah H. Rampuri, Michael K. Stickland
Summary: During submaximal exercise, minute ventilation (V'(E)) increases in proportion to metabolic rate, and the ratio V'(E)/V'(CO2) is used as a useful tool to evaluate exercise responses in healthy individuals and patients with chronic disease. Some chronic respiratory and cardiovascular conditions show abnormal ventilatory responses to exercise, which may be due to mechanical ventilatory constraint.
EUROPEAN RESPIRATORY REVIEW
(2021)
Article
Cardiac & Cardiovascular Systems
Masashi Ichinose, Mikie Nakabayashi, Yumie Ono
Summary: This study demonstrates that single muscle contractions induce rapid, intensity-dependent hyperemia within the contracted skeletal muscle microvasculature in humans, showing different characteristics compared to responses in the upstream conduit artery. Through the use of diffuse correlation spectroscopy and Doppler ultrasound, the magnitude and time course of the contraction-induced rapid hyperemia and vasodilatory responses within skeletal muscle microvessels significantly differ from those in the conduit artery.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Article
Clinical Neurology
Orna Gera, Efrat Shavit-Stein, Taly Amichai, Vera Nikitin, Merav Ben David, Lior Greenbaum, Joab Chapman, Amir Dori
Summary: Post-exercise intramuscular blood flow is reduced in patients with polyneuropathy due to Charcot-Marie-Tooth disease type 1 (CMT1), and this reduction is present in both impaired distal and minimally affected proximal muscles, correlating with muscle strength, disease severity, and age.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Physiology
Gary Marshall Long, Ashley D. Troutman, Derrick A. Gray, Amanda J. Fisher, Tim Lahm, Andrew R. Coggan, Mary Beth Brown
Summary: A study in a rat model of pulmonary arterial hypertension has shown that skeletal muscle blood flow is significantly reduced during exercise, which may be due to reduced exercise intensity in patients with pulmonary arterial hypertension. This adds further evidence of peripheral muscle dysfunction and exercise intolerance in PAH.
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
(2022)
Article
Respiratory System
Tian Jiang, Rudi Samapati, Sergej Klassen, Disi Lei, Lasti Erfinanda, Vera Jankowski, Szandor Simmons, Jun Yin, Christoph Arenz, Alexander Dietrich, Thomas Gudermann, Dieter Adam, Michael Schaefer, Joachim Jankowski, Veit Flockerzi, Rolf Nuesing, Stefan Uhlig, Wolfgang M. Kuebler
Summary: The study found that EP3 receptor activation triggers pulmonary edema through Gi-dependent activation of PLC and subsequent SrcFK-dependent tyrosine phosphorylation of TRPC6. In PAF-induced lung edema, this TRPC6 activation coincides with ASMase-dependent caveolar recruitment of TRPC6, resulting in rapid endothelial Ca2+ influx and barrier failure.
EUROPEAN RESPIRATORY JOURNAL
(2022)
Article
Biotechnology & Applied Microbiology
Emanuel Wyler, Julia M. Adler, Kathrin Eschke, G. Teixeira Alves, Stefan Peidli, Fabian Pott, Julia Kazmierski, Laura Michalick, Olivia Kershaw, Judith Bushe, Sandro Andreotti, Peter Pennitz, Azza Abdelgawad, Dylan Postmus, Christine Goffinet, Jakob Kreye, S. Momsen Reincke, Harald Pruess, Nils Bluethgen, Achim D. Gruber, Wolfgang M. Kuebler, Martin Witzenrath, Markus Landthaler, Geraldine Nouailles, Jakob Trimpert
Summary: This study investigated the effects of dexamethasone and anti-SARS-CoV-2 antibodies on COVID-19 treatment. Dexamethasone exhibited strong anti-inflammatory properties and prevented severe disease outbreaks. Anti-SARS-CoV-2 antibody treatment reduced pulmonary viral burden. Combination therapy showed additive benefits in both antiviral and anti-inflammatory effects.
Editorial Material
Physiology
Shama Ahmad, Sadis Matalon, Wolfgang M. Kuebler
PHYSIOLOGICAL REVIEWS
(2022)
Article
Critical Care Medicine
Ye Fan, An -Mei Zhang, Xian-Li Wu, Zan-Sheng Huang, Konstantina Kontogianni, Kai Sun, Wan -Lei Fu, Na Wu, Wolfgang M. Kuebler, Felix J. F. Herth
Summary: The study evaluated the safety and value of combining transbronchial mediastinal cryobiopsy with standard EBUS-TBNA for diagnosing mediastinal diseases. Results showed that this combined approach significantly increased the overall diagnostic yield for mediastinal lesions, particularly in benign disorders.
LANCET RESPIRATORY MEDICINE
(2023)
Article
Critical Care Medicine
Matthias Felten, Sebastian Ferencik, Luiz-Gustavo Teixeira Alves, Eleftheria Letsiou, Jasmin Lienau, Holger C. Mueller-Redetzky, Alina Katharina Langenhagen, Anne Voss, Kristina Dietert, Olivia Kershaw, Achim D. Gruber, Laura Michalick, Wolfgang M. Kuebler, Bharath Ananthasubramaniam, Bert Maier, Henriette Uhlenhaut, Achim Kramer, Martin Witzenrath
Summary: This study investigated the role of the core clock component BMAL1 in myeloid cells in modulating the severity of ventilator-induced lung injury (VILI). The results showed that inflammatory response and lung barrier dysfunction during mechanical ventilation exhibit diurnal variations regulated by the circadian clock. Mice without BMAL1 are less susceptible to VILI and do not show circadian variation in severity.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Review
Physiology
Wolfgang M. Kuebler, Nishaka William, Martin Post, Jason P. Acker, Mark J. Mcvey
Summary: Respiratory transfusion reactions, especially transfusion-related acute lung injury (TRALI), have significant morbidity and mortality. Current methods of diagnosing and treating TRALI are limited. EVs play a role in mediating TRALI by acting as triggers for the first and/ or second hit. Further research is needed to explore EVs as therapeutic targets and biomarkers for TRALI diagnosis.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Moritz Hertel, Saskia Preissner, Bjorn O. Gohike, Wolfgang M. Kuebler, Gema Hernandez, Mehmet Akyuz, Robert Preissner
Summary: This study analyzed the difference in ventilation procedures and hospitalization risk between patients with pulmonary hypertension (PH) who used dipyrone and those who did not. The results showed that patients who used dipyrone had significantly lower risks of ventilation and hospitalization. These findings are important for patients with PH and may encourage further research.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Peripheral Vascular Disease
Rui Zhang, Ji Zhang, Yun-Long Zhang, Su-Gang Gong, Qin-Hua Zhao, Xiao-Juan Wang, Jia-Yu Zhao, Rong Jiang, Hong-Ling Qiu, Hui-Ting Li, Jing He, Shao-Fei Liu, Wolfgang M. Kuebler, Lan Wang
Summary: This study provides a reference atlas of neutrophils in patients with IPAH and identifies MMP9 as a potential biomarker for prognosis.
Article
Cell Biology
Richa Tambi, Binte Zehra, Sharon Nandkishore, Shermin Sharafat, Faiza Kader, Nasna Nassir, Nesrin Mohamed, Awab Ahmed, Reem Abdel Hameid, Samah Alasrawi, Martina Brueckner, Wolfgang M. Kuebler, Wendy K. Chung, Alawi Alsheikh-Ali, Roberto M. Di Donato, Mohammed Uddin, Bakhrom K. Berdiev
Summary: This study conducted a comprehensive meta-analysis to identify the most frequently mutated genes in congenital heart disease (CHD) and revealed the heterogeneity of CHD genes. It also identified cardiomyocytes and endocardial cells as major cell types related to CHD.
PHYSIOLOGICAL GENOMICS
(2023)
Article
Multidisciplinary Sciences
Mariya M. Kucherenko, Pengchao Sang, Juquan Yao, Tara Gransar, Saphala Dhital, Jana Grune, Szandor Simmons, Laura Michalick, Dag Wulsten, Mario Thiele, Orr Shomroni, Felix Hennig, Ruhi Yeter, Natalia Solowjowa, Gabriela Salinas, Georg N. Duda, Volkmar Falk, Naren R. Vyavahare, Wolfgang M. Kuebler, Christoph Knosalla
Summary: Pulmonary hypertension worsens prognosis in left heart disease. Increased stiffness of the pulmonary artery may contribute to this by causing right ventricular dysfunction and lung vascular remodeling. Targeting extracellular matrix remodeling may be a therapeutic approach for pulmonary hypertension in left heart disease.
NATURE COMMUNICATIONS
(2023)
Article
Cardiac & Cardiovascular Systems
Niklas Hegemann, Willem Bintig, Paul-Lennard Perret, Judith Rees, Alessandra Viperino, Britta Eickholt, Wolfgang M. M. Kuebler, Michael Hoepfner, Bianca Nitzsche, Jana Grune
Summary: Preclinical cardiovascular research heavily relies on non-invasive echocardiography in mice and rats to assess cardiac function and morphology. This study tested the feasibility of using an in-ovo system of incubated chicken eggs interfaced with small animal echocardiography as an alternative tool for cardiovascular research. Detailed standard operating procedures and reference values were provided, demonstrating the sensitivity of in-ovo echocardiography.
BASIC RESEARCH IN CARDIOLOGY
(2023)
Letter
Biochemistry & Molecular Biology
Dwi Cahyo Budi Setiawan, Szandor Simmons, Laura Michalick, Wolfgang M. Kuebler
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Philipp Georg, Rosario Astaburuaga-Garcia, Lorenzo Bonaguro, Sophia Brumhard, Laura Michalick, Lena J. Lippert, Tomislav Kostevc, Christiane Gaebel, Maria Schneider, Mathias Streitz, Vadim Demichev, Ioanna Gemuend, Matthias Barone, Pinkus Tober-Lau, Elisa T. Helbig, David Hillus, Lev Petrov, Julia Stein, Hannah-Philine Dey, Daniela Paclik, Christina Iwert, Michael Muelleder, Simran Kaur Aulakh, Sonja Djudjaj, Roman D. Buelow, Henrik E. Mei, Axel R. Schulz, Andreas Thiel, Stefan Hippenstiel, Antoine-Emmanuel Saliba, Roland Eils, Irina Lehmann, Marcus A. Mall, Sebastian Stricker, Jobst Roehmel, Victor M. Corman, Dieter Beule, Emanuel Wyler, Markus Landthaler, Benedikt Obermayer, Saskia von Stillfried, Peter Boor, Munevver Demir, Hans Wesselmann, Norbert Suttorp, Alexander Uhrig, Holger Mueller-Redetzky, Jacob Nattermann, Wolfgang M. Kuebler, Christian Meisel, Markus Ralser, Joachim L. Schultze, Anna C. Aschenbrenner, Charlotte Thibeault, Florian Kurth, Leif E. Sander, Nils Bluethgen, Birgit Sawitzki
Summary: Severe COVID-19 is associated with highly activated CD16(+) T cells that exhibit cytotoxic functions and contribute to endothelial injury. These CD16(+) T cells can degranulate and induce cytotoxicity through immune-complex-mediated mechanisms independent of the T cell receptor, which is not observed in other diseases. The presence of activated CD16(+) T cells and elevated levels of complement proteins upstream of C3a are associated with a fatal outcome of COVID-19, indicating the pathological role of enhanced cytotoxicity and complement activation in the disease.
Article
Critical Care Medicine
Jan A. Graw, Philip Hildebrandt, Alexander Krannich, Felix Balzer, Claudia Spies, Roland C. Francis, Wolfgang M. Kuebler, Steffen Weber-Carstens, Mario Menk, Oliver Hunsicker
Summary: Increased plasma concentration of CFH is associated with AKI in critically ill patients with ARDS requiring VV ECMO therapy. Higher plasma haptoglobin concentrations may protect against CFH-associated AKI.
Article
Critical Care Medicine
Bhushan H. Katira, Doreen Engelberts, Sheena Bouch, Jordan Fliss, Luca Bastia, Kohei Osada, Kim A. Connelly, Marcelo B. P. Amato, Niall D. Ferguson, Wolfgang M. Kuebler, Brian P. Kavanagh, Laurent J. Brochard, Martin Post
Summary: The experiment conducted on a large animal model showed that single abrupt deflation from high positive end-expiratory pressure (PEEP) or repeated short deflations from moderate PEEP can cause pulmonary edema, impaired oxygenation, and increased pulmonary vascular resistance (PVR), consistent with previous findings in rodents. Rapid deflation may therefore be a clinically relevant cause of impaired lung function, which can be attenuated by gradual pressure release.