Review
Endocrinology & Metabolism
Jody A. Rusch, Brian T. Layden, Lara R. Dugas
Summary: Cognitive function in humans relies on the complex interplay between multiple body systems, including the HPA axis. The gut microbiota, which outnumbers human cells and has a greater genetic potential, plays a crucial role through the MGB axis, a bidirectional communication pathway. Stress can affect the MGB axis through the HPA axis and other pathways, and animal research has contributed to a paradigm shift in understanding the influence of microbiota on human health and disease. Preclinical and human trials are currently investigating the applicability of these findings in humans.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Multidisciplinary Sciences
Svetlana Minakhina, Vanessa De Oliveira, Sun Young Kim, Haiyan Zheng, Fredric E. Wondisford
Summary: Fasting induces significant changes in the HPT axis, with THRB2 S101 phosphorylation playing a key role in the repression of the axis by TH and AMPK activation. CDK2 is proposed as a direct kinase phosphorylating THRB2 S101, suggesting a common mechanism for acute suppression of the HPT axis by nutritional deprivation and TH.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Endocrinology & Metabolism
Skand Shekhar, Raven McGlotten, Sunyoung Auh, Kristina Rother, Lynnette K. Nieman
Summary: The study revealed that abnormal thyroid function, likely mediated by subnormal nocturnal TSH levels, is prevalent in patients with Cushing syndrome. This abnormality can be reversed after cure.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Cell Biology
Yongjie Yang, Yanlin He, Hailan Liu, Wenjun Zhou, Chunmei Wang, Pingwen Xu, Xing Cai, Hesong Liu, Kaifan Yu, Zhou Pei, Ilirjana Hyseni, Makoto Fukuda, Qingchun Tong, Jianming Xu, Zheng Sun, Bert W. O'Malley, Yong Xu
Summary: SRC-2 in POMC neurons is a key regulator of responses to fasting, with specific deletion leading to inadequate suppression of energy expenditure, impaired counterregulation, and insufficient refeeding. These mutant mice also show enhanced satiation, discoordination of anxiety and food-seeking behavior when food becomes available.
Article
Endocrinology & Metabolism
Olivia E. Smith, Vickie Roussel, Fanny Morin, Luisina Ongaro, Xiang Zhou, Micka C. Bertucci, Daniel J. Bernard, Bruce D. Murphy
Summary: This study demonstrates the essential role of SF-1 in female reproductive function. Depletion of SF-1 leads to infertility in female mice due to the absence of ovulation. Abnormal signaling and lipid accumulation may contribute to these outcomes.
Review
Endocrinology & Metabolism
Yehan Bian, Heidi Hahn, Anja Uhmann
Summary: Hedgehog signaling plays essential roles in embryonic development, adult homeostasis, and tumorigenesis. Despite its close connection with pituitary embryonic development, the engagement of Hedgehog signaling in the pituitary gland has been underestimated. Dysfunction of this signaling pathway during pituitary development leads to gland malformation. Recent research also suggests a regulatory role of Hedgehog signaling in the adult pituitary, affecting homeostasis, hormone production, and possibly formation of neoplasms. Targeting this pathway with therapeutic strategies shows promise in treating pituitary diseases.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yael Korem Kohanim, Tomer Milo, Moriya Raz, Omer Karin, Alon Bar, Avi Mayo, Netta Mendelson Cohen, Yoel Toledano, Uri Alon
Summary: Treating thyroid disorders involves a delay in which it takes several weeks for TSH concentration to normalize after thyroid hormones return to normal. A feedback mechanism involving peripheral thyroid hormones and TSH controls the growth of the thyroid and pituitary glands, leading to this delay.
MOLECULAR SYSTEMS BIOLOGY
(2022)
Article
Endocrinology & Metabolism
Jerome M. M. Hershman, Paolo Beck-Peccoz
Summary: Many members of the American Thyroid Association have made significant contributions to the understanding of the hypothalamic-pituitary-thyroid axis. This axis is crucial for maintaining normal levels of circulating thyroid hormones and thyroid gland function. Thyrotropin, a pituitary glycoprotein hormone, regulates the activity of the thyroid gland. The synthesis and secretion of thyrotropin are controlled by thyrotropin-releasing hormone and the negative feedback mechanism of circulating thyroid hormones.
Article
Multidisciplinary Sciences
Amelia M. Douglass, Jon M. Resch, Joseph C. Madara, Hakan Kucukdereli, Ofer Yizhar, Abhinav Grama, Masahito Yamagata, Zongfang Yang, Bradford B. Lowell
Summary: Fasting activates the HPA axis through the inhibition of GABAergic afferents by AgRP neurons in the PVH. This study reveals the neural basis for fasting-induced HPA axis activation and provides insights into the mechanisms underlying stress-induced HPA axis activation.
Article
Oncology
Ramadevi Subramani, Adriana Estrada, Madeline Dixon, Maria Parada, Sheryl Rodriguez, Diego A. Pedroza, Matthew D. Ramirez, Alexa Clift, Lilia Garcia, Rajkumar Lakshmanaswamy
Summary: Early pregnancy reduces the lifetime risk of breast cancer by persistently altering the hypothalamic-pituitary hormonal axis, although the exact physiological mechanisms involved are not clear.
Review
Endocrinology & Metabolism
Pardis Mohammadzadeh, Gregory C. Amberg
Summary: AXL is a receptor tyrosine kinase that is commonly associated with various human cancers. It has been found to play a crucial role in neuroendocrine development and function, along with its ligand Gas6. AXL signaling, triggered by Gas6 binding, affects neuroendocrine structure and function in the brain, pituitary, and gonads. AXL has been identified as an upstream inhibitor of gonadotropin receptor hormone (GnRH) production during development and is also involved in the migration of GnRH neurons. It is implicated in reproductive diseases and spermatogenesis. The research on AXL/Gas6 signaling mechanisms provides valuable insights into neuroendocrine function in health and disease.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Fisheries
Yan-Qiu Liang, Yanjie Situ, Linchun Xie, Jialiang Huo, Zhongdian Dong, Chengyong Li, Zhong Lin
Summary: The study found that AED significantly affects the thyroid system in female zebrafish by increasing T4 levels and inhibiting the transcription of HPT axis-related genes. However, the adverse effects of AED on the thyroid system in male zebrafish were minimal, mainly affecting down-regulation of the tshb gene and up regulation of the thrb gene. Overall, AED interferes with the thyroid endocrine system in fish.
AQUACULTURE REPORTS
(2021)
Article
Biotechnology & Applied Microbiology
Xiujin Li, Bingjin Lin, Xumeng Zhang, Xu Shen, Hongjia Ouyang, Zhongping Wu, Yunbo Tian, Lingzhao Fang, Yunmao Huang
Summary: This study collected 175 high-quality RNA-seq samples from mammals and poultry to compare gene expression in the HPG axis, revealing significant differences between mammalian and avian species. Two key pathways, neuroactive ligand-receptor interaction and calcium signaling pathway, were identified to play important roles in animal reproduction.
Article
Biotechnology & Applied Microbiology
Xiujin Li, Bingjin Lin, Xumeng Zhang, Xu Shen, Hongjia Ouyang, Zhongping Wu, Yunbo Tian, Lingzhao Fang, Yunmao Huang
Summary: This study compares the gene expression in the hypothalamic-pituitary-gonad (HPG) axis between mammals and birds, revealing significant differences and identifying key pathways, such as neuroactive ligand-receptor interaction and calcium signaling pathway, that play important roles in animal reproduction.
Article
Environmental Sciences
Cuiying Liu, Jian Yang, Xiangnan Du, Xiaokun Geng
Summary: The study demonstrates that filtered air (FA) intervention can modulate the hormonal balance of the hypothalamic-pituitary-thyroid (HPT) and hypothalamic-pituitary-gonadal (HPG) axes in rats exposed to fine particulate matter (PM2.5) and attenuate the inflammatory responses in the thyroid and gonads.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Public, Environmental & Occupational Health
Patricia Novaes Soares, Rosiane Aparecida Miranda, Iala Milene Bertasso, Carla Bruna Pietrobon, Vanessa Silva Tavares Rodrigues, Elaine de Oliveira, Alex Christian Manhaes, Egberto Gaspar de Moura, Patricia Cristina Lisboa
Summary: Early weaning is associated with obesity later in life and affects feeding behavior and the dopaminergic and endocannabinoid systems in adult offspring in a sex-dependent manner.
JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE
(2022)
Article
Public, Environmental & Occupational Health
Vanessa da Silva Tavares Rodrigues, Rosiane A. Miranda, Patricia Novaes Soares, Thamara Cherem Peixoto, Elaine de Oliveira, Alex C. Manhaes, Egberto Gaspar de Moura, Patricia Cristina Lisboa
Summary: Nicotine exposure through breast milk affects the hormone status and fat depots of adult progeny, with different impacts on males and females. In this study, nicotine-exposed male rats showed increased fat mass, hypercortisolism, hyperinsulinemia, and higher vitamin D levels, whereas nicotine-exposed females had hyperglycemia and altered insulin signaling in specific fat depots.
JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Ginislene Dias Souza Miranda, Thalyne Aparecida Leite de Lima, Hercules de Oliveira Costermani, Camila Luiza Rodrigues dos Santos Ricken, Jocemara Patricia Silva de Souza Parrela, Barbara Leticia Antonio Membrive, Raul Evangelista de Almeida, Julia Cristina Facchi, Lucas Ryba de Oliveira, Rosiane Aparecida Miranda, Egberto Gaspar de Moura, Patricia Cristina Lisboa, Julio Cezar de Oliveira
Summary: This study suggests that maternal food restriction during early breastfeeding programs rat offspring to have a lean phenotype, despite hyperphagia, and increased interscapular brown adipose tissue (iBAT) uncoupled protein 1 (UCP1) and peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1α) protein expression.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Article
Public, Environmental & Occupational Health
T. Fante, L. A. P. Simino, Marina Figueiredo Fontana, Andressa Reginato, Thomaz Guadagnini Ramalheira, Hosana Gomes Rodrigues, Patricia Cristina Lisboa, Egberto Gaspar de Moura, Leticia Martins Ignacio-Souza, Marciane Milanski, Marcio Alberto Torsoni, Adriana Souza Torsoni
Summary: Offspring of obese dams are more susceptible to developing nonalcoholic fatty liver disease but are programmed to be protected from the damage promoted by a high fat diet, despite a lower impact on survival rate after surgery.
JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE
(2022)
Article
Physiology
Vanessa S. T. Rodrigues, Egberto G. Moura, Thamara C. Peixoto, Patricia N. Soares, Bruna P. Lopes, Iala M. Bertasso, Beatriz S. Silva, S. S. Cabral, G. E. G. Kluck, G. C. Atella, P. L. Trindade, J. B. Daleprane, Elaine Oliveira, Patricia Cristina Lisboa
Summary: The gut microbiota affects the host's metabolic phenotype, impacting health and disease. The gut-brain axis connects the intestine with the centers of hunger and satiety, affecting eating behavior. Overfeeding during lactation changes the gut-brain axis, leading to hyperphagia and obesity in the offspring.
PHYSIOLOGICAL REPORTS
(2022)
Review
Nutrition & Dietetics
Luana L. Souza, Egberto G. Moura, Patricia C. Lisboa
Summary: Overfeeding during lactation can negatively impact the health of the baby, increasing the risk of obesity and metabolic disorders. Using a small litter model, similar metabolic profiles have been observed in rodents, making it an efficient tool to study the adaptive mechanisms involved in obesity. Hormones, such as leptin, insulin, and adrenal hormones, as well as hypothyroidism, play a role in satiety, glucose homeostasis, adipogenesis, and energy metabolism. Other reported effects include behavioral modifications, hepatic metabolism changes, and reproductive dysfunctions. This review highlights the complex adaptive mechanisms involved in the obesity phenotype induced by early overnutrition, emphasizing the importance of proper nutritional habits during lactation.
Review
Environmental Sciences
Alana Galvao Guimaraes, Vania Lima Coutinho, Armando Meyer, Patricia Cristina Lisboa, Egberto Gaspar de Moura
Summary: This systematic review investigated the literature on patient exposure to bisphenol A (BPA) through medical-hospital devices. The PICO framework was used to guide the review process. A total of 12 articles were included in the final analysis, and the findings suggest that there is an association between the use of medical-hospital devices and patients' exposure to BPA. Further research is needed to explore the clinical outcomes of patients exposed to medical-hospital materials containing BPA.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Rosiane Aparecida Miranda, Vanessa Silva Tavares Rodrigues, Thamara Cherem Peixoto, Alex C. C. Manhaes, Egberto Gaspar de Moura, Patricia Cristina Lisboa
Summary: Early nicotine exposure affects offspring’s long-term phenotype, with breastfeeding during nicotine exposure leading to deregulation of the central and peripheral endocannabinoid system (ECS) and compromising multiple aspects of metabolism in the offspring.
JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE
(2023)
Article
Public, Environmental & Occupational Health
Juliana de Oliveira-Silva, Patricia C. Lisboa, Bruna Lotufo-Denucci, Mabel Fraga, Egberto G. de Moura, Fernanda C. Nunes, Anderson Ribeiro-Carvalho, Claudio C. Filgueiras, Yael Abreu-Villaca, Alex C. Manhaes
Summary: Neonatal undernutrition in rats leads to behavioral and hormonal changes in offspring, with effects present from an early age to adulthood. Protein restriction during lactation has complex effects on the development of anxiety-like behaviors, exploration, and memory/learning in rats. The study also reveals age-dependent variations in these parameters, as well as changes in corticosterone and catecholamine levels.
JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE
(2023)
Article
Endocrinology & Metabolism
Daiana Araujo Santana-Oliveira, Henrique Souza-Tavares, Aline Fernandes-da-Silva, Flavia Maria Silva-Veiga, Gustavo Casimiro-Lopes, Patricia Cristina Lisboa, Carlos Alberto Mandarim-de-Lacerda, Vanessa Souza-Mello
Summary: This study shows that high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) can prevent obesity by modulating gut microbiota and inflammatory signals. These exercise modalities restore body weight, improve glucose tolerance, and reduce insulin levels in high-fat-fed mice. Furthermore, they prevent gut dysbiosis and maintain the integrity of the gut barrier, leading to decreased inflammatory signals to brown adipose tissue. These findings are important for understanding the impact of exercise on obesity and metabolic health.
JOURNAL OF ENDOCRINOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Luana Lopes Souza, Camila Ludke Rossetti, Thamara Cherem Peixoto, Alex Christian Manhaes, Egberto Gaspar de Moura, Patricia Cristina Lisboa
Summary: Neonatal exposure to nicotine affects the signaling pathways involved in hepatic homeostasis of the offspring in a sex-dependent manner, leading to the development of liver steatosis only in adult male offspring. Smoking cessation during breastfeeding is crucial for reducing the risk of NAFLD development.
JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE
(2023)
Review
Endocrinology & Metabolism
Rosiane Aparecida Miranda, Beatriz Souza Silva, Egberto Gaspar de Moura, Patricia Cristina Lisboa
Summary: This article reviews epidemiological and experimental studies on the association between pesticide exposure during gestation and lactation and the programming of obesity and diabetes in offspring. The findings reveal that maternal exposure to organochlorine, organophosphate, and neonicotinoid pesticides can lead to reproductive and behavioral dysfunctions in progeny. However, there is limited research on the impact of pesticide exposure on glucose metabolism and obesity as outcomes.
Review
Endocrinology & Metabolism
Rosiane Aparecida Miranda, Egberto Gaspar de Moura, Patricia Cristina Lisboa
Summary: The article discusses the association between perinatal conditions and the risk of developing thyroid dysfunction in offspring. It highlights the impact of factors such as nutrition, hormones, and environmental contaminants on the normal maturation of the thyroid gland.
Article
Biochemistry & Molecular Biology
Jessica Ristow Branco, Amanda Moreira Esteves, Ricardo Imbroisi Filho, Thaina M. Demaria, Patricia C. Lisboa, Bruna Pereira Lopes, Egberto G. Moura, Patricia Zancan, Mauro Sola-Penna
Summary: The addition of citrate can prevent lipid deposition caused by a high-fat, high-sucrose diet and induce browning of white adipose tissues. However, the citrate-enhanced diet cannot prevent insulin resistance and may cause liver inflammation and injury.
Article
Multidisciplinary Sciences
Mendalli Froelich, Suelem A. F. Lemes, Maisa P. S. Elias, Ana Paula S. S. Oliveira, Patricia C. Lisboa, Jose Ricardo De Souza, Egberto G. Moura, Fhelipe J. S. Almeida, Mayara P. Pereira, Marcia Q. Latorraca, Nair H. Kawashita
Summary: This study found that low-protein, high-carbohydrate diet leads to overeating and fat deposition in rats, mainly by reducing leptin receptor and POMC levels in the hypothalamus. Medium-term administration of this diet or reverting to a normal diet can restore the levels of these proteins and improve body lipid distribution.
ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS
(2022)