Article
Engineering, Biomedical
Robin Rohlen, Jonathan Lundsberg, Christian Antfolk
Summary: A convolutive blind source separation (CBSS) algorithm was used to estimate spike trains of unfused tetanic signals and compared to the Haar wavelet method (HWM). The CBSS showed better performance than the HWM in simulated and experimental conditions. This suggests that CBSS can be directly used in the ultrasound-based motor unit identification pipeline, and has the potential to decompose ultrasound images into spike trains.
BIOMEDICAL ENGINEERING ONLINE
(2023)
Article
Mathematics
Dmitry Efrosinin, Natalia Stepanova
Summary: This paper investigates the optimal control problem of random degradation processes in dynamical systems with a random law of motion. It considers two degradation models and uses threshold-based control policy and Markov models for numerical calculations.
Article
Physiology
Mandy E. Parra, Jonathan D. Miller, Adam J. Sterczala, Melani R. Kelly, Trent J. Herda
Summary: This study found that electromyographic signal decomposition can be used to reliably detect intervention-related changes in neural drive. The relationships between firing rate versus recruitment threshold, as well as AP amplitude versus recruitment threshold, are reliable when recorded MU recruitment thresholds are similar across days.
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
(2021)
Article
Clinical Neurology
Somin Lee, Shasha Wu, James X. Tao, Sandra Rose, Peter C. Warnke, Naoum P. Issa, Wim van Drongelen
Summary: The purpose of this study is to investigate the relationship between hippocampal epileptiform activity and scalp signals. Analysis of paired intracranial and scalp EEG recordings from 16 patients revealed a temporal relationship between hippocampal activity and scalp signals. The study also discovered distinctive characteristics on the scalp that can differentiate activity from different brain areas.
JOURNAL OF CLINICAL NEUROPHYSIOLOGY
(2023)
Article
Engineering, Civil
Yinghong Zhao, Xiao He, Donghua Zhou, Michael G. Pecht
Summary: This paper presents a new method for real-time detection and isolation of wheelset intermittent over-creeps (WIOs), combining the variable-to-minimum difference (VMD) index and the weighted moving average (WMA) technique. Experimental results demonstrate the effectiveness of the developed method.
IEEE TRANSACTIONS ON INTELLIGENT TRANSPORTATION SYSTEMS
(2022)
Article
Physics, Fluids & Plasmas
Xiaoang Li, Shenghui Wan, Pan Jiang, Ningbo Zhang, Zhibing Li, Qiaogen Zhang
Summary: This study designed and tested a gas switch triggered by ejected plasma for a 10-kV smart distribution network. The switch achieved fast and reliable triggering at an extremely low operating coefficient. Adjusting the capillary cavity structure and pulse transformer parameters could enhance the plasma ejection, leading to improved triggering reliability and lower trigger threshold voltage.
IEEE TRANSACTIONS ON PLASMA SCIENCE
(2022)
Article
Automation & Control Systems
Yang Yang, Xue Wang, Chang Qi, Chao Deng, Liang Yu, Wenbin Yue
Summary: This paper proposes a distributed event-triggered dynamic average consensus (DAC) scheme with a time-varying threshold for a multi-agent system (MAS) in a directed graph. In this scheme, each agent is not required to monitor its neighbors in real time, and a threshold is chosen related to consensus performance directly in an MAS, where the threshold is adjusted adaptively according to average consensus performance. Stability analysis shows that the tracking error is eventually bounded and the MAS achieves DAC without Zeno behaviors. Furthermore, the proposed event-triggered DAC scheme is applied to voltage restoration and adjustable current sharing in DC microgrid. The effectiveness of the proposed scheme is verified by two examples.
ASIAN JOURNAL OF CONTROL
(2023)
Article
Clinical Neurology
Roohi Katyal, Shirin Jamal-Omidi, Takafumi Kubota, Naiara Garcia-Losarcos, Hans Luders
Summary: This study describes blinking as the sole manifestation of seizures from isolated focal and generalized cortical spikes, and investigates the relationship between blinking and epileptic discharges. The results indicate that blinks usually occur within 150-450 ms after the onset of spike, and the median latency between blinking and spike is 294 ms. In addition, a new technique to demonstrate the temporal relationship between cortical discharges and specific movements is proposed.
EPILEPTIC DISORDERS
(2023)
Article
Physiology
Brendan McCarthy, Luke A. Henderson, Vaughan G. Macefield
Summary: This article aims to discuss brain regions involved in the processing of spatial information and to highlight the less widely known function of the vestibular system in regulating blood pressure through vestibulosympathetic reflexes. When transitioning from lying to standing, an increase in muscle sympathetic nerve activity prevents a drop in blood pressure associated with blood pooling in the feet. The vestibulosympathetic reflexes compensate for postural changes by interacting with the central sympathetic connectome, particularly the insula and dorsolateral prefrontal cortex.
COMPREHENSIVE PHYSIOLOGY
(2023)
Article
Clinical Neurology
Yuka Oono, Hidenori Kubo, Saori Takagi, Kelun Wang, Lars Arendt-Nielsen, Hikaru Kohase
Summary: This study examined the interaction between conditioned pain modulation and thermal pain illusions. The results showed that conditioned pain modulation can be induced by alternating painful cold-heat pulse stimulation, and the presence of thermal pain illusions does not influence this modulation.
SCANDINAVIAN JOURNAL OF PAIN
(2023)
Article
Dermatology
Giulia Erica Aliotta, Silvia Lo Vecchio, Jesper Elberling, Lars Arendt-Nielsen
Summary: This study aims to evaluate the antipruritic effects of topical doxepin on histaminergic and nonhistaminergic itch induced by histamine, BAM8-22, and cowhage. The results showed that doxepin cream almost eliminated histamine-induced itch and slightly reduced BAM8-22- and cowhage-induced itch.
DERMATOLOGIC THERAPY
(2023)
Article
Anesthesiology
Cesar Fernandez-de-las-Penas, Jo Nijs, Rocco Giordano, Lars Arendt-Nielsen
Summary: Pain after a SARS-CoV-2 acute infection (post-COVID pain) is a healthcare emergency that is not given enough attention and treatment due to a lack of recognition and understanding of its mechanisms. There is no specific treatment approach for post-COVID pain, as patients show varied responses to standard pain treatments. Precision pain medicine, taking into account individual factors, could improve the management of post-COVID pain.
EUROPEAN JOURNAL OF PAIN
(2023)
Editorial Material
Anesthesiology
Lars Arendt-Nielsen, Kristian Kjaer-Staal Pedersen, Lene Dreyer, Salome Kristensen, Sten Rasmussen, Bo Biering-Sorensen, Helge Kasch, Andrew Rice
EUROPEAN JOURNAL OF PAIN
(2023)
Review
Clinical Neurology
Cesar Fernandez-de-Las-Penas, Maria L. Cuadrado, Victor Gomez-Mayordomo, David Garcia-Azorin, Lars Arendt-Nielsen
Summary: This article analyzes the differences in the prevalence of headache as an onset symptom and in post-COVID headache among the different SARS-CoV-2 variants (historical strain, Alpha, Delta, and Omicron) and discusses the different pathophysiological mechanisms by which SARS-CoV-2 infection may cause headache.
EXPERT REVIEW OF NEUROTHERAPEUTICS
(2023)
Article
Rehabilitation
Stefano Di Antonio, Lars Arendt-Nielsen, Marta Ponzano, Francesca Bovis, Paola Torelli, Elisa Pelosin, Cinzia Finocchi, Matteo Castaldo
Summary: This study found that migraine patients with neck pain had worse headache characteristics, more pronounced cervical musculoskeletal impairments, enhanced signs and symptoms related to sensitization, and worse psychological burden compared to migraine patients without neck pain.
MUSCULOSKELETAL SCIENCE AND PRACTICE
(2023)
Article
Cardiac & Cardiovascular Systems
Morten Schmidt, Lars Arendt-Nielsen, Ellen-Margrethe Hauge, Henrik Toft Sorensen, Lars Pedersen
Summary: This study investigated the dose dependency of diclofenac's cardiovascular risks by using Danish health registries and a target trial emulation design. The results showed that both high-dose and low-dose diclofenac users had a similar increased risk of cardiovascular events compared to non-users. This finding challenges the assumption that low-dose diclofenac is risk-neutral.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR PHARMACOTHERAPY
(2023)
Article
Anesthesiology
J. Vela, L. Dreyer, K. K. Petersen, L. Arendt-Nielsen, K. Skjaerbaek Duch, K. Amris, S. Kristensen
Summary: This study compared the differences in quantitative sensory testing between patients with Psoriatic Arthritis (PsA) and Hand Osteoarthritis (hand-OA) and a pain-free control group, as well as the differences between patients with and without concomitant Fibromyalgia (cFM). The results showed that patients with PsA and hand-OA exhibited higher pain sensitization, greater psychological distress, and disability. Patients with cFM had even higher levels of pain sensitization, psychological burden, and disability when compared to patients without cFM.
EUROPEAN JOURNAL OF PAIN
(2023)
Article
Genetics & Heredity
Cesar Fernandez-de-las-Penas, Lars Arendt-Nielsen, Gema Diaz-Gil, Francisco Gomez-Esquer, Antonio Gil-Crujera, Stella M. Gomez-Sanchez, Silvia Ambite-Quesada, Maria A. Palomar-Gallego, Oscar J. Pellicer-Valero, Rocco Giordano
Summary: The study aimed to investigate the association between the Apolipoprotein E (ApoE) gene and long COVID symptoms. The results showed no significant relationship between different genotypes of the ApoE gene (ApoE ε2, ApoE ε3, ApoE ε4) and the presence of long COVID symptoms.
Article
Rehabilitation
Ignacio Cancela-Cilleruelo, Jorge Rodriguez-Jimenez, Cesar Fernandez-de-Las-Penas, Lars Arendt-Nielsen, Jose L. Arias-Buria
Summary: This explorative study found that 16% and 35% of the people with lateral elbow tendinopathy had sensitization- and neuropathic-associated symptoms respectively. Sensitization- and neuropathic-associated symptoms were associated, and pressure pain sensitivity at the elbow was related to neuropathic-associated symptoms.
PHYSIOTHERAPY THEORY AND PRACTICE
(2023)
Review
Medicine, General & Internal
Cesar Fernandez-de-las-Penas, Lidiane L. Florencio, Ana I. de-la-Llave-Rincon, Ricardo Ortega-Santiago, Margarita Cigaran-Mendez, Stella Fuensalida-Novo, Gustavo Plaza-Manzano, Lars Arendt-Nielsen, Juan A. Valera-Calero, Marcos J. Navarro-Santana
Summary: This study synthesized current evidence on prognostic factors for predicting postoperative pain after knee or hip replacement. The findings suggest that various preoperative factors, including race, opioid use, preoperative function, neuropathic pain symptoms, and anxiety, are associated with postoperative chronic pain. Additionally, certain comorbidities, such as heart disease and lung disease, are not associated with postoperative chronic pain.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Clinical Neurology
Lars Arendt-Nielsen, Henrik Klitgaard, Stine N. Hansen
Summary: Adenosine modulation demonstrates predictive validity across preclinical, human experimental, and clinical investigations. The most compelling evidence is in the field of neuropathic pain, where adenosine has been found to alleviate hyperexcitability and has the potential to be disease-modifying.
SCANDINAVIAN JOURNAL OF PAIN
(2023)
Article
Clinical Neurology
Svetlana Solgaard Nielsen, Soren T. Skou, Anette Enemark Larsen, Romanas Polianskis, Lars Arendt-Nielsen, Anne Skov Ostergaard, Kristian Kjaer-Staal Petersen, Henrik Bjarke Vaegter, Jens Sondergaard, Jeanette Reffstrup Christensen
Summary: This study investigated the impact of an occupational therapy lifestyle intervention on pain-related parameters, occupational function, occupational balance, lifestyle factors, and self-perceived health status in adults with chronic high-impact pain. The study found that the intervention appeared to improve motor skills but did not have clear effects on other outcomes. Further research, such as a randomized trial, is needed to confirm these findings.
SCANDINAVIAN JOURNAL OF PAIN
(2023)
Article
Anesthesiology
L. Arendt-Nielsen, J. T. Pedersen, S. Dreier, T. A. Nielsen, A. L. Hoj, L. Thomsen
Summary: Over the last 45 years, more than 60,000 pain-related papers have been published, developing from mono-disciplinary to multi-disciplinary studies. The overall publication profile in Eur. J. Pain and PAIN (R) was almost similar, including preclinical, human (experimental/clinical) and translational papers.
EUROPEAN JOURNAL OF PAIN
(2023)
Article
Neurosciences
Cesar Fernandez-de-las-Penas, Ignacio Cancela-Cilleruelo, Jorge Rodriguez-Jimenez, Jose A. Arias-Navalon, Jose D. Martin-Guerrero, Oscar J. Pellicer-Valero, Lars Arendt-Nielsen, Margarita Cigaran-Mendez
Summary: This study aimed to investigate the trajectory of post-COVID brain fog, memory loss, and concentration loss in previously hospitalized COVID-19 survivors. The results showed a gradual recovery of these cognitive symptoms in the years after hospital discharge, with no identified long-term medical record data associated with these symptoms.
FRONTIERS IN HUMAN NEUROSCIENCE
(2023)