Article
Neurosciences
Melina Engelhardt, Jana Kimmel, Giovanni Raffa, Alfredo Conti, Thomas Picht
Summary: The study demonstrates that accelerated low-frequency rTMS is a safe and feasible method for stimulating the motor cortex, and may make rTMS protocols more accessible to patients.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Clinical Neurology
Yu-Ting Hu, Xi-Wen Hu, Jin-Fang Han, Jian-Feng Zhang, Ying-Ying Wang, Annemarie Wolff, Sara Tremblay, Dusan Hirjak, Zhong-Lin Tan, Georg Northoff
Summary: This study compared the therapeutic efficacy of rTMS at the left motor cortex (lMC) and left dorsolateral prefrontal cortex (lDLPFC) in MDD patients. The results showed no significant difference in treatment outcomes and tolerability between the two groups. The findings suggest that lMC can be a potential and easily accessible rTMS target.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Review
Neurosciences
George M. Opie, Wei-Yeh Liao, John G. Semmler
Summary: Research indicates that interactions between the cerebellum and primary motor cortex are crucial for effective motor function. A review of emerging literature on this topic offers valuable insights into the nature of these interactions.
Review
Geriatrics & Gerontology
Abdulhameed Tomeh, Abdul Hanif Khan Yusof Khan, Wan Aliaa Wan Sulaiman
Summary: Stroke is a major cause of disability and death among the elderly population. Restoring blood circulation in the early phase of stroke is crucial for protecting neurons. Rehabilitation techniques can help stroke survivors regain their affected functions, and transcranial magnetic stimulation (TMS) has emerged as a novel method to aid in this process. TMS can be used to assess and modulate cortical excitability non-invasively, and repetitive TMS (rTMS) of the primary motor cortex (M1) shows promising results in post-stroke motor rehabilitation. It has also been found to have potential therapeutic uses in treating other symptoms such as dysphagia, speech impairments, central post-stroke pain, depression, and cognitive dysfunction.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
Andrea Mazoll, Kazuhis Shibata, Taro Toyoizumi, Isha Chavva, Takeo Watanabe
Summary: This study examined the effect of repetitive high-frequency visual stimulation on visual perceptual learning. The findings suggest that high-frequency stimulation can enhance orientation detection performance after a single task session, but can impair performance after training-based perceptual learning. These results may indicate reversal dynamics in elevated network excitation.
Article
Rehabilitation
Yan Gong, Xian-Ming Long, Ying Xu, Xiu-Ying Cai, Ming Ye
Summary: The study demonstrated that 1Hz rTMS combined with anodal tDCS stimulation protocol showed significant effects on motor function and cortex excitability in subacute stroke patients, making it a potential preferred rehabilitative strategy for motor recovery.
CLINICAL REHABILITATION
(2021)
Article
Neurosciences
Jack W. Zimdahl, Harrison Thomas, Samuel J. Bolland, Kerry Leggett, Kristin M. Barry, Jennifer Rodger, Wilhelmina H. A. M. Mulders
Summary: Tinnitus, a phantom auditory perception caused by cochlear trauma, can be alleviated by repetitive transcranial magnetic stimulation (rTMS) of the prefrontal cortex. However, the therapeutic effects of two common rTMS protocols on tinnitus are achieved through different mechanisms involving modulation of auditory thalamus activity and direct effects on prefrontal cortex.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Clinical Neurology
Alexander D. Tang, William Bennett, Aidan D. Bindoff, Samuel Bolland, Jessica Collins, Ross C. Langley, Michael Garry, Jeffery J. Summers, Mark R. Hinder, Jennifer Rodger, Alison J. Canty
Summary: The study examined the effects of subthreshold rTMS on structural synaptic plasticity in the mouse motor cortex of young and aged mice. The results showed that subthreshold rTMS can alter the rate of dendritic spine losses and gains, and effectively drive structural synaptic plasticity in both young adult and aged mice.
Article
Psychiatry
Chun-Hung Chang, Wen-Lung Wang, Yu-Hui Shieh, Han-Yuan Peng, Chen-Syuan Ho, Hsin-Chi Tsai
Summary: This study reports the case of a 62-year-old male patient with treatment-refractory tinnitus and depression who significantly improved after undergoing low-frequency rTMS over the right-side dorsolateral prefrontal cortex and left auditory cortex area. The findings suggest that sequential stimulation of multiple brain regions using low-frequency rTMS may have clinical benefits for patients with tinnitus and depression.
FRONTIERS IN PSYCHIATRY
(2022)
Review
Clinical Neurology
Zhiqing Tang, Kaiyue Han, Rongrong Wang, Yue Zhang, Hao Zhang
Summary: Excitatory rTMS over the ipsilesional hemisphere significantly improves upper limb motor function, hand strength, and hand dexterity in stroke patients. Both iTBS and HF-rTMS can significantly promote upper limb motor function and hand dexterity, with excitatory rTMS being most beneficial when applied within the first 3 months after stroke.
FRONTIERS IN NEUROLOGY
(2022)
Review
Neurosciences
Abdulhameed Tomeh, Abdul Hanif Khan Yusof Khan, Liyana Najwa Inche Mat, Hamidon Basri, Wan Aliaa Wan Sulaiman
Summary: Transcranial magnetic stimulation (TMS) is a novel technique that stimulates the human brain through the scalp. The primary motor cortex (M1) has traditionally been targeted for treatment, but recent studies have shown that M1-rTMS can also be effective in treating non-motor symptoms.
Article
Neurosciences
Ryoki Sasaki, Wei-Yeh Liao, George M. Opie, John G. Semmler
Summary: Repetitive paired-pulse transcranial magnetic stimulation can enhance the plasticity of the primary motor cortex. The orientation of the TMS coil and muscle activation can affect the activity of I-waves, but their influence on M1 plasticity with iTMS is still unclear.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2023)
Article
Neurosciences
Dongting Tian, Shin-Ichi Izumi
Summary: This study investigates the modulation of interhemispheric interaction by periodic repetitive transcranial magnetic stimulation (iTMS) in different current directions. The results show that iTMS can enhance cortical excitability and modulate interhemispheric inhibition.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Multidisciplinary Sciences
Pasquale Cardellicchio, Elisa Dolfini, Alessandro D'Ausilio
Summary: Evidence suggests that human sensorimotor interaction requires mutual behavioral adaptation and shared cognitive task representations. It has been shown that the left dorsal premotor cortex plays a role in sculpting movements and modulating stopping performance in joint action coordination.
Article
Clinical Neurology
Mengmeng Fu, Hua Wei, Xianghong Meng, Hai Chen, Baoxiang Shang, Fuyong Chen, Zhaoyang Huang, Ying Sun, Yuping Wang
Summary: This study aimed to assess the efficacy and safety of low-frequency rTMS targeting the bilateral parietal cortex in patients with TS. The results showed that bilateral rTMS significantly improved motor tics, phonic tics, and premonitory urges in TS patients, with improvements lasting for at least 1 month.
FRONTIERS IN NEUROLOGY
(2021)
Review
Cell Biology
Fioravante Capone, Mariagrazia Rossi, Alessandro Cruciani, Francesco Motolese, Fabio Pilato, Vincenzo Di Lazzaro
Summary: This review summarizes the safety, efficacy, and acceptability of COVID-19 vaccination for patients with multiple sclerosis. Despite some patients' hesitations, available data suggest that COVID-19 vaccination is safe and effective in multiple sclerosis patients.
NEURAL REGENERATION RESEARCH
(2023)
Article
Clinical Neurology
Rosalinda Calandrelli, Francesca Colo, Aldobrando Broccolini, Giacomo Della Marca, Giovanni Frisullo, Cesare Colosimo, Fabio Pilato
Summary: The purpose of this study is to develop a neuroradiological score for assessing deep cerebral venous thrombosis (DCVT) in patients, and to evaluate the relationship between neuroradiological and clinical features at follow-up. The study found that the neuroradiological score is correlated with clinical outcome and venous recanalization status, enhancing the diagnostic accuracy for DCVT.
NEUROLOGICAL SCIENCES
(2023)
Review
Medicine, General & Internal
Rosalinda Calandrelli, Luca Massimi, Fabio Pilato, Tommaso Verdolotti, Antonio Ruggiero, Giorgio Attina, Marco Gessi, Cesare Colosimo
Summary: This study aims to assess the main imaging and clinical features in adult- and pediatric-onset atypical teratoid rhabdoid tumor (ATRT) and build a predefined pathway for diagnosis. Clinical evaluation showed that ATRT was more common in children under 3 years old, with infratentorial localization reported more frequently in children under 24 months. Imaging findings revealed that ATRT had a preferential location near the ventricles and liquor spaces, with eccentric cysts as a hallmark feature. Histopathological analysis confirmed the diagnosis using specific immunohistochemical markers. The diagnosis of ATRT is more challenging in adults and relies solely on neuropathological examination.
Article
Clinical Neurology
Francesco Motolese, Fioravante Capone, Alessandro Magliozzi, Carlo Vico, Gianmarco Iaccarino, Emma Falato, Fabio Pilato, Vincenzo Di Lazzaro
Summary: This study aimed to test the feasibility of a smart device-based secondary prevention program in patients with cryptogenic stroke. The results showed that providing patients with smartwatches and smart devices for monitoring could effectively improve compliance and detect more episodes of atrial fibrillation. Therefore, using new technologies for preventing cerebrovascular disease is beneficial.
FRONTIERS IN NEUROLOGY
(2023)
Review
Clinical Neurology
Francesco Motolese, Jacopo Lanzone, Antonio Todisco, Mariagrazia Rossi, Francesca Santoro, Alessandro Cruciani, Fioravante Capone, Vincenzo Di Lazzaro, Fabio Pilato
Summary: Ischemic stroke is a complex process involving vessel occlusion and subsequent changes in brain tissue. The penumbra, or hypo-perfused tissue surrounding the core of the stroke, can potentially be recovered with restored blood flow. Neurophysiological changes occur in both the core and penumbra, as well as in overall neural networks due to disrupted connectivity.
FRONTIERS IN NEUROLOGY
(2023)
Article
Health Care Sciences & Services
Valerio Brunetti, Elisa Testani, Anna Losurdo, Catello Vollono, Aldobrando Broccolini, Riccardo Di Iorio, Giovanni Frisullo, Fabio Pilato, Paolo Profice, Jessica Marotta, Eleonora Rollo, Irene Scala, Paolo Calabresi, Giacomo Della Marca
Summary: This study aimed to evaluate the association between obstructive sleep apnea (OSA) and atrial fibrillation (AF) in acute ischemic stroke. The results showed that OSA and AF are highly prevalent but not associated in acute stroke. Furthermore, OSA acts as an independent risk factor for stroke.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Letter
Clinical Neurology
Duncan Austin, John Rothwell
CLINICAL NEUROPHYSIOLOGY
(2023)
Review
Clinical Neurology
Anna Latorre, Daniele Belvisi, John C. Rothwell, Kailash P. Bhatia, Lorenzo Rocchi
Summary: Cortical myoclonus is a result of abnormal electrical discharges in the sensorimotor cortex. Electrophysiological criteria for diagnosing cortical myoclonus have been proposed, but their application can be challenging. Combining observations from multiple tests is necessary to increase the diagnostic accuracy of cortical myoclonus. Further research is needed to standardize methods, resolve methodological issues, establish diagnostic criteria sensitivity and specificity, and develop additional methods to clarify the pathophysiology of myoclonus.
CLINICAL NEUROPHYSIOLOGY
(2023)
Article
Neurosciences
Po-Yu Fong, Danny Spampinato, Kevin Michell, Marco Mancuso, Katlyn Brown, Jaime Ibanez, Alessandro Di Santo, Anna Latorre, Kailash Bhatia, John C. Rothwell, Lorenzo Rocchi
Summary: The study found that magnetically-induced activity in the cerebral cortex can provide valuable insights into the connectivity between the cortex and the cerebellum, as well as the function of the cerebellum. By using this method, researchers were able to detect brain activity evoked by cerebellar stimulation and demonstrated its involvement in learning and executing complex behaviors.
Article
Genetics & Heredity
Alessia Azzara, Ilaria Cassano, Carla Lintas, Fabio Pilato, Fioravante Capone, Vincenzo Di Lazzaro, Fiorella Gurrieri
Summary: Peripheral facial palsy rarely occurs as part of Melkersson-Rosenthal syndrome (MRS), we identified a c.3521C>G missense heterozygous variant in SCN1A carried only by the affected sister, which adds knowledge to the clinical spectrum of SCN1A alterations and suggests a potential overlap between MRS and FHM.
Article
Neurosciences
Irene Scala, Simone Bellavia, Pier Andrea Rizzo, Jacopo Di Giovanni, Mauro Monforte, Roberta Morosetti, Giacomo Della Marca, Fabio Pilato, Aldobrando Broccolini, Paolo Profice, Giovanni Frisullo
Summary: This study evaluated the long-term safety and efficacy of edoxaban. The results showed that edoxaban was effective and safe in anticoagulant treatment, with a low incidence of thromboembolic events.
Letter
Neurosciences
Fabio Pilato, Fioravante Capone, Mario Ferrante, Marilena Marcosano, Vincenzo Di Lazzaro
Article
Clinical Neurology
Francesca Ginatempo, Nicola Loi, John C. Rothwell, Franca Deriu
Summary: This study comprehensively investigated sensorimotor integration in the cranial-cervical muscles of healthy adults and found that the integration of sensory inputs with motor output is profoundly influenced by the type of sensory afferent involved and the functional role played by the target muscle.
CLINICAL NEUROPHYSIOLOGY
(2024)
Article
Clinical Neurology
Gabriella Musumeci, Marco D'Alonzo, Federico Ranieri, Emma Falato, Fioravante Capone, Francesco Motolese, Giovanni Di Pino, Vincenzo Di Lazzaro, Fabio Pilato
Summary: This study evaluated cortical circuits and excitability in the motor cortex of upper limb amputees, finding increased corticospinal excitability and preserved intracortical inhibition in trans-radial amputees, but not in trans-humeral amputees.
CLINICAL NEUROPHYSIOLOGY
(2023)
