Review
Cell Biology
Jirong Lv, Xue Xiao, Mingxia Bi, Tingting Tang, Deao Kong, Meining Diao, Qian Jiao, Xi Chen, Chunling Yan, Xixun Du, Hong Jiang
Summary: ATP-sensitive potassium channels (KATP channels) play a crucial role in linking the electrical activity of the cell membrane with cell metabolism. They have been found to be expressed in various cells and play important roles in neurodegenerative diseases. The KATP channel openers and inhibitors have protective effects on neurons by regulating neuronal excitability and neurotransmitter release, reducing abnormal protein aggregation and Ca2+ overload, and decreasing reactive oxygen species (ROS) production and microglia activation. However, KATP channels also exhibit dual effects in some cases.
AGEING RESEARCH REVIEWS
(2022)
Review
Biochemistry & Molecular Biology
Fatima Maqoud, Domenico Tricarico, Rosanna Mallamaci, Antonella Orlando, Francesco Russo
Summary: This study summarizes the correlation between ion channel abnormalities and functional gastrointestinal disorders (FGIDs), and highlights the associations of ABCC7/CFTR and SCN5A gene mutations with constipation, diarrhea, and irritable bowel syndrome.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Food Science & Technology
Evelyne Benoit, Sebastien Schlumberger, Jordi Molgo, Makoto Sasaki, Haruhiko Fuwa, Roland Bournaud
Summary: Gambierol inhibits K+ channels in rat fetal adrenomedullary cells, but has no effect on other channels. It does not alter membrane potential or increase catecholamine release events.
Review
Pharmacology & Pharmacy
Zhicheng Wang, Weikang Bian, Yufeng Yan, Dai-Min Zhang
Summary: ATP-sensitive potassium channels (K-ATP channels) play important roles in cellular excitability and metabolism. Activation of K-ATP channels can repolarize the membrane potential and reduce the occurrence of arrhythmias. Under severe and prolonged anoxia, K-ATP channels open to decrease cellular excitability and prevent action potential generation. Small active molecules can enhance the opening of K-ATP channels, leading to membrane repolarization and decreased malignant arrhythmias. Mutations in K-ATP channels worsen the regulatory roles in mutation-related diseases. However, efficient treatments for patients with K-ATP channel mutations are still lacking.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Chemistry, Medicinal
Mohammad Al-Mahdi Al-Karagholi
Summary: Migraine is a complex headache disorder involving various signaling pathways, with potassium channels playing a crucial role. Activation of potassium channels activates and sensitizes trigeminovascular neurons, leading to migraine attacks. Clinical trials have shown that potassium channel openers cause headache and migraine attacks associated with arterial dilation. Understanding the molecular structure and physiological function of potassium channels can provide insights into migraine pathophysiology and the development of potential treatments.
Article
Cell Biology
Thuong Ho, Evgeniy Potapenko, Dawn B. Davis, Matthew J. Merrins
Summary: We provide evidence that a glycolytic metabolon locally controls ATP-sensitive K+ channels in pancreatic islet endocrine cells, and demonstrate the presence of a plasma membrane-associated NAD+/NADH cycle.
Article
Biochemistry & Molecular Biology
Michela Pecoraro, Stefania Marzocco, Ada Popolo
Summary: This study demonstrates a cooperative relationship between mCx43 and K-ATP channels in inducing cytoprotection in cardiomyocytes under hypoxic conditions. The presence of mCx43 is essential for the protective effects of diazoxide, an opener of K-ATP channels, against CoCl2-induced mitochondrial damage. These findings highlight the close functional link between mCx43 and K-ATP channels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Pharmacology & Pharmacy
Menizibeya O. Welcome, Nikos E. Mastorakis
Summary: Evidence suggests that neuroinflammatory response plays a critical role in central nervous system disorders, and the discovery of bitter taste receptors outside the oral cavity has increased research interest in their functions. Bitter taste receptors not only sense toxins, but also act as immune sentinels mobilizing defense mechanisms against pathogenic aggression.
PHARMACOLOGICAL RESEARCH
(2021)
Review
Genetics & Heredity
Mohamed Chamlali, Lise Rodat-Despoix, Halima Ouadid-Ahidouch
Summary: This review aims to summarize the findings on store-independent Ca2+ entry (SICE) in the field of breast cancer progression, as most literature focuses on store-dependent Ca2+ entry, neglecting the role of SICE.
Article
Endocrinology & Metabolism
Julia K. Panzer, Alejandro Caicedo
Summary: The article explores the life-threatening hypoglycemia issue in the management of type 1 diabetes and the underlying mechanisms. The authors suggest that targeting alpha-cells pharmacologically could help manage type 1 diabetes more effectively.
Article
Cell Biology
Dae Hoon Kim, Jin Young Choi, Su Mi Kim, Seung-Myoung Son, Song-Yi Choi, Beommo Koo, Cheong-Sil Rah, Ji Hyun Nam, Moon Jin Ju, Jong Sung Lee, Ra Young You, Seung Hwa Hong, Junyoung Lee, Jang-Whan Bae, Chan Hyung Kim, Woong Choi, Hun Sik Kim, Wen-Xie Xu, Sang Jin Lee, Young Chul Kim, Hyo-Yung Yun
Summary: This study aimed to elucidate the underlying mechanisms and physiological function of vasomotion in human arteries. The results showed that vasomotion is sensitive to Ca2+-activated Cl- channels and metabolic changes, and may play an important role in the regulation of microcirculation dynamics.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Article
Medicine, Research & Experimental
Asser F. Bedair, Ahmed Wahid, Nesrine S. El-Mezayen, Amira F. El-Yazbi, Hadeel A. Khalil, Nayera W. Hassan, Elham A. Afify
Summary: Previous studies showed that nicorandil enhances morphine's antinociceptive effect and attenuates liver injury in rats with liver fibrosis. In this study, the underlying mechanisms of the nicorandil/morphine interaction were investigated, revealing that the combined therapy provides potent antinociception and hepatoprotection by modulating opioid receptors and cGMP signaling pathway.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Food Science & Technology
Wei He, Li Liang, Yuyu Zhang
Summary: The perception of pungency, which combines pain and heat, has significant effects on food flavor and consumption preferences. Studies have focused on evaluating pungent substances and understanding their mechanism of perception, as well as exploring the interaction between pungency and basic tastes. However, due to the complexity of perception and the uncertainty of many receptors or channels, current research in this area is still controversial.
Article
Pharmacology & Pharmacy
Francesc Jimenez-Altayo, Anna Cabrera, Andrea Bagan, Lydia Gimenez-Llort, Pilar D'Ocon, Belen Perez, Merce Pallas, Carmen Escolano
Summary: This study provides evidence that I2R does not play a functional role in modulating vascular tone in mouse aorta. MCR5, an I2R ligand, acts as an endothelium-independent vasodilator and is resistant to aging.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Endocrinology & Metabolism
Bilal Singh, Firas Khattab, Patrick Gilon
Summary: The study reveals that glucose controls alpha-cell [Ca2+](c) and glucagon secretion through multiple mechanisms. Increasing glucose concentration modestly decreases [Ca2+](c) in alpha-cells independently of their K-ATP channels and partly via somatostatin (SST). The changes in [Ca2+](c) parallel changes in glucagon release. Glucose also attenuates the efficacy of Ca2+ on exocytosis.
MOLECULAR METABOLISM
(2022)
Article
Immunology
Caoimhe M. K. Lynch, Caitlin S. M. Cowan, Thomaz F. S. Bastiaanssen, Gerard M. Moloney, Nigel Theune, Marcel van de Wouw, Eva Florensa Zanuy, Ana Paula Ventura-Silva, Martin G. Codagnone, Francisca Villalobos-Manriquez, Matilde Segalla, Fatma Koc, Catherine Stanton, Paul Ross, Timothy G. Dinan, Gerard Clarke, John F. Cryan
Summary: Numerous studies have shown that the gut microbiota plays a crucial role in neurodevelopment and behavior. Early-life exposure to antibiotics has been associated with increased risk of immune and metabolic diseases. Targeted antibiotic-induced disruption of the microbiota during critical developmental periods has enduring effects on physiology and behavior. This study demonstrates that microbiota disruption during early life alters the structure and function of the caecal microbiome, as well as immune cells and neurophysiology in adolescence. However, the effects on behavior are limited and subtle, suggesting the importance of the gut microbiota during critical windows of development.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Article
Biochemistry & Molecular Biology
Mingjie Li, Jiuhong Ding, Catherine Stanton, R. Paul Ross, Jianxin Zhao, Bo Yang, Wei Chen
Summary: In this study, it was found that B. longum subsp. infantis FJSYZ1M3 could alleviate DSS-induced colitis through various mechanisms, including maintaining the intestinal barrier, regulating inflammatory cytokines, and modifying the gut microbiota.
Article
Biochemistry & Molecular Biology
Shane E. E. Somers, Gabrielle L. L. Davidson, Crystal N. N. Johnson, Michael S. S. Reichert, Jodie M. S. Crane, R. Paul Ross, Catherine Stanton, John L. L. Quinn
Summary: This study investigates the gut microbiota of wild great tits and finds that they are closely related to the host's state and the environment, especially for nestlings. The study also discovers that the gut microbiota is most sensitive during early development and is associated with environmental factors such as reproductive timing and hatching location. These findings are crucial for understanding the role of gut microbiota in the fitness of animals.
Article
Food Science & Technology
Serena Boscaini, Peter Skuse, Kanishka N. Nilaweera, John F. Cryan, Paul D. Cotter
Summary: This review provides an overview of the beneficial effects of whey protein (WP) and its components on human health, particularly in controlling obesity and its comorbidities. WP consumption positively impacts energy balance and obesity-related parameters, primarily through modulation in adipose tissue metabolism and changes that occur in the gastrointestinal tract. Furthermore, WP also has a positive impact on gut microbiota, mood, and behavior. This review emphasizes the importance of WP supplementation in preventing or treating obesity and highlights areas for further research.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2023)
Review
Food Science & Technology
Kevin Linehan, R. Paul Ross, Catherine Stanton
Summary: Bovine colostrum contains various bioactive components that can be used for the development of functional foods, nutraceuticals, and pharmaceuticals in veterinary and human health applications. It is safe for all age groups and can be used to promote health and improve various diseases. The global market for colostrum-based products has grown significantly due to increased milk production and novel processing technologies. This review provides an overview of the bioactive components in bovine colostrum, the processing techniques used to produce high-value products, and recent studies on its applications in veterinary and human health.
ANNUAL REVIEW OF FOOD SCIENCE AND TECHNOLOGY
(2023)
Article
Multidisciplinary Sciences
Amel Sami, Imad Elimairi, C. Anthony Ryan, Catherine Stanton, Dhrati Patangia, R. Paul Ross
Summary: There are an estimated 6-10 million smokeless tobacco (Toombak) users in Sudan, the majority being males. This study explores the oral microbiome in Toombak users and non-users, finding significant differences in the abundance of certain bacterial and fungal genera. Toombak users carry an altered oral microbiome that may contribute to the development and progression of oral cancer, while also increasing the potential for a poorer prognosis.
SCIENTIFIC REPORTS
(2023)
Article
Biology
Stephen R. Stockdale, Andrey N. Shkoporov, Ekaterina V. Khokhlova, Karen M. Daly, Siobhan A. McDonnell, Orla O' Regan, James A. Nolan, Thomas D. S. Sutton, Adam G. Clooney, Feargal J. Ryan, Donal Sheehan, Aonghus Lavelle, Lorraine A. Draper, Fergus Shanahan, R. Paul Ross, Colin Hill
Summary: Viruses play important roles in the human microbiome, but our understanding of the human gut virome is limited due to previous sequencing requirements that introduced amplification bias. In this study, without amplification bias, we analyzed the viromes of healthy controls, Crohn's disease patients, and ulcerative colitis patients longitudinally. The results revealed and emphasized the interpersonal variability of the human gut virome, challenging our ability to identify disease associations.
COMMUNICATIONS BIOLOGY
(2023)
Article
Microbiology
Neda Nezam-Abadi, Christopher J. R. Turkington, Lorraine A. Draper, Andrey N. Shkoporov, R. Paul Ross, Colin Hill
Summary: Here, we present the draft genome sequence of Legionella pneumophila subsp. pneumophila strain DSM 25199, a serogroup 1 strain with a genome size of 3,426,844 bp. The assembly consists of 24 contigs with an N-50 of 300,843 bp.
MICROBIOLOGY RESOURCE ANNOUNCEMENTS
(2023)
Article
Pediatrics
David B. Healy, Benjamin Campbell-Green, Vicki Livingstone, C. Anthony Ryan, R. Paul Ross, Catherine Stanton, Eugene M. Dempsey
Summary: The aim of this study was to evaluate the combined outcome of death and/or severe grade necrotising enterocolitis (NEC) in very preterm infants before and after the introduction of routine supplementation with Bifidobacterium bifidum and Lactobacillus acidophilus probiotics. The results showed a reduction in the composite outcome of severe grade NEC and/or death after the introduction of routine administration of probiotics.
Article
Chemistry, Medicinal
Shona Uniacke-Lowe, Fergus W. J. Collins, Colin Hill, R. Paul Ross
Summary: With the increase in antimicrobial resistance, the deep-sea fish microbiome can serve as a potential source of antimicrobials, including bacteriocins. In this study, bacterial isolates recovered from deep-sea fish were screened for antimicrobial activity and their genomic DNA was analyzed for bacteriocin and other antimicrobial metabolite genes. The study identified 147 candidate biosynthetic gene clusters, including 35 bacteriocin clusters, and discovered unique bacteriocin gene clusters encoding novel peptides. This dual approach provided insights into the bacteriocinogenic potential and antimicrobial molecules of the deep-sea isolates.
Review
Endocrinology & Metabolism
Kanishka N. N. Nilaweera, Paul D. D. Cotter
Summary: Calorie restriction and bariatric surgery can reduce both visceral and subcutaneous adipose tissues, whereas the effects of monounsaturated fatty acids and polyunsaturated fatty acids are inconsistent. Dietary proteins, especially whey proteins, can reduce one or both depots based on their interaction with other macronutrients. This specificity is related to changes in gut microbiota and their metabolites, and the effect may vary with the host's sex. This knowledge can contribute to the development of nutritional strategies to improve metabolic health in humans and other species.
Article
Food Science & Technology
Yang Chen, He Gao, Jianxin Zhao, R. Paul Ross, Catherine Stanton, Hao Zhang, Wei Chen, Bo Yang
Summary: This review comprehensively summarizes the epidemic trend and pathogenesis of inflammatory bowel disease (IBD), and highlights the potential regulatory mode and mechanisms of lactic acid bacteria (LAB) in alleviating IBD. LAB exhibits numerous advantages, such as producing bioactive metabolites, regulating gut immunity, protecting the intestinal mechanical barriers, inhibiting oxidative damage, and restoring unbalanced gut microbiota. The review also provides recommendations for screening effective LAB, controlling optimal intake, encapsulating LAB, investigating mechanisms, and improving clinical study design to improve the lives of IBD patients.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2023)
Review
Gastroenterology & Hepatology
Lauren Walsh, Colin Hill, R. Paul Ross
Summary: This review focuses on the potential effect of glyphosate exposure on the composition and functionality of the gut microbiome, highlighting the significance of gut microbiota to health.
Article
Infectious Diseases
Dhrati V. Patangia, Ghjuvan Grimaud, Kevin Linehan, R. Paul Ross, Catherine Stanton
Summary: This study investigated the impact of different drying off methods on the microbiota and resistome profile in colostrum and milk samples from cows. The results showed that the use of antibiotics during drying off increased microbial diversity and antibiotic resistance genes in milk. In contrast, the non-antibiotic group had a lower abundance of mastitis-causing pathogens and was associated with specific genera. These findings support the use of non-antibiotic alternatives for drying off in cows.
Article
Food Science & Technology
Han Du, Yichen Lin, Catherine Stanton, Davor Daniloski, Emanuele Zannini, R. Paul Ross, Song Miao
Summary: In this study, red lentil isolate protein (RLPI) was heated at different pH values for different time periods, and its structure and emulsifying properties were analyzed. The results showed that the molecular weight of RLPI decreased over time and formed fibrillar and particulate aggregates at different pH levels. The fibrillar aggregates had higher emulsifying capabilities due to their structure and surface charge, and formed stronger interactions at pH 2.
FOOD STRUCTURE-NETHERLANDS
(2023)
