Article
Multidisciplinary Sciences
H. Gregersen, D. Sun, S. C. Chen, W. W. Leung, C. Wong, T. Mak, S. Ng, K. Futaba, Kar Man Lo, G. S. Kassab
Summary: Defecation is a complex process, and disorders related to anorectal diseases can significantly impact quality of life. Through the advancement of integrated technology and new analytical methods, Fecobionics has shown promising results in the assessment of anorectal function.
JOURNAL OF ADVANCED RESEARCH
(2022)
Article
Peripheral Vascular Disease
Qing Pan, Weida Feng, Ruofan Wang, Arata Tabuchi, Peilun Li, Bianca Nitzsche, Luping Fang, Wolfgang M. Kuebler, Axel R. Pries, Gangmin Ning
Summary: The study found that blood flow pulsatility is predominantly damped at the arteriolar side and remains at a low level at the venular side. Pulsatility is sensitive to pulse frequency, vascular viscous resistance, and vascular compliance. Viscoelasticity of the vessel wall or wave propagation and reflection have little contribution to pulsatility damping.
MICROVASCULAR RESEARCH
(2022)
Article
Physiology
Andrew M. Roberts, Nayeem Z. Moulana, Rekha Jagadapillai, Lu Cai, Evelyne Gozal
Summary: The study suggests that diabetes mellitus affects pulmonary microcirculation through reducing nitric oxide bioavailability, increasing precapillary arteriolar tone, and causing endothelial injury. These findings may potentially lead to ventilation-perfusion abnormalities and exacerbate systemic diabetes complications.
JOURNAL OF APPLIED PHYSIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Caitlin E. M. Vink, Tim P. van de Hoef, M. J. W. Goette, E. C. Eringa, Yolande Appelman
Summary: INOCA, a subtype of ischemic heart disease, is more common in women. MBV may be reduced in INOCA patients, potentially due to conditions like diabetes and obesity.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Carlos Galan-Arriola, Jean Paul Vilchez-Tschischke, Manuel Lobo, Gonzalo J. Lopez, Antonio De Molina-Iracheta, Claudia Perez-Martinez, Rocio Villena-Gutierrez, Alvaro Macias, Ivan A. Diaz-Rengifo, Eduardo Oliver, Valentin Fuster, Javier Sanchez-Gonzalez, Borja Ibanez
Summary: The aim of this study was to investigate the changes in coronary microcirculation status during and after repeated anthracycline treatment. The results showed that anthracycline treatment is associated with progressive and irreversible damage to the microcirculation. The damage to the microcirculation persists even in low cumulative dose regimes and may explain the increased incidence of cardiovascular events in cancer survivors who received anthracyclines without cardiac contractile defects.
CARDIOVASCULAR RESEARCH
(2022)
Article
Medicine, Research & Experimental
Adam A. Rizk, Michael P. Dybala, Khalil C. Rodriguez, Marjan Slak Rupnik, Manami Hara
Summary: An increasing number of studies have shown that disease states of the endocrine or exocrine pancreas exacerbate each other, suggesting bidirectional blood flow between islets and exocrine cells. This contradicts the current unidirectional blood flow model from islets to exocrine tissues. The traditional model proposed in 1932 has not been revisited to date.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Hematology
Nicholas A. Hodges, Arinola O. Lampejo, Hulan Shang, Gabrielle Rowe, Amanda Jo LeBlanc, Adam J. Katz, Walter L. Murfee
Summary: This study demonstrates the innovation and utility of mesenteric tissue culture for studying microvascular growth dynamics associated with adipose-derived stromal vascular fraction transplantation. The findings show that stromal vascular fraction cells contribute to de novo vessel growth and host network angiogenesis, highlighting the importance of model selection for visualization.
Article
Medicine, General & Internal
Ah-Reum Cho, Hyeon-Jeong Lee, Hyae-Jin Kim, Wangseok Do, Soeun Jeon, Seung-Hoon Baek, Eun-Soo Kim, Jae-Young Kwon, Hae-Kyu Kim
Summary: General anesthesia can enhance microvascular reactivity and decrease tissue metabolism, leading to improved tissue oxygen saturation. However, the improvement in microvascular reactivity under general anesthesia is more significant in younger patients compared to older patients.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2021)
Article
Hematology
T. Gori
Summary: The coronary circulation is a complex system comprising the epicardial, microvascular, and venous districts. Understanding of coronary microvascular disease remains incomplete and specific therapy is lacking. The role of the coronary venous circulation is not well explored but may have potential in improving coronary perfusion.
CLINICAL HEMORHEOLOGY AND MICROCIRCULATION
(2021)
Article
Multidisciplinary Sciences
Karin Pola, Elsa Bergstrom, Johannes Toger, Goran Radegran, Per M. Arvidsson, Marcus Carlsson, Hakan Arheden, Ellen Ostenfeld
Summary: Hemodynamic force analysis provides complementary information to established parameters in precapillary pulmonary hypertension, showing differences in ventricular HDF between patients and healthy controls. The right ventricle compensates for the increased afterload by augmenting transverse forces, while left ventricular abnormalities are mainly a result of underfilling.
SCIENTIFIC REPORTS
(2022)
Review
Cardiac & Cardiovascular Systems
Laura Maitre-Ballesteros, Laurent Riou, Stephanie Marliere, Marjorie Canu, Estelle Vautrin, Nicola Piliero, Oliviez Ormezzano, Helene Bouvaist, Alexis Broisat, Catherine Ghezzi, Daniel Fagret, Gerald Vanzetto, Loic Djaileb, Gilles Barone-Rochette
Summary: Coronary physiological assessment is widely used to evaluate coronary lesions. Fractional flow reserve (FFR) is the gold standard method for selecting revascularization. In addition to FFR, other indexes are available for exploring the coronary microcirculation. Coronary physiological assessment offers the potential of precision medicine for patients with coronary artery disease.
REVIEWS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Otorhinolaryngology
Sophia M. Colevas, Lily N. Stalter, Corinne A. Jones, Timothy M. Mcculloch
Summary: This study describes the manometric representation of the resting upper esophageal sphincter (UES) using a clinically accessible method of measurement. The results demonstrate excellent within-subject reliability of the resting UES mean pressures and significant effects of age, number of sensors contained within the resting UES, and preceding swallow volume on mean resting UES pressure.
Article
Cardiac & Cardiovascular Systems
Li Liang, Yongxiang Zhu, Fangfang Li, Kai Guo, Shang Chang, Qian Li, Yaojun Zhang, Dongye Li
Summary: The field of coronary artery physiology is rapidly developing and changing the practice of interventional cardiology. Instantaneous wave-free ratio (iFR) has emerged as an alternative to fractional flow reserve for evaluating myocardial perfusion. This study demonstrates the correlation between iFR and myocardial perfusion parameters, as well as the high sensitivity and specificity of iFR in detecting myocardial microcirculation perfusion.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Medicine, General & Internal
Junyu Chen, Lianying Ding, Taiwei Wang, Mengqi Wang, Shuhua Zhao, Yang Xia
Summary: Dedifferentiated liposarcoma (DL) of the ovary is a rare mesenchymal tumor that is challenging to diagnose preoperatively. The diagnosis of DL typically relies on morphological evidence, immunohistochemical stains, and fluorescence in situ hybridization. We present a case of a patient initially thought to have a primary ovarian tumor but was eventually diagnosed with DL arising from the mesentery and developing in the ovary. The patient has remained asymptomatic without recurrence for 12 months following bilateral salpingo-oophorectomy.
Article
Respiratory System
Thor Ueland, Aurelija Abraityte, Hilde Norum, Sharanga Varathalingam, Lars Gullestad, Pal Aukrust, Arne K. Andreassen
Summary: This study revealed that patients with precapillary PH have enhanced systemic Wnt activity, with certain Wnt-related molecules like Wnt5a and DKK3 correlating with poor prognosis. Elevations of Wnt5a and DKK3 levels during follow-up were also independently associated with worse outcomes, suggesting that the Wnt signaling pathways may play a role in the pathogenesis of precapillary PH.
Article
Anatomy & Morphology
Koichiro Ichimura, Shota Kinose, Yuto Kawasaki, Kota Kato, Tatsuo Sakai
ANATOMICAL SCIENCE INTERNATIONAL
(2018)
Article
Urology & Nephrology
Koichiro Ichimura, Takayuki Miyaki, Yuto Kawasaki, Mui Kinoshita, Soichiro Kakuta, Tatsuo Sakai
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2019)
Article
Anatomy & Morphology
Yuto Kawasaki, Shota Kinose, Kota Kato, Tatsuo Sakai, Koichiro Ichimura
Review
Cell Biology
Takayuki Miyaki, Yuto Kawasaki, Yasue Hosoyamada, Takashi Amari, Mui Kinoshita, Hironori Matsuda, Soichiro Kakuta, Tatsuo Sakai, Koichiro Ichimura
CELL AND TISSUE RESEARCH
(2020)
Article
Orthopedics
Akihisa Koga, Yoshiaki Itoigawa, Tomoki Wada, Daichi Morikawa, Koichiro Ichimura, Tatsuo Sakai, Takayuki Kawasaki, Yuichiro Maruyama, Kazuo Kaneko
ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY
(2020)
Article
Anatomy & Morphology
Naoaki Kimura, Kota Kato, Hidaka Anetai, Yuto Kawasaki, Takayuki Miyaki, Hiroyuki Kudoh, Tatsuo Sakai, Koichiro Ichimura
Summary: The study evaluated the precise anatomy of the soleus muscle and found a broad aponeurotic posterior insertion tendon on the posterior surface, and three aponeurotic origin tendons on the anterior surface. The soleus muscle has a broad musculotendinous junction with wide structural diversity in the anterior bipennate muscle portion.
Article
Anatomy & Morphology
Hidaka Anetai, Shota Kinose, Riku Sakamoto, Rumiko Onodera, Kota Kato, Yuto Kawasaki, Takayuki Miyaki, Hiroyuki Kudoh, Tatsuo Sakai, Koichiro Ichimura
Summary: The location and course of nutrient arteries in long bones are crucial for operative procedures. The tibial and fibular nutrient arteries typically arise from the posterior tibial and fibular arteries respectively, penetrating different muscles to enter their respective nutrient foramina.
ANATOMICAL SCIENCE INTERNATIONAL
(2021)
Article
Cell Biology
Takayuki Miyaki, Yuto Kawasaki, Akira Matsumoto, Soichiro Kakuta, Tatsuo Sakai, Koichiro Ichimura
CELL AND TISSUE RESEARCH
(2020)
Article
Cell Biology
Yuto Kawasaki, Yasue Hosoyamada, Takayuki Miyaki, Junji Yamaguchi, Soichiro Kakuta, Tatsuo Sakai, Koichiro Ichimura
Summary: In this study, FIB-SEM tomography with reconstruction was successfully used to describe the 3D architecture of normal GEnCs in adult rats, revealing three major subcellular compartments and two associated subcellular compartments. The reconstructed GEnCs showed high accuracy in visualizing the luminal and basal surface structures, providing valuable morphological information for the 3D pathologic evaluation of GEnCs and structural analysis of glomerular capillary system development.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Clinical Neurology
Shigeaki Kobayashi, Toshio Matsushima, Tatsuo Sakai, Ken Matsushima, Helmut Bertalanffy, James T. Rutka
Summary: This article reviews the evolution of microneurosurgical anatomy with special reference to the development of anatomy, surgical anatomy, and microsurgery. It highlights the importance of detailed anatomical knowledge for the accurate and safe performance of microneurosurgical procedures. The development of surgical anatomy and microsurgery has greatly benefited from each other, leading to the fuller development of microneurosurgical anatomy by many neurosurgeons.
NEUROSURGICAL REVIEW
(2022)
Article
Anatomy & Morphology
Hidaka Anetai, Kounosuke Tokita, Ryuhei Kojima, Eishi Hirasaki, Tatsuo Sakai, Koichiro Ichimura
Summary: The study found that in Japanese macaques, the caudal deviation of the LSP origin is correlated with the elongation of the 12th rib, similar to humans. This suggests that the deviation of the LSP origin may have a correlation in different mammalian groups.
ANATOMICAL SCIENCE INTERNATIONAL
(2022)
Article
Multidisciplinary Sciences
Yuki Mochida, Koji Ochiai, Takashi Nagase, Keiko Nonomura, Yoshihiro Akimoto, Hiroshi Fukuhara, Tatsuo Sakai, George Matsumura, Yoshihiro Yamaguchi, Miki Nagase
Summary: The kidney plays a central role in body fluid homeostasis, and Piezo2 has been found to have important functions in the kidney. This study discovered that Piezo2 is primarily localized in mesangial cells and renin-producing cells in the kidney. In a mouse model of dehydration, Piezo2 expression was downregulated in mesangial cells and upregulated in renin-producing cells, accompanied by excessive renin production and enlargement of the renin-producing cell area. Additionally, in vitro cell experiments showed that knocking down the Piezo2 gene reduced the expression of the renin coding gene Ren1.
SCIENTIFIC REPORTS
(2022)
Review
Microbiology
Tatsuo Sakai, Yuh Morimoto
Summary: This paper reviews various infectious diseases in the five-period scheme of medical history and emphasizes the tremendous development of medicine and medical treatment.
Article
Anatomy & Morphology
Koichi Takeda, Kota Kato, Koichiro Ichimura, Tatsuo Sakai
Summary: This study aimed to clarify the morphological architecture of the hamstrings, including the superficial tendons, and quantify the structural parameters of the muscle. The study found that the hamstrings have different structural parameters that play an important role in their functional properties.
JOURNAL OF ANATOMY
(2023)
Article
Surgery
Hidetoshi Nojiri, Takatoshi Okuda, Kei Miyagawa, Nozomu Kobayashi, Tatsuya Sato, Takeshi Hara, Yukoh Ohara, Hiroyuki Kudo, Tatsuo Sakai, Kazuo Kaneko
Summary: This study found that the lumbar plexus localization in the psoas muscle varies with the level of the intervertebral disc, especially at the L4/5 level. It is important to consider the position of the psoas muscle relative to the intervertebral disc to avoid neuropathy.
SPINE SURGERY AND RELATED RESEARCH
(2021)