Article
Nutrition & Dietetics
Myunghee Kim, Hyeyoon Eo, Josephine Gahyun Lim, Hyunjung Lim, Yunsook Lim
Summary: This meta-analysis found that dietary vitamin E supplementation can attenuate exercise-induced muscle damage, especially when the supplementation is less than 500 IU.
Article
Nutrition & Dietetics
Virginia Boccardi, Giulia Poli, Roberta Cecchetti, Patrizia Bastiani, Michela Scamosci, Marta Febo, Emanuela Mazzon, Stefano Bruscoli, Stefano Brancorsini, Patrizia Mecocci
Summary: Alzheimer's disease (AD) is the leading cause of dementia globally and is a major contributor to disability in older individuals. Vitamin E levels are lower in AD patients, and inflammation and microRNAs also play significant roles in the development of AD. MiR-122 may be a modulating factor, correlating with alpha-tocopherol and inflammation molecules.
Article
Chemistry, Multidisciplinary
Xinhao Yan, Wenjie Lin, Huan Liu, Wendan Pu, Junhong Li, Peng Wu, Jun Ding, Gaoxing Luo, Jianxiang Zhang
Summary: The OVE-based nanoprobes can effectively detect inflammation and oxidative stress, offering a highly sensitive imaging method. By combining with different fluorophores, OVE can generate luminescence systems with emission wavelengths ranging from blue to near-infrared light, providing guidance for the progression of various diseases.
Review
Biochemistry & Molecular Biology
Thi Thuy Uyen Nguyen, Ji-hyun Yeom, Won Kim
Summary: Vitamin E supplementation significantly decreased inflammation and oxidative stress biomarkers in adult patients receiving hemodialysis, suggesting that it may help alleviate endothelial dysfunction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Teodora-Irina Adam-Bonci, Eduard-Alexandru Bonci, Alina-Elena Parvu, Andrei-Ioan Herdean, Augustin Mot, Marian Taulescu, Andrei Ungur, Raluca-Maria Pop, Corina Bocsan, Alexandru Irimie
Summary: The study showed that oral vitamin D supplementation can reduce oxidative forces and increase antioxidant capacity, while also exhibiting anti-inflammatory effects to protect against acute airway inflammation related to oxidative stress processes induced by ovalbumin.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Francesco Violi, Cristina Nocella, Lorenzo Loffredo, Roberto Carnevale, Pasquale Pignatelli
Summary: Vitamin E possesses antioxidant and anti-inflammatory properties that have an impact on atherosclerosis and thrombus formation, but intervention trials have yielded negative results.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Elham Moslemi, Vali Musazadeh, Zeynab Kavyani, Navid Naghsh, Seyyed Morteza Seyyed Shoura, Parvin Dehghan
Summary: This umbrella meta-analysis summarized existing systematic reviews and meta-analyses of clinical trials on vitamin D supplementation. The findings revealed that vitamin D supplementation significantly reduced serum levels of CRP, TNF-alpha, and MDA, but did not show significant changes in IL-6, TAC, and GSH. Vitamin D could be considered as an adjuvant therapy for relieving inflammation and oxidative stress.
PHARMACOLOGICAL RESEARCH
(2022)
Review
Nutrition & Dietetics
Dongli Xie, Jianchen Hu, Zhenhua Yang, Tong Wu, Wei Xu, Qingyang Meng, Kangli Cao, Xiaogang Luo
Summary: Supplementation of vitamin E can effectively reduce oxidative stress and inflammatory responses induced by nanomaterials, providing a cost-effective option for prevention.
Article
Immunology
Hong-Qian Wang, Meng-Xue Zhao, Shao-Cheng Hong, Xue He, Li Tao, Cheng-Cheng Tong, Jing Guan, De-Xiang Xu, Xi Chen
Summary: By up-regulating HMGCS2, 1,25(OH)2D3 protects against oxidative stress and inflammation in experimental colitis. These findings offer a potential therapeutic strategy for alleviating colitis-associated oxidative stress and inflammation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Nanoscience & Nanotechnology
Qiong Zhang
Summary: The study demonstrates that Rg1 exerts antioxidant and anti-inflammatory effects in eccentric exercise-induced muscle damage by suppressing the NF-KB signaling pathway.
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
(2023)
Article
Sport Sciences
Josh Thorley, Craig Thomas, Stephen J. Bailey, Neil R. W. Martin, Nicolette C. Bishop, Tom Clifford
Summary: This study examined the impact of eccentric exercise on NRF2 activity in PBMCs. The results showed that eccentric exercise increased NRF2/ARE binding in PBMCs compared to resting.
JOURNAL OF SPORTS SCIENCES
(2023)
Review
Food Science & Technology
Katieli Santos de Lima, Felipe Barreto Schuch, Natiele Camponogara Righi, Patricia Chagas, Mireli Hemann Lamberti, Gustavo Orione Puntel, Antonio Marcos Vargas da Silva, Luis Ulisses Signori
Summary: The combined supplementation of vitamins C and E can alleviate oxidative stress, inflammatory response, and muscle damage following exercise.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Medicine, Research & Experimental
Aman B. Upaganlawar, Nitu L. Wankhede, Mayur B. Kale, Mohit D. Umare, Aayush Sehgal, Sukhbir Singh, Saurabh Bhatia, Ahmed Al-Harrasi, Agnieszka Najda, Renata Nurzynska-Wierdak, Simona Bungau, Tapan Behl
Summary: Epilepsy, affecting nearly 50 million people worldwide, can be caused by genetic predisposition or acquired acute insult leading to alteration of cellular and molecular mechanisms. The imbalanced state of enhanced excitatory glutamatergic and reduced inhibitory GABAergic signaling is considered to be accountable for seizures associated damage. Neurodegeneration contributing to epileptogenesis has become increasingly appreciated, with potential intervention through vitamin E therapy in managing epilepsy.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Jing Zhang, Yuecheng Sun, Wentao Song, Anshan Shan
Summary: This study found that exposure to phoxim at low levels can cause bioaccumulation with neurotoxicity, oxidative stress, tissue damage, and abnormal nutrient metabolism. Vitamin E was found to alleviate phoxim-induced nephrotoxicity by inhibiting mitochondrial apoptosis.
Review
Food Science & Technology
Vivek Rihal, Heena Khan, Amarjot Kaur, Thakur Gurjeet Singh
Summary: Vitamin D deficiency is associated with chronic diseases such as cardiovascular and neurodegenerative diseases, diabetes, and cancer. Therapeutic approaches targeting vitamin D inadequacies and its downstream effects may delay the onset and severity of cerebrovascular disorders such as stroke and neurologic malformations.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Biotechnology & Applied Microbiology
Monique Michels, Emily Corneo, Luana Cucker, Carla Sasso Simon, Gabriel Fernandes Alves de Jesus, Carolina Michels, Kristian Madeira, Ana Paula Voytena, Marina Rossetto, Fernanda Ramlov, Danusa de Castro Damasio, Felipe Dal-Pizzol
Summary: This study evaluated the efficacy of Bifidobacterium lactis CCT 7858 in preventing antibiotic-related diarrhea and improving gastrointestinal symptoms. The results showed that this strain can reduce diarrhea and gastrointestinal symptoms.
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2023)
Article
Nutrition & Dietetics
Pauline S. Effting, Anand Thirupathi, Alexandre P. Muller, Barbara C. Pereira, Diane M. Sepa-Kishi, Luis F. B. Marqueze, Franciane T. F. Vasconcellos, Renata T. Nesi, Talita C. B. Pereira, Luiza W. Kist, Mauricio R. Bogo, Rolando B. Ceddia, Ricardo A. Pinho
Summary: This study found that ladder climbing, as a model of resistance exercise, can reverse the metabolic and inflammatory effects of high-fat diet-induced obesity in mice. The training reduced body weight, adipocyte size, improved glycemic control, and reduced inflammation in skeletal muscles.
Article
Pharmacology & Pharmacy
Daniela Pacheco dos Santos Haupenthal, Marcus Barg Resmini, Leandro Almeida Da Silva, Mateus Cardoso Colares, Laura de Roch Casagrande, Ligia Milanez Venturini, Thiago Antonio Moretti de Andrade, Fernando Russo Costa do Bomfim, Anand Thirupathi, Paulo Emilio Feuser, Felipe Dal Pizzol, Paulo Cesar Lock Silveira
Summary: This study evaluated the effects of intra-articular treatment of triamcinolone hexacetonide (TH) associated with gold nanoparticles (GNPs) in osteoarthritis. The results showed that the combined treatment with TH and GNPs can reduce pro-inflammatory cytokines, increase anti-inflammatory cytokines, improve oxidative damage in joints, and increase antioxidant levels. Additionally, the combination therapy also increases cartilage thickness and chondrocyte count, preventing the progression of the disease.
CURRENT DRUG TARGETS
(2023)
Review
Critical Care Medicine
Pedro Povoa, Luis Coelho, Felipe Dal-Pizzol, Ricard Ferrer, Angela Huttner, Andrew Conway Morris, Vandack Nobre, Paula Ramirez, Anahita Rouze, Jorge Salluh, Mervyn Singer, Daniel A. Sweeney, Antoni Torres, Grant Waterer, Andre C. Kalil
Summary: Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. Biomarkers can be used as indicators for infection, dysregulated host response, treatment response, and can aid in prognosticating patient risk. Over 250 biomarkers have been identified and evaluated, but none can accurately differentiate between sepsis and sepsis-like syndrome.
INTENSIVE CARE MEDICINE
(2023)
Article
Medicine, Research & Experimental
Heloisa de Medeiros Borges, Caroline Serafim Dagostin, Emily Corneo, Eduardo Ronconi Dondossola, Henrique Teza Bernardo, Karolyne De Pieri Pickler, Barbara da Costa Pereira, Mariane Amanda de Oliveira, Rahisa Scussel, Monique Michels, Ricardo Andrez Machado-de-Avila, Felipe Dal-Pizzol, Eduardo Pacheco Rico
Summary: Animal models have contributed significantly to the understanding of cerebral ischemia and the development of potential therapies. The zebrafish model has shown promise in modeling human diseases. This study evaluated the neuroprotective effects of minocycline using zebrafish and compared the results with other models.
Article
Microbiology
Monique Michels, Emily Corneo, Luana Bezerra Goncalves Rocha, Rodrigo Dias, Ana Paula Lorenzen Voytena, Marina Rossetto, Fernanda Ramlov, Felipe Dal-Pizzol, Gabriel Fernandes Alves Jesus
Summary: This study aimed to evaluate the potential and specificity of Microbe-Associated Molecular Patterns (MAMPs) in inflammatory and antioxidant response in NIH-3T3 fibroblast cells and wound healing process. The findings showed that MAMPs significantly promoted wound healing and exhibited specific effects in anti-inflammatory and antioxidant activities.
ARCHIVES OF MICROBIOLOGY
(2023)
Article
Neurosciences
Melina More Bertotti, Evandro Tostes Martins, Fernando Zanela Areas, Helena Dresch Vascouto, Norma Beatriz Rangel, Hiago Murilo Melo, Katia Lin, Emil Kupek, Felipe Dal Pizzol, Alexandra J. Golby, Roger Walz
Summary: The accuracy of the GCS-P score as a prognostic index for predicting hospital mortality in patients with severe traumatic brain injury was evaluated and compared with a model combining GCS, pupil response, and other prognostic factors. The results show that the GCS-P score can accurately predict the mortality of patients with severe traumatic brain injury.
ARQUIVOS DE NEURO-PSIQUIATRIA
(2023)
Review
Medicine, Research & Experimental
Tatiana Barichello, Vijayasree V. Giridharan, Carlos Henrique R. Catalao, Cristiane Ritter, Felipe Dal-Pizzol
Summary: Sepsis is a life-threatening disorder caused by an unregulated immune response to infection. This response triggers a complex process that promotes the production of inflammatory mediators, resulting in the disruption of blood-brain barrier function and the activation of glial cells. These changes lead to sepsis-associated encephalopathy, which can contribute to cognitive deterioration and increased susceptibility to cognitive decline later in life.
Article
Neurosciences
Samira S. Valvassori, Taise Possamai-Della, Jorge M. Aguiar-Geraldo, Romulo Goronci Sant'Ana, Gustavo C. Dal-Pont, Bruna Pescador, Alexandra I. Zugno, Joao Quevedo, Felipe Dal-Pizzol
Summary: The study aimed to investigate the effects of sepsis on behavioural and biochemical responses induced by m-amphetamine. Rats underwent cecal ligation and puncture surgery and were then injected with saline or m-amphetamine. The results showed that sepsis enhanced the behavioural responses to m-amphetamine, induced inflammatory response, and altered neurotrophic factors in the brain.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2023)
Article
Environmental Sciences
Ramiro Doyenart, Daniel Boeira, Yuri Pinheiro Milhomens, Vitoria Oliveira Silva da Silva, Gislaine Zilli Reus, Paulo Cesar Lock Silveira, Luciano Acordi da Silva
Summary: The study examined the effects of aquatic exercise on functional autonomy, mental health, and oxidative dysfunction in elderly DM2 patients. A total of 130 elderly individuals were included and divided into non-diabetic and diabetic groups. Both groups participated in 24 sessions of Hydro-HIIT, and changes in various parameters were measured. The intervention resulted in improvements in functional autonomy, mental health, oxidative stress, and inflammatory response in elderly DM2 patients.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL HEALTH RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Isio Carvalho de Souza, Aline Luri Takejima, Rossana Baggio Simeoni, Luize Kremer Gamba, Victoria Stadler Tasca Ribeiro, Katia Martins Foltz, Lucia de Noronha, Meila Bastos de Almeida, Jose Rocha Faria Neto, Katherine Athayde Teixeira de Carvalho, Paulo Cesar Lock da Silveira, Ricardo Aurino Pinho, Julio Cesar Francisco, Luiz Cesar Guarita-Souza
Summary: This study aimed to evaluate the effect of BMSCs and AM therapeutic strategies on tissue repair and found that AM + BMSCs could promote skin wound healing by promoting the production of new collagen through extracellular signaling.
Article
Engineering, Biomedical
Iago Carvalho Vendramini, Calue Papcke, Pedro Soares da Veiga Neto, Christiano Francisco dos Santos, Ricardo Aurino de Pinho, Eduardo Mendonca Scheeren
Summary: The study aimed to investigate the influence of pre-sarcopenia/sarcopenia on the ability of older adults to recover postural stability during balance perturbation. The results showed that older adults with pre-sarcopenia/sarcopenia required greater ankle plantarflexor activation to remain standing in response to perturbation compared to those without sarcopenia.
JOURNAL OF MEDICAL AND BIOLOGICAL ENGINEERING
(2023)
Article
Immunology
Bruna Spolador de Alencar Silva, Telmo Pereira, Luciele Guerra Minuzzi, Camila Souza Padilha, Caique Figueiredo, Tiago Olean-Oliveira, Ivete Vera Medeiros dos Santos, Ana Elisa von Ah Morano, Osmar Marchioto, Jose Procopio Jabur Ribeiro, Vanessa Ribeiro Dos Santos, Marilia Seelaender, Alexandre Abilio Teixeira, Ronaldo Vagner T. Dos Santos, Valdir de Aquino Lemos, Ana Paula Coelho Figueira Freire, Gilson Pires Dorneles, Bruna Marmett, Andre Olean-Oliveira, Marcos F. S. Teixeira, Patricia M. Seraphim, Armando Caseiro, Ricardo Aurino Pinho, Hashim Islam, Jonathan Peter Little, Karsten Krueger, Jose Cesar Rosa-Neto, Manuel-Joao Coelho-E-Silva, Fabio Santos Lira
Summary: This study aimed to evaluate the association between physical activity and immunometabolic responses in young adults after mild-to-moderate COVID-19 infection. The results showed that COVID-19 patients had lower physical activity levels and exhibited impacts on lung function, immune cell phenotype, and cytokine production.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Luis F. B. Marqueze, Amanda K. Costa, Giulia S. Pedroso, Franciane F. Vasconcellos, Bruna I. Pilger, Schellen Kindermann, Vanessa M. Andrade, Tatyana Nery, Ana C. B. Alves, Aderbal A. Silva, Stephanie R. S. Carvalhal, Matheus F. Zazula, Katya Naliwaiko, Luiz C. Fernandes, Zsolt Radak, Ricardo A. Pinho
Summary: This study investigated the effects of physical training on behavior, redox balance, and genomic stability in models of aggressive brain cancer. The results showed that moderate aerobic exercise could have a beneficial impact on GBM treatment by improving behavior and reducing genomic instability.
Article
Biotechnology & Applied Microbiology
Ana Paula Pesarico, Gabriel Fernandes Alves Jesus, Emily Corneo, Heloisa de Medeiros Borges, Karen de Vasconcelos Calixto, Michelle Lima Garcez, Tatiani Bellettini-Santos, Ana Paula Lorenzen Voytena, Marina Rossetto, Fernanda Ramlov, Felipe Dal-Pizzol, Monique Michels
Summary: This study investigates the protective effects of several Bacillus strains against LPS-induced intestinal inflammation. The results show that B. coagulans and B. amyloliquefaciens have significant protective effects against pathological changes and increased inflammatory cytokines.
JOURNAL OF APPLIED MICROBIOLOGY
(2023)