期刊
JOURNAL OF PHYSIOLOGICAL SCIENCES
卷 58, 期 7, 页码 447-458出版社
SPRINGER JAPAN KK
DOI: 10.2170/physiolsci.RP013308
关键词
model descriptive language; multiscale modeling; model sharing; physiome
类别
资金
- Global COE program
- Ministry of Education, Culture, Sports, Science and Technology of Japan [20650012, 19650072]
- Grants-in-Aid for Scientific Research [19650072, 20650012] Funding Source: KAKEN
An extensible markup language format, insilicoML (ISML), version 0.1, describing multilevel biophysical models has been developed and is available in the public domain. ISML is fully compatible with CeIIML 1.0, a model description standard developed by the UPS Physiome Project, for enhancing knowledge integration and model sharing. This article illustrates the new specifications of ISML 1.0 that largely extend the capability of ISML 0.1. ISML 1.0 can describe various types of mathematical models, including ordinary/partial differential/difference equations representing the dynamics of physiological functions and the geometry of living organisms underlying the functions. ISML 1.0 describes a model using a set of functional elements (modules), each of which can specify mathematical expressions of the module functions. Structural and logical relationships between any two modules are specified by edges, which allow modular, hierarchical, and/or network representations of the model. The role of edge relationships is enriched by key words in order for use in constructing a physiological ontology. The ontology is further improved by the traceability of history of the model's development and by linking between different ISML models stored in the model's database using meta-information. ISML 1.0 is designed to operate with a model database and integrated environments for model development and simulations for knowledge integration and discovery.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据